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Fusion gene ID: 25395 |
FusionGeneSummary for OIP5-AS1_ITGB5 |
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Fusion gene information | Fusion gene name: OIP5-AS1_ITGB5 | Fusion gene ID: 25395 | Hgene | Tgene | Gene symbol | OIP5-AS1 | ITGB5 | Gene ID | 729082 | 3693 |
Gene name | OIP5 antisense RNA 1 | integrin subunit beta 5 | |
Synonyms | cyrano|linc-OIP5 | - | |
Cytomap | 15q15.1 | 3q21.2 | |
Type of gene | ncRNA | protein-coding | |
Description | OIP5 antisense RNA 1 (non-protein coding) | integrin beta-5testis secretory sperm-binding protein Li 217p | |
Modification date | 20180428 | 20180523 | |
UniProtAcc | P18084 | ||
Ensembl transtripts involved in fusion gene | ENST00000500949, | ENST00000296181, ENST00000461306, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 3 X 3 X 2=18 |
# samples | 3 | 3 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: OIP5-AS1 [Title/Abstract] AND ITGB5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA453768 | OIP5-AS1 | chr15 | 41578299 | + | ITGB5 | chr3 | 124578293 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000500949 | ENST00000296181 | OIP5-AS1 | chr15 | 41578299 | + | ITGB5 | chr3 | 124578293 | - |
3UTR-intron | ENST00000500949 | ENST00000461306 | OIP5-AS1 | chr15 | 41578299 | + | ITGB5 | chr3 | 124578293 | - |
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FusionProtFeatures for OIP5-AS1_ITGB5 |
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Hgene | Tgene |
OIP5-AS1 | ITGB5 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor forfibronectin. It recognizes the sequence R-G-D in its ligand. (Microbial infection) Integrin ITGAV:ITGB5 acts as areceptor for adenovirus type C. {ECO:0000269|PubMed:20615244}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for OIP5-AS1_ITGB5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for OIP5-AS1_ITGB5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
OIP5-AS1 | ITGB5 | ANXA5, PTK2, CYR61, PAK4, ITGB3BP, ITGA3, PPARD, MERTK, MYC, PDIA3, ALB, SNTA1, EWSR1, SRSF9, EPHA2, EHMT2, MTUS2, KRT40, KRTAP10-9, KRTAP10-8, NOTCH2NL, ITGA5, ATP1B3, KLK5, MFGE8, EDIL3, SPP1, ZBTB17, PLP1, ADAM9, VTN, ST8SIA4, ADAM21, ADAM33, PRG3, ST8SIA3, INSL5, LRRC4, ITGAV |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for OIP5-AS1_ITGB5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OIP5-AS1_ITGB5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ITGB5 | C0040128 | Thyroid Diseases | 1 | CTD_human |
Tgene | ITGB5 | C3495559 | Juvenile arthritis | 1 | CTD_human |