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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25524

FusionGeneSummary for OSBPL10_UBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: OSBPL10_UBP1
Fusion gene ID: 25524
HgeneTgene
Gene symbol

OSBPL10

UBP1

Gene ID

114884

7342

Gene nameoxysterol binding protein like 10upstream binding protein 1
SynonymsORP10|OSBP9LBP-1B|LBP-1a|LBP1A|LBP1B
Cytomap

3p23

3p22.3

Type of geneprotein-codingprotein-coding
Descriptionoxysterol-binding protein-related protein 10ORP-10OSBP-related protein 10upstream-binding protein 1transcription factor LBP-1
Modification date2018052320180523
UniProtAcc

Q9BXB5

Q9NZI7

Ensembl transtripts involved in fusion geneENST00000396556, ENST00000438237, 
ENST00000467647, 
ENST00000283629, 
ENST00000447368, ENST00000283628, 
ENST00000486388, 
Fusion gene scores* DoF score7 X 5 X 4=1402 X 2 X 2=8
# samples 72
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: OSBPL10 [Title/Abstract] AND UBP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-79-5596-01AOSBPL10chr3

32022391

-UBP1chr3

33467233

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000396556ENST00000283629OSBPL10chr3

32022391

-UBP1chr3

33467233

-
Frame-shiftENST00000396556ENST00000447368OSBPL10chr3

32022391

-UBP1chr3

33467233

-
Frame-shiftENST00000396556ENST00000283628OSBPL10chr3

32022391

-UBP1chr3

33467233

-
5CDS-intronENST00000396556ENST00000486388OSBPL10chr3

32022391

-UBP1chr3

33467233

-
Frame-shiftENST00000438237ENST00000283629OSBPL10chr3

32022391

-UBP1chr3

33467233

-
Frame-shiftENST00000438237ENST00000447368OSBPL10chr3

32022391

-UBP1chr3

33467233

-
Frame-shiftENST00000438237ENST00000283628OSBPL10chr3

32022391

-UBP1chr3

33467233

-
5CDS-intronENST00000438237ENST00000486388OSBPL10chr3

32022391

-UBP1chr3

33467233

-
intron-3CDSENST00000467647ENST00000283629OSBPL10chr3

32022391

-UBP1chr3

33467233

-
intron-3CDSENST00000467647ENST00000447368OSBPL10chr3

32022391

-UBP1chr3

33467233

-
intron-3CDSENST00000467647ENST00000283628OSBPL10chr3

32022391

-UBP1chr3

33467233

-
intron-intronENST00000467647ENST00000486388OSBPL10chr3

32022391

-UBP1chr3

33467233

-

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FusionProtFeatures for OSBPL10_UBP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OSBPL10

Q9BXB5

UBP1

Q9NZI7

Probable lipid transporter involved in lipidcountertransport between the endoplasmic reticulum and the plasmamembrane. Its ability to bind phosphatidylserine, suggests that itspecifically exchanges phosphatidylserine withphosphatidylinositol 4-phosphate (PI4P), deliveringphosphatidylserine to the plasma membrane in exchange for PI4P(PubMed:23934110) (Probable). Plays a role in negative regulationof lipid biosynthesis (PubMed:19554302). Negatively regulates APOBsecretion from hepatocytes (PubMed:19554302, PubMed:22906437).Binds cholesterol and acidic phospholipids (PubMed:22906437). Alsobinds 25-hydroxycholesterol (PubMed:17428193). Bindsphosphatidylserine (PubMed:23934110).{ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302,ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110,ECO:0000305}. Functions as a transcriptional activator in a promotercontext-dependent manner. Modulates the placental expression ofCYP11A1. Involved in regulation of the alpha-globin gene inerythroid cells. Activation of the alpha-globin promoter inerythroid cells is via synergistic interaction with TFCP2 (Bysimilarity). Involved in regulation of the alpha-globin gene inerythroid cells. Binds strongly to sequences around the HIV-1initiation site and weakly over the TATA-box. Represses HIV-1transcription by inhibiting the binding of TFIID to the TATA-box.{ECO:0000250, ECO:0000269|PubMed:10644752,ECO:0000269|PubMed:2006421, ECO:0000269|PubMed:8114710}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OSBPL10_UBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OSBPL10_UBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
OSBPL10AP2B1, ALDOA, BBS1, GBAS, MMP2, CUL1, CLINT1, KEAP1, SAP18, SRRM2, WRNIP1, CLPB, USP11, OSBPL9, ZC3H18, PGAM5, IKBKG, VAPB, VAPAUBP1TFCP2, WWP2, ELAVL1, TFAP4, WDR4, USP5, TRIM28, GLYCTK, ZNF184, JAK2, ANKRD29, PRMT6, XPO1, FOXA1, FOXC1, FOXC2, FOXD3, FOXE1, FOXN1, FOXP1, FOXP3, STK35, EVL, FAM19A3, GK, MTHFD2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OSBPL10_UBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for OSBPL10_UBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource