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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 25478

FusionGeneSummary for ORC4_MAPK4

check button Fusion gene summary
Fusion gene informationFusion gene name: ORC4_MAPK4
Fusion gene ID: 25478
HgeneTgene
Gene symbol

ORC4

MAPK4

Gene ID

5000

5596

Gene nameorigin recognition complex subunit 4mitogen-activated protein kinase 4
SynonymsORC4L|ORC4PERK-4|ERK4|PRKM4|p63-MAPK|p63MAPK
Cytomap

2q23.1

18q21.1-q21.2

Type of geneprotein-codingprotein-coding
Descriptionorigin recognition complex subunit 4origin recognition complex, subunit 4 homologmitogen-activated protein kinase 4Erk3-relatedMAP kinase isoform p63MAPK 4extracellular signal-regulated kinase 4
Modification date2018052320180523
UniProtAcc

O43929

P31152

Ensembl transtripts involved in fusion geneENST00000392857, ENST00000392858, 
ENST00000535373, ENST00000536575, 
ENST00000540442, ENST00000264169, 
ENST00000542387, ENST00000488761, 
ENST00000400384, ENST00000540640, 
ENST00000592595, ENST00000588540, 
ENST00000587823, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: ORC4 [Title/Abstract] AND MAPK4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-EE-A2GU-06AORC4chr2

148709942

-MAPK4chr18

48255528

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000392857ENST00000400384ORC4chr2

148709942

-MAPK4chr18

48255528

+
Frame-shiftENST00000392857ENST00000540640ORC4chr2

148709942

-MAPK4chr18

48255528

+
Frame-shiftENST00000392857ENST00000592595ORC4chr2

148709942

-MAPK4chr18

48255528

+
5CDS-intronENST00000392857ENST00000588540ORC4chr2

148709942

-MAPK4chr18

48255528

+
5CDS-intronENST00000392857ENST00000587823ORC4chr2

148709942

-MAPK4chr18

48255528

+
Frame-shiftENST00000392858ENST00000400384ORC4chr2

148709942

-MAPK4chr18

48255528

+
In-frameENST00000392858ENST00000540640ORC4chr2

148709942

-MAPK4chr18

48255528

+
In-frameENST00000392858ENST00000592595ORC4chr2

148709942

-MAPK4chr18

48255528

+
5CDS-intronENST00000392858ENST00000588540ORC4chr2

148709942

-MAPK4chr18

48255528

+
5CDS-intronENST00000392858ENST00000587823ORC4chr2

148709942

-MAPK4chr18

48255528

+
Frame-shiftENST00000535373ENST00000400384ORC4chr2

148709942

-MAPK4chr18

48255528

+
In-frameENST00000535373ENST00000540640ORC4chr2

148709942

-MAPK4chr18

48255528

+
In-frameENST00000535373ENST00000592595ORC4chr2

148709942

-MAPK4chr18

48255528

+
5CDS-intronENST00000535373ENST00000588540ORC4chr2

148709942

-MAPK4chr18

48255528

+
5CDS-intronENST00000535373ENST00000587823ORC4chr2

148709942

-MAPK4chr18

48255528

+
In-frameENST00000536575ENST00000400384ORC4chr2

148709942

-MAPK4chr18

48255528

+
Frame-shiftENST00000536575ENST00000540640ORC4chr2

148709942

-MAPK4chr18

48255528

+
Frame-shiftENST00000536575ENST00000592595ORC4chr2

148709942

-MAPK4chr18

48255528

+
5CDS-intronENST00000536575ENST00000588540ORC4chr2

148709942

-MAPK4chr18

48255528

+
5CDS-intronENST00000536575ENST00000587823ORC4chr2

148709942

-MAPK4chr18

48255528

+
In-frameENST00000540442ENST00000400384ORC4chr2

148709942

-MAPK4chr18

48255528

+
Frame-shiftENST00000540442ENST00000540640ORC4chr2

148709942

-MAPK4chr18

48255528

+
Frame-shiftENST00000540442ENST00000592595ORC4chr2

148709942

-MAPK4chr18

48255528

+
5CDS-intronENST00000540442ENST00000588540ORC4chr2

148709942

-MAPK4chr18

48255528

+
5CDS-intronENST00000540442ENST00000587823ORC4chr2

148709942

-MAPK4chr18

48255528

+
Frame-shiftENST00000264169ENST00000400384ORC4chr2

148709942

-MAPK4chr18

48255528

+
In-frameENST00000264169ENST00000540640ORC4chr2

148709942

-MAPK4chr18

48255528

+
In-frameENST00000264169ENST00000592595ORC4chr2

148709942

-MAPK4chr18

48255528

+
5CDS-intronENST00000264169ENST00000588540ORC4chr2

148709942

-MAPK4chr18

48255528

+
5CDS-intronENST00000264169ENST00000587823ORC4chr2

148709942

-MAPK4chr18

48255528

+
intron-3CDSENST00000542387ENST00000400384ORC4chr2

148709942

-MAPK4chr18

48255528

+
intron-3CDSENST00000542387ENST00000540640ORC4chr2

148709942

-MAPK4chr18

48255528

+
intron-3CDSENST00000542387ENST00000592595ORC4chr2

148709942

-MAPK4chr18

48255528

+
intron-intronENST00000542387ENST00000588540ORC4chr2

148709942

-MAPK4chr18

48255528

+
intron-intronENST00000542387ENST00000587823ORC4chr2

148709942

-MAPK4chr18

48255528

+
intron-3CDSENST00000488761ENST00000400384ORC4chr2

148709942

-MAPK4chr18

48255528

+
intron-3CDSENST00000488761ENST00000540640ORC4chr2

148709942

-MAPK4chr18

48255528

+
intron-3CDSENST00000488761ENST00000592595ORC4chr2

148709942

-MAPK4chr18

48255528

+
intron-intronENST00000488761ENST00000588540ORC4chr2

148709942

-MAPK4chr18

48255528

+
intron-intronENST00000488761ENST00000587823ORC4chr2

148709942

-MAPK4chr18

48255528

+

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FusionProtFeatures for ORC4_MAPK4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ORC4

O43929

MAPK4

P31152

Component of the origin recognition complex (ORC) thatbinds origins of replication. DNA-binding is ATP-dependent. Thespecific DNA sequences that define origins of replication have notbeen identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Bindshistone H3 and H4 trimethylation marks H3K9me3, H3K27me3 andH4K20me3. {ECO:0000269|PubMed:22427655}. Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of thecomplex formed with MAPKAPK5 is still unclear, but the complexfollows a complex set of phosphorylation events: upon interactionwith atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186and then mediates phosphorylation and activation of MAPKAPK5,which in turn phosphorylates ERK4/MAPK4. May promote entry in thecell cycle (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneORC4chr2:148709942chr18:48255528ENST00000264169-81467_74196437Nucleotide bindingATP
HgeneORC4chr2:148709942chr18:48255528ENST00000392857-81467_74196437Nucleotide bindingATP
HgeneORC4chr2:148709942chr18:48255528ENST00000392858-81467_74196437Nucleotide bindingATP
HgeneORC4chr2:148709942chr18:48255528ENST00000535373-91567_74196437Nucleotide bindingATP
HgeneORC4chr2:148709942chr18:48255528ENST00000536575-51167_74112353Nucleotide bindingATP
HgeneORC4chr2:148709942chr18:48255528ENST00000540442-71367_74122363Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMAPK4chr2:148709942chr18:48255528ENST00000400384+4620_312355588DomainProtein kinase
TgeneMAPK4chr2:148709942chr18:48255528ENST00000400384+46186_188355588MotifNote=SEG motif
TgeneMAPK4chr2:148709942chr18:48255528ENST00000400384+46328_333355588MotifNote=FRIEDE motif
TgeneMAPK4chr2:148709942chr18:48255528ENST00000400384+4626_34355588Nucleotide bindingATP


Top

FusionGeneSequence for ORC4_MAPK4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ORC4_ENST00000392857_chr2_148709942_-_MAPK4_ENST00000400384_chr18_48255528_+_428aa
MSSRKSKSNSLIHTECLSQVQRILRERFCRQSPHSNLFGVQVQYKHLSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEV
SENVLQVHLNGLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDIS
QSAQTPIAVIGLTCRLVPCEPVVGPGVAAXPVPGRQRGTARPARGFGATGXGRAGGPAQGLAQQLRALPRAVALVHGARLRGRLRALLRL
QGGVAVLPGQAAVARQQAAPLLGAQAHPGPVALEAGGRRAPHGHGAGGHGGARGRAGQPLPGDRAVGQEHAGRPRARQPARRRPRAPLVC

>In-frame_ORC4_ENST00000392858_chr2_148709942_-_MAPK4_ENST00000540640_chr18_48255528_+_428aa
MSSRKSKSNSLIHTECLSQVQRILRERFCRQSPHSNLFGVQVQYKHLSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEV
SENVLQVHLNGLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDIS
QSAQTPIAVIGLTCRLVPCEPVVGPGVAAXPVPGRQRGTARPARGFGATGXGRAGGPAQGLAQQLRALPRAVALVHGARLRGRLRALLRL
QGGVAVLPGQAAVARQQAAPLLGAQAHPGPVALEAGGRRAPHGHGAGGHGGARGRAGQPLPGDRAVGQEHAGRPRARQPARRRPRAPLVC

>In-frame_ORC4_ENST00000392858_chr2_148709942_-_MAPK4_ENST00000592595_chr18_48255528_+_199aa
MSSRKSKSNSLIHTECLSQVQRILRERFCRQSPHSNLFGVQVQYKHLSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEV
SENVLQVHLNGLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDIS

>In-frame_ORC4_ENST00000535373_chr2_148709942_-_MAPK4_ENST00000540640_chr18_48255528_+_428aa
MSSRKSKSNSLIHTECLSQVQRILRERFCRQSPHSNLFGVQVQYKHLSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEV
SENVLQVHLNGLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDIS
QSAQTPIAVIGLTCRLVPCEPVVGPGVAAXPVPGRQRGTARPARGFGATGXGRAGGPAQGLAQQLRALPRAVALVHGARLRGRLRALLRL
QGGVAVLPGQAAVARQQAAPLLGAQAHPGPVALEAGGRRAPHGHGAGGHGGARGRAGQPLPGDRAVGQEHAGRPRARQPARRRPRAPLVC

>In-frame_ORC4_ENST00000535373_chr2_148709942_-_MAPK4_ENST00000592595_chr18_48255528_+_199aa
MSSRKSKSNSLIHTECLSQVQRILRERFCRQSPHSNLFGVQVQYKHLSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEV
SENVLQVHLNGLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDIS

>In-frame_ORC4_ENST00000536575_chr2_148709942_-_MAPK4_ENST00000400384_chr18_48255528_+_344aa
MEIEEVSENVLQVHLNGLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLY
NLFDISQSAQTPIAVIGLTCRLVPCEPVVGPGVAAXPVPGRQRGTARPARGFGATGXGRAGGPAQGLAQQLRALPRAVALVHGARLRGRL
RALLRLQGGVAVLPGQAAVARQQAAPLLGAQAHPGPVALEAGGRRAPHGHGAGGHGGARGRAGQPLPGDRAVGQEHAGRPRARQPARRRP

>In-frame_ORC4_ENST00000540442_chr2_148709942_-_MAPK4_ENST00000400384_chr18_48255528_+_354aa
MLINHALKELMEIEEVSENVLQVHLNGLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLF
AHHKNQTLLYNLFDISQSAQTPIAVIGLTCRLVPCEPVVGPGVAAXPVPGRQRGTARPARGFGATGXGRAGGPAQGLAQQLRALPRAVAL
VHGARLRGRLRALLRLQGGVAVLPGQAAVARQQAAPLLGAQAHPGPVALEAGGRRAPHGHGAGGHGGARGRAGQPLPGDRAVGQEHAGRP

>In-frame_ORC4_ENST00000264169_chr2_148709942_-_MAPK4_ENST00000540640_chr18_48255528_+_428aa
MSSRKSKSNSLIHTECLSQVQRILRERFCRQSPHSNLFGVQVQYKHLSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEV
SENVLQVHLNGLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDIS
QSAQTPIAVIGLTCRLVPCEPVVGPGVAAXPVPGRQRGTARPARGFGATGXGRAGGPAQGLAQQLRALPRAVALVHGARLRGRLRALLRL
QGGVAVLPGQAAVARQQAAPLLGAQAHPGPVALEAGGRRAPHGHGAGGHGGARGRAGQPLPGDRAVGQEHAGRPRARQPARRRPRAPLVC

>In-frame_ORC4_ENST00000264169_chr2_148709942_-_MAPK4_ENST00000592595_chr18_48255528_+_199aa
MSSRKSKSNSLIHTECLSQVQRILRERFCRQSPHSNLFGVQVQYKHLSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEV
SENVLQVHLNGLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDIS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ORC4_ENST00000392857_chr2_148709942_-_MAPK4_ENST00000400384_chr18_48255528_+_1285nt
ATGAGCAGTCGTAAATCAAAGAGTAACAGCTTAATTCACACAGAGTGCCTTTCACAGGTACAAAGAATTTTACGTGAAAGATTTTGTCGT
CAGAGTCCACATAGTAACCTATTTGGAGTGCAAGTACAATACAAACACTTAAGTGAGCTGCTGAAAAGAACTGCTCTCCATGGAGAGAGT
AACTCTGTCCTTATTATCGGACCCCGAGGATCAGGAAAAACTATGTTAATAAATCATGCTTTGAAAGAACTCATGGAAATAGAAGAAGTG
AGTGAAAATGTATTACAAGTTCACTTAAATGGACTGCTGCAGATCAATGACAAAATCGCCCTAAAGGAAATCACAAGGCAGTTAAATCTG
GAAAATGTAGTTGGAGATAAAGTTTTTGGAAGCTTTGCTGAAAACCTTTCATTTCTTCTGGAAGCTTTAAAAAAAGGTGACCGAACTAGC
AGTTGCCCAGTGATCTTCATATTAGATGAATTTGATCTTTTTGCTCATCATAAAAACCAAACACTTCTCTATAATCTTTTTGACATTTCT
CAGTCTGCACAGACCCCAATAGCAGTTATTGGTCTTACATGTAGATTGGTACCCTGTGAGCCTGTCGTCGGACCTGGAGTGGCGGCCTGA
CCGGTGCCAGGACGCCAGCGAGGTACAGCGCGACCCGCGCGCGGGTTCGGCGCCACTGGCTGAGGACGTGCAGGTGGACCCGCGCAAGGA
CTCGCACAGCAGCTCCGAGCGCTTCCTAGAGCAGTCGCACTCGTCCATGGAGCGCGCCTTCGAGGCCGACTACGGGCGCTCCTGCGACTA
CAAGGTGGGGTCGCCGTCCTACCTGGACAAGCTGCTGTGGCGCGACAACAAGCCGCACCACTACTCGGAGCCCAAGCTCATCCTGGACCT
GTCGCACTGGAAGCAGGCGGCCGGCGCGCCCCCCACGGCCACGGGGCTGGCGGACACGGGGGCGCGCGAGGACGAGCCGGCCAGCCTCTT
CCTGGAGATCGCGCAGTGGGTCAAGAGCACGCAGGGCGGCCCAGAGCACGCCAGCCCGCCCGCCGACGACCCCGAGCGCCGCTTGTCTGC
CTCGCCCCCCGGCCGCCCGGCCCCGGTGGACGGCGGCGCCAGCCCCCAGTTCGACCTGGACGTGTTCATCTCCCGCGCCCTGAAGCTCTG
CACCAAGCCCGAGGACCTGCCGGACAATAAACTGGGCGACCTCAATGGTGCGTGCATCCCCGAGCACCCTGGCGACCTCGTGCAGACCGA

>In-frame_ORC4_ENST00000392858_chr2_148709942_-_MAPK4_ENST00000540640_chr18_48255528_+_1285nt
ATGAGCAGTCGTAAATCAAAGAGTAACAGCTTAATTCACACAGAGTGCCTTTCACAGGTACAAAGAATTTTACGTGAAAGATTTTGTCGT
CAGAGTCCACATAGTAACCTATTTGGAGTGCAAGTACAATACAAACACTTAAGTGAGCTGCTGAAAAGAACTGCTCTCCATGGAGAGAGT
AACTCTGTCCTTATTATCGGACCCCGAGGATCAGGAAAAACTATGTTAATAAATCATGCTTTGAAAGAACTCATGGAAATAGAAGAAGTG
AGTGAAAATGTATTACAAGTTCACTTAAATGGACTGCTGCAGATCAATGACAAAATCGCCCTAAAGGAAATCACAAGGCAGTTAAATCTG
GAAAATGTAGTTGGAGATAAAGTTTTTGGAAGCTTTGCTGAAAACCTTTCATTTCTTCTGGAAGCTTTAAAAAAAGGTGACCGAACTAGC
AGTTGCCCAGTGATCTTCATATTAGATGAATTTGATCTTTTTGCTCATCATAAAAACCAAACACTTCTCTATAATCTTTTTGACATTTCT
CAGTCTGCACAGACCCCAATAGCAGTTATTGGTCTTACATGTAGATTGGTACCCTGTGAGCCTGTCGTCGGACCTGGAGTGGCGGCCTGA
CCGGTGCCAGGACGCCAGCGAGGTACAGCGCGACCCGCGCGCGGGTTCGGCGCCACTGGCTGAGGACGTGCAGGTGGACCCGCGCAAGGA
CTCGCACAGCAGCTCCGAGCGCTTCCTAGAGCAGTCGCACTCGTCCATGGAGCGCGCCTTCGAGGCCGACTACGGGCGCTCCTGCGACTA
CAAGGTGGGGTCGCCGTCCTACCTGGACAAGCTGCTGTGGCGCGACAACAAGCCGCACCACTACTCGGAGCCCAAGCTCATCCTGGACCT
GTCGCACTGGAAGCAGGCGGCCGGCGCGCCCCCCACGGCCACGGGGCTGGCGGACACGGGGGCGCGCGAGGACGAGCCGGCCAGCCTCTT
CCTGGAGATCGCGCAGTGGGTCAAGAGCACGCAGGGCGGCCCAGAGCACGCCAGCCCGCCCGCCGACGACCCCGAGCGCCGCTTGTCTGC
CTCGCCCCCCGGCCGCCCGGCCCCGGTGGACGGCGGCGCCAGCCCCCAGTTCGACCTGGACGTGTTCATCTCCCGCGCCCTGAAGCTCTG
CACCAAGCCCGAGGACCTGCCGGACAATAAACTGGGCGACCTCAATGGTGCGTGCATCCCCGAGCACCCTGGCGACCTCGTGCAGACCGA

>In-frame_ORC4_ENST00000392858_chr2_148709942_-_MAPK4_ENST00000592595_chr18_48255528_+_599nt
ATGAGCAGTCGTAAATCAAAGAGTAACAGCTTAATTCACACAGAGTGCCTTTCACAGGTACAAAGAATTTTACGTGAAAGATTTTGTCGT
CAGAGTCCACATAGTAACCTATTTGGAGTGCAAGTACAATACAAACACTTAAGTGAGCTGCTGAAAAGAACTGCTCTCCATGGAGAGAGT
AACTCTGTCCTTATTATCGGACCCCGAGGATCAGGAAAAACTATGTTAATAAATCATGCTTTGAAAGAACTCATGGAAATAGAAGAAGTG
AGTGAAAATGTATTACAAGTTCACTTAAATGGACTGCTGCAGATCAATGACAAAATCGCCCTAAAGGAAATCACAAGGCAGTTAAATCTG
GAAAATGTAGTTGGAGATAAAGTTTTTGGAAGCTTTGCTGAAAACCTTTCATTTCTTCTGGAAGCTTTAAAAAAAGGTGACCGAACTAGC
AGTTGCCCAGTGATCTTCATATTAGATGAATTTGATCTTTTTGCTCATCATAAAAACCAAACACTTCTCTATAATCTTTTTGACATTTCT

>In-frame_ORC4_ENST00000535373_chr2_148709942_-_MAPK4_ENST00000540640_chr18_48255528_+_1285nt
ATGAGCAGTCGTAAATCAAAGAGTAACAGCTTAATTCACACAGAGTGCCTTTCACAGGTACAAAGAATTTTACGTGAAAGATTTTGTCGT
CAGAGTCCACATAGTAACCTATTTGGAGTGCAAGTACAATACAAACACTTAAGTGAGCTGCTGAAAAGAACTGCTCTCCATGGAGAGAGT
AACTCTGTCCTTATTATCGGACCCCGAGGATCAGGAAAAACTATGTTAATAAATCATGCTTTGAAAGAACTCATGGAAATAGAAGAAGTG
AGTGAAAATGTATTACAAGTTCACTTAAATGGACTGCTGCAGATCAATGACAAAATCGCCCTAAAGGAAATCACAAGGCAGTTAAATCTG
GAAAATGTAGTTGGAGATAAAGTTTTTGGAAGCTTTGCTGAAAACCTTTCATTTCTTCTGGAAGCTTTAAAAAAAGGTGACCGAACTAGC
AGTTGCCCAGTGATCTTCATATTAGATGAATTTGATCTTTTTGCTCATCATAAAAACCAAACACTTCTCTATAATCTTTTTGACATTTCT
CAGTCTGCACAGACCCCAATAGCAGTTATTGGTCTTACATGTAGATTGGTACCCTGTGAGCCTGTCGTCGGACCTGGAGTGGCGGCCTGA
CCGGTGCCAGGACGCCAGCGAGGTACAGCGCGACCCGCGCGCGGGTTCGGCGCCACTGGCTGAGGACGTGCAGGTGGACCCGCGCAAGGA
CTCGCACAGCAGCTCCGAGCGCTTCCTAGAGCAGTCGCACTCGTCCATGGAGCGCGCCTTCGAGGCCGACTACGGGCGCTCCTGCGACTA
CAAGGTGGGGTCGCCGTCCTACCTGGACAAGCTGCTGTGGCGCGACAACAAGCCGCACCACTACTCGGAGCCCAAGCTCATCCTGGACCT
GTCGCACTGGAAGCAGGCGGCCGGCGCGCCCCCCACGGCCACGGGGCTGGCGGACACGGGGGCGCGCGAGGACGAGCCGGCCAGCCTCTT
CCTGGAGATCGCGCAGTGGGTCAAGAGCACGCAGGGCGGCCCAGAGCACGCCAGCCCGCCCGCCGACGACCCCGAGCGCCGCTTGTCTGC
CTCGCCCCCCGGCCGCCCGGCCCCGGTGGACGGCGGCGCCAGCCCCCAGTTCGACCTGGACGTGTTCATCTCCCGCGCCCTGAAGCTCTG
CACCAAGCCCGAGGACCTGCCGGACAATAAACTGGGCGACCTCAATGGTGCGTGCATCCCCGAGCACCCTGGCGACCTCGTGCAGACCGA

>In-frame_ORC4_ENST00000535373_chr2_148709942_-_MAPK4_ENST00000592595_chr18_48255528_+_599nt
ATGAGCAGTCGTAAATCAAAGAGTAACAGCTTAATTCACACAGAGTGCCTTTCACAGGTACAAAGAATTTTACGTGAAAGATTTTGTCGT
CAGAGTCCACATAGTAACCTATTTGGAGTGCAAGTACAATACAAACACTTAAGTGAGCTGCTGAAAAGAACTGCTCTCCATGGAGAGAGT
AACTCTGTCCTTATTATCGGACCCCGAGGATCAGGAAAAACTATGTTAATAAATCATGCTTTGAAAGAACTCATGGAAATAGAAGAAGTG
AGTGAAAATGTATTACAAGTTCACTTAAATGGACTGCTGCAGATCAATGACAAAATCGCCCTAAAGGAAATCACAAGGCAGTTAAATCTG
GAAAATGTAGTTGGAGATAAAGTTTTTGGAAGCTTTGCTGAAAACCTTTCATTTCTTCTGGAAGCTTTAAAAAAAGGTGACCGAACTAGC
AGTTGCCCAGTGATCTTCATATTAGATGAATTTGATCTTTTTGCTCATCATAAAAACCAAACACTTCTCTATAATCTTTTTGACATTTCT

>In-frame_ORC4_ENST00000536575_chr2_148709942_-_MAPK4_ENST00000400384_chr18_48255528_+_1033nt
ATGGAAATAGAAGAAGTGAGTGAAAATGTATTACAAGTTCACTTAAATGGACTGCTGCAGATCAATGACAAAATCGCCCTAAAGGAAATC
ACAAGGCAGTTAAATCTGGAAAATGTAGTTGGAGATAAAGTTTTTGGAAGCTTTGCTGAAAACCTTTCATTTCTTCTGGAAGCTTTAAAA
AAAGGTGACCGAACTAGCAGTTGCCCAGTGATCTTCATATTAGATGAATTTGATCTTTTTGCTCATCATAAAAACCAAACACTTCTCTAT
AATCTTTTTGACATTTCTCAGTCTGCACAGACCCCAATAGCAGTTATTGGTCTTACATGTAGATTGGTACCCTGTGAGCCTGTCGTCGGA
CCTGGAGTGGCGGCCTGACCGGTGCCAGGACGCCAGCGAGGTACAGCGCGACCCGCGCGCGGGTTCGGCGCCACTGGCTGAGGACGTGCA
GGTGGACCCGCGCAAGGACTCGCACAGCAGCTCCGAGCGCTTCCTAGAGCAGTCGCACTCGTCCATGGAGCGCGCCTTCGAGGCCGACTA
CGGGCGCTCCTGCGACTACAAGGTGGGGTCGCCGTCCTACCTGGACAAGCTGCTGTGGCGCGACAACAAGCCGCACCACTACTCGGAGCC
CAAGCTCATCCTGGACCTGTCGCACTGGAAGCAGGCGGCCGGCGCGCCCCCCACGGCCACGGGGCTGGCGGACACGGGGGCGCGCGAGGA
CGAGCCGGCCAGCCTCTTCCTGGAGATCGCGCAGTGGGTCAAGAGCACGCAGGGCGGCCCAGAGCACGCCAGCCCGCCCGCCGACGACCC
CGAGCGCCGCTTGTCTGCCTCGCCCCCCGGCCGCCCGGCCCCGGTGGACGGCGGCGCCAGCCCCCAGTTCGACCTGGACGTGTTCATCTC
CCGCGCCCTGAAGCTCTGCACCAAGCCCGAGGACCTGCCGGACAATAAACTGGGCGACCTCAATGGTGCGTGCATCCCCGAGCACCCTGG

>In-frame_ORC4_ENST00000540442_chr2_148709942_-_MAPK4_ENST00000400384_chr18_48255528_+_1063nt
ATGTTAATAAATCATGCTTTGAAAGAACTCATGGAAATAGAAGAAGTGAGTGAAAATGTATTACAAGTTCACTTAAATGGACTGCTGCAG
ATCAATGACAAAATCGCCCTAAAGGAAATCACAAGGCAGTTAAATCTGGAAAATGTAGTTGGAGATAAAGTTTTTGGAAGCTTTGCTGAA
AACCTTTCATTTCTTCTGGAAGCTTTAAAAAAAGGTGACCGAACTAGCAGTTGCCCAGTGATCTTCATATTAGATGAATTTGATCTTTTT
GCTCATCATAAAAACCAAACACTTCTCTATAATCTTTTTGACATTTCTCAGTCTGCACAGACCCCAATAGCAGTTATTGGTCTTACATGT
AGATTGGTACCCTGTGAGCCTGTCGTCGGACCTGGAGTGGCGGCCTGACCGGTGCCAGGACGCCAGCGAGGTACAGCGCGACCCGCGCGC
GGGTTCGGCGCCACTGGCTGAGGACGTGCAGGTGGACCCGCGCAAGGACTCGCACAGCAGCTCCGAGCGCTTCCTAGAGCAGTCGCACTC
GTCCATGGAGCGCGCCTTCGAGGCCGACTACGGGCGCTCCTGCGACTACAAGGTGGGGTCGCCGTCCTACCTGGACAAGCTGCTGTGGCG
CGACAACAAGCCGCACCACTACTCGGAGCCCAAGCTCATCCTGGACCTGTCGCACTGGAAGCAGGCGGCCGGCGCGCCCCCCACGGCCAC
GGGGCTGGCGGACACGGGGGCGCGCGAGGACGAGCCGGCCAGCCTCTTCCTGGAGATCGCGCAGTGGGTCAAGAGCACGCAGGGCGGCCC
AGAGCACGCCAGCCCGCCCGCCGACGACCCCGAGCGCCGCTTGTCTGCCTCGCCCCCCGGCCGCCCGGCCCCGGTGGACGGCGGCGCCAG
CCCCCAGTTCGACCTGGACGTGTTCATCTCCCGCGCCCTGAAGCTCTGCACCAAGCCCGAGGACCTGCCGGACAATAAACTGGGCGACCT

>In-frame_ORC4_ENST00000264169_chr2_148709942_-_MAPK4_ENST00000540640_chr18_48255528_+_1285nt
ATGAGCAGTCGTAAATCAAAGAGTAACAGCTTAATTCACACAGAGTGCCTTTCACAGGTACAAAGAATTTTACGTGAAAGATTTTGTCGT
CAGAGTCCACATAGTAACCTATTTGGAGTGCAAGTACAATACAAACACTTAAGTGAGCTGCTGAAAAGAACTGCTCTCCATGGAGAGAGT
AACTCTGTCCTTATTATCGGACCCCGAGGATCAGGAAAAACTATGTTAATAAATCATGCTTTGAAAGAACTCATGGAAATAGAAGAAGTG
AGTGAAAATGTATTACAAGTTCACTTAAATGGACTGCTGCAGATCAATGACAAAATCGCCCTAAAGGAAATCACAAGGCAGTTAAATCTG
GAAAATGTAGTTGGAGATAAAGTTTTTGGAAGCTTTGCTGAAAACCTTTCATTTCTTCTGGAAGCTTTAAAAAAAGGTGACCGAACTAGC
AGTTGCCCAGTGATCTTCATATTAGATGAATTTGATCTTTTTGCTCATCATAAAAACCAAACACTTCTCTATAATCTTTTTGACATTTCT
CAGTCTGCACAGACCCCAATAGCAGTTATTGGTCTTACATGTAGATTGGTACCCTGTGAGCCTGTCGTCGGACCTGGAGTGGCGGCCTGA
CCGGTGCCAGGACGCCAGCGAGGTACAGCGCGACCCGCGCGCGGGTTCGGCGCCACTGGCTGAGGACGTGCAGGTGGACCCGCGCAAGGA
CTCGCACAGCAGCTCCGAGCGCTTCCTAGAGCAGTCGCACTCGTCCATGGAGCGCGCCTTCGAGGCCGACTACGGGCGCTCCTGCGACTA
CAAGGTGGGGTCGCCGTCCTACCTGGACAAGCTGCTGTGGCGCGACAACAAGCCGCACCACTACTCGGAGCCCAAGCTCATCCTGGACCT
GTCGCACTGGAAGCAGGCGGCCGGCGCGCCCCCCACGGCCACGGGGCTGGCGGACACGGGGGCGCGCGAGGACGAGCCGGCCAGCCTCTT
CCTGGAGATCGCGCAGTGGGTCAAGAGCACGCAGGGCGGCCCAGAGCACGCCAGCCCGCCCGCCGACGACCCCGAGCGCCGCTTGTCTGC
CTCGCCCCCCGGCCGCCCGGCCCCGGTGGACGGCGGCGCCAGCCCCCAGTTCGACCTGGACGTGTTCATCTCCCGCGCCCTGAAGCTCTG
CACCAAGCCCGAGGACCTGCCGGACAATAAACTGGGCGACCTCAATGGTGCGTGCATCCCCGAGCACCCTGGCGACCTCGTGCAGACCGA

>In-frame_ORC4_ENST00000264169_chr2_148709942_-_MAPK4_ENST00000592595_chr18_48255528_+_599nt
ATGAGCAGTCGTAAATCAAAGAGTAACAGCTTAATTCACACAGAGTGCCTTTCACAGGTACAAAGAATTTTACGTGAAAGATTTTGTCGT
CAGAGTCCACATAGTAACCTATTTGGAGTGCAAGTACAATACAAACACTTAAGTGAGCTGCTGAAAAGAACTGCTCTCCATGGAGAGAGT
AACTCTGTCCTTATTATCGGACCCCGAGGATCAGGAAAAACTATGTTAATAAATCATGCTTTGAAAGAACTCATGGAAATAGAAGAAGTG
AGTGAAAATGTATTACAAGTTCACTTAAATGGACTGCTGCAGATCAATGACAAAATCGCCCTAAAGGAAATCACAAGGCAGTTAAATCTG
GAAAATGTAGTTGGAGATAAAGTTTTTGGAAGCTTTGCTGAAAACCTTTCATTTCTTCTGGAAGCTTTAAAAAAAGGTGACCGAACTAGC
AGTTGCCCAGTGATCTTCATATTAGATGAATTTGATCTTTTTGCTCATCATAAAAACCAAACACTTCTCTATAATCTTTTTGACATTTCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_ORC4_ENST00000392857_chr2_148709942_-_MAPK4_ENST00000400384_chr18_48255528_+_3363nt
GTCCGCAGCGGCAGGTGAAGTCTAGCAGAGGACGCGGCCAGGCGATTCGGTGAAGCGATTCCTGCAGGCGTTGGTTCCCCTCTTTGACCT
GGATTTGAATTTGTTGAAATGAGCAGTCGTAAATCAAAGAGTAACAGCTTAATTCACACAGAGTGCCTTTCACAGGTACAAAGAATTTTA
CGTGAAAGATTTTGTCGTCAGAGTCCACATAGTAACCTATTTGGAGTGCAAGTACAATACAAACACTTAAGTGAGCTGCTGAAAAGAACT
GCTCTCCATGGAGAGAGTAACTCTGTCCTTATTATCGGACCCCGAGGATCAGGAAAAACTATGTTAATAAATCATGCTTTGAAAGAACTC
ATGGAAATAGAAGAAGTGAGTGAAAATGTATTACAAGTTCACTTAAATGGACTGCTGCAGATCAATGACAAAATCGCCCTAAAGGAAATC
ACAAGGCAGTTAAATCTGGAAAATGTAGTTGGAGATAAAGTTTTTGGAAGCTTTGCTGAAAACCTTTCATTTCTTCTGGAAGCTTTAAAA
AAAGGTGACCGAACTAGCAGTTGCCCAGTGATCTTCATATTAGATGAATTTGATCTTTTTGCTCATCATAAAAACCAAACACTTCTCTAT
AATCTTTTTGACATTTCTCAGTCTGCACAGACCCCAATAGCAGTTATTGGTCTTACATGTAGATTGGTACCCTGTGAGCCTGTCGTCGGA
CCTGGAGTGGCGGCCTGACCGGTGCCAGGACGCCAGCGAGGTACAGCGCGACCCGCGCGCGGGTTCGGCGCCACTGGCTGAGGACGTGCA
GGTGGACCCGCGCAAGGACTCGCACAGCAGCTCCGAGCGCTTCCTAGAGCAGTCGCACTCGTCCATGGAGCGCGCCTTCGAGGCCGACTA
CGGGCGCTCCTGCGACTACAAGGTGGGGTCGCCGTCCTACCTGGACAAGCTGCTGTGGCGCGACAACAAGCCGCACCACTACTCGGAGCC
CAAGCTCATCCTGGACCTGTCGCACTGGAAGCAGGCGGCCGGCGCGCCCCCCACGGCCACGGGGCTGGCGGACACGGGGGCGCGCGAGGA
CGAGCCGGCCAGCCTCTTCCTGGAGATCGCGCAGTGGGTCAAGAGCACGCAGGGCGGCCCAGAGCACGCCAGCCCGCCCGCCGACGACCC
CGAGCGCCGCTTGTCTGCCTCGCCCCCCGGCCGCCCGGCCCCGGTGGACGGCGGCGCCAGCCCCCAGTTCGACCTGGACGTGTTCATCTC
CCGCGCCCTGAAGCTCTGCACCAAGCCCGAGGACCTGCCGGACAATAAACTGGGCGACCTCAATGGTGCGTGCATCCCCGAGCACCCTGG
CGACCTCGTGCAGACCGAGGCCTTCTCCAAAGAAAGGTGGTGAGGGCGGAGGGGCCGCTCCAGGCCCCACAGAGCAGGAGACCCCCAGAG
AAAGCCGGGGCTGGCAGGAGGCGGCCGCCCTTCCCGCCCCTCTCTGCTGCCTTGGGGTTGGCAGAACACGTGAAGGATCCGAGGAGCGAG
AGGAATGTCCATTTCTTAAACTGCCTTAATAACTAGCCTTTAACCTGTGGGAGCGGGTTTGAACAGGACCCTGGCTTAGGGGTTGATCAC
TTTCCTAGCAAAGGGGAGACCACATGTGGTGCACAGGGAAGAAACGGCTTTAGACAGCAGTCTGCGGGCCCCACCTGGGTGGCAGGATGC
CGAGAAATCTTGCAGAGGTAGCTCCGAAACCATCTGGCCCAACTAGCCTCAACTGACAGCTGAGGAAAGGCAATTAGGCCCAGAGAGGCA
GAGACACTCGCTTAAGATCACAGGCTTAGTGTGAGGACGAGCTTGAAATCCCAGTCTCCTGGCCCCCAGGCCAGGGTCTGTCCACCATAG
AATGTCTTCCTCTACTGGGGTCGTTCTGGCTTTTTGTTAGAAACTTGGTCTGAGATGTTTCTTCCCTGTCCATTACCATTCGATGTTCTT
TTATTCAGAGCAATGTTTCTTGTATTCTGAAACTGGAAACTGAACCAGTTTGTTTCTCCTAGTCACCAAGCATACTTTCCTGGCTCCCCA
AGTACTTAAATGTTCTCATCTGTCGCACCCCTGTATTTGCCTCACCCCTGCATGGTCGGAAATCTTCGTTTCAGGTCAGAACAGCCTGGG
GTCTGTGGGTAAAATCAGCCCTTCTCCCAGGCCTGTGCACACACCCCCTCAGCACTCCCTATGCACTTTCCTGACACGCAAAGACACAGC
CCTCTTTCCCCACTGGGCGTCCTACCCCAGTGAGGTTGAAGGCACCAATTCCAAGAATCCCTCCAACCTCCCTGCCAGCACTCCCCCTTC
ACCCCACACCCGGCCCCCCCACCTAACCACAGCGCCTCTCCAGACCTACCTCGGGACCTAATGTTCTCTACATGAACTGCTCATTTGGAG
GACAGCAGTGAGGTCCTGCCATAGAGCAAATGTGTTAGGAGAGAAGGTTTCACATGGGACCCAACATCCTTCATCAATACTTTCCTGAGT
TTGATCATCCATTTAGCCTTGACAAACAGCAGACCCTACAGAGATGTGTTGGAGAGCACGTCGTGACCTTGGGGGCAAGGAATCCAGAAA
GGTAGGAAGATATGAAAAGAGAGGTGTCAACAGCAAGGGCTCTTAGGGGTCAGGCACCAGCATGGAGACCTCATGACAAAGGAAGGGACT
CAAAGCAGCAATGCCCCTCATAGTGTAGGCTAAGGTGAGTTTGGTGCATGCAAACCTGTGTGCTCACCCACAGAGCATGGGGTAATGGTG
TGTAGACACAGGCCCTCTGCAGAAGCGTGGGGTGGGGACACTGACAGCCCCTATCTGGTCCCCAGGAACATTCTACCATTTCTGCCACTG
GTGTTCAGCTCCTTCTCTTCCCCCAACACTCCCAAAGATACCCACAGGAAGTCCAGCCAGTTTCCAGGTAGAGGATTCCACCAGTTGGTC
TTGGGCTGCGTTCACCCTCACATCACAGCACCTTAAATCTAATCAGCAAACTATAATTTGTACGTTGAAACCTGCAACACATTAGAAACT
TATATTTAAAAACAGAATTAATCACACTGACCAACTTTTAAATGGAAAATATGTAAATAGGAAGTGTTTGGGTTTTGTTTTTTCTTTAAG
AAAAAGAAATGTACACCACTCCTCATGTGCCATTTTGTCCTCAGAGGGCGGCTTTACTTTTTTGGTAAAGGAACAAGCTGCTGGCCTTGA
CCAGGAGTTCATATATAACTGTTATTACAGAGGAATTGTTATAACTACTAATGTTTTTAAAAAATTTATTAAACATTATTAAACTTGATC

>In-frame_ORC4_ENST00000392858_chr2_148709942_-_MAPK4_ENST00000540640_chr18_48255528_+_1692nt
GGGGCATGCCGGGAGTGGTTGTGTACGGTCCGCAGCGGCAGGTGAAGTCTAGCAGAGGACGCGGCCAGGCGATTCGGTGAAGCGATTCCT
GCAGGCGTTGGTTCCCCTCTTTGACCTGGTAAATGCAGGCTTTTATGCGAGAGGATTTGAATTTGTTGAAATGAGCAGTCGTAAATCAAA
GAGTAACAGCTTAATTCACACAGAGTGCCTTTCACAGGTACAAAGAATTTTACGTGAAAGATTTTGTCGTCAGAGTCCACATAGTAACCT
ATTTGGAGTGCAAGTACAATACAAACACTTAAGTGAGCTGCTGAAAAGAACTGCTCTCCATGGAGAGAGTAACTCTGTCCTTATTATCGG
ACCCCGAGGATCAGGAAAAACTATGTTAATAAATCATGCTTTGAAAGAACTCATGGAAATAGAAGAAGTGAGTGAAAATGTATTACAAGT
TCACTTAAATGGACTGCTGCAGATCAATGACAAAATCGCCCTAAAGGAAATCACAAGGCAGTTAAATCTGGAAAATGTAGTTGGAGATAA
AGTTTTTGGAAGCTTTGCTGAAAACCTTTCATTTCTTCTGGAAGCTTTAAAAAAAGGTGACCGAACTAGCAGTTGCCCAGTGATCTTCAT
ATTAGATGAATTTGATCTTTTTGCTCATCATAAAAACCAAACACTTCTCTATAATCTTTTTGACATTTCTCAGTCTGCACAGACCCCAAT
AGCAGTTATTGGTCTTACATGTAGATTGGTACCCTGTGAGCCTGTCGTCGGACCTGGAGTGGCGGCCTGACCGGTGCCAGGACGCCAGCG
AGGTACAGCGCGACCCGCGCGCGGGTTCGGCGCCACTGGCTGAGGACGTGCAGGTGGACCCGCGCAAGGACTCGCACAGCAGCTCCGAGC
GCTTCCTAGAGCAGTCGCACTCGTCCATGGAGCGCGCCTTCGAGGCCGACTACGGGCGCTCCTGCGACTACAAGGTGGGGTCGCCGTCCT
ACCTGGACAAGCTGCTGTGGCGCGACAACAAGCCGCACCACTACTCGGAGCCCAAGCTCATCCTGGACCTGTCGCACTGGAAGCAGGCGG
CCGGCGCGCCCCCCACGGCCACGGGGCTGGCGGACACGGGGGCGCGCGAGGACGAGCCGGCCAGCCTCTTCCTGGAGATCGCGCAGTGGG
TCAAGAGCACGCAGGGCGGCCCAGAGCACGCCAGCCCGCCCGCCGACGACCCCGAGCGCCGCTTGTCTGCCTCGCCCCCCGGCCGCCCGG
CCCCGGTGGACGGCGGCGCCAGCCCCCAGTTCGACCTGGACGTGTTCATCTCCCGCGCCCTGAAGCTCTGCACCAAGCCCGAGGACCTGC
CGGACAATAAACTGGGCGACCTCAATGGTGCGTGCATCCCCGAGCACCCTGGCGACCTCGTGCAGACCGAGGCCTTCTCCAAAGAAAGGT
GGTGAGGGCGGAGGGGCCGCTCCAGGCCCCACAGAGCAGGAGACCCCCAGAGAAAGCCGGGGCTGGCAGGAGGCGGCCGCCCTTCCCGCC
CCTCTCTGCTGCCTTGGGGTTGGCAGAACACGTGAAGGATCCGAGGAGCGAGAGGAATGTCCATTTCTTAAACTGCCTTAATAACTAGCC

>In-frame_ORC4_ENST00000392858_chr2_148709942_-_MAPK4_ENST00000592595_chr18_48255528_+_3415nt
GGGGCATGCCGGGAGTGGTTGTGTACGGTCCGCAGCGGCAGGTGAAGTCTAGCAGAGGACGCGGCCAGGCGATTCGGTGAAGCGATTCCT
GCAGGCGTTGGTTCCCCTCTTTGACCTGGTAAATGCAGGCTTTTATGCGAGAGGATTTGAATTTGTTGAAATGAGCAGTCGTAAATCAAA
GAGTAACAGCTTAATTCACACAGAGTGCCTTTCACAGGTACAAAGAATTTTACGTGAAAGATTTTGTCGTCAGAGTCCACATAGTAACCT
ATTTGGAGTGCAAGTACAATACAAACACTTAAGTGAGCTGCTGAAAAGAACTGCTCTCCATGGAGAGAGTAACTCTGTCCTTATTATCGG
ACCCCGAGGATCAGGAAAAACTATGTTAATAAATCATGCTTTGAAAGAACTCATGGAAATAGAAGAAGTGAGTGAAAATGTATTACAAGT
TCACTTAAATGGACTGCTGCAGATCAATGACAAAATCGCCCTAAAGGAAATCACAAGGCAGTTAAATCTGGAAAATGTAGTTGGAGATAA
AGTTTTTGGAAGCTTTGCTGAAAACCTTTCATTTCTTCTGGAAGCTTTAAAAAAAGGTGACCGAACTAGCAGTTGCCCAGTGATCTTCAT
ATTAGATGAATTTGATCTTTTTGCTCATCATAAAAACCAAACACTTCTCTATAATCTTTTTGACATTTCTCAGTCTGCACAGACCCCAAT
AGCAGTTATTGGTCTTACATGTAGATTGGTACCCTGTGAGCCTGTCGTCGGACCTGGAGTGGCGGCCTGACCGGTGCCAGGACGCCAGCG
AGGTACAGCGCGACCCGCGCGCGGGTTCGGCGCCACTGGCTGAGGACGTGCAGGTGGACCCGCGCAAGGACTCGCACAGCAGCTCCGAGC
GCTTCCTAGAGCAGTCGCACTCGTCCATGGAGCGCGCCTTCGAGGCCGACTACGGGCGCTCCTGCGACTACAAGGTGGGGTCGCCGTCCT
ACCTGGACAAGCTGCTGTGGCGCGACAACAAGCCGCACCACTACTCGGAGCCCAAGCTCATCCTGGACCTGTCGCACTGGAAGCAGGCGG
CCGGCGCGCCCCCCACGGCCACGGGGCTGGCGGACACGGGGGCGCGCGAGGACGAGCCGGCCAGCCTCTTCCTGGAGATCGCGCAGTGGG
TCAAGAGCACGCAGGGCGGCCCAGAGCACGCCAGCCCGCCCGCCGACGACCCCGAGCGCCGCTTGTCTGCCTCGCCCCCCGGCCGCCCGG
CCCCGGTGGACGGCGGCGCCAGCCCCCAGTTCGACCTGGACGTGTTCATCTCCCGCGCCCTGAAGCTCTGCACCAAGCCCGAGGACCTGC
CGGACAATAAACTGGGCGACCTCAATGGTGCGTGCATCCCCGAGCACCCTGGCGACCTCGTGCAGACCGAGGCCTTCTCCAAAGAAAGGT
GGTGAGGGCGGAGGGGCCGCTCCAGGCCCCACAGAGCAGGAGACCCCCAGAGAAAGCCGGGGCTGGCAGGAGGCGGCCGCCCTTCCCGCC
CCTCTCTGCTGCCTTGGGGTTGGCAGAACACGTGAAGGATCCGAGGAGCGAGAGGAATGTCCATTTCTTAAACTGCCTTAATAACTAGCC
TTTAACCTGTGGGAGCGGGTTTGAACAGGACCCTGGCTTAGGGGTTGATCACTTTCCTAGCAAAGGGGAGACCACATGTGGTGCACAGGG
AAGAAACGGCTTTAGACAGCAGTCTGCGGGCCCCACCTGGGTGGCAGGATGCCGAGAAATCTTGCAGAGGTAGCTCCGAAACCATCTGGC
CCAACTAGCCTCAACTGACAGCTGAGGAAAGGCAATTAGGCCCAGAGAGGCAGAGACACTCGCTTAAGATCACAGGCTTAGTGTGAGGAC
GAGCTTGAAATCCCAGTCTCCTGGCCCCCAGGCCAGGGTCTGTCCACCATAGAATGTCTTCCTCTACTGGGGTCGTTCTGGCTTTTTGTT
AGAAACTTGGTCTGAGATGTTTCTTCCCTGTCCATTACCATTCGATGTTCTTTTATTCAGAGCAATGTTTCTTGTATTCTGAAACTGGAA
ACTGAACCAGTTTGTTTCTCCTAGTCACCAAGCATACTTTCCTGGCTCCCCAAGTACTTAAATGTTCTCATCTGTCGCACCCCTGTATTT
GCCTCACCCCTGCATGGTCGGAAATCTTCGTTTCAGGTCAGAACAGCCTGGGGTCTGTGGGTAAAATCAGCCCTTCTCCCAGGCCTGTGC
ACACACCCCCTCAGCACTCCCTATGCACTTTCCTGACACGCAAAGACACAGCCCTCTTTCCCCACTGGGCGTCCTACCCCAGTGAGGTTG
AAGGCACCAATTCCAAGAATCCCTCCAACCTCCCTGCCAGCACTCCCCCTTCACCCCACACCCGGCCCCCCCACCTAACCACAGCGCCTC
TCCAGACCTACCTCGGGACCTAATGTTCTCTACATGAACTGCTCATTTGGAGGACAGCAGTGAGGTCCTGCCATAGAGCAAATGTGTTAG
GAGAGAAGGTTTCACATGGGACCCAACATCCTTCATCAATACTTTCCTGAGTTTGATCATCCATTTAGCCTTGACAAACAGCAGACCCTA
CAGAGATGTGTTGGAGAGCACGTCGTGACCTTGGGGGCAAGGAATCCAGAAAGGTAGGAAGATATGAAAAGAGAGGTGTCAACAGCAAGG
GCTCTTAGGGGTCAGGCACCAGCATGGAGACCTCATGACAAAGGAAGGGACTCAAAGCAGCAATGCCCCTCATAGTGTAGGCTAAGGTGA
GTTTGGTGCATGCAAACCTGTGTGCTCACCCACAGAGCATGGGGTAATGGTGTGTAGACACAGGCCCTCTGCAGAAGCGTGGGGTGGGGA
CACTGACAGCCCCTATCTGGTCCCCAGGAACATTCTACCATTTCTGCCACTGGTGTTCAGCTCCTTCTCTTCCCCCAACACTCCCAAAGA
TACCCACAGGAAGTCCAGCCAGTTTCCAGGTAGAGGATTCCACCAGTTGGTCTTGGGCTGCGTTCACCCTCACATCACAGCACCTTAAAT
CTAATCAGCAAACTATAATTTGTACGTTGAAACCTGCAACACATTAGAAACTTATATTTAAAAACAGAATTAATCACACTGACCAACTTT
TAAATGGAAAATATGTAAATAGGAAGTGTTTGGGTTTTGTTTTTTCTTTAAGAAAAAGAAATGTACACCACTCCTCATGTGCCATTTTGT
CCTCAGAGGGCGGCTTTACTTTTTTGGTAAAGGAACAAGCTGCTGGCCTTGACCAGGAGTTCATATATAACTGTTATTACAGAGGAATTG

>In-frame_ORC4_ENST00000535373_chr2_148709942_-_MAPK4_ENST00000540640_chr18_48255528_+_1965nt
GGAAGTCGCTACGCTTTTAACACCCCCAGCTCCCTCCTCCTTCCTAAGGGAAAGTGGAGGAACGGAAGTGGGCGTGGACGGAGACGAAAG
GAGGTCACGTGTTTGGGCGGGAGAGGGGCGGGGTGGGAGAGGTAGTGCGTGCGCGGGGCATGCCGGGAGTGGTTGTGTACGGTCCGCAGC
GGCAGGTGAAGTCTAGCAGAGGACGCGGCCAGGCGATTCGGTGAAGCGATTCCTGCAGGCGTTGGTTCCCCTCTTTGACCTGGAAGCCTG
GAGCCAGAGGACTTTTGGTGGCTGAGGCCTTAGCTACCTGGCTTACACATTAAGGAGGACACAGATTTGCTTGCTGTCTGTCTGTCAAGG
CCTGGCTCAGCTAAGGACCTGTTAACATTTCTAGAGAAGAAAACAGCATTACCATGGATTTGAATTTGTTGAAATGAGCAGTCGTAAATC
AAAGAGTAACAGCTTAATTCACACAGAGTGCCTTTCACAGGTACAAAGAATTTTACGTGAAAGATTTTGTCGTCAGAGTCCACATAGTAA
CCTATTTGGAGTGCAAGTACAATACAAACACTTAAGTGAGCTGCTGAAAAGAACTGCTCTCCATGGAGAGAGTAACTCTGTCCTTATTAT
CGGACCCCGAGGATCAGGAAAAACTATGTTAATAAATCATGCTTTGAAAGAACTCATGGAAATAGAAGAAGTGAGTGAAAATGTATTACA
AGTTCACTTAAATGGACTGCTGCAGATCAATGACAAAATCGCCCTAAAGGAAATCACAAGGCAGTTAAATCTGGAAAATGTAGTTGGAGA
TAAAGTTTTTGGAAGCTTTGCTGAAAACCTTTCATTTCTTCTGGAAGCTTTAAAAAAAGGTGACCGAACTAGCAGTTGCCCAGTGATCTT
CATATTAGATGAATTTGATCTTTTTGCTCATCATAAAAACCAAACACTTCTCTATAATCTTTTTGACATTTCTCAGTCTGCACAGACCCC
AATAGCAGTTATTGGTCTTACATGTAGATTGGTACCCTGTGAGCCTGTCGTCGGACCTGGAGTGGCGGCCTGACCGGTGCCAGGACGCCA
GCGAGGTACAGCGCGACCCGCGCGCGGGTTCGGCGCCACTGGCTGAGGACGTGCAGGTGGACCCGCGCAAGGACTCGCACAGCAGCTCCG
AGCGCTTCCTAGAGCAGTCGCACTCGTCCATGGAGCGCGCCTTCGAGGCCGACTACGGGCGCTCCTGCGACTACAAGGTGGGGTCGCCGT
CCTACCTGGACAAGCTGCTGTGGCGCGACAACAAGCCGCACCACTACTCGGAGCCCAAGCTCATCCTGGACCTGTCGCACTGGAAGCAGG
CGGCCGGCGCGCCCCCCACGGCCACGGGGCTGGCGGACACGGGGGCGCGCGAGGACGAGCCGGCCAGCCTCTTCCTGGAGATCGCGCAGT
GGGTCAAGAGCACGCAGGGCGGCCCAGAGCACGCCAGCCCGCCCGCCGACGACCCCGAGCGCCGCTTGTCTGCCTCGCCCCCCGGCCGCC
CGGCCCCGGTGGACGGCGGCGCCAGCCCCCAGTTCGACCTGGACGTGTTCATCTCCCGCGCCCTGAAGCTCTGCACCAAGCCCGAGGACC
TGCCGGACAATAAACTGGGCGACCTCAATGGTGCGTGCATCCCCGAGCACCCTGGCGACCTCGTGCAGACCGAGGCCTTCTCCAAAGAAA
GGTGGTGAGGGCGGAGGGGCCGCTCCAGGCCCCACAGAGCAGGAGACCCCCAGAGAAAGCCGGGGCTGGCAGGAGGCGGCCGCCCTTCCC
GCCCCTCTCTGCTGCCTTGGGGTTGGCAGAACACGTGAAGGATCCGAGGAGCGAGAGGAATGTCCATTTCTTAAACTGCCTTAATAACTA

>In-frame_ORC4_ENST00000535373_chr2_148709942_-_MAPK4_ENST00000592595_chr18_48255528_+_3688nt
GGAAGTCGCTACGCTTTTAACACCCCCAGCTCCCTCCTCCTTCCTAAGGGAAAGTGGAGGAACGGAAGTGGGCGTGGACGGAGACGAAAG
GAGGTCACGTGTTTGGGCGGGAGAGGGGCGGGGTGGGAGAGGTAGTGCGTGCGCGGGGCATGCCGGGAGTGGTTGTGTACGGTCCGCAGC
GGCAGGTGAAGTCTAGCAGAGGACGCGGCCAGGCGATTCGGTGAAGCGATTCCTGCAGGCGTTGGTTCCCCTCTTTGACCTGGAAGCCTG
GAGCCAGAGGACTTTTGGTGGCTGAGGCCTTAGCTACCTGGCTTACACATTAAGGAGGACACAGATTTGCTTGCTGTCTGTCTGTCAAGG
CCTGGCTCAGCTAAGGACCTGTTAACATTTCTAGAGAAGAAAACAGCATTACCATGGATTTGAATTTGTTGAAATGAGCAGTCGTAAATC
AAAGAGTAACAGCTTAATTCACACAGAGTGCCTTTCACAGGTACAAAGAATTTTACGTGAAAGATTTTGTCGTCAGAGTCCACATAGTAA
CCTATTTGGAGTGCAAGTACAATACAAACACTTAAGTGAGCTGCTGAAAAGAACTGCTCTCCATGGAGAGAGTAACTCTGTCCTTATTAT
CGGACCCCGAGGATCAGGAAAAACTATGTTAATAAATCATGCTTTGAAAGAACTCATGGAAATAGAAGAAGTGAGTGAAAATGTATTACA
AGTTCACTTAAATGGACTGCTGCAGATCAATGACAAAATCGCCCTAAAGGAAATCACAAGGCAGTTAAATCTGGAAAATGTAGTTGGAGA
TAAAGTTTTTGGAAGCTTTGCTGAAAACCTTTCATTTCTTCTGGAAGCTTTAAAAAAAGGTGACCGAACTAGCAGTTGCCCAGTGATCTT
CATATTAGATGAATTTGATCTTTTTGCTCATCATAAAAACCAAACACTTCTCTATAATCTTTTTGACATTTCTCAGTCTGCACAGACCCC
AATAGCAGTTATTGGTCTTACATGTAGATTGGTACCCTGTGAGCCTGTCGTCGGACCTGGAGTGGCGGCCTGACCGGTGCCAGGACGCCA
GCGAGGTACAGCGCGACCCGCGCGCGGGTTCGGCGCCACTGGCTGAGGACGTGCAGGTGGACCCGCGCAAGGACTCGCACAGCAGCTCCG
AGCGCTTCCTAGAGCAGTCGCACTCGTCCATGGAGCGCGCCTTCGAGGCCGACTACGGGCGCTCCTGCGACTACAAGGTGGGGTCGCCGT
CCTACCTGGACAAGCTGCTGTGGCGCGACAACAAGCCGCACCACTACTCGGAGCCCAAGCTCATCCTGGACCTGTCGCACTGGAAGCAGG
CGGCCGGCGCGCCCCCCACGGCCACGGGGCTGGCGGACACGGGGGCGCGCGAGGACGAGCCGGCCAGCCTCTTCCTGGAGATCGCGCAGT
GGGTCAAGAGCACGCAGGGCGGCCCAGAGCACGCCAGCCCGCCCGCCGACGACCCCGAGCGCCGCTTGTCTGCCTCGCCCCCCGGCCGCC
CGGCCCCGGTGGACGGCGGCGCCAGCCCCCAGTTCGACCTGGACGTGTTCATCTCCCGCGCCCTGAAGCTCTGCACCAAGCCCGAGGACC
TGCCGGACAATAAACTGGGCGACCTCAATGGTGCGTGCATCCCCGAGCACCCTGGCGACCTCGTGCAGACCGAGGCCTTCTCCAAAGAAA
GGTGGTGAGGGCGGAGGGGCCGCTCCAGGCCCCACAGAGCAGGAGACCCCCAGAGAAAGCCGGGGCTGGCAGGAGGCGGCCGCCCTTCCC
GCCCCTCTCTGCTGCCTTGGGGTTGGCAGAACACGTGAAGGATCCGAGGAGCGAGAGGAATGTCCATTTCTTAAACTGCCTTAATAACTA
GCCTTTAACCTGTGGGAGCGGGTTTGAACAGGACCCTGGCTTAGGGGTTGATCACTTTCCTAGCAAAGGGGAGACCACATGTGGTGCACA
GGGAAGAAACGGCTTTAGACAGCAGTCTGCGGGCCCCACCTGGGTGGCAGGATGCCGAGAAATCTTGCAGAGGTAGCTCCGAAACCATCT
GGCCCAACTAGCCTCAACTGACAGCTGAGGAAAGGCAATTAGGCCCAGAGAGGCAGAGACACTCGCTTAAGATCACAGGCTTAGTGTGAG
GACGAGCTTGAAATCCCAGTCTCCTGGCCCCCAGGCCAGGGTCTGTCCACCATAGAATGTCTTCCTCTACTGGGGTCGTTCTGGCTTTTT
GTTAGAAACTTGGTCTGAGATGTTTCTTCCCTGTCCATTACCATTCGATGTTCTTTTATTCAGAGCAATGTTTCTTGTATTCTGAAACTG
GAAACTGAACCAGTTTGTTTCTCCTAGTCACCAAGCATACTTTCCTGGCTCCCCAAGTACTTAAATGTTCTCATCTGTCGCACCCCTGTA
TTTGCCTCACCCCTGCATGGTCGGAAATCTTCGTTTCAGGTCAGAACAGCCTGGGGTCTGTGGGTAAAATCAGCCCTTCTCCCAGGCCTG
TGCACACACCCCCTCAGCACTCCCTATGCACTTTCCTGACACGCAAAGACACAGCCCTCTTTCCCCACTGGGCGTCCTACCCCAGTGAGG
TTGAAGGCACCAATTCCAAGAATCCCTCCAACCTCCCTGCCAGCACTCCCCCTTCACCCCACACCCGGCCCCCCCACCTAACCACAGCGC
CTCTCCAGACCTACCTCGGGACCTAATGTTCTCTACATGAACTGCTCATTTGGAGGACAGCAGTGAGGTCCTGCCATAGAGCAAATGTGT
TAGGAGAGAAGGTTTCACATGGGACCCAACATCCTTCATCAATACTTTCCTGAGTTTGATCATCCATTTAGCCTTGACAAACAGCAGACC
CTACAGAGATGTGTTGGAGAGCACGTCGTGACCTTGGGGGCAAGGAATCCAGAAAGGTAGGAAGATATGAAAAGAGAGGTGTCAACAGCA
AGGGCTCTTAGGGGTCAGGCACCAGCATGGAGACCTCATGACAAAGGAAGGGACTCAAAGCAGCAATGCCCCTCATAGTGTAGGCTAAGG
TGAGTTTGGTGCATGCAAACCTGTGTGCTCACCCACAGAGCATGGGGTAATGGTGTGTAGACACAGGCCCTCTGCAGAAGCGTGGGGTGG
GGACACTGACAGCCCCTATCTGGTCCCCAGGAACATTCTACCATTTCTGCCACTGGTGTTCAGCTCCTTCTCTTCCCCCAACACTCCCAA
AGATACCCACAGGAAGTCCAGCCAGTTTCCAGGTAGAGGATTCCACCAGTTGGTCTTGGGCTGCGTTCACCCTCACATCACAGCACCTTA
AATCTAATCAGCAAACTATAATTTGTACGTTGAAACCTGCAACACATTAGAAACTTATATTTAAAAACAGAATTAATCACACTGACCAAC
TTTTAAATGGAAAATATGTAAATAGGAAGTGTTTGGGTTTTGTTTTTTCTTTAAGAAAAAGAAATGTACACCACTCCTCATGTGCCATTT
TGTCCTCAGAGGGCGGCTTTACTTTTTTGGTAAAGGAACAAGCTGCTGGCCTTGACCAGGAGTTCATATATAACTGTTATTACAGAGGAA

>In-frame_ORC4_ENST00000536575_chr2_148709942_-_MAPK4_ENST00000400384_chr18_48255528_+_3292nt
GGAAGTCGCTACGCTTTTAACACCCCCAGCTCCCTCCTCCTTCCTAAGGGAAAGTGGAGGAACGGAAGTGGGCGTGGACGGAGACGAAAG
GAGGTCACGTGTTTGGGCGGGAGAGGGGCGGGGTGGGAGAGGTAGTGCGTGCGCGGGGCATGCCGGGAGTGGTTGTGTACGGTCCGCAGC
GGCAGGTGAAGTCTAGCAGAGGACGCGGCCAGGCGATTCGGTGAAGCGATTCCTGCAGGCGTTGGTTCCCCTCTTTGACCTGTTAATAAA
TCATGCTTTGAAAGAACTCATGGAAATAGAAGAAGTGAGTGAAAATGTATTACAAGTTCACTTAAATGGACTGCTGCAGATCAATGACAA
AATCGCCCTAAAGGAAATCACAAGGCAGTTAAATCTGGAAAATGTAGTTGGAGATAAAGTTTTTGGAAGCTTTGCTGAAAACCTTTCATT
TCTTCTGGAAGCTTTAAAAAAAGGTGACCGAACTAGCAGTTGCCCAGTGATCTTCATATTAGATGAATTTGATCTTTTTGCTCATCATAA
AAACCAAACACTTCTCTATAATCTTTTTGACATTTCTCAGTCTGCACAGACCCCAATAGCAGTTATTGGTCTTACATGTAGATTGGTACC
CTGTGAGCCTGTCGTCGGACCTGGAGTGGCGGCCTGACCGGTGCCAGGACGCCAGCGAGGTACAGCGCGACCCGCGCGCGGGTTCGGCGC
CACTGGCTGAGGACGTGCAGGTGGACCCGCGCAAGGACTCGCACAGCAGCTCCGAGCGCTTCCTAGAGCAGTCGCACTCGTCCATGGAGC
GCGCCTTCGAGGCCGACTACGGGCGCTCCTGCGACTACAAGGTGGGGTCGCCGTCCTACCTGGACAAGCTGCTGTGGCGCGACAACAAGC
CGCACCACTACTCGGAGCCCAAGCTCATCCTGGACCTGTCGCACTGGAAGCAGGCGGCCGGCGCGCCCCCCACGGCCACGGGGCTGGCGG
ACACGGGGGCGCGCGAGGACGAGCCGGCCAGCCTCTTCCTGGAGATCGCGCAGTGGGTCAAGAGCACGCAGGGCGGCCCAGAGCACGCCA
GCCCGCCCGCCGACGACCCCGAGCGCCGCTTGTCTGCCTCGCCCCCCGGCCGCCCGGCCCCGGTGGACGGCGGCGCCAGCCCCCAGTTCG
ACCTGGACGTGTTCATCTCCCGCGCCCTGAAGCTCTGCACCAAGCCCGAGGACCTGCCGGACAATAAACTGGGCGACCTCAATGGTGCGT
GCATCCCCGAGCACCCTGGCGACCTCGTGCAGACCGAGGCCTTCTCCAAAGAAAGGTGGTGAGGGCGGAGGGGCCGCTCCAGGCCCCACA
GAGCAGGAGACCCCCAGAGAAAGCCGGGGCTGGCAGGAGGCGGCCGCCCTTCCCGCCCCTCTCTGCTGCCTTGGGGTTGGCAGAACACGT
GAAGGATCCGAGGAGCGAGAGGAATGTCCATTTCTTAAACTGCCTTAATAACTAGCCTTTAACCTGTGGGAGCGGGTTTGAACAGGACCC
TGGCTTAGGGGTTGATCACTTTCCTAGCAAAGGGGAGACCACATGTGGTGCACAGGGAAGAAACGGCTTTAGACAGCAGTCTGCGGGCCC
CACCTGGGTGGCAGGATGCCGAGAAATCTTGCAGAGGTAGCTCCGAAACCATCTGGCCCAACTAGCCTCAACTGACAGCTGAGGAAAGGC
AATTAGGCCCAGAGAGGCAGAGACACTCGCTTAAGATCACAGGCTTAGTGTGAGGACGAGCTTGAAATCCCAGTCTCCTGGCCCCCAGGC
CAGGGTCTGTCCACCATAGAATGTCTTCCTCTACTGGGGTCGTTCTGGCTTTTTGTTAGAAACTTGGTCTGAGATGTTTCTTCCCTGTCC
ATTACCATTCGATGTTCTTTTATTCAGAGCAATGTTTCTTGTATTCTGAAACTGGAAACTGAACCAGTTTGTTTCTCCTAGTCACCAAGC
ATACTTTCCTGGCTCCCCAAGTACTTAAATGTTCTCATCTGTCGCACCCCTGTATTTGCCTCACCCCTGCATGGTCGGAAATCTTCGTTT
CAGGTCAGAACAGCCTGGGGTCTGTGGGTAAAATCAGCCCTTCTCCCAGGCCTGTGCACACACCCCCTCAGCACTCCCTATGCACTTTCC
TGACACGCAAAGACACAGCCCTCTTTCCCCACTGGGCGTCCTACCCCAGTGAGGTTGAAGGCACCAATTCCAAGAATCCCTCCAACCTCC
CTGCCAGCACTCCCCCTTCACCCCACACCCGGCCCCCCCACCTAACCACAGCGCCTCTCCAGACCTACCTCGGGACCTAATGTTCTCTAC
ATGAACTGCTCATTTGGAGGACAGCAGTGAGGTCCTGCCATAGAGCAAATGTGTTAGGAGAGAAGGTTTCACATGGGACCCAACATCCTT
CATCAATACTTTCCTGAGTTTGATCATCCATTTAGCCTTGACAAACAGCAGACCCTACAGAGATGTGTTGGAGAGCACGTCGTGACCTTG
GGGGCAAGGAATCCAGAAAGGTAGGAAGATATGAAAAGAGAGGTGTCAACAGCAAGGGCTCTTAGGGGTCAGGCACCAGCATGGAGACCT
CATGACAAAGGAAGGGACTCAAAGCAGCAATGCCCCTCATAGTGTAGGCTAAGGTGAGTTTGGTGCATGCAAACCTGTGTGCTCACCCAC
AGAGCATGGGGTAATGGTGTGTAGACACAGGCCCTCTGCAGAAGCGTGGGGTGGGGACACTGACAGCCCCTATCTGGTCCCCAGGAACAT
TCTACCATTTCTGCCACTGGTGTTCAGCTCCTTCTCTTCCCCCAACACTCCCAAAGATACCCACAGGAAGTCCAGCCAGTTTCCAGGTAG
AGGATTCCACCAGTTGGTCTTGGGCTGCGTTCACCCTCACATCACAGCACCTTAAATCTAATCAGCAAACTATAATTTGTACGTTGAAAC
CTGCAACACATTAGAAACTTATATTTAAAAACAGAATTAATCACACTGACCAACTTTTAAATGGAAAATATGTAAATAGGAAGTGTTTGG
GTTTTGTTTTTTCTTTAAGAAAAAGAAATGTACACCACTCCTCATGTGCCATTTTGTCCTCAGAGGGCGGCTTTACTTTTTTGGTAAAGG
AACAAGCTGCTGGCCTTGACCAGGAGTTCATATATAACTGTTATTACAGAGGAATTGTTATAACTACTAATGTTTTTAAAAAATTTATTA

