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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25367

FusionGeneSummary for ODF2L_F8

check button Fusion gene summary
Fusion gene informationFusion gene name: ODF2L_F8
Fusion gene ID: 25367
HgeneTgene
Gene symbol

ODF2L

F8

Gene ID

57489

2157

Gene nameouter dense fiber of sperm tails 2 likecoagulation factor VIII
SynonymsdJ977L11.1AHF|DXS1253E|F8B|F8C|FVIII|HEMA
Cytomap

1p22.3

Xq28

Type of geneprotein-codingprotein-coding
Descriptionouter dense fiber protein 2-likecoagulation factor VIIIantihemophilic factorcoagulation factor VIII A1 domaincoagulation factor VIII C2 domaincoagulation factor VIII, procoagulant componentcoagulation factor VIIIcfactor VIII F8B
Modification date2018051920180527
UniProtAcc

Q9ULJ1

P00451

Ensembl transtripts involved in fusion geneENST00000359242, ENST00000370567, 
ENST00000394731, ENST00000317336, 
ENST00000370566, ENST00000294678, 
ENST00000524695, ENST00000478286, 
ENST00000486215, 
ENST00000360256, 
ENST00000330287, ENST00000483822, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 4=64
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ODF2L [Title/Abstract] AND F8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-FS-A1Z4-06AODF2Lchr1

86861716

-F8chrX

154159951

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000359242ENST00000360256ODF2Lchr1

86861716

-F8chrX

154159951

-
5UTR-intronENST00000359242ENST00000330287ODF2Lchr1

86861716

-F8chrX

154159951

-
5UTR-intronENST00000359242ENST00000483822ODF2Lchr1

86861716

-F8chrX

154159951

-
5UTR-3CDSENST00000370567ENST00000360256ODF2Lchr1

86861716

-F8chrX

154159951

-
5UTR-intronENST00000370567ENST00000330287ODF2Lchr1

86861716

-F8chrX

154159951

-
5UTR-intronENST00000370567ENST00000483822ODF2Lchr1

86861716

-F8chrX

154159951

-
5UTR-3CDSENST00000394731ENST00000360256ODF2Lchr1

86861716

-F8chrX

154159951

-
5UTR-intronENST00000394731ENST00000330287ODF2Lchr1

86861716

-F8chrX

154159951

-
5UTR-intronENST00000394731ENST00000483822ODF2Lchr1

86861716

-F8chrX

154159951

-
5UTR-3CDSENST00000317336ENST00000360256ODF2Lchr1

86861716

-F8chrX

154159951

-
5UTR-intronENST00000317336ENST00000330287ODF2Lchr1

86861716

-F8chrX

154159951

-
5UTR-intronENST00000317336ENST00000483822ODF2Lchr1

86861716

-F8chrX

154159951

-
5UTR-3CDSENST00000370566ENST00000360256ODF2Lchr1

86861716

-F8chrX

154159951

-
5UTR-intronENST00000370566ENST00000330287ODF2Lchr1

86861716

-F8chrX

154159951

-
5UTR-intronENST00000370566ENST00000483822ODF2Lchr1

86861716

-F8chrX

154159951

-
5UTR-3CDSENST00000294678ENST00000360256ODF2Lchr1

86861716

-F8chrX

154159951

-
5UTR-intronENST00000294678ENST00000330287ODF2Lchr1

86861716

-F8chrX

154159951

-
5UTR-intronENST00000294678ENST00000483822ODF2Lchr1

86861716

-F8chrX

154159951

-
intron-3CDSENST00000524695ENST00000360256ODF2Lchr1

86861716

-F8chrX

154159951

-
intron-intronENST00000524695ENST00000330287ODF2Lchr1

86861716

-F8chrX

154159951

-
intron-intronENST00000524695ENST00000483822ODF2Lchr1

86861716

-F8chrX

154159951

-
5UTR-3CDSENST00000478286ENST00000360256ODF2Lchr1

86861716

-F8chrX

154159951

-
5UTR-intronENST00000478286ENST00000330287ODF2Lchr1

86861716

-F8chrX

154159951

-
5UTR-intronENST00000478286ENST00000483822ODF2Lchr1

86861716

-F8chrX

154159951

-
intron-3CDSENST00000486215ENST00000360256ODF2Lchr1

86861716

-F8chrX

154159951

-
intron-intronENST00000486215ENST00000330287ODF2Lchr1

86861716

-F8chrX

154159951

-
intron-intronENST00000486215ENST00000483822ODF2Lchr1

86861716

-F8chrX

154159951

-

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FusionProtFeatures for ODF2L_F8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ODF2L

Q9ULJ1

F8

P00451

Acts as a suppressor of ciliogenesis, specifically, theinitiation of ciliogenesis. {ECO:0000269|PubMed:28775150}. Factor VIII, along with calcium and phospholipid, actsas a cofactor for F9/factor IXa when it converts F10/factor X tothe activated form, factor Xa.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ODF2L_F8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ODF2L_F8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ODF2LERBB3, KIAA1377, PRSS23, APP, NXF1, C17orf59, MED4, PCM1, CEP128, ODF2, EMILIN1, NPM2, GAPDHS, ZMAT2, HACL1F8PHYH, LMAN1, VWF, LRP1, F10, CANX, PROS1, GGA1, UBQLN1, CALR, TSC22D2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ODF2L_F8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneF8P00451DB00100Coagulation Factor IX (Recombinant)Coagulation factor VIIIbiotechapproved|investigational
TgeneF8P00451DB13133Von Willebrand Factor HumanCoagulation factor VIIIbiotechapproved|investigational
TgeneF8P00451DB13151Anti-inhibitor coagulant complexCoagulation factor VIIIbiotechapproved|investigational
TgeneF8P00451DB00055Drotrecogin alfaCoagulation factor VIIIbiotechapproved|investigational|withdrawn

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RelatedDiseases for ODF2L_F8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneF8C0019069Hemophilia A62CTD_human;UNIPROT
TgeneF8C0004364Autoimmune Diseases1CTD_human
TgeneF8C0042487Venous Thrombosis1CTD_human
TgeneF8C0272325Factor 8 deficiency, acquired1CTD_human
TgeneF8C0398623Thrombophilia1CTD_human