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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25365

FusionGeneSummary for OCLN_RAD17

check button Fusion gene summary
Fusion gene informationFusion gene name: OCLN_RAD17
Fusion gene ID: 25365
HgeneTgene
Gene symbol

OCLN

RAD17

Gene ID

100506658

5884

Gene nameoccludinRAD17 checkpoint clamp loader component
SynonymsBLCPMG|PPP1R115|PTORCH1CCYC|HRAD17|R24L|RAD17SP|RAD24
Cytomap

5q13.2

5q13.2

Type of geneprotein-codingprotein-coding
Descriptionoccludinphosphatase 1, regulatory subunit 115tight junction protein occludincell cycle checkpoint protein RAD17RAD1 homologRAD17 homologRF-C activator 1 homologRad17-like proteincell cycle checkpoint protein (RAD17)
Modification date2018051920180523
UniProtAcc

Q16625

O75943

Ensembl transtripts involved in fusion geneENST00000355237, ENST00000396442, 
ENST00000380766, ENST00000538151, 
ENST00000542132, ENST00000514370, 
ENST00000361732, ENST00000509734, 
ENST00000354868, ENST00000521422, 
ENST00000504177, ENST00000354312, 
ENST00000345306, ENST00000305138, 
ENST00000282891, ENST00000358030, 
ENST00000380774, 
Fusion gene scores* DoF score6 X 4 X 5=1205 X 5 X 4=100
# samples 65
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OCLN [Title/Abstract] AND RAD17 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationDDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-CG-5732-01AOCLNchr5

68800121

+RAD17chr5

68709858

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000355237ENST00000361732OCLNchr5

68800121

+RAD17chr5

68709858

+
Frame-shiftENST00000355237ENST00000509734OCLNchr5

68800121

+RAD17chr5

68709858

+
Frame-shiftENST00000355237ENST00000354868OCLNchr5

68800121

+RAD17chr5

68709858

+
Frame-shiftENST00000355237ENST00000521422OCLNchr5

68800121

+RAD17chr5

68709858

+
5CDS-3UTRENST00000355237ENST00000504177OCLNchr5

68800121

+RAD17chr5

68709858

+
5CDS-3UTRENST00000355237ENST00000354312OCLNchr5

68800121

+RAD17chr5

68709858

+
5CDS-3UTRENST00000355237ENST00000345306OCLNchr5

68800121

+RAD17chr5

68709858

+
5CDS-3UTRENST00000355237ENST00000305138OCLNchr5

68800121

+RAD17chr5

68709858

+
5CDS-3UTRENST00000355237ENST00000282891OCLNchr5

68800121

+RAD17chr5

68709858

+
5CDS-3UTRENST00000355237ENST00000358030OCLNchr5

68800121

+RAD17chr5

68709858

+
5CDS-3UTRENST00000355237ENST00000380774OCLNchr5

68800121

+RAD17chr5

68709858

+
Frame-shiftENST00000396442ENST00000361732OCLNchr5

68800121

+RAD17chr5

68709858

+
Frame-shiftENST00000396442ENST00000509734OCLNchr5

68800121

+RAD17chr5

68709858

+
Frame-shiftENST00000396442ENST00000354868OCLNchr5

68800121

+RAD17chr5

68709858

+
Frame-shiftENST00000396442ENST00000521422OCLNchr5

68800121

+RAD17chr5

68709858

+
5CDS-3UTRENST00000396442ENST00000504177OCLNchr5

68800121

+RAD17chr5

68709858

+
5CDS-3UTRENST00000396442ENST00000354312OCLNchr5

68800121

+RAD17chr5

68709858

+
5CDS-3UTRENST00000396442ENST00000345306OCLNchr5

68800121

+RAD17chr5

68709858

+
5CDS-3UTRENST00000396442ENST00000305138OCLNchr5

68800121

+RAD17chr5

68709858

+
5CDS-3UTRENST00000396442ENST00000282891OCLNchr5

68800121

+RAD17chr5

68709858

+
5CDS-3UTRENST00000396442ENST00000358030OCLNchr5

68800121

+RAD17chr5

68709858

+
5CDS-3UTRENST00000396442ENST00000380774OCLNchr5

68800121

+RAD17chr5

68709858

+
Frame-shiftENST00000380766ENST00000361732OCLNchr5

68800121

+RAD17chr5

68709858

+
Frame-shiftENST00000380766ENST00000509734OCLNchr5

68800121

+RAD17chr5

68709858

+
Frame-shiftENST00000380766ENST00000354868OCLNchr5

68800121

+RAD17chr5

68709858

+
Frame-shiftENST00000380766ENST00000521422OCLNchr5

68800121

+RAD17chr5

68709858

+
5CDS-3UTRENST00000380766ENST00000504177OCLNchr5

68800121

+RAD17chr5

68709858

+
5CDS-3UTRENST00000380766ENST00000354312OCLNchr5

68800121

+RAD17chr5

68709858

+
5CDS-3UTRENST00000380766ENST00000345306OCLNchr5

68800121

+RAD17chr5

68709858

+
5CDS-3UTRENST00000380766ENST00000305138OCLNchr5

68800121

+RAD17chr5

68709858

+
5CDS-3UTRENST00000380766ENST00000282891OCLNchr5

68800121

+RAD17chr5

68709858

+
5CDS-3UTRENST00000380766ENST00000358030OCLNchr5

68800121

+RAD17chr5

68709858

+
5CDS-3UTRENST00000380766ENST00000380774OCLNchr5

68800121

+RAD17chr5

68709858

+
5UTR-3CDSENST00000538151ENST00000361732OCLNchr5

68800121

+RAD17chr5

68709858

+
5UTR-3CDSENST00000538151ENST00000509734OCLNchr5

68800121

+RAD17chr5

68709858

+
5UTR-3CDSENST00000538151ENST00000354868OCLNchr5

68800121

+RAD17chr5

68709858

+
5UTR-3CDSENST00000538151ENST00000521422OCLNchr5

68800121

+RAD17chr5

68709858

+
5UTR-3UTRENST00000538151ENST00000504177OCLNchr5

68800121

+RAD17chr5

68709858

+
5UTR-3UTRENST00000538151ENST00000354312OCLNchr5

68800121

+RAD17chr5

68709858

+
5UTR-3UTRENST00000538151ENST00000345306OCLNchr5

68800121

+RAD17chr5

68709858

+
5UTR-3UTRENST00000538151ENST00000305138OCLNchr5

68800121

+RAD17chr5

68709858

+
5UTR-3UTRENST00000538151ENST00000282891OCLNchr5

68800121

+RAD17chr5

68709858

+
5UTR-3UTRENST00000538151ENST00000358030OCLNchr5

68800121

+RAD17chr5

68709858

+
5UTR-3UTRENST00000538151ENST00000380774OCLNchr5

68800121

+RAD17chr5

68709858

+
5UTR-3CDSENST00000542132ENST00000361732OCLNchr5

68800121

+RAD17chr5

68709858

+
5UTR-3CDSENST00000542132ENST00000509734OCLNchr5

68800121

+RAD17chr5

68709858

+
5UTR-3CDSENST00000542132ENST00000354868OCLNchr5

68800121

+RAD17chr5

68709858

+
5UTR-3CDSENST00000542132ENST00000521422OCLNchr5

68800121

+RAD17chr5

68709858

+
5UTR-3UTRENST00000542132ENST00000504177OCLNchr5

68800121

+RAD17chr5

68709858

+
5UTR-3UTRENST00000542132ENST00000354312OCLNchr5

68800121

+RAD17chr5

68709858

+
5UTR-3UTRENST00000542132ENST00000345306OCLNchr5

68800121

+RAD17chr5

68709858

+
5UTR-3UTRENST00000542132ENST00000305138OCLNchr5

68800121

+RAD17chr5

68709858

+
5UTR-3UTRENST00000542132ENST00000282891OCLNchr5

68800121

+RAD17chr5

68709858

+
5UTR-3UTRENST00000542132ENST00000358030OCLNchr5

68800121

+RAD17chr5

68709858

+
5UTR-3UTRENST00000542132ENST00000380774OCLNchr5

68800121

+RAD17chr5

68709858

+
intron-3CDSENST00000514370ENST00000361732OCLNchr5

68800121

+RAD17chr5

68709858

+
intron-3CDSENST00000514370ENST00000509734OCLNchr5

68800121

+RAD17chr5

68709858

+
intron-3CDSENST00000514370ENST00000354868OCLNchr5

68800121

+RAD17chr5

68709858

+
intron-3CDSENST00000514370ENST00000521422OCLNchr5

68800121

+RAD17chr5

68709858

+
intron-3UTRENST00000514370ENST00000504177OCLNchr5

68800121

+RAD17chr5

68709858

+
intron-3UTRENST00000514370ENST00000354312OCLNchr5

68800121

+RAD17chr5

68709858

+
intron-3UTRENST00000514370ENST00000345306OCLNchr5

68800121

+RAD17chr5

68709858

+
intron-3UTRENST00000514370ENST00000305138OCLNchr5

68800121

+RAD17chr5

68709858

+
intron-3UTRENST00000514370ENST00000282891OCLNchr5

68800121

+RAD17chr5

68709858

+
intron-3UTRENST00000514370ENST00000358030OCLNchr5

68800121

+RAD17chr5

68709858

+
intron-3UTRENST00000514370ENST00000380774OCLNchr5

68800121

+RAD17chr5

68709858

+

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FusionProtFeatures for OCLN_RAD17


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OCLN

Q16625

RAD17

O75943


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OCLN_RAD17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OCLN_RAD17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
OCLNTJP2, RAB8B, YES1, TJP1, GJB1, ITCH, EPN1, EPS15, HGS, NEDD4L, TGFBR1, TGFBR2, LYN, TNFAIP3, CLEC7A, SYNE4, SNW1, CSNK1E, ULK1, CSNK1A1, MPZL2, CD1B, TMEM171, IGSF8, SLAMF1, DLK1, SLC18A1, TMEM17, TMEM216, FATE1, CDH1, PTPN2, FBLN1, MFAP4, CTAGE5, TMEM30B, C4A, SDC1, SIGLECL1, NEDD4, NDUFAF1, TNFSF8, ANTXR1, ACAD9, EFEMP1, SYT12, DNAJC13, PREB, MAN1A1, TNFSF9, CSNK2A1, OCLNRAD17ATM, ATR, PRKDC, RAD9B, RAD9A, RFC2, RFC3, RFC4, RFC5, POLE, POLE2, POLE3, POLE4, HUS1, RAD1, NHP2L1, RFC1, USP20, ALK, CLSPN, FOXO3, H2AFX, CDH1, CBX6, CBX7, PRMT6, COPS7A, CHEK2, CHEK1, TOP1, TOP2A, TOP3A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OCLN_RAD17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for OCLN_RAD17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneOCLNC1458155Mammary Neoplasms2CTD_human
HgeneOCLNC0007621Neoplastic Cell Transformation1CTD_human
HgeneOCLNC0019156Hepatic Veno-Occlusive Disease1CTD_human
HgeneOCLNC0035309Retinal Diseases1CTD_human
HgeneOCLNC0038002Splenomegaly1CTD_human
HgeneOCLNC2609414Acute kidney injury1CTD_human
HgeneOCLNC3489725Pseudo-TORCH syndrome1CTD_human;ORPHANET;UNIPROT