>In-frame_ORC4_ENST00000540442_chr2_148709942_-_MAPK4_ENST00000400384_chr18_48255528_+_3460nt
GGAAGTCGCTACGCTTTTAACACCCCCAGCTCCCTCCTCCTTCCTAAGGGAAAGTGGAGGAACGGAAGTGGGCGTGGACGGAGACGAAAG
GAGGTCACGTGTTTGGGCGGGAGAGGGGCGGGGTGGGAGAGGTAGTGCGTGCGCGGGGCATGCCGGGAGTGGTTGTGTACGGTCCGCAGC
GGCAGGTGAAGTCTAGCAGAGGACGCGGCCAGGCGATTCGGTGAAGCGATTCCTGCAGGCGTTGGTTCCCCTCTTTGACCTGGTACAAAG
AATTTTACGTGAAAGATTTTGTCGTCAGAGTCCACATAGTAACCTATTTGGAGTGCAAGTACAATACAAACACTTAAGTGAGCTGCTGAA
AAGAACTGCTCTCCATGGAGAGAGTAACTCTGTCCTTATTATCGGACCCCGAGGATCAGGAAAAACTATGTTAATAAATCATGCTTTGAA
AGAACTCATGGAAATAGAAGAAGTGAGTGAAAATGTATTACAAGTTCACTTAAATGGACTGCTGCAGATCAATGACAAAATCGCCCTAAA
GGAAATCACAAGGCAGTTAAATCTGGAAAATGTAGTTGGAGATAAAGTTTTTGGAAGCTTTGCTGAAAACCTTTCATTTCTTCTGGAAGC
TTTAAAAAAAGGTGACCGAACTAGCAGTTGCCCAGTGATCTTCATATTAGATGAATTTGATCTTTTTGCTCATCATAAAAACCAAACACT
TCTCTATAATCTTTTTGACATTTCTCAGTCTGCACAGACCCCAATAGCAGTTATTGGTCTTACATGTAGATTGGTACCCTGTGAGCCTGT
CGTCGGACCTGGAGTGGCGGCCTGACCGGTGCCAGGACGCCAGCGAGGTACAGCGCGACCCGCGCGCGGGTTCGGCGCCACTGGCTGAGG
ACGTGCAGGTGGACCCGCGCAAGGACTCGCACAGCAGCTCCGAGCGCTTCCTAGAGCAGTCGCACTCGTCCATGGAGCGCGCCTTCGAGG
CCGACTACGGGCGCTCCTGCGACTACAAGGTGGGGTCGCCGTCCTACCTGGACAAGCTGCTGTGGCGCGACAACAAGCCGCACCACTACT
CGGAGCCCAAGCTCATCCTGGACCTGTCGCACTGGAAGCAGGCGGCCGGCGCGCCCCCCACGGCCACGGGGCTGGCGGACACGGGGGCGC
GCGAGGACGAGCCGGCCAGCCTCTTCCTGGAGATCGCGCAGTGGGTCAAGAGCACGCAGGGCGGCCCAGAGCACGCCAGCCCGCCCGCCG
ACGACCCCGAGCGCCGCTTGTCTGCCTCGCCCCCCGGCCGCCCGGCCCCGGTGGACGGCGGCGCCAGCCCCCAGTTCGACCTGGACGTGT
TCATCTCCCGCGCCCTGAAGCTCTGCACCAAGCCCGAGGACCTGCCGGACAATAAACTGGGCGACCTCAATGGTGCGTGCATCCCCGAGC
ACCCTGGCGACCTCGTGCAGACCGAGGCCTTCTCCAAAGAAAGGTGGTGAGGGCGGAGGGGCCGCTCCAGGCCCCACAGAGCAGGAGACC
CCCAGAGAAAGCCGGGGCTGGCAGGAGGCGGCCGCCCTTCCCGCCCCTCTCTGCTGCCTTGGGGTTGGCAGAACACGTGAAGGATCCGAG
GAGCGAGAGGAATGTCCATTTCTTAAACTGCCTTAATAACTAGCCTTTAACCTGTGGGAGCGGGTTTGAACAGGACCCTGGCTTAGGGGT
TGATCACTTTCCTAGCAAAGGGGAGACCACATGTGGTGCACAGGGAAGAAACGGCTTTAGACAGCAGTCTGCGGGCCCCACCTGGGTGGC
AGGATGCCGAGAAATCTTGCAGAGGTAGCTCCGAAACCATCTGGCCCAACTAGCCTCAACTGACAGCTGAGGAAAGGCAATTAGGCCCAG
AGAGGCAGAGACACTCGCTTAAGATCACAGGCTTAGTGTGAGGACGAGCTTGAAATCCCAGTCTCCTGGCCCCCAGGCCAGGGTCTGTCC
ACCATAGAATGTCTTCCTCTACTGGGGTCGTTCTGGCTTTTTGTTAGAAACTTGGTCTGAGATGTTTCTTCCCTGTCCATTACCATTCGA
TGTTCTTTTATTCAGAGCAATGTTTCTTGTATTCTGAAACTGGAAACTGAACCAGTTTGTTTCTCCTAGTCACCAAGCATACTTTCCTGG
CTCCCCAAGTACTTAAATGTTCTCATCTGTCGCACCCCTGTATTTGCCTCACCCCTGCATGGTCGGAAATCTTCGTTTCAGGTCAGAACA
GCCTGGGGTCTGTGGGTAAAATCAGCCCTTCTCCCAGGCCTGTGCACACACCCCCTCAGCACTCCCTATGCACTTTCCTGACACGCAAAG
ACACAGCCCTCTTTCCCCACTGGGCGTCCTACCCCAGTGAGGTTGAAGGCACCAATTCCAAGAATCCCTCCAACCTCCCTGCCAGCACTC
CCCCTTCACCCCACACCCGGCCCCCCCACCTAACCACAGCGCCTCTCCAGACCTACCTCGGGACCTAATGTTCTCTACATGAACTGCTCA
TTTGGAGGACAGCAGTGAGGTCCTGCCATAGAGCAAATGTGTTAGGAGAGAAGGTTTCACATGGGACCCAACATCCTTCATCAATACTTT
CCTGAGTTTGATCATCCATTTAGCCTTGACAAACAGCAGACCCTACAGAGATGTGTTGGAGAGCACGTCGTGACCTTGGGGGCAAGGAAT
CCAGAAAGGTAGGAAGATATGAAAAGAGAGGTGTCAACAGCAAGGGCTCTTAGGGGTCAGGCACCAGCATGGAGACCTCATGACAAAGGA
AGGGACTCAAAGCAGCAATGCCCCTCATAGTGTAGGCTAAGGTGAGTTTGGTGCATGCAAACCTGTGTGCTCACCCACAGAGCATGGGGT
AATGGTGTGTAGACACAGGCCCTCTGCAGAAGCGTGGGGTGGGGACACTGACAGCCCCTATCTGGTCCCCAGGAACATTCTACCATTTCT
GCCACTGGTGTTCAGCTCCTTCTCTTCCCCCAACACTCCCAAAGATACCCACAGGAAGTCCAGCCAGTTTCCAGGTAGAGGATTCCACCA
GTTGGTCTTGGGCTGCGTTCACCCTCACATCACAGCACCTTAAATCTAATCAGCAAACTATAATTTGTACGTTGAAACCTGCAACACATT
AGAAACTTATATTTAAAAACAGAATTAATCACACTGACCAACTTTTAAATGGAAAATATGTAAATAGGAAGTGTTTGGGTTTTGTTTTTT
CTTTAAGAAAAAGAAATGTACACCACTCCTCATGTGCCATTTTGTCCTCAGAGGGCGGCTTTACTTTTTTGGTAAAGGAACAAGCTGCTG
GCCTTGACCAGGAGTTCATATATAACTGTTATTACAGAGGAATTGTTATAACTACTAATGTTTTTAAAAAATTTATTAAACATTATTAAA

>In-frame_ORC4_ENST00000264169_chr2_148709942_-_MAPK4_ENST00000540640_chr18_48255528_+_1680nt
GAGCTGGGGAAGTGGCTGCTCCTGGGTGTAGTGAGATGTCTCCAGCCAGGGCCAAGCAGCAGCAGTAGCAGCAGCAGCAGTAGCAGCAGC
AGCAGCAACAGCAGCAGCAGCAGCAACAGCAGCAGCAAAGGGATTTGAATTTGTTGAAATGAGCAGTCGTAAATCAAAGAGTAACAGCTT
AATTCACACAGAGTGCCTTTCACAGGTACAAAGAATTTTACGTGAAAGATTTTGTCGTCAGAGTCCACATAGTAACCTATTTGGAGTGCA
AGTACAATACAAACACTTAAGTGAGCTGCTGAAAAGAACTGCTCTCCATGGAGAGAGTAACTCTGTCCTTATTATCGGACCCCGAGGATC
AGGAAAAACTATGTTAATAAATCATGCTTTGAAAGAACTCATGGAAATAGAAGAAGTGAGTGAAAATGTATTACAAGTTCACTTAAATGG
ACTGCTGCAGATCAATGACAAAATCGCCCTAAAGGAAATCACAAGGCAGTTAAATCTGGAAAATGTAGTTGGAGATAAAGTTTTTGGAAG
CTTTGCTGAAAACCTTTCATTTCTTCTGGAAGCTTTAAAAAAAGGTGACCGAACTAGCAGTTGCCCAGTGATCTTCATATTAGATGAATT
TGATCTTTTTGCTCATCATAAAAACCAAACACTTCTCTATAATCTTTTTGACATTTCTCAGTCTGCACAGACCCCAATAGCAGTTATTGG
TCTTACATGTAGATTGGTACCCTGTGAGCCTGTCGTCGGACCTGGAGTGGCGGCCTGACCGGTGCCAGGACGCCAGCGAGGTACAGCGCG
ACCCGCGCGCGGGTTCGGCGCCACTGGCTGAGGACGTGCAGGTGGACCCGCGCAAGGACTCGCACAGCAGCTCCGAGCGCTTCCTAGAGC
AGTCGCACTCGTCCATGGAGCGCGCCTTCGAGGCCGACTACGGGCGCTCCTGCGACTACAAGGTGGGGTCGCCGTCCTACCTGGACAAGC
TGCTGTGGCGCGACAACAAGCCGCACCACTACTCGGAGCCCAAGCTCATCCTGGACCTGTCGCACTGGAAGCAGGCGGCCGGCGCGCCCC
CCACGGCCACGGGGCTGGCGGACACGGGGGCGCGCGAGGACGAGCCGGCCAGCCTCTTCCTGGAGATCGCGCAGTGGGTCAAGAGCACGC
AGGGCGGCCCAGAGCACGCCAGCCCGCCCGCCGACGACCCCGAGCGCCGCTTGTCTGCCTCGCCCCCCGGCCGCCCGGCCCCGGTGGACG
GCGGCGCCAGCCCCCAGTTCGACCTGGACGTGTTCATCTCCCGCGCCCTGAAGCTCTGCACCAAGCCCGAGGACCTGCCGGACAATAAAC
TGGGCGACCTCAATGGTGCGTGCATCCCCGAGCACCCTGGCGACCTCGTGCAGACCGAGGCCTTCTCCAAAGAAAGGTGGTGAGGGCGGA
GGGGCCGCTCCAGGCCCCACAGAGCAGGAGACCCCCAGAGAAAGCCGGGGCTGGCAGGAGGCGGCCGCCCTTCCCGCCCCTCTCTGCTGC
CTTGGGGTTGGCAGAACACGTGAAGGATCCGAGGAGCGAGAGGAATGTCCATTTCTTAAACTGCCTTAATAACTAGCCTTTAACCTGTGG

>In-frame_ORC4_ENST00000264169_chr2_148709942_-_MAPK4_ENST00000592595_chr18_48255528_+_3403nt
GAGCTGGGGAAGTGGCTGCTCCTGGGTGTAGTGAGATGTCTCCAGCCAGGGCCAAGCAGCAGCAGTAGCAGCAGCAGCAGTAGCAGCAGC
AGCAGCAACAGCAGCAGCAGCAGCAACAGCAGCAGCAAAGGGATTTGAATTTGTTGAAATGAGCAGTCGTAAATCAAAGAGTAACAGCTT
AATTCACACAGAGTGCCTTTCACAGGTACAAAGAATTTTACGTGAAAGATTTTGTCGTCAGAGTCCACATAGTAACCTATTTGGAGTGCA
AGTACAATACAAACACTTAAGTGAGCTGCTGAAAAGAACTGCTCTCCATGGAGAGAGTAACTCTGTCCTTATTATCGGACCCCGAGGATC
AGGAAAAACTATGTTAATAAATCATGCTTTGAAAGAACTCATGGAAATAGAAGAAGTGAGTGAAAATGTATTACAAGTTCACTTAAATGG
ACTGCTGCAGATCAATGACAAAATCGCCCTAAAGGAAATCACAAGGCAGTTAAATCTGGAAAATGTAGTTGGAGATAAAGTTTTTGGAAG
CTTTGCTGAAAACCTTTCATTTCTTCTGGAAGCTTTAAAAAAAGGTGACCGAACTAGCAGTTGCCCAGTGATCTTCATATTAGATGAATT
TGATCTTTTTGCTCATCATAAAAACCAAACACTTCTCTATAATCTTTTTGACATTTCTCAGTCTGCACAGACCCCAATAGCAGTTATTGG
TCTTACATGTAGATTGGTACCCTGTGAGCCTGTCGTCGGACCTGGAGTGGCGGCCTGACCGGTGCCAGGACGCCAGCGAGGTACAGCGCG
ACCCGCGCGCGGGTTCGGCGCCACTGGCTGAGGACGTGCAGGTGGACCCGCGCAAGGACTCGCACAGCAGCTCCGAGCGCTTCCTAGAGC
AGTCGCACTCGTCCATGGAGCGCGCCTTCGAGGCCGACTACGGGCGCTCCTGCGACTACAAGGTGGGGTCGCCGTCCTACCTGGACAAGC
TGCTGTGGCGCGACAACAAGCCGCACCACTACTCGGAGCCCAAGCTCATCCTGGACCTGTCGCACTGGAAGCAGGCGGCCGGCGCGCCCC
CCACGGCCACGGGGCTGGCGGACACGGGGGCGCGCGAGGACGAGCCGGCCAGCCTCTTCCTGGAGATCGCGCAGTGGGTCAAGAGCACGC
AGGGCGGCCCAGAGCACGCCAGCCCGCCCGCCGACGACCCCGAGCGCCGCTTGTCTGCCTCGCCCCCCGGCCGCCCGGCCCCGGTGGACG
GCGGCGCCAGCCCCCAGTTCGACCTGGACGTGTTCATCTCCCGCGCCCTGAAGCTCTGCACCAAGCCCGAGGACCTGCCGGACAATAAAC
TGGGCGACCTCAATGGTGCGTGCATCCCCGAGCACCCTGGCGACCTCGTGCAGACCGAGGCCTTCTCCAAAGAAAGGTGGTGAGGGCGGA
GGGGCCGCTCCAGGCCCCACAGAGCAGGAGACCCCCAGAGAAAGCCGGGGCTGGCAGGAGGCGGCCGCCCTTCCCGCCCCTCTCTGCTGC
CTTGGGGTTGGCAGAACACGTGAAGGATCCGAGGAGCGAGAGGAATGTCCATTTCTTAAACTGCCTTAATAACTAGCCTTTAACCTGTGG
GAGCGGGTTTGAACAGGACCCTGGCTTAGGGGTTGATCACTTTCCTAGCAAAGGGGAGACCACATGTGGTGCACAGGGAAGAAACGGCTT
TAGACAGCAGTCTGCGGGCCCCACCTGGGTGGCAGGATGCCGAGAAATCTTGCAGAGGTAGCTCCGAAACCATCTGGCCCAACTAGCCTC
AACTGACAGCTGAGGAAAGGCAATTAGGCCCAGAGAGGCAGAGACACTCGCTTAAGATCACAGGCTTAGTGTGAGGACGAGCTTGAAATC
CCAGTCTCCTGGCCCCCAGGCCAGGGTCTGTCCACCATAGAATGTCTTCCTCTACTGGGGTCGTTCTGGCTTTTTGTTAGAAACTTGGTC
TGAGATGTTTCTTCCCTGTCCATTACCATTCGATGTTCTTTTATTCAGAGCAATGTTTCTTGTATTCTGAAACTGGAAACTGAACCAGTT
TGTTTCTCCTAGTCACCAAGCATACTTTCCTGGCTCCCCAAGTACTTAAATGTTCTCATCTGTCGCACCCCTGTATTTGCCTCACCCCTG
CATGGTCGGAAATCTTCGTTTCAGGTCAGAACAGCCTGGGGTCTGTGGGTAAAATCAGCCCTTCTCCCAGGCCTGTGCACACACCCCCTC
AGCACTCCCTATGCACTTTCCTGACACGCAAAGACACAGCCCTCTTTCCCCACTGGGCGTCCTACCCCAGTGAGGTTGAAGGCACCAATT
CCAAGAATCCCTCCAACCTCCCTGCCAGCACTCCCCCTTCACCCCACACCCGGCCCCCCCACCTAACCACAGCGCCTCTCCAGACCTACC
TCGGGACCTAATGTTCTCTACATGAACTGCTCATTTGGAGGACAGCAGTGAGGTCCTGCCATAGAGCAAATGTGTTAGGAGAGAAGGTTT
CACATGGGACCCAACATCCTTCATCAATACTTTCCTGAGTTTGATCATCCATTTAGCCTTGACAAACAGCAGACCCTACAGAGATGTGTT
GGAGAGCACGTCGTGACCTTGGGGGCAAGGAATCCAGAAAGGTAGGAAGATATGAAAAGAGAGGTGTCAACAGCAAGGGCTCTTAGGGGT
CAGGCACCAGCATGGAGACCTCATGACAAAGGAAGGGACTCAAAGCAGCAATGCCCCTCATAGTGTAGGCTAAGGTGAGTTTGGTGCATG
CAAACCTGTGTGCTCACCCACAGAGCATGGGGTAATGGTGTGTAGACACAGGCCCTCTGCAGAAGCGTGGGGTGGGGACACTGACAGCCC
CTATCTGGTCCCCAGGAACATTCTACCATTTCTGCCACTGGTGTTCAGCTCCTTCTCTTCCCCCAACACTCCCAAAGATACCCACAGGAA
GTCCAGCCAGTTTCCAGGTAGAGGATTCCACCAGTTGGTCTTGGGCTGCGTTCACCCTCACATCACAGCACCTTAAATCTAATCAGCAAA
CTATAATTTGTACGTTGAAACCTGCAACACATTAGAAACTTATATTTAAAAACAGAATTAATCACACTGACCAACTTTTAAATGGAAAAT
ATGTAAATAGGAAGTGTTTGGGTTTTGTTTTTTCTTTAAGAAAAAGAAATGTACACCACTCCTCATGTGCCATTTTGTCCTCAGAGGGCG
GCTTTACTTTTTTGGTAAAGGAACAAGCTGCTGGCCTTGACCAGGAGTTCATATATAACTGTTATTACAGAGGAATTGTTATAACTACTA


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FusionGenePPI for ORC4_MAPK4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ORC4MCM2, MCM3, ORC1, ORC2, ORC5, ORC6, MCM4, MCM6, RPA2, DBF4, ORC3, CCL2, XRCC5, XRCC6, APP, MCM7, MCM10, CCND1, CDKN2A, FBXO6, CTBP1, KPNA1, MLH1, FBXL5, FBXO25, FBXL8, MTUS1, TCF4, RRM2B, HIST3H3, HIST4H4, LACC1, PABPC1, CAPZA2, TSNAX, KLC3, LRWD1, TEAD2, FOXL1, SNW1, CDC5L, MTMR3, CD93, LAMP1, DLK1, IL1R2, TXNDC15, P2RX4MAPK4MAPKAPK5, HSP90AA1, CALML3, CRK, ERC1, TECR, FASTKD5, FAM57A, PFKP, PSMA7, SFXN2, ACSL3, ATP1A1, DUSP2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ORC4_MAPK4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ORC4_MAPK4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneORC4C1868684EAR, PATELLA, SHORT STATURE SYNDROME2CTD_human;ORPHANET
HgeneORC4C3151097MEIER-GORLIN SYNDROME 21UNIPROT