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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25357

FusionGeneSummary for OCIAD1_SH3GLB2

check button Fusion gene summary
Fusion gene informationFusion gene name: OCIAD1_SH3GLB2
Fusion gene ID: 25357
HgeneTgene
Gene symbol

OCIAD1

SH3GLB2

Gene ID

54940

56904

Gene nameOCIA domain containing 1SH3 domain containing GRB2 like, endophilin B2
SynonymsASRIJ|OCIA|TPA018PP6569|PP9455|RRIG1
Cytomap

4p11

9q34.11

Type of geneprotein-codingprotein-coding
DescriptionOCIA domain-containing protein 1ovarian cancer immunoreactive antigen domain containing 1ovarian cancer immunoreactive antigen domain containing 1Aovarian carcinoma immunoreactive antigenendophilin-B2SH3 domain-containing GRB2-like protein B2SH3-containing protein SH3GLB2SH3-domain GRB2-like endophilin B2retinoid receptor-induced gene 1
Modification date2018051920180522
UniProtAcc

Q9NX40

Q9NR46

Ensembl transtripts involved in fusion geneENST00000509122, ENST00000512981, 
ENST00000396448, ENST00000264312, 
ENST00000381473, ENST00000444354, 
ENST00000506801, ENST00000425583, 
ENST00000508293, ENST00000513391, 
ENST00000372564, ENST00000372559, 
ENST00000372554, ENST00000417224, 
ENST00000416629, 
Fusion gene scores* DoF score5 X 5 X 3=751 X 1 X 1=1
# samples 51
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: OCIAD1 [Title/Abstract] AND SH3GLB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI018597OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000509122ENST00000372564OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000509122ENST00000372559OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000509122ENST00000372554OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000509122ENST00000417224OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000509122ENST00000416629OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000512981ENST00000372564OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000512981ENST00000372559OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000512981ENST00000372554OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000512981ENST00000417224OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000512981ENST00000416629OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000396448ENST00000372564OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000396448ENST00000372559OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000396448ENST00000372554OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000396448ENST00000417224OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000396448ENST00000416629OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000264312ENST00000372564OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000264312ENST00000372559OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000264312ENST00000372554OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000264312ENST00000417224OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000264312ENST00000416629OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000381473ENST00000372564OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000381473ENST00000372559OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000381473ENST00000372554OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000381473ENST00000417224OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000381473ENST00000416629OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000444354ENST00000372564OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000444354ENST00000372559OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000444354ENST00000372554OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000444354ENST00000417224OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000444354ENST00000416629OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000506801ENST00000372564OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000506801ENST00000372559OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000506801ENST00000372554OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000506801ENST00000417224OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000506801ENST00000416629OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000425583ENST00000372564OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000425583ENST00000372559OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000425583ENST00000372554OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000425583ENST00000417224OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000425583ENST00000416629OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000508293ENST00000372564OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000508293ENST00000372559OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000508293ENST00000372554OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000508293ENST00000417224OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000508293ENST00000416629OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000513391ENST00000372564OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000513391ENST00000372559OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000513391ENST00000372554OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000513391ENST00000417224OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+
intron-intronENST00000513391ENST00000416629OCIAD1chr4

48862220

+SH3GLB2chr9

131783369

+

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FusionProtFeatures for OCIAD1_SH3GLB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OCIAD1

Q9NX40

SH3GLB2

Q9NR46

Maintains stem cell potency (By similarity). IncreasesSTAT3 phosphorylation and controls ERK phosphorylation (Bysimilarity). May act as a scaffold, increasing STAT3 recruitmentonto endosomes (By similarity). Involved in integrin-mediatedcancer cell adhesion and colony formation in ovarian cancer(PubMed:20515946). {ECO:0000250|UniProtKB:Q9CRD0,ECO:0000269|PubMed:20515946}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OCIAD1_SH3GLB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OCIAD1_SH3GLB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OCIAD1_SH3GLB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for OCIAD1_SH3GLB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource