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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25323

FusionGeneSummary for OASL_NUPL2

check button Fusion gene summary
Fusion gene informationFusion gene name: OASL_NUPL2
Fusion gene ID: 25323
HgeneTgene
Gene symbol

OASL

NUPL2

Gene ID

8638

11097

Gene name2'-5'-oligoadenylate synthetase likenucleoporin like 2
SynonymsOASL1|OASLd|TRIP-14|TRIP14|p59 OASL|p59-OASL|p59OASLCG1|NLP-1|NLP_1|hCG1
Cytomap

12q24.31

7p15.3

Type of geneprotein-codingprotein-coding
Description2'-5'-oligoadenylate synthase-like protein2'-5'-OAS-RP2'-5'-OAS-related protein59 kDa 2'-5'-oligoadenylate synthase-like protein59 kDa 2'-5'-oligoadenylate synthetase-like proteinTR-interacting protein 14thyroid receptor-interacting protein 14nucleoporin-like protein 2H_RG271G13.9NUP42 homolognucleoporin hCG1nucleoporin-like protein 1
Modification date2018052320180523
UniProtAcc

Q15646

O15504

Ensembl transtripts involved in fusion geneENST00000257570, ENST00000339275, 
ENST00000258742, ENST00000410002, 
ENST00000487595, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 2 X 2=12
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: OASL [Title/Abstract] AND NUPL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOASL

GO:0009615

response to virus

18931074|20074559

HgeneOASL

GO:0045071

negative regulation of viral genome replication

18931074|20074559

HgeneOASL

GO:0051607

defense response to virus

21478870


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A3LT-01AOASLchr12

121476577

-NUPL2chr7

23239077

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000257570ENST00000258742OASLchr12

121476577

-NUPL2chr7

23239077

+
5CDS-intronENST00000257570ENST00000410002OASLchr12

121476577

-NUPL2chr7

23239077

+
5CDS-intronENST00000257570ENST00000487595OASLchr12

121476577

-NUPL2chr7

23239077

+
In-frameENST00000339275ENST00000258742OASLchr12

121476577

-NUPL2chr7

23239077

+
5CDS-intronENST00000339275ENST00000410002OASLchr12

121476577

-NUPL2chr7

23239077

+
5CDS-intronENST00000339275ENST00000487595OASLchr12

121476577

-NUPL2chr7

23239077

+

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FusionProtFeatures for OASL_NUPL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OASL

Q15646

NUPL2

O15504

Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity againstencephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) viaan alternative antiviral pathway independent of RNase L.{ECO:0000269|PubMed:18931074, ECO:0000269|PubMed:20074559,ECO:0000269|PubMed:9826176}. Required for the export of mRNAs containing poly(A)tails from the nucleus into the cytoplasm. In case of infection byHIV-1, it may participate in the docking of viral Vpr at thenuclear envelope. {ECO:0000269|PubMed:10610322,ECO:0000269|PubMed:16000379}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNUPL2chr12:121476577chr7:23239077ENST00000258742+47238_378203424Compositional biasNote=Ser-rich
TgeneNUPL2chr12:121476577chr7:23239077ENST00000258742+47218_219203424RepeatNote=FG 3
TgeneNUPL2chr12:121476577chr7:23239077ENST00000258742+47220_221203424RepeatNote=FG 4
TgeneNUPL2chr12:121476577chr7:23239077ENST00000258742+47265_266203424RepeatNote=FG 5
TgeneNUPL2chr12:121476577chr7:23239077ENST00000258742+47271_272203424RepeatNote=FG 6
TgeneNUPL2chr12:121476577chr7:23239077ENST00000258742+47288_289203424RepeatNote=FG 7
TgeneNUPL2chr12:121476577chr7:23239077ENST00000258742+47290_291203424RepeatNote=FG 8
TgeneNUPL2chr12:121476577chr7:23239077ENST00000258742+47311_312203424RepeatNote=FG 9
TgeneNUPL2chr12:121476577chr7:23239077ENST00000258742+47336_337203424RepeatNote=FG 10
TgeneNUPL2chr12:121476577chr7:23239077ENST00000258742+47345_346203424RepeatNote=FG 11
TgeneNUPL2chr12:121476577chr7:23239077ENST00000258742+47364_365203424RepeatNote=FG 12

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOASLchr12:121476577chr7:23239077ENST00000257570-16354_43366515DomainUbiquitin-like 1
HgeneOASLchr12:121476577chr7:23239077ENST00000257570-16434_50966515DomainUbiquitin-like 2
HgeneOASLchr12:121476577chr7:23239077ENST00000339275-15354_43366250DomainUbiquitin-like 1
HgeneOASLchr12:121476577chr7:23239077ENST00000339275-15434_50966250DomainUbiquitin-like 2
TgeneNUPL2chr12:121476577chr7:23239077ENST00000258742+4714_15203424RepeatNote=FG 1
TgeneNUPL2chr12:121476577chr7:23239077ENST00000258742+4795_96203424RepeatNote=FG 2
TgeneNUPL2chr12:121476577chr7:23239077ENST00000258742+471_25203424Zinc fingerC3H1-type


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FusionGeneSequence for OASL_NUPL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_OASL_ENST00000257570_chr12_121476577_-_NUPL2_ENST00000258742_chr7_23239077_+_287aa
MALMQELYSTPASRLDSFVAQWLQPHREWKEEVLDAVRTVEEFLRQEHFQGKRGLDQDVRVLKVVKLSDVKDGVNQAAPAFGFGSSQAAT
FMSPGFPVNNSSSDNAQNFSFKTNSGFAAASSGSPAGFGSSPAFGAAASTSSGISTSAPAFGFGKPEVTSAASFSFKSPAASSFGSPGFS
GLPASLATGPVRAPVAPAFGGGSSVAGFGSPGSHSHTAFSKPSSDTFGNSSISTSLSASSSIIATDNVLFTPRDKLTVEELEQFQSKKFT

>In-frame_OASL_ENST00000339275_chr12_121476577_-_NUPL2_ENST00000258742_chr7_23239077_+_287aa
MALMQELYSTPASRLDSFVAQWLQPHREWKEEVLDAVRTVEEFLRQEHFQGKRGLDQDVRVLKVVKLSDVKDGVNQAAPAFGFGSSQAAT
FMSPGFPVNNSSSDNAQNFSFKTNSGFAAASSGSPAGFGSSPAFGAAASTSSGISTSAPAFGFGKPEVTSAASFSFKSPAASSFGSPGFS
GLPASLATGPVRAPVAPAFGGGSSVAGFGSPGSHSHTAFSKPSSDTFGNSSISTSLSASSSIIATDNVLFTPRDKLTVEELEQFQSKKFT


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_OASL_ENST00000257570_chr12_121476577_-_NUPL2_ENST00000258742_chr7_23239077_+_861nt
ATGGCACTGATGCAGGAACTGTATAGCACACCAGCCTCCAGGCTGGACTCCTTCGTGGCTCAGTGGCTGCAGCCCCACCGGGAGTGGAAG
GAAGAGGTGCTAGACGCTGTGCGGACCGTGGAGGAGTTTCTGAGGCAGGAGCATTTCCAGGGGAAGCGTGGGCTGGACCAGGATGTGCGG
GTGCTGAAGGTAGTCAAGCTCTCTGATGTAAAGGATGGAGTAAATCAAGCAGCACCTGCATTTGGATTTGGCAGCAGTCAAGCAGCAACA
TTTATGTCGCCAGGCTTTCCAGTCAATAACAGCAGCAGTGATAATGCTCAGAACTTTAGTTTTAAAACAAACTCTGGATTTGCTGCTGCC
TCTTCTGGAAGCCCTGCTGGTTTTGGGAGTTCCCCAGCATTTGGAGCTGCAGCCTCTACCAGTTCAGGTATCTCTACTTCTGCTCCAGCT
TTTGGATTTGGGAAGCCTGAAGTCACATCGGCTGCATCATTTTCATTCAAAAGCCCTGCAGCTTCCAGTTTTGGATCACCTGGATTTTCA
GGACTTCCAGCTTCCTTGGCAACAGGTCCTGTCAGAGCTCCAGTGGCCCCAGCCTTTGGAGGTGGCAGTTCTGTGGCTGGTTTTGGTAGT
CCGGGCTCACATTCTCACACTGCTTTTTCTAAGCCATCCAGTGACACTTTTGGAAATAGCAGCATATCCACTTCTCTGTCAGCCTCAAGC
AGCATCATTGCAACAGATAATGTGTTATTCACACCCAGAGATAAACTAACAGTAGAAGAACTGGAACAATTTCAATCCAAGAAATTTACT

>In-frame_OASL_ENST00000339275_chr12_121476577_-_NUPL2_ENST00000258742_chr7_23239077_+_861nt
ATGGCACTGATGCAGGAACTGTATAGCACACCAGCCTCCAGGCTGGACTCCTTCGTGGCTCAGTGGCTGCAGCCCCACCGGGAGTGGAAG
GAAGAGGTGCTAGACGCTGTGCGGACCGTGGAGGAGTTTCTGAGGCAGGAGCATTTCCAGGGGAAGCGTGGGCTGGACCAGGATGTGCGG
GTGCTGAAGGTAGTCAAGCTCTCTGATGTAAAGGATGGAGTAAATCAAGCAGCACCTGCATTTGGATTTGGCAGCAGTCAAGCAGCAACA
TTTATGTCGCCAGGCTTTCCAGTCAATAACAGCAGCAGTGATAATGCTCAGAACTTTAGTTTTAAAACAAACTCTGGATTTGCTGCTGCC
TCTTCTGGAAGCCCTGCTGGTTTTGGGAGTTCCCCAGCATTTGGAGCTGCAGCCTCTACCAGTTCAGGTATCTCTACTTCTGCTCCAGCT
TTTGGATTTGGGAAGCCTGAAGTCACATCGGCTGCATCATTTTCATTCAAAAGCCCTGCAGCTTCCAGTTTTGGATCACCTGGATTTTCA
GGACTTCCAGCTTCCTTGGCAACAGGTCCTGTCAGAGCTCCAGTGGCCCCAGCCTTTGGAGGTGGCAGTTCTGTGGCTGGTTTTGGTAGT
CCGGGCTCACATTCTCACACTGCTTTTTCTAAGCCATCCAGTGACACTTTTGGAAATAGCAGCATATCCACTTCTCTGTCAGCCTCAAGC
AGCATCATTGCAACAGATAATGTGTTATTCACACCCAGAGATAAACTAACAGTAGAAGAACTGGAACAATTTCAATCCAAGAAATTTACT


* Fusion transcript sequences (Full-length transcript).
>In-frame_OASL_ENST00000257570_chr12_121476577_-_NUPL2_ENST00000258742_chr7_23239077_+_1396nt
TGACTAGACGGCCAGCCTGTTAAGGTGGCCCCAGATATTCCAGCCTCAGCCCAGAGTCCTCCTGTGCCCCTACTGCAGCAAGGGTGTCTC
CAAGAAGGGGGACCTGGAGTCAGCCCGTCACACCTGGTTTCCTCTCTGCTAGGGTCