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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25385

FusionGeneSummary for OGFOD1_PARP14

check button Fusion gene summary
Fusion gene informationFusion gene name: OGFOD1_PARP14
Fusion gene ID: 25385
HgeneTgene
Gene symbol

OGFOD1

PARP14

Gene ID

55239

54625

Gene name2-oxoglutarate and iron dependent oxygenase domain containing 1poly(ADP-ribose) polymerase family member 14
SynonymsTPA1ARTD8|BAL2|PARP-14|pART8
Cytomap

16q13

3q21.1

Type of geneprotein-codingprotein-coding
Descriptionprolyl 3-hydroxylase OGFOD12-oxoglutarate and iron-dependent oxygenase domain-containing protein 1TPA1, termination and polyadenylation 1, homologtermination and polyadenylation 1 homologuS12 prolyl 3-hydroxylasepoly [ADP-ribose] polymerase 14ADP-ribosyltransferase diphtheria toxin-like 8B-aggressive lymphoma 2b aggressive lymphoma protein 2collaborator of STAT6
Modification date2018052320180519
UniProtAcc

Q8N543

Q460N5

Ensembl transtripts involved in fusion geneENST00000566157, ENST00000568397, 
ENST00000565209, 
ENST00000474629, 
ENST00000475640, 
Fusion gene scores* DoF score3 X 3 X 2=185 X 6 X 2=60
# samples 36
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/60*10)=0
Context

PubMed: OGFOD1 [Title/Abstract] AND PARP14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOGFOD1

GO:0018126

protein hydroxylation

24550447|24550462

HgeneOGFOD1

GO:0019511

peptidyl-proline hydroxylation

24550447

TgenePARP14

GO:0006471

protein ADP-ribosylation

27796300


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CD368875OGFOD1chr16

56511042

-PARP14chr3

122448055

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000566157ENST00000474629OGFOD1chr16

56511042

-PARP14chr3

122448055

-
3UTR-intronENST00000566157ENST00000475640OGFOD1chr16

56511042

-PARP14chr3

122448055

-
intron-3UTRENST00000568397ENST00000474629OGFOD1chr16

56511042

-PARP14chr3

122448055

-
intron-intronENST00000568397ENST00000475640OGFOD1chr16

56511042

-PARP14chr3

122448055

-
intron-3UTRENST00000565209ENST00000474629OGFOD1chr16

56511042

-PARP14chr3

122448055

-
intron-intronENST00000565209ENST00000475640OGFOD1chr16

56511042

-PARP14chr3

122448055

-

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FusionProtFeatures for OGFOD1_PARP14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OGFOD1

Q8N543

PARP14

Q460N5

Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of'Pro-62' of small ribosomal subunit uS12 (RPS23), therebyregulating protein translation termination efficiency. Involved instress granule formation. {ECO:0000269|PubMed:20154146,ECO:0000269|PubMed:24550447, ECO:0000269|PubMed:24550462}. ADP-ribosyltransferase (PubMed:16061477,PubMed:27796300). By mono-ADP-ribosylating STAT1 at 'Glu-657' and'Glu-705' and thus decreasing STAT1 phosphorylation, negativelyregulates pro-inflammatory cytokines production in macrophages inresponse to IFNG stimulation (PubMed:27796300). Mono-ADP-ribosylates STAT6 (By similarity). Enhances STAT6-dependenttranscription (By similarity). In macrophages, positivelyregulates MRC1 expression in response to IL4 stimulation bypromoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (PubMed:27796300).{ECO:0000250|UniProtKB:Q2EMV9, ECO:0000269|PubMed:16061477,ECO:0000269|PubMed:27796300}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OGFOD1_PARP14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OGFOD1_PARP14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OGFOD1_PARP14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneOGFOD1Q8N543DB00126Vitamin CProlyl 3-hydroxylase OGFOD1small moleculeapproved|nutraceutical

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RelatedDiseases for OGFOD1_PARP14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource