FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 25354

FusionGeneSummary for OCIAD1_GLIPR2

check button Fusion gene summary
Fusion gene informationFusion gene name: OCIAD1_GLIPR2
Fusion gene ID: 25354
HgeneTgene
Gene symbol

OCIAD1

GLIPR2

Gene ID

54940

152007

Gene nameOCIA domain containing 1GLI pathogenesis related 2
SynonymsASRIJ|OCIA|TPA018C9orf19|GAPR-1|GAPR1
Cytomap

4p11

9p13.3

Type of geneprotein-codingprotein-coding
DescriptionOCIA domain-containing protein 1ovarian cancer immunoreactive antigen domain containing 1ovarian cancer immunoreactive antigen domain containing 1Aovarian carcinoma immunoreactive antigenGolgi-associated plant pathogenesis-related protein 117kD fetal brain proteingliPR 2glioma pathogenesis-related protein 2golgi-associated PR-1 protein
Modification date2018051920180523
UniProtAcc

Q9NX40

Q9H4G4

Ensembl transtripts involved in fusion geneENST00000509122, ENST00000512981, 
ENST00000396448, ENST00000264312, 
ENST00000381473, ENST00000444354, 
ENST00000506801, ENST00000425583, 
ENST00000508293, ENST00000513391, 
ENST00000396613, ENST00000377959, 
ENST00000377960, ENST00000474050, 
Fusion gene scores* DoF score5 X 5 X 3=759 X 4 X 5=180
# samples 57
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OCIAD1 [Title/Abstract] AND GLIPR2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGLIPR2

GO:0010634

positive regulation of epithelial cell migration

23516513

TgeneGLIPR2

GO:0010718

positive regulation of epithelial to mesenchymal transition

23516513

TgeneGLIPR2

GO:0070374

positive regulation of ERK1 and ERK2 cascade

23516513


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CN-A63U-01AOCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000509122ENST00000396613OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
intron-3UTRENST00000509122ENST00000377959OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
intron-3UTRENST00000509122ENST00000377960OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
intron-3UTRENST00000509122ENST00000474050OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
3UTR-3UTRENST00000512981ENST00000396613OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
3UTR-3UTRENST00000512981ENST00000377959OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
3UTR-3UTRENST00000512981ENST00000377960OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
3UTR-3UTRENST00000512981ENST00000474050OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000396448ENST00000396613OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000396448ENST00000377959OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000396448ENST00000377960OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000396448ENST00000474050OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000264312ENST00000396613OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000264312ENST00000377959OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000264312ENST00000377960OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000264312ENST00000474050OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000381473ENST00000396613OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000381473ENST00000377959OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000381473ENST00000377960OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000381473ENST00000474050OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000444354ENST00000396613OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000444354ENST00000377959OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000444354ENST00000377960OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000444354ENST00000474050OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000506801ENST00000396613OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000506801ENST00000377959OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000506801ENST00000377960OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000506801ENST00000474050OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000425583ENST00000396613OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000425583ENST00000377959OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000425583ENST00000377960OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
5UTR-3UTRENST00000425583ENST00000474050OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
intron-3UTRENST00000508293ENST00000396613OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
intron-3UTRENST00000508293ENST00000377959OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
intron-3UTRENST00000508293ENST00000377960OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
intron-3UTRENST00000508293ENST00000474050OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
intron-3UTRENST00000513391ENST00000396613OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
intron-3UTRENST00000513391ENST00000377959OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
intron-3UTRENST00000513391ENST00000377960OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+
intron-3UTRENST00000513391ENST00000474050OCIAD1chr4

48833266

+GLIPR2chr9

36162359

+

Top

FusionProtFeatures for OCIAD1_GLIPR2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OCIAD1

Q9NX40

GLIPR2

Q9H4G4

Maintains stem cell potency (By similarity). IncreasesSTAT3 phosphorylation and controls ERK phosphorylation (Bysimilarity). May act as a scaffold, increasing STAT3 recruitmentonto endosomes (By similarity). Involved in integrin-mediatedcancer cell adhesion and colony formation in ovarian cancer(PubMed:20515946). {ECO:0000250|UniProtKB:Q9CRD0,ECO:0000269|PubMed:20515946}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for OCIAD1_GLIPR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for OCIAD1_GLIPR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
OCIAD1UBC, FLOT1, ELAVL1, SDHB, ATF7, SHMT2, MOV10, NXF1, BLVRA, RGL4, GNAT2, GNAS, LANCL1, LPAR1, CPVL, AKAP14, UNK, PCBP1, TMEM67, XPO1, TIMMDC1, RAB5C, OCIAD1, CHCHD3, FUNDC2, AFG3L2, NDUFA4, STOML2, CISD1, PMPCB, CLPB, CYB5R3, COX6A1, TOMM5, ABCD3, UQCC2, C2orf47, USMG5, ATP5E, COX6C, IMMT, NRD1, TIMM44, NDUFV1, ECH1, ATP5H, ATAD3A, SLC25A1, NDUFS8, NDUFS2, MTX1, ATAD1, MTCH2, ATP5C1, COX7A2, ATP5O, TOMM20, TOMM40, YME1L1, C1QBP, BAX, NDUFS3, ATP5J, TIMM50, SCO1, POLDIP2, NDUFA9, NDUFB1, CTDNEP1, IPPK, SYCE3, UST, EXOC8, CLU, RALBGLIPR2ELAVL1, CDV3, SVIL, CAV1, PNMA5, KRTAP10-3, ANKRD12


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for OCIAD1_GLIPR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for OCIAD1_GLIPR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource