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Fusion gene ID: 25396 |
FusionGeneSummary for OIP5-AS1_PTN |
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Fusion gene information | Fusion gene name: OIP5-AS1_PTN | Fusion gene ID: 25396 | Hgene | Tgene | Gene symbol | OIP5-AS1 | PTN | Gene ID | 729082 | 5764 |
Gene name | OIP5 antisense RNA 1 | pleiotrophin | |
Synonyms | cyrano|linc-OIP5 | HARP|HB-GAM|HBBM|HBGF-8|HBGF8|HBNF|HBNF-1|NEGF1|OSF-1 | |
Cytomap | 15q15.1 | 7q33 | |
Type of gene | ncRNA | protein-coding | |
Description | OIP5 antisense RNA 1 (non-protein coding) | pleiotrophinheparin affin regulatory proteinheparin-binding brain mitogenheparin-binding growth factor 8heparin-binding growth-associated moleculeheparin-binding neurite outgrowth promoting factorheparin-binding neurite outgrowth-promoting factor 1 | |
Modification date | 20180428 | 20180523 | |
UniProtAcc | P21246 | ||
Ensembl transtripts involved in fusion gene | ENST00000500949, | ENST00000348225, ENST00000393083, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 6 X 2 X 5=60 |
# samples | 3 | 6 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/60*10)=0 | |
Context | PubMed: OIP5-AS1 [Title/Abstract] AND PTN [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PTN | GO:0008284 | positive regulation of cell proliferation | 1733956 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW379067 | OIP5-AS1 | chr15 | 41587819 | - | PTN | chr7 | 136912767 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000500949 | ENST00000348225 | OIP5-AS1 | chr15 | 41587819 | - | PTN | chr7 | 136912767 | - |
intron-3UTR | ENST00000500949 | ENST00000393083 | OIP5-AS1 | chr15 | 41587819 | - | PTN | chr7 | 136912767 | - |
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FusionProtFeatures for OIP5-AS1_PTN |
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Hgene | Tgene |
OIP5-AS1 | PTN |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Secreted growth factor that induces neurite outgrowthand which is mitogenic for fibroblasts, epithelial, andendothelial cells (PubMed:1768439, PubMed:1733956). Bindsanaplastic lymphoma kinase (ALK) which induces MAPK pathwayactivation, an important step in the anti-apoptotic signaling ofPTN and regulation of cell proliferation (PubMed:11278720). Bindsto cell-surface target proteins via their chondroitin sulfategroups (PubMed:26896299). Down-regulates PTPRZ1 activity(PubMed:16814777). {ECO:0000269|PubMed:11278720,ECO:0000269|PubMed:16814777, ECO:0000269|PubMed:1768439,ECO:0000269|PubMed:26896299}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for OIP5-AS1_PTN |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for OIP5-AS1_PTN |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for OIP5-AS1_PTN |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OIP5-AS1_PTN |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PTN | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | PTN | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Tgene | PTN | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |