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Fusion gene ID: 25367 |
FusionGeneSummary for ODF2L_F8 |
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Fusion gene information | Fusion gene name: ODF2L_F8 | Fusion gene ID: 25367 | Hgene | Tgene | Gene symbol | ODF2L | F8 | Gene ID | 57489 | 2157 |
Gene name | outer dense fiber of sperm tails 2 like | coagulation factor VIII | |
Synonyms | dJ977L11.1 | AHF|DXS1253E|F8B|F8C|FVIII|HEMA | |
Cytomap | 1p22.3 | Xq28 | |
Type of gene | protein-coding | protein-coding | |
Description | outer dense fiber protein 2-like | coagulation factor VIIIantihemophilic factorcoagulation factor VIII A1 domaincoagulation factor VIII C2 domaincoagulation factor VIII, procoagulant componentcoagulation factor VIIIcfactor VIII F8B | |
Modification date | 20180519 | 20180527 | |
UniProtAcc | Q9ULJ1 | P00451 | |
Ensembl transtripts involved in fusion gene | ENST00000359242, ENST00000370567, ENST00000394731, ENST00000317336, ENST00000370566, ENST00000294678, ENST00000524695, ENST00000478286, ENST00000486215, | ENST00000360256, ENST00000330287, ENST00000483822, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 4=64 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ODF2L [Title/Abstract] AND F8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-FS-A1Z4-06A | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000359242 | ENST00000360256 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
5UTR-intron | ENST00000359242 | ENST00000330287 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
5UTR-intron | ENST00000359242 | ENST00000483822 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
5UTR-3CDS | ENST00000370567 | ENST00000360256 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
5UTR-intron | ENST00000370567 | ENST00000330287 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
5UTR-intron | ENST00000370567 | ENST00000483822 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
5UTR-3CDS | ENST00000394731 | ENST00000360256 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
5UTR-intron | ENST00000394731 | ENST00000330287 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
5UTR-intron | ENST00000394731 | ENST00000483822 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
5UTR-3CDS | ENST00000317336 | ENST00000360256 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
5UTR-intron | ENST00000317336 | ENST00000330287 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
5UTR-intron | ENST00000317336 | ENST00000483822 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
5UTR-3CDS | ENST00000370566 | ENST00000360256 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
5UTR-intron | ENST00000370566 | ENST00000330287 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
5UTR-intron | ENST00000370566 | ENST00000483822 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
5UTR-3CDS | ENST00000294678 | ENST00000360256 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
5UTR-intron | ENST00000294678 | ENST00000330287 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
5UTR-intron | ENST00000294678 | ENST00000483822 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
intron-3CDS | ENST00000524695 | ENST00000360256 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
intron-intron | ENST00000524695 | ENST00000330287 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
intron-intron | ENST00000524695 | ENST00000483822 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
5UTR-3CDS | ENST00000478286 | ENST00000360256 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
5UTR-intron | ENST00000478286 | ENST00000330287 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
5UTR-intron | ENST00000478286 | ENST00000483822 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
intron-3CDS | ENST00000486215 | ENST00000360256 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
intron-intron | ENST00000486215 | ENST00000330287 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
intron-intron | ENST00000486215 | ENST00000483822 | ODF2L | chr1 | 86861716 | - | F8 | chrX | 154159951 | - |
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FusionProtFeatures for ODF2L_F8 |
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Hgene | Tgene |
ODF2L | F8 |
Acts as a suppressor of ciliogenesis, specifically, theinitiation of ciliogenesis. {ECO:0000269|PubMed:28775150}. | Factor VIII, along with calcium and phospholipid, actsas a cofactor for F9/factor IXa when it converts F10/factor X tothe activated form, factor Xa. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ODF2L_F8 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ODF2L_F8 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ODF2L | ERBB3, KIAA1377, PRSS23, APP, NXF1, C17orf59, MED4, PCM1, CEP128, ODF2, EMILIN1, NPM2, GAPDHS, ZMAT2, HACL1 | F8 | PHYH, LMAN1, VWF, LRP1, F10, CANX, PROS1, GGA1, UBQLN1, CALR, TSC22D2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ODF2L_F8 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | F8 | P00451 | DB00100 | Coagulation Factor IX (Recombinant) | Coagulation factor VIII | biotech | approved|investigational |
Tgene | F8 | P00451 | DB13133 | Von Willebrand Factor Human | Coagulation factor VIII | biotech | approved|investigational |
Tgene | F8 | P00451 | DB13151 | Anti-inhibitor coagulant complex | Coagulation factor VIII | biotech | approved|investigational |
Tgene | F8 | P00451 | DB00055 | Drotrecogin alfa | Coagulation factor VIII | biotech | approved|investigational|withdrawn |
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RelatedDiseases for ODF2L_F8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | F8 | C0019069 | Hemophilia A | 62 | CTD_human;UNIPROT |
Tgene | F8 | C0004364 | Autoimmune Diseases | 1 | CTD_human |
Tgene | F8 | C0042487 | Venous Thrombosis | 1 | CTD_human |
Tgene | F8 | C0272325 | Factor 8 deficiency, acquired | 1 | CTD_human |
Tgene | F8 | C0398623 | Thrombophilia | 1 | CTD_human |