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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25521

FusionGeneSummary for OSBPL10_MRPL51

check button Fusion gene summary
Fusion gene informationFusion gene name: OSBPL10_MRPL51
Fusion gene ID: 25521
HgeneTgene
Gene symbol

OSBPL10

MRPL51

Gene ID

114884

51258

Gene nameoxysterol binding protein like 10mitochondrial ribosomal protein L51
SynonymsORP10|OSBP9CDA09|HSPC241|MRP64|bMRP64
Cytomap

3p23

12p13.31

Type of geneprotein-codingprotein-coding
Descriptionoxysterol-binding protein-related protein 10ORP-10OSBP-related protein 1039S ribosomal protein L51, mitochondrialL51mtMRP-L51bMRP-64mitochondrial large ribosomal subunit protein mL51mitochondrial ribosomal protein 64mitochondrial ribosomal protein bMRP64
Modification date2018052320180523
UniProtAcc

Q9BXB5

Q4U2R6

Ensembl transtripts involved in fusion geneENST00000396556, ENST00000438237, 
ENST00000467647, 
ENST00000229238, 
ENST00000543164, ENST00000543703, 
Fusion gene scores* DoF score7 X 5 X 4=1406 X 5 X 3=90
# samples 76
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OSBPL10 [Title/Abstract] AND MRPL51 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA906776OSBPL10chr3

31725260

+MRPL51chr12

6602979

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000396556ENST00000229238OSBPL10chr3

31725260

+MRPL51chr12

6602979

-
intron-5UTRENST00000396556ENST00000543164OSBPL10chr3

31725260

+MRPL51chr12

6602979

-
intron-5UTRENST00000396556ENST00000543703OSBPL10chr3

31725260

+MRPL51chr12

6602979

-
intron-intronENST00000438237ENST00000229238OSBPL10chr3

31725260

+MRPL51chr12

6602979

-
intron-5UTRENST00000438237ENST00000543164OSBPL10chr3

31725260

+MRPL51chr12

6602979

-
intron-5UTRENST00000438237ENST00000543703OSBPL10chr3

31725260

+MRPL51chr12

6602979

-
intron-intronENST00000467647ENST00000229238OSBPL10chr3

31725260

+MRPL51chr12

6602979

-
intron-5UTRENST00000467647ENST00000543164OSBPL10chr3

31725260

+MRPL51chr12

6602979

-
intron-5UTRENST00000467647ENST00000543703OSBPL10chr3

31725260

+MRPL51chr12

6602979

-

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FusionProtFeatures for OSBPL10_MRPL51


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OSBPL10

Q9BXB5

MRPL51

Q4U2R6

Probable lipid transporter involved in lipidcountertransport between the endoplasmic reticulum and the plasmamembrane. Its ability to bind phosphatidylserine, suggests that itspecifically exchanges phosphatidylserine withphosphatidylinositol 4-phosphate (PI4P), deliveringphosphatidylserine to the plasma membrane in exchange for PI4P(PubMed:23934110) (Probable). Plays a role in negative regulationof lipid biosynthesis (PubMed:19554302). Negatively regulates APOBsecretion from hepatocytes (PubMed:19554302, PubMed:22906437).Binds cholesterol and acidic phospholipids (PubMed:22906437). Alsobinds 25-hydroxycholesterol (PubMed:17428193). Bindsphosphatidylserine (PubMed:23934110).{ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302,ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110,ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OSBPL10_MRPL51


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OSBPL10_MRPL51


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OSBPL10_MRPL51


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for OSBPL10_MRPL51


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource