FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 25396

FusionGeneSummary for OIP5-AS1_PTN

check button Fusion gene summary
Fusion gene informationFusion gene name: OIP5-AS1_PTN
Fusion gene ID: 25396
HgeneTgene
Gene symbol

OIP5-AS1

PTN

Gene ID

729082

5764

Gene nameOIP5 antisense RNA 1pleiotrophin
Synonymscyrano|linc-OIP5HARP|HB-GAM|HBBM|HBGF-8|HBGF8|HBNF|HBNF-1|NEGF1|OSF-1
Cytomap

15q15.1

7q33

Type of genencRNAprotein-coding
DescriptionOIP5 antisense RNA 1 (non-protein coding)pleiotrophinheparin affin regulatory proteinheparin-binding brain mitogenheparin-binding growth factor 8heparin-binding growth-associated moleculeheparin-binding neurite outgrowth promoting factorheparin-binding neurite outgrowth-promoting factor 1
Modification date2018042820180523
UniProtAcc

P21246

Ensembl transtripts involved in fusion geneENST00000500949, ENST00000348225, 
ENST00000393083, 
Fusion gene scores* DoF score3 X 3 X 1=96 X 2 X 5=60
# samples 36
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/60*10)=0
Context

PubMed: OIP5-AS1 [Title/Abstract] AND PTN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePTN

GO:0008284

positive regulation of cell proliferation

1733956


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW379067OIP5-AS1chr15

41587819

-PTNchr7

136912767

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000500949ENST00000348225OIP5-AS1chr15

41587819

-PTNchr7

136912767

-
intron-3UTRENST00000500949ENST00000393083OIP5-AS1chr15

41587819

-PTNchr7

136912767

-

Top

FusionProtFeatures for OIP5-AS1_PTN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OIP5-AS1

PTN

P21246

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Secreted growth factor that induces neurite outgrowthand which is mitogenic for fibroblasts, epithelial, andendothelial cells (PubMed:1768439, PubMed:1733956). Bindsanaplastic lymphoma kinase (ALK) which induces MAPK pathwayactivation, an important step in the anti-apoptotic signaling ofPTN and regulation of cell proliferation (PubMed:11278720). Bindsto cell-surface target proteins via their chondroitin sulfategroups (PubMed:26896299). Down-regulates PTPRZ1 activity(PubMed:16814777). {ECO:0000269|PubMed:11278720,ECO:0000269|PubMed:16814777, ECO:0000269|PubMed:1768439,ECO:0000269|PubMed:26896299}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for OIP5-AS1_PTN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for OIP5-AS1_PTN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for OIP5-AS1_PTN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for OIP5-AS1_PTN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePTNC0023893Liver Cirrhosis, Experimental1CTD_human
TgenePTNC0024667Animal Mammary Neoplasms1CTD_human
TgenePTNC0024668Mammary Neoplasms, Experimental1CTD_human