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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25377

FusionGeneSummary for OFCC1_SSR1

check button Fusion gene summary
Fusion gene informationFusion gene name: OFCC1_SSR1
Fusion gene ID: 25377
HgeneTgene
Gene symbol

OFCC1

SSR1

Gene ID

266553

6745

Gene nameorofacial cleft 1 candidate 1signal sequence receptor subunit 1
SynonymsMRDS1|OpoTRAPA
Cytomap

6p24.3

6p24.3

Type of geneprotein-codingprotein-coding
Descriptionorofacial cleft 1 candidate gene 1 proteinorofacial clefting chromosomal breakpoint region candidate 1 proteintranslocon-associated protein subunit alphaSSR alpha subunitSSR-alphaTRAP alphasignal sequence receptor subunit alphasignal sequence receptor, alphatranslocon-associated protein alpha subunit
Modification date2018052320180523
UniProtAcc

Q8IZS5

P43307

Ensembl transtripts involved in fusion geneENST00000316020, ENST00000472329, 
ENST00000488834, ENST00000474597, 
ENST00000244763, ENST00000397511, 
ENST00000534851, ENST00000489567, 
ENST00000479365, ENST00000462112, 
Fusion gene scores* DoF score3 X 7 X 2=425 X 6 X 3=90
# samples 86
** MAII scorelog2(8/42*10)=0.929610672108602
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OFCC1 [Title/Abstract] AND SSR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A2-A0CX-01AOFCC1chr6

9769164

-SSR1chr6

7310262

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000316020ENST00000488834OFCC1chr6

9769164

-SSR1chr6

7310262

-
intron-5UTRENST00000316020ENST00000474597OFCC1chr6

9769164

-SSR1chr6

7310262

-
intron-5UTRENST00000316020ENST00000244763OFCC1chr6

9769164

-SSR1chr6

7310262

-
intron-5UTRENST00000316020ENST00000397511OFCC1chr6

9769164

-SSR1chr6

7310262

-
intron-5UTRENST00000316020ENST00000534851OFCC1chr6

9769164

-SSR1chr6

7310262

-
intron-5UTRENST00000316020ENST00000489567OFCC1chr6

9769164

-SSR1chr6

7310262

-
intron-5UTRENST00000316020ENST00000479365OFCC1chr6

9769164

-SSR1chr6

7310262

-
intron-5UTRENST00000316020ENST00000462112OFCC1chr6

9769164

-SSR1chr6

7310262

-
intron-5UTRENST00000472329ENST00000488834OFCC1chr6

9769164

-SSR1chr6

7310262

-
intron-5UTRENST00000472329ENST00000474597OFCC1chr6

9769164

-SSR1chr6

7310262

-
intron-5UTRENST00000472329ENST00000244763OFCC1chr6

9769164

-SSR1chr6

7310262

-
intron-5UTRENST00000472329ENST00000397511OFCC1chr6

9769164

-SSR1chr6

7310262

-
intron-5UTRENST00000472329ENST00000534851OFCC1chr6

9769164

-SSR1chr6

7310262

-
intron-5UTRENST00000472329ENST00000489567OFCC1chr6

9769164

-SSR1chr6

7310262

-
intron-5UTRENST00000472329ENST00000479365OFCC1chr6

9769164

-SSR1chr6

7310262

-
intron-5UTRENST00000472329ENST00000462112OFCC1chr6

9769164

-SSR1chr6

7310262

-

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FusionProtFeatures for OFCC1_SSR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OFCC1

Q8IZS5

SSR1

P43307


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OFCC1_SSR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OFCC1_SSR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
OFCC1CUL3, KDM1A, PRMT1, PRMT8, ZDHHC17, CRK, STAT3, SELENBP1, FLNC, TTC5SSR1DKC1, UTP14A, EEF1A1, PTN, HSPA13, HDGF, ELAVL1, CUL3, CAND1, FBXO6, ACAD9, FLOT2, CCT2, ABCC2, SFXN1, ILF3, FKBP8, HNRNPM, TCP1, CCT5, ATP6V1C1, CCT4, SRSF1, PSAP, HM13, MDC1, SERPINA1, EDEM1, HSPA5, MYC, ODC1, SERPINF2, ILK, HUWE1, RPS6KB2, NTRK1, ATP5C1, CYC1, DDOST, PHB, ATAD3A, ATAD3B, ATP5L, ATP6V0D1, LMAN1, MAGT1, COX2, NDUFA9, NDUFB8, PHB2, RPN1, SSR3, TECR, TMX1, VDAC3, SSR4, UQCRC2, MED23, TCTN3, TMEM216, EZH2, SORT1, SEC61B, LTN1, ERBB3, ESRRB, DUSP23, ERGIC3, EDEM3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OFCC1_SSR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for OFCC1_SSR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneOFCC1C0036341Schizophrenia1PSYGENET