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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25454

FusionGeneSummary for OPRM1_TCEAL1

check button Fusion gene summary
Fusion gene informationFusion gene name: OPRM1_TCEAL1
Fusion gene ID: 25454
HgeneTgene
Gene symbol

OPRM1

TCEAL1

Gene ID

4988

9338

Gene nameopioid receptor mu 1transcription elongation factor A like 1
SynonymsLMOR|M-OR-1|MOP|MOR|MOR1|OPRMSIIR|WEX9|p21|pp21
Cytomap

6q25.2

Xq22.2

Type of geneprotein-codingprotein-coding
Descriptionmu-type opioid receptormu opiate receptormu opioid receptor hMOR-1atranscription elongation factor A protein-like 1TCEA-like protein 1nuclear phosphoprotein p21/SIIRtranscription elongation factor A (SII)-like 1transcription elongation factor S-II protein-like 1
Modification date2018052320180523
UniProtAcc

P35372

Q15170

Ensembl transtripts involved in fusion geneENST00000434900, ENST00000520708, 
ENST00000518759, ENST00000360422, 
ENST00000330432, ENST00000428397, 
ENST00000452687, ENST00000229768, 
ENST00000524163, ENST00000419506, 
ENST00000414028, ENST00000435918, 
ENST00000337049, ENST00000523520, 
ENST00000522555, ENST00000522236, 
ENST00000372626, ENST00000372625, 
ENST00000469820, ENST00000372624, 
Fusion gene scores* DoF score2 X 1 X 1=21 X 1 X 1=1
# samples 11
** MAII scorelog2(1/2*10)=2.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: OPRM1 [Title/Abstract] AND TCEAL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-HB-A3YV-01AOPRM1chr6

154567894

+TCEAL1chrX

102884400

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000434900ENST00000372626OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000434900ENST00000372625OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000434900ENST00000469820OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000434900ENST00000372624OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000520708ENST00000372626OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000520708ENST00000372625OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000520708ENST00000469820OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000520708ENST00000372624OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000518759ENST00000372626OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000518759ENST00000372625OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000518759ENST00000469820OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000518759ENST00000372624OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000360422ENST00000372626OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000360422ENST00000372625OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000360422ENST00000469820OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000360422ENST00000372624OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000330432ENST00000372626OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000330432ENST00000372625OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000330432ENST00000469820OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000330432ENST00000372624OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000428397ENST00000372626OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000428397ENST00000372625OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000428397ENST00000469820OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000428397ENST00000372624OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000452687ENST00000372626OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000452687ENST00000372625OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000452687ENST00000469820OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000452687ENST00000372624OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000229768ENST00000372626OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000229768ENST00000372625OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000229768ENST00000469820OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000229768ENST00000372624OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000524163ENST00000372626OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000524163ENST00000372625OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000524163ENST00000469820OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000524163ENST00000372624OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000419506ENST00000372626OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000419506ENST00000372625OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000419506ENST00000469820OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000419506ENST00000372624OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000414028ENST00000372626OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000414028ENST00000372625OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000414028ENST00000469820OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000414028ENST00000372624OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000435918ENST00000372626OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000435918ENST00000372625OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000435918ENST00000469820OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000435918ENST00000372624OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
5CDS-intronENST00000337049ENST00000372626OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
5CDS-intronENST00000337049ENST00000372625OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
5CDS-intronENST00000337049ENST00000469820OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
5CDS-intronENST00000337049ENST00000372624OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000523520ENST00000372626OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000523520ENST00000372625OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000523520ENST00000469820OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000523520ENST00000372624OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000522555ENST00000372626OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000522555ENST00000372625OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000522555ENST00000469820OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000522555ENST00000372624OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000522236ENST00000372626OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000522236ENST00000372625OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000522236ENST00000469820OPRM1chr6

154567894

+TCEAL1chrX

102884400

+
intron-intronENST00000522236ENST00000372624OPRM1chr6

154567894

+TCEAL1chrX

102884400

+

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FusionProtFeatures for OPRM1_TCEAL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OPRM1

P35372

TCEAL1

Q15170

May be involved in transcriptional regulation. Modulatesvarious viral and cellular promoters in a promoter context-dependent manner. For example, transcription from the FOS promoteris increased, while Rous sarcoma virus (RSV) long terminal repeat(LTR) promoter activity is repressed. Does not bind DNA directly.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OPRM1_TCEAL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OPRM1_TCEAL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
OPRM1CALM1, OPRD1, PLD2, ARF1, GNAO1, UBC, GPRASP1, AUP1, COPS5, GJA4, DOK4, DOK5, KCNF1, RANBP9, SIAH1, SIAH2, VAPA, WLS, ZYX, ZFYVE26, MMS22L, THADA, LPCAT3, XPO6, XPO4, HTT, BRAT1, MZT2B, TUBGCP2, ZWILCH, COG2, ATM, URB2, MTFP1, COG8, COX1, C1orf112, FANCA, PI4KA, COG7, DNAAF5, NDUFB3, COG1, CHPT1, FASTKD1, INTS1, TTI2, KIAA0368, ATR, IPO11, COG3, XPO7, COG4, TUBGCP3, TUBGCP4, SYNGR2, IPO13, ZW10, ADCK1, LMBRD2, ABHD17B, EXOC5, GEMIN4, SLC25A46, DEGS1, GCN1L1, TNPO3, SLC5A3, RINT1, DYM, MON2, NOM1, STAG2TCEAL1USP11, HSPA4L, SSR3, PPP2R2A, TCEB1, USP7, CUL2, GMPS, PDCD5, TIPIN, FEM1A, KDM3A, PPP2R2D, FEM1C, TCEAL4, TCEAL2, HOXB6, MAPK14, DYRK1B, SCNM1, UROS, HAUS7, PHF7, TP53, USP4, EYA3, HOXB9, MCMBP, POGK, TRIM25, ZNF703, ZNF503, UHRF1, ZUFSP, STAT3, SASS6, PTPN11, UBE2Q1, ZKSCAN4, CHEK1, C9orf40, FAF1, DTL, CDCA2, TDP2, IFT43, WDR4, TRUB1, UBC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OPRM1_TCEAL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneOPRM1P35372DB00321AmitriptylineMu-type opioid receptorsmall moleculeapproved
HgeneOPRM1P35372DB00333MethadoneMu-type opioid receptorsmall moleculeapproved
HgeneOPRM1P35372DB00454PethidineMu-type opioid receptorsmall moleculeapproved
HgeneOPRM1P35372DB00514DextromethorphanMu-type opioid receptorsmall moleculeapproved
HgeneOPRM1P35372DB00836LoperamideMu-type opioid receptorsmall moleculeapproved
HgeneOPRM1P35372DB00844NalbuphineMu-type opioid receptorsmall moleculeapproved
HgeneOPRM1P35372DB00899RemifentanilMu-type opioid receptorsmall moleculeapproved
HgeneOPRM1P35372DB00904OndansetronMu-type opioid receptorsmall moleculeapproved
HgeneOPRM1P35372DB06204TapentadolMu-type opioid receptorsmall moleculeapproved
HgeneOPRM1P35372DB06800MethylnaltrexoneMu-type opioid receptorsmall moleculeapproved
HgeneOPRM1P35372DB09049NaloxegolMu-type opioid receptorsmall moleculeapproved
HgeneOPRM1P35372DB09089TrimebutineMu-type opioid receptorsmall moleculeapproved
HgeneOPRM1P35372DB00318CodeineMu-type opioid receptorsmall moleculeapproved|illicit
HgeneOPRM1P35372DB00327HydromorphoneMu-type opioid receptorsmall moleculeapproved|illicit
HgeneOPRM1P35372DB00802AlfentanilMu-type opioid receptorsmall moleculeapproved|illicit
HgeneOPRM1P35372DB00913AnileridineMu-type opioid receptorsmall moleculeapproved|illicit
HgeneOPRM1P35372DB00956HydrocodoneMu-type opioid receptorsmall moleculeapproved|illicit
HgeneOPRM1P35372DB01081DiphenoxylateMu-type opioid receptorsmall moleculeapproved|illicit
HgeneOPRM1P35372DB01466EthylmorphineMu-type opioid receptorsmall moleculeapproved|illicit
HgeneOPRM1P35372DB09209PholcodineMu-type opioid receptorsmall moleculeapproved|illicit
HgeneOPRM1P35372DB11130OpiumMu-type opioid receptorsmall moleculeapproved|illicit
HgeneOPRM1P35372DB00497OxycodoneMu-type opioid receptorsmall moleculeapproved|illicit|investigational
HgeneOPRM1P35372DB01452HeroinMu-type opioid receptorsmall moleculeapproved|illicit|investigational
HgeneOPRM1P35372DB00813FentanylMu-type opioid receptorsmall moleculeapproved|illicit|investigational|vet_approved
HgeneOPRM1P35372DB00921BuprenorphineMu-type opioid receptorsmall moleculeapproved|illicit|investigational|vet_approved
HgeneOPRM1P35372DB00647DextropropoxypheneMu-type opioid receptorsmall moleculeapproved|illicit|investigational|withdrawn
HgeneOPRM1P35372DB00611ButorphanolMu-type opioid receptorsmall moleculeapproved|illicit|vet_approved
HgeneOPRM1P35372DB00193TramadolMu-type opioid receptorsmall moleculeapproved|investigational
HgeneOPRM1P35372DB00295MorphineMu-type opioid receptorsmall moleculeapproved|investigational
HgeneOPRM1P35372DB00708SufentanilMu-type opioid receptorsmall moleculeapproved|investigational
HgeneOPRM1P35372DB01209DezocineMu-type opioid receptorsmall moleculeapproved|investigational
HgeneOPRM1P35372DB01227Levomethadyl AcetateMu-type opioid receptorsmall moleculeapproved|investigational
HgeneOPRM1P35372DB06274AlvimopanMu-type opioid receptorsmall moleculeapproved|investigational
HgeneOPRM1P35372DB06738KetobemidoneMu-type opioid receptorsmall moleculeapproved|investigational
HgeneOPRM1P35372DB00704NaltrexoneMu-type opioid receptorsmall moleculeapproved|investigational|vet_approved
HgeneOPRM1P35372DB06230NalmefeneMu-type opioid receptorsmall moleculeapproved|investigational|withdrawn
HgeneOPRM1P35372DB00652PentazocineMu-type opioid receptorsmall moleculeapproved|vet_approved
HgeneOPRM1P35372DB01183NaloxoneMu-type opioid receptorsmall moleculeapproved|vet_approved
HgeneOPRM1P35372DB01221KetamineMu-type opioid receptorsmall moleculeapproved|vet_approved

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RelatedDiseases for OPRM1_TCEAL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneOPRM1C0001973Alcoholic Intoxication, Chronic6CTD_human;PSYGENET
HgeneOPRM1C0001969Alcoholic Intoxication5PSYGENET
HgeneOPRM1C0011570Mental Depression4PSYGENET
HgeneOPRM1C0011581Depressive disorder4PSYGENET
HgeneOPRM1C0036341Schizophrenia3PSYGENET
HgeneOPRM1C0236736Cocaine-Related Disorders3CTD_human
HgeneOPRM1C0600427Cocaine Dependence3PSYGENET
HgeneOPRM1C0019196Hepatitis C2CTD_human
HgeneOPRM1C0027796Neuralgia2CTD_human
HgeneOPRM1C0033975Psychotic Disorders2PSYGENET
HgeneOPRM1C0036572Seizures2CTD_human
HgeneOPRM1C0085762Alcohol abuse2PSYGENET
HgeneOPRM1C0349204Nonorganic psychosis2PSYGENET
HgeneOPRM1C0009806Constipation1CTD_human
HgeneOPRM1C0013384Dyskinetic syndrome1CTD_human
HgeneOPRM1C0014544Epilepsy1CTD_human
HgeneOPRM1C0019151Hepatic Encephalopathy1CTD_human
HgeneOPRM1C0019337Heroin Dependence1CTD_human
HgeneOPRM1C0020429Hyperalgesia1CTD_human
HgeneOPRM1C0020651Hypotension, Orthostatic1CTD_human
HgeneOPRM1C0026552Morphine Dependence1CTD_human
HgeneOPRM1C0026650Movement Disorders1CTD_human
HgeneOPRM1C0027497Nausea1CTD_human
HgeneOPRM1C0033774Pruritus1CTD_human
HgeneOPRM1C0033941Psychoses, Substance-Induced1CTD_human
HgeneOPRM1C0035229Respiratory Insufficiency1CTD_human
HgeneOPRM1C0221074Depression, Postpartum1PSYGENET
HgeneOPRM1C0233477Dysphoric mood1PSYGENET
HgeneOPRM1C0236733Amphetamine-Related Disorders1CTD_human
HgeneOPRM1C0236969Substance-Related Disorders1CTD_human
HgeneOPRM1C1837893SCHIZOPHRENIA 121PSYGENET