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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25519

FusionGeneSummary for OSBPL10_FOS

check button Fusion gene summary
Fusion gene informationFusion gene name: OSBPL10_FOS
Fusion gene ID: 25519
HgeneTgene
Gene symbol

OSBPL10

FOS

Gene ID

114884

2353

Gene nameoxysterol binding protein like 10Fos proto-oncogene, AP-1 transcription factor subunit
SynonymsORP10|OSBP9AP-1|C-FOS|p55
Cytomap

3p23

14q24.3

Type of geneprotein-codingprotein-coding
Descriptionoxysterol-binding protein-related protein 10ORP-10OSBP-related protein 10proto-oncogene c-FosFBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)FBJ murine osteosarcoma viral oncogene homologFos proto-oncogene, AP-1 trancription factor subunitG0/G1 switch regulatory protein 7activator protein 1cellular o
Modification date2018052320180523
UniProtAcc

Q9BXB5

P01100

Ensembl transtripts involved in fusion geneENST00000396556, ENST00000438237, 
ENST00000467647, 		ENST00000303562, 
ENST00000554617, ENST00000556324, 
ENST00000535987, ENST00000555242, 
ENST00000555686, ENST00000555347, 
Fusion gene scores* DoF score7 X 5 X 4=1404 X 7 X 2=56
# samples 77
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/56*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: OSBPL10 [Title/Abstract] AND FOS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFOS

GO:0007179

transforming growth factor beta receptor signaling pathway

9732876

TgeneFOS

GO:0034614

cellular response to reactive oxygen species

17217916

TgeneFOS

GO:0045893

positive regulation of transcription, DNA-templated

9732876

TgeneFOS

GO:0045944

positive regulation of transcription by RNA polymerase II

10508860

TgeneFOS

GO:0060395

SMAD protein signal transduction

9732876


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW939698OSBPL10chr3

31871532

-FOSchr14

75748373

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000396556ENST00000303562OSBPL10chr3

31871532

-FOSchr14

75748373

+
5CDS-intronENST00000396556ENST00000554617OSBPL10chr3

31871532

-FOSchr14

75748373

+
5CDS-intronENST00000396556ENST00000556324OSBPL10chr3

31871532

-FOSchr14

75748373

+
5CDS-intronENST00000396556ENST00000535987OSBPL10chr3

31871532

-FOSchr14

75748373

+
5CDS-intronENST00000396556ENST00000555242OSBPL10chr3

31871532

-FOSchr14

75748373

+
5CDS-3UTRENST00000396556ENST00000555686OSBPL10chr3

31871532

-FOSchr14

75748373

+
5CDS-intronENST00000396556ENST00000555347OSBPL10chr3

31871532

-FOSchr14

75748373

+
intron-3UTRENST00000438237ENST00000303562OSBPL10chr3

31871532

-FOSchr14

75748373

+
intron-intronENST00000438237ENST00000554617OSBPL10chr3

31871532

-FOSchr14

75748373

+
intron-intronENST00000438237ENST00000556324OSBPL10chr3

31871532

-FOSchr14

75748373

+
intron-intronENST00000438237ENST00000535987OSBPL10chr3

31871532

-FOSchr14

75748373

+
intron-intronENST00000438237ENST00000555242OSBPL10chr3

31871532

-FOSchr14

75748373

+
intron-3UTRENST00000438237ENST00000555686OSBPL10chr3

31871532

-FOSchr14

75748373

+
intron-intronENST00000438237ENST00000555347OSBPL10chr3

31871532

-FOSchr14

75748373

+
5UTR-3UTRENST00000467647ENST00000303562OSBPL10chr3

31871532

-FOSchr14

75748373

+
5UTR-intronENST00000467647ENST00000554617OSBPL10chr3

31871532

-FOSchr14

75748373

+
5UTR-intronENST00000467647ENST00000556324OSBPL10chr3

31871532

-FOSchr14

75748373

+
5UTR-intronENST00000467647ENST00000535987OSBPL10chr3

31871532

-FOSchr14

75748373

+
5UTR-intronENST00000467647ENST00000555242OSBPL10chr3

31871532

-FOSchr14

75748373

+
5UTR-3UTRENST00000467647ENST00000555686OSBPL10chr3

31871532

-FOSchr14

75748373

+
5UTR-intronENST00000467647ENST00000555347OSBPL10chr3

31871532

-FOSchr14

75748373

+

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FusionProtFeatures for OSBPL10_FOS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OSBPL10

Q9BXB5

FOS

P01100

Probable lipid transporter involved in lipidcountertransport between the endoplasmic reticulum and the plasmamembrane. Its ability to bind phosphatidylserine, suggests that itspecifically exchanges phosphatidylserine withphosphatidylinositol 4-phosphate (PI4P), deliveringphosphatidylserine to the plasma membrane in exchange for PI4P(PubMed:23934110) (Probable). Plays a role in negative regulationof lipid biosynthesis (PubMed:19554302). Negatively regulates APOBsecretion from hepatocytes (PubMed:19554302, PubMed:22906437).Binds cholesterol and acidic phospholipids (PubMed:22906437). Alsobinds 25-hydroxycholesterol (PubMed:17428193). Bindsphosphatidylserine (PubMed:23934110).{ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302,ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110,ECO:0000305}. Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor.In the heterodimer, FOS and JUN/AP-1 basic regions each seems tointeract with symmetrical DNA half sites. On TGF-beta activation,forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has acritical function in regulating the development of cells destinedto form and maintain the skeleton. It is thought to have animportant role in signal transduction, cell proliferation anddifferentiation. In growing cells, activates phospholipidsynthesis, possibly by activating CDS1 and PI4K2A. This activityrequires Tyr-dephosphorylation and association with theendoplasmic reticulum. {ECO:0000269|PubMed:16055710,ECO:0000269|PubMed:17160021, ECO:0000269|PubMed:22105363,ECO:0000269|PubMed:7588633, ECO:0000269|PubMed:9732876}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OSBPL10_FOS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OSBPL10_FOS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OSBPL10_FOS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFOSP01100DB08813NadroparinProto-oncogene c-Fossmall moleculeapproved|investigational

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RelatedDiseases for OSBPL10_FOS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFOSC0036572Seizures4CTD_human
TgeneFOSC0038220Status Epilepticus4CTD_human
TgeneFOSC0038587Substance Withdrawal Syndrome3CTD_human
TgeneFOSC0236736Cocaine-Related Disorders3CTD_human
TgeneFOSC0020538Hypertensive disease2CTD_human
TgeneFOSC0003469Anxiety Disorders1CTD_human
TgeneFOSC0011570Mental Depression1PSYGENET
TgeneFOSC0011581Depressive disorder1PSYGENET
TgeneFOSC0014175Endometriosis1CTD_human
TgeneFOSC0014544Epilepsy1CTD_human
TgeneFOSC0016063Osteitis Fibrosa Disseminata1CTD_human
TgeneFOSC0018843Heat Stroke1CTD_human
TgeneFOSC0019080Hemorrhage1CTD_human
TgeneFOSC0020429Hyperalgesia1CTD_human
TgeneFOSC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneFOSC0024121Lung Neoplasms1CTD_human
TgeneFOSC0027765nervous system disorder1CTD_human
TgeneFOSC0035126Reperfusion Injury1CTD_human
TgeneFOSC0040997Trigeminal Neuralgia1CTD_human
TgeneFOSC0041696Unipolar Depression1PSYGENET
TgeneFOSC0235032Neurotoxicity Syndromes1CTD_human
TgeneFOSC0236733Amphetamine-Related Disorders1CTD_human
TgeneFOSC0270458Severe major depression with psychotic features1PSYGENET
TgeneFOSC0424295Hyperactive behavior1CTD_human
TgeneFOSC0740392Infarction, Middle Cerebral Artery1CTD_human
TgeneFOSC0743072Depression, psychotic1PSYGENET
TgeneFOSC1269683Major Depressive Disorder1PSYGENET
TgeneFOSC1458155Mammary Neoplasms1CTD_human
TgeneFOSC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgeneFOSC2239176Liver carcinoma1CTD_human
TgeneFOSC3495559Juvenile arthritis1CTD_human