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Fusion gene ID: 25365 |
FusionGeneSummary for OCLN_RAD17 |
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Fusion gene information | Fusion gene name: OCLN_RAD17 | Fusion gene ID: 25365 | Hgene | Tgene | Gene symbol | OCLN | RAD17 | Gene ID | 100506658 | 5884 |
Gene name | occludin | RAD17 checkpoint clamp loader component | |
Synonyms | BLCPMG|PPP1R115|PTORCH1 | CCYC|HRAD17|R24L|RAD17SP|RAD24 | |
Cytomap | 5q13.2 | 5q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | occludinphosphatase 1, regulatory subunit 115tight junction protein occludin | cell cycle checkpoint protein RAD17RAD1 homologRAD17 homologRF-C activator 1 homologRad17-like proteincell cycle checkpoint protein (RAD17) | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q16625 | O75943 | |
Ensembl transtripts involved in fusion gene | ENST00000355237, ENST00000396442, ENST00000380766, ENST00000538151, ENST00000542132, ENST00000514370, | ENST00000361732, ENST00000509734, ENST00000354868, ENST00000521422, ENST00000504177, ENST00000354312, ENST00000345306, ENST00000305138, ENST00000282891, ENST00000358030, ENST00000380774, | |
Fusion gene scores | * DoF score | 6 X 4 X 5=120 | 5 X 5 X 4=100 |
# samples | 6 | 5 | |
** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: OCLN [Title/Abstract] AND RAD17 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | STAD | TCGA-CG-5732-01A | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000355237 | ENST00000361732 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
Frame-shift | ENST00000355237 | ENST00000509734 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
Frame-shift | ENST00000355237 | ENST00000354868 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
Frame-shift | ENST00000355237 | ENST00000521422 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5CDS-3UTR | ENST00000355237 | ENST00000504177 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5CDS-3UTR | ENST00000355237 | ENST00000354312 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5CDS-3UTR | ENST00000355237 | ENST00000345306 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5CDS-3UTR | ENST00000355237 | ENST00000305138 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5CDS-3UTR | ENST00000355237 | ENST00000282891 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5CDS-3UTR | ENST00000355237 | ENST00000358030 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5CDS-3UTR | ENST00000355237 | ENST00000380774 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
Frame-shift | ENST00000396442 | ENST00000361732 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
Frame-shift | ENST00000396442 | ENST00000509734 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
Frame-shift | ENST00000396442 | ENST00000354868 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
Frame-shift | ENST00000396442 | ENST00000521422 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5CDS-3UTR | ENST00000396442 | ENST00000504177 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5CDS-3UTR | ENST00000396442 | ENST00000354312 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5CDS-3UTR | ENST00000396442 | ENST00000345306 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5CDS-3UTR | ENST00000396442 | ENST00000305138 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5CDS-3UTR | ENST00000396442 | ENST00000282891 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5CDS-3UTR | ENST00000396442 | ENST00000358030 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5CDS-3UTR | ENST00000396442 | ENST00000380774 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
Frame-shift | ENST00000380766 | ENST00000361732 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
Frame-shift | ENST00000380766 | ENST00000509734 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
Frame-shift | ENST00000380766 | ENST00000354868 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
Frame-shift | ENST00000380766 | ENST00000521422 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5CDS-3UTR | ENST00000380766 | ENST00000504177 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5CDS-3UTR | ENST00000380766 | ENST00000354312 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5CDS-3UTR | ENST00000380766 | ENST00000345306 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5CDS-3UTR | ENST00000380766 | ENST00000305138 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5CDS-3UTR | ENST00000380766 | ENST00000282891 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5CDS-3UTR | ENST00000380766 | ENST00000358030 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5CDS-3UTR | ENST00000380766 | ENST00000380774 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5UTR-3CDS | ENST00000538151 | ENST00000361732 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5UTR-3CDS | ENST00000538151 | ENST00000509734 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5UTR-3CDS | ENST00000538151 | ENST00000354868 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5UTR-3CDS | ENST00000538151 | ENST00000521422 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5UTR-3UTR | ENST00000538151 | ENST00000504177 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5UTR-3UTR | ENST00000538151 | ENST00000354312 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5UTR-3UTR | ENST00000538151 | ENST00000345306 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5UTR-3UTR | ENST00000538151 | ENST00000305138 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5UTR-3UTR | ENST00000538151 | ENST00000282891 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5UTR-3UTR | ENST00000538151 | ENST00000358030 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5UTR-3UTR | ENST00000538151 | ENST00000380774 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5UTR-3CDS | ENST00000542132 | ENST00000361732 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5UTR-3CDS | ENST00000542132 | ENST00000509734 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5UTR-3CDS | ENST00000542132 | ENST00000354868 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5UTR-3CDS | ENST00000542132 | ENST00000521422 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5UTR-3UTR | ENST00000542132 | ENST00000504177 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5UTR-3UTR | ENST00000542132 | ENST00000354312 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5UTR-3UTR | ENST00000542132 | ENST00000345306 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5UTR-3UTR | ENST00000542132 | ENST00000305138 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5UTR-3UTR | ENST00000542132 | ENST00000282891 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5UTR-3UTR | ENST00000542132 | ENST00000358030 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
5UTR-3UTR | ENST00000542132 | ENST00000380774 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
intron-3CDS | ENST00000514370 | ENST00000361732 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
intron-3CDS | ENST00000514370 | ENST00000509734 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
intron-3CDS | ENST00000514370 | ENST00000354868 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
intron-3CDS | ENST00000514370 | ENST00000521422 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
intron-3UTR | ENST00000514370 | ENST00000504177 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
intron-3UTR | ENST00000514370 | ENST00000354312 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
intron-3UTR | ENST00000514370 | ENST00000345306 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
intron-3UTR | ENST00000514370 | ENST00000305138 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
intron-3UTR | ENST00000514370 | ENST00000282891 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
intron-3UTR | ENST00000514370 | ENST00000358030 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
intron-3UTR | ENST00000514370 | ENST00000380774 | OCLN | chr5 | 68800121 | + | RAD17 | chr5 | 68709858 | + |
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FusionProtFeatures for OCLN_RAD17 |
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Hgene | Tgene |
OCLN | RAD17 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for OCLN_RAD17 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for OCLN_RAD17 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
OCLN | TJP2, RAB8B, YES1, TJP1, GJB1, ITCH, EPN1, EPS15, HGS, NEDD4L, TGFBR1, TGFBR2, LYN, TNFAIP3, CLEC7A, SYNE4, SNW1, CSNK1E, ULK1, CSNK1A1, MPZL2, CD1B, TMEM171, IGSF8, SLAMF1, DLK1, SLC18A1, TMEM17, TMEM216, FATE1, CDH1, PTPN2, FBLN1, MFAP4, CTAGE5, TMEM30B, C4A, SDC1, SIGLECL1, NEDD4, NDUFAF1, TNFSF8, ANTXR1, ACAD9, EFEMP1, SYT12, DNAJC13, PREB, MAN1A1, TNFSF9, CSNK2A1, OCLN | RAD17 | ATM, ATR, PRKDC, RAD9B, RAD9A, RFC2, RFC3, RFC4, RFC5, POLE, POLE2, POLE3, POLE4, HUS1, RAD1, NHP2L1, RFC1, USP20, ALK, CLSPN, FOXO3, H2AFX, CDH1, CBX6, CBX7, PRMT6, COPS7A, CHEK2, CHEK1, TOP1, TOP2A, TOP3A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for OCLN_RAD17 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OCLN_RAD17 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | OCLN | C1458155 | Mammary Neoplasms | 2 | CTD_human |
Hgene | OCLN | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Hgene | OCLN | C0019156 | Hepatic Veno-Occlusive Disease | 1 | CTD_human |
Hgene | OCLN | C0035309 | Retinal Diseases | 1 | CTD_human |
Hgene | OCLN | C0038002 | Splenomegaly | 1 | CTD_human |
Hgene | OCLN | C2609414 | Acute kidney injury | 1 | CTD_human |
Hgene | OCLN | C3489725 | Pseudo-TORCH syndrome | 1 | CTD_human;ORPHANET;UNIPROT |