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Fusion gene ID: 25385 |
FusionGeneSummary for OGFOD1_PARP14 |
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Fusion gene information | Fusion gene name: OGFOD1_PARP14 | Fusion gene ID: 25385 | Hgene | Tgene | Gene symbol | OGFOD1 | PARP14 | Gene ID | 55239 | 54625 |
Gene name | 2-oxoglutarate and iron dependent oxygenase domain containing 1 | poly(ADP-ribose) polymerase family member 14 | |
Synonyms | TPA1 | ARTD8|BAL2|PARP-14|pART8 | |
Cytomap | 16q13 | 3q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | prolyl 3-hydroxylase OGFOD12-oxoglutarate and iron-dependent oxygenase domain-containing protein 1TPA1, termination and polyadenylation 1, homologtermination and polyadenylation 1 homologuS12 prolyl 3-hydroxylase | poly [ADP-ribose] polymerase 14ADP-ribosyltransferase diphtheria toxin-like 8B-aggressive lymphoma 2b aggressive lymphoma protein 2collaborator of STAT6 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q8N543 | Q460N5 | |
Ensembl transtripts involved in fusion gene | ENST00000566157, ENST00000568397, ENST00000565209, | ENST00000474629, ENST00000475640, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 5 X 6 X 2=60 |
# samples | 3 | 6 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/60*10)=0 | |
Context | PubMed: OGFOD1 [Title/Abstract] AND PARP14 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | OGFOD1 | GO:0018126 | protein hydroxylation | 24550447|24550462 |
Hgene | OGFOD1 | GO:0019511 | peptidyl-proline hydroxylation | 24550447 |
Tgene | PARP14 | GO:0006471 | protein ADP-ribosylation | 27796300 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CD368875 | OGFOD1 | chr16 | 56511042 | - | PARP14 | chr3 | 122448055 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000566157 | ENST00000474629 | OGFOD1 | chr16 | 56511042 | - | PARP14 | chr3 | 122448055 | - |
3UTR-intron | ENST00000566157 | ENST00000475640 | OGFOD1 | chr16 | 56511042 | - | PARP14 | chr3 | 122448055 | - |
intron-3UTR | ENST00000568397 | ENST00000474629 | OGFOD1 | chr16 | 56511042 | - | PARP14 | chr3 | 122448055 | - |
intron-intron | ENST00000568397 | ENST00000475640 | OGFOD1 | chr16 | 56511042 | - | PARP14 | chr3 | 122448055 | - |
intron-3UTR | ENST00000565209 | ENST00000474629 | OGFOD1 | chr16 | 56511042 | - | PARP14 | chr3 | 122448055 | - |
intron-intron | ENST00000565209 | ENST00000475640 | OGFOD1 | chr16 | 56511042 | - | PARP14 | chr3 | 122448055 | - |
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FusionProtFeatures for OGFOD1_PARP14 |
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Hgene | Tgene |
OGFOD1 | PARP14 |
Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of'Pro-62' of small ribosomal subunit uS12 (RPS23), therebyregulating protein translation termination efficiency. Involved instress granule formation. {ECO:0000269|PubMed:20154146,ECO:0000269|PubMed:24550447, ECO:0000269|PubMed:24550462}. | ADP-ribosyltransferase (PubMed:16061477,PubMed:27796300). By mono-ADP-ribosylating STAT1 at 'Glu-657' and'Glu-705' and thus decreasing STAT1 phosphorylation, negativelyregulates pro-inflammatory cytokines production in macrophages inresponse to IFNG stimulation (PubMed:27796300). Mono-ADP-ribosylates STAT6 (By similarity). Enhances STAT6-dependenttranscription (By similarity). In macrophages, positivelyregulates MRC1 expression in response to IL4 stimulation bypromoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (PubMed:27796300).{ECO:0000250|UniProtKB:Q2EMV9, ECO:0000269|PubMed:16061477,ECO:0000269|PubMed:27796300}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for OGFOD1_PARP14 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for OGFOD1_PARP14 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for OGFOD1_PARP14 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | OGFOD1 | Q8N543 | DB00126 | Vitamin C | Prolyl 3-hydroxylase OGFOD1 | small molecule | approved|nutraceutical |
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RelatedDiseases for OGFOD1_PARP14 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |