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Fusion gene ID: 25341 |
FusionGeneSummary for OBFC1_PCGF3 |
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Fusion gene information | Fusion gene name: OBFC1_PCGF3 | Fusion gene ID: 25341 | Hgene | Tgene | Gene symbol | OBFC1 | PCGF3 | Gene ID | 79991 | 10336 |
Gene name | STN1, CST complex subunit | polycomb group ring finger 3 | |
Synonyms | AAF-44|AAF44|OBFC1|RPA-32|bA541N10.2 | DONG1|RNF3|RNF3A | |
Cytomap | 10q24.33 | 4p16.3 | |
Type of gene | protein-coding | protein-coding | |
Description | CST complex subunit STN1alpha accessory factor 44oligonucleotide/oligosaccharide binding fold containing 1oligonucleotide/oligosaccharide-binding fold-containing protein 1replication protein A 32 kDa subunitsuppressor of cdc thirteen homolog | polycomb group RING finger protein 3RING finger protein 3Aring finger protein 3 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q3KNV8 | ||
Ensembl transtripts involved in fusion gene | ENST00000224950, ENST00000369764, ENST00000466828, | ENST00000362003, ENST00000400151, ENST00000482726, ENST00000470161, ENST00000521023, ENST00000505655, | |
Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 4 X 4 X 3=48 |
# samples | 4 | 4 | |
** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: OBFC1 [Title/Abstract] AND PCGF3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | OBFC1 | GO:0032211 | negative regulation of telomere maintenance via telomerase | 22763445 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-GU-A42Q-01A | OBFC1 | chr10 | 105664849 | - | PCGF3 | chr4 | 755067 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000224950 | ENST00000362003 | OBFC1 | chr10 | 105664849 | - | PCGF3 | chr4 | 755067 | + |
5CDS-intron | ENST00000224950 | ENST00000400151 | OBFC1 | chr10 | 105664849 | - | PCGF3 | chr4 | 755067 | + |
5CDS-intron | ENST00000224950 | ENST00000482726 | OBFC1 | chr10 | 105664849 | - | PCGF3 | chr4 | 755067 | + |
5CDS-intron | ENST00000224950 | ENST00000470161 | OBFC1 | chr10 | 105664849 | - | PCGF3 | chr4 | 755067 | + |
5CDS-intron | ENST00000224950 | ENST00000521023 | OBFC1 | chr10 | 105664849 | - | PCGF3 | chr4 | 755067 | + |
5CDS-intron | ENST00000224950 | ENST00000505655 | OBFC1 | chr10 | 105664849 | - | PCGF3 | chr4 | 755067 | + |
Frame-shift | ENST00000369764 | ENST00000362003 | OBFC1 | chr10 | 105664849 | - | PCGF3 | chr4 | 755067 | + |
5CDS-intron | ENST00000369764 | ENST00000400151 | OBFC1 | chr10 | 105664849 | - | PCGF3 | chr4 | 755067 | + |
5CDS-intron | ENST00000369764 | ENST00000482726 | OBFC1 | chr10 | 105664849 | - | PCGF3 | chr4 | 755067 | + |
5CDS-intron | ENST00000369764 | ENST00000470161 | OBFC1 | chr10 | 105664849 | - | PCGF3 | chr4 | 755067 | + |
5CDS-intron | ENST00000369764 | ENST00000521023 | OBFC1 | chr10 | 105664849 | - | PCGF3 | chr4 | 755067 | + |
5CDS-intron | ENST00000369764 | ENST00000505655 | OBFC1 | chr10 | 105664849 | - | PCGF3 | chr4 | 755067 | + |
5UTR-3CDS | ENST00000466828 | ENST00000362003 | OBFC1 | chr10 | 105664849 | - | PCGF3 | chr4 | 755067 | + |
5UTR-intron | ENST00000466828 | ENST00000400151 | OBFC1 | chr10 | 105664849 | - | PCGF3 | chr4 | 755067 | + |
5UTR-intron | ENST00000466828 | ENST00000482726 | OBFC1 | chr10 | 105664849 | - | PCGF3 | chr4 | 755067 | + |
5UTR-intron | ENST00000466828 | ENST00000470161 | OBFC1 | chr10 | 105664849 | - | PCGF3 | chr4 | 755067 | + |
5UTR-intron | ENST00000466828 | ENST00000521023 | OBFC1 | chr10 | 105664849 | - | PCGF3 | chr4 | 755067 | + |
5UTR-intron | ENST00000466828 | ENST00000505655 | OBFC1 | chr10 | 105664849 | - | PCGF3 | chr4 | 755067 | + |
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FusionProtFeatures for OBFC1_PCGF3 |
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Hgene | Tgene |
OBFC1 | PCGF3 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain thetranscriptionally repressive state of many genes, including Hoxgenes, throughout development. PcG PRC1 complex acts via chromatinremodeling and modification of histones; it mediatesmonoubiquitination of histone H2A 'Lys-119', rendering chromatinheritably changed in its expressibility. Within the PRC1-likecomplex, regulates RNF2 ubiquitin ligase activity(PubMed:26151332). Plays a redundant role with PCGF5 as part of aPRC1-like complex that mediates monoubiquitination of histone H2A'Lys-119' on the X chromosome and is required for normal silencingof one copy of the X chromosome in XX females (By similarity).{ECO:0000250|UniProtKB:Q8BTQ0, ECO:0000269|PubMed:26151332}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for OBFC1_PCGF3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for OBFC1_PCGF3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
OBFC1 | TUBGCP4, MED12, MED13, MED25, MED16, MED17, MED1, MED24, MED23, MED4, MED29, MED8, MED6, MED14, MED30, POLR2A, MED9, RCOR1, MED27, APP, MVP, TPP1, LDLRAP1, ZDHHC17, TEN1, USP47, USP4, USP15, SPECC1L, GRN, CTC1, LRWD1, PRIM2, POLA1, MGEA5, FAM136A, ACTR3C, NDNL2, SMC6, SMC5, ORC3, USP33, SMCO3, KIF3A, ORC2, NSMCE1, PRIM1, XPO1, GMNN, TFAP4, CNPY2, CACNG5, HNRNPF, POLA2 | PCGF3 | RNF2, RING1, RYBP, YAF2, CBX4, MGA, BCORL1, KDM2B, USP7, AUTS2, FBRS, FBRSL1, CSNK2A1, CSNK2A2, CSNK2B, HSP90AA1, CBX8, CBX7, CBX6, BCOR, BMI1, TRIM9, DZIP3, UBE2C, PHC2, PCGF3, UBE2D3, DCAF7, UBE2E3, KIAA0430, HELZ, CREBBP, EIF4ENIF1, ARID3A, SOWAHA, PAN2, NISCH, RB1, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for OBFC1_PCGF3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OBFC1_PCGF3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |