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Fusion gene ID: 25354 |
FusionGeneSummary for OCIAD1_GLIPR2 |
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Fusion gene information | Fusion gene name: OCIAD1_GLIPR2 | Fusion gene ID: 25354 | Hgene | Tgene | Gene symbol | OCIAD1 | GLIPR2 | Gene ID | 54940 | 152007 |
Gene name | OCIA domain containing 1 | GLI pathogenesis related 2 | |
Synonyms | ASRIJ|OCIA|TPA018 | C9orf19|GAPR-1|GAPR1 | |
Cytomap | 4p11 | 9p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | OCIA domain-containing protein 1ovarian cancer immunoreactive antigen domain containing 1ovarian cancer immunoreactive antigen domain containing 1Aovarian carcinoma immunoreactive antigen | Golgi-associated plant pathogenesis-related protein 117kD fetal brain proteingliPR 2glioma pathogenesis-related protein 2golgi-associated PR-1 protein | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9NX40 | Q9H4G4 | |
Ensembl transtripts involved in fusion gene | ENST00000509122, ENST00000512981, ENST00000396448, ENST00000264312, ENST00000381473, ENST00000444354, ENST00000506801, ENST00000425583, ENST00000508293, ENST00000513391, | ENST00000396613, ENST00000377959, ENST00000377960, ENST00000474050, | |
Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 9 X 4 X 5=180 |
# samples | 5 | 7 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: OCIAD1 [Title/Abstract] AND GLIPR2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | GLIPR2 | GO:0010634 | positive regulation of epithelial cell migration | 23516513 |
Tgene | GLIPR2 | GO:0010718 | positive regulation of epithelial to mesenchymal transition | 23516513 |
Tgene | GLIPR2 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 23516513 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | HNSC | TCGA-CN-A63U-01A | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000509122 | ENST00000396613 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
intron-3UTR | ENST00000509122 | ENST00000377959 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
intron-3UTR | ENST00000509122 | ENST00000377960 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
intron-3UTR | ENST00000509122 | ENST00000474050 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
3UTR-3UTR | ENST00000512981 | ENST00000396613 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
3UTR-3UTR | ENST00000512981 | ENST00000377959 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
3UTR-3UTR | ENST00000512981 | ENST00000377960 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
3UTR-3UTR | ENST00000512981 | ENST00000474050 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000396448 | ENST00000396613 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000396448 | ENST00000377959 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000396448 | ENST00000377960 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000396448 | ENST00000474050 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000264312 | ENST00000396613 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000264312 | ENST00000377959 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000264312 | ENST00000377960 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000264312 | ENST00000474050 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000381473 | ENST00000396613 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000381473 | ENST00000377959 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000381473 | ENST00000377960 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000381473 | ENST00000474050 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000444354 | ENST00000396613 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000444354 | ENST00000377959 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000444354 | ENST00000377960 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000444354 | ENST00000474050 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000506801 | ENST00000396613 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000506801 | ENST00000377959 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000506801 | ENST00000377960 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000506801 | ENST00000474050 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000425583 | ENST00000396613 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000425583 | ENST00000377959 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000425583 | ENST00000377960 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
5UTR-3UTR | ENST00000425583 | ENST00000474050 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
intron-3UTR | ENST00000508293 | ENST00000396613 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
intron-3UTR | ENST00000508293 | ENST00000377959 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
intron-3UTR | ENST00000508293 | ENST00000377960 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
intron-3UTR | ENST00000508293 | ENST00000474050 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
intron-3UTR | ENST00000513391 | ENST00000396613 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
intron-3UTR | ENST00000513391 | ENST00000377959 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
intron-3UTR | ENST00000513391 | ENST00000377960 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
intron-3UTR | ENST00000513391 | ENST00000474050 | OCIAD1 | chr4 | 48833266 | + | GLIPR2 | chr9 | 36162359 | + |
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FusionProtFeatures for OCIAD1_GLIPR2 |
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Hgene | Tgene |
OCIAD1 | GLIPR2 |
Maintains stem cell potency (By similarity). IncreasesSTAT3 phosphorylation and controls ERK phosphorylation (Bysimilarity). May act as a scaffold, increasing STAT3 recruitmentonto endosomes (By similarity). Involved in integrin-mediatedcancer cell adhesion and colony formation in ovarian cancer(PubMed:20515946). {ECO:0000250|UniProtKB:Q9CRD0,ECO:0000269|PubMed:20515946}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for OCIAD1_GLIPR2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for OCIAD1_GLIPR2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
OCIAD1 | UBC, FLOT1, ELAVL1, SDHB, ATF7, SHMT2, MOV10, NXF1, BLVRA, RGL4, GNAT2, GNAS, LANCL1, LPAR1, CPVL, AKAP14, UNK, PCBP1, TMEM67, XPO1, TIMMDC1, RAB5C, OCIAD1, CHCHD3, FUNDC2, AFG3L2, NDUFA4, STOML2, CISD1, PMPCB, CLPB, CYB5R3, COX6A1, TOMM5, ABCD3, UQCC2, C2orf47, USMG5, ATP5E, COX6C, IMMT, NRD1, TIMM44, NDUFV1, ECH1, ATP5H, ATAD3A, SLC25A1, NDUFS8, NDUFS2, MTX1, ATAD1, MTCH2, ATP5C1, COX7A2, ATP5O, TOMM20, TOMM40, YME1L1, C1QBP, BAX, NDUFS3, ATP5J, TIMM50, SCO1, POLDIP2, NDUFA9, NDUFB1, CTDNEP1, IPPK, SYCE3, UST, EXOC8, CLU, RALB | GLIPR2 | ELAVL1, CDV3, SVIL, CAV1, PNMA5, KRTAP10-3, ANKRD12 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for OCIAD1_GLIPR2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OCIAD1_GLIPR2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |