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Fusion gene ID: 25443 |
FusionGeneSummary for OPCML_SMARCD2 |
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Fusion gene information | Fusion gene name: OPCML_SMARCD2 | Fusion gene ID: 25443 | Hgene | Tgene | Gene symbol | OPCML | SMARCD2 | Gene ID | 4978 | 6603 |
Gene name | opioid binding protein/cell adhesion molecule like | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | |
Synonyms | IGLON1|OBCAM|OPCM | BAF60B|CRACD2|PRO2451|Rsc6p|SGD2 | |
Cytomap | 11q25 | 17q23.3 | |
Type of gene | protein-coding | protein-coding | |
Description | opioid-binding protein/cell adhesion moleculeIgLON family member 1opioid binding protein/cell adhesion molecule-like preprotein | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 260 kDa BRG-1/Brm-associated factor subunit BBRG1-associated factor 60BSWI/SNF complex 60 kDa subunit BSwp73-like proteinchromatin remodeling complex BAF60B s | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | Q14982 | Q92925 | |
Ensembl transtripts involved in fusion gene | ENST00000524381, ENST00000529038, ENST00000331898, ENST00000374778, ENST00000541867, | ENST00000448276, ENST00000323347, ENST00000225742, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 3 X 3 X 2=18 |
# samples | 2 | 3 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: OPCML [Title/Abstract] AND SMARCD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SMARCD2 | GO:0006337 | nucleosome disassembly | 8895581 |
Tgene | SMARCD2 | GO:0006338 | chromatin remodeling | 11726552 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI471650 | OPCML | chr11 | 132777519 | - | SMARCD2 | chr17 | 61909445 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000524381 | ENST00000448276 | OPCML | chr11 | 132777519 | - | SMARCD2 | chr17 | 61909445 | + |
intron-intron | ENST00000524381 | ENST00000323347 | OPCML | chr11 | 132777519 | - | SMARCD2 | chr17 | 61909445 | + |
intron-intron | ENST00000524381 | ENST00000225742 | OPCML | chr11 | 132777519 | - | SMARCD2 | chr17 | 61909445 | + |
intron-intron | ENST00000529038 | ENST00000448276 | OPCML | chr11 | 132777519 | - | SMARCD2 | chr17 | 61909445 | + |
intron-intron | ENST00000529038 | ENST00000323347 | OPCML | chr11 | 132777519 | - | SMARCD2 | chr17 | 61909445 | + |
intron-intron | ENST00000529038 | ENST00000225742 | OPCML | chr11 | 132777519 | - | SMARCD2 | chr17 | 61909445 | + |
intron-intron | ENST00000331898 | ENST00000448276 | OPCML | chr11 | 132777519 | - | SMARCD2 | chr17 | 61909445 | + |
intron-intron | ENST00000331898 | ENST00000323347 | OPCML | chr11 | 132777519 | - | SMARCD2 | chr17 | 61909445 | + |
intron-intron | ENST00000331898 | ENST00000225742 | OPCML | chr11 | 132777519 | - | SMARCD2 | chr17 | 61909445 | + |
intron-intron | ENST00000374778 | ENST00000448276 | OPCML | chr11 | 132777519 | - | SMARCD2 | chr17 | 61909445 | + |
intron-intron | ENST00000374778 | ENST00000323347 | OPCML | chr11 | 132777519 | - | SMARCD2 | chr17 | 61909445 | + |
intron-intron | ENST00000374778 | ENST00000225742 | OPCML | chr11 | 132777519 | - | SMARCD2 | chr17 | 61909445 | + |
intron-intron | ENST00000541867 | ENST00000448276 | OPCML | chr11 | 132777519 | - | SMARCD2 | chr17 | 61909445 | + |
intron-intron | ENST00000541867 | ENST00000323347 | OPCML | chr11 | 132777519 | - | SMARCD2 | chr17 | 61909445 | + |
intron-intron | ENST00000541867 | ENST00000225742 | OPCML | chr11 | 132777519 | - | SMARCD2 | chr17 | 61909445 | + |
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FusionProtFeatures for OPCML_SMARCD2 |
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Hgene | Tgene |
OPCML | SMARCD2 |
Binds opioids in the presence of acidic lipids; probablyinvolved in cell contact. | Involved in transcriptional activation and repression ofselect genes by chromatin remodeling (alteration of DNA-nucleosometopology). Component of SWI/SNF chromatin remodeling complexesthat carry out key enzymatic activities, changing chromatinstructure by altering DNA-histone contacts within a nucleosome inan ATP-dependent manner (PubMed:22952240, PubMed:26601204).Critical regulator of myeloid differentiation, controllinggranulocytopoiesis and the expression of genes involved inneutrophil granule formation (PubMed:28369036).{ECO:0000269|PubMed:28369036, ECO:0000303|PubMed:22952240,ECO:0000303|PubMed:26601204}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for OPCML_SMARCD2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for OPCML_SMARCD2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for OPCML_SMARCD2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OPCML_SMARCD2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | OPCML | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | OPCML | C1140680 | Malignant neoplasm of ovary | 1 | UNIPROT |