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Fusion gene ID: 25398 |
FusionGeneSummary for OIP5_GPR176 |
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Fusion gene information | Fusion gene name: OIP5_GPR176 | Fusion gene ID: 25398 | Hgene | Tgene | Gene symbol | OIP5 | GPR176 | Gene ID | 11339 | 11245 |
Gene name | Opa interacting protein 5 | G protein-coupled receptor 176 | |
Synonyms | 5730547N13Rik|CT86|LINT-25|MIS18B|MIS18beta|hMIS18beta | HB-954 | |
Cytomap | 15q15.1 | 15q14-q15.1 | |
Type of gene | protein-coding | protein-coding | |
Description | protein Mis18-betaLAP2alpha interactor-25MIS18 kinetochore protein homolog Bcancer/testis antigen 86opa-interacting protein 5 | G-protein coupled receptor 176probable G-protein coupled receptor 176 | |
Modification date | 20180523 | 20180517 | |
UniProtAcc | O43482 | Q14439 | |
Ensembl transtripts involved in fusion gene | ENST00000220514, | ENST00000299092, ENST00000561100, ENST00000543580, ENST00000560729, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 1 X 4=16 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: OIP5 [Title/Abstract] AND GPR176 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LIHC | TCGA-BC-A8YO-01A | OIP5 | chr15 | 41605471 | - | GPR176 | chr15 | 40099459 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000220514 | ENST00000299092 | OIP5 | chr15 | 41605471 | - | GPR176 | chr15 | 40099459 | - |
5CDS-intron | ENST00000220514 | ENST00000561100 | OIP5 | chr15 | 41605471 | - | GPR176 | chr15 | 40099459 | - |
5CDS-intron | ENST00000220514 | ENST00000543580 | OIP5 | chr15 | 41605471 | - | GPR176 | chr15 | 40099459 | - |
5CDS-5UTR | ENST00000220514 | ENST00000560729 | OIP5 | chr15 | 41605471 | - | GPR176 | chr15 | 40099459 | - |
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FusionProtFeatures for OIP5_GPR176 |
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Hgene | Tgene |
OIP5 | GPR176 |
Required for recruitment of CENPA to centromeres andnormal chromosome segregation during mitosis.{ECO:0000269|PubMed:17199038}. | Orphan receptor involved in normal circadian rhythmbehavior. Acts through the G-protein subclass G(z)-alpha and hasan agonist-independent basal activity to repress cAMP production.{ECO:0000250|UniProtKB:Q80WT4}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for OIP5_GPR176 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for OIP5_GPR176 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
OIP5 | RAF1, TMPO, ABL2, PEX19, CASP10, FOXJ1, RARG, TSSK3, KDM1A, CUL1, CUL3, CUL4B, BTRC, KRT15, SKIL, TPM3, TRIP6, NUP62, TFIP11, MIS18A, EIF4ENIF1, GCC1, C1orf94, CEP170P1, CEP170, UBE2T, RNF40, QKI, TRAF7, SNAP47, PDZRN3, CYTH3, MED29, STX1A, MIS18BP1, CUEDC1, C9orf16, KRAS, EZH2, GTF2E2, TACC3, CENPA, NCAPH2, CAV3, NOS1AP, PKN3, NCKAP5L, TFPT, CCHCR1, YEATS4, TUFT1, RABGAP1L, GOLGA5, CLOCK, PSMD9, VPS53, DZIP3, GRIPAP1, RCOR1, HMG20A, CCDC132, CCDC93, PHF21A, PTRF, PHLDB3, HAUS6, RPRD1A, ARNTL, MAX, GIT2, RABGEF1, NUF2, THAP11, VPS51, TSSC1, JUN, OIP5, HJURP | GPR176 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for OIP5_GPR176 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OIP5_GPR176 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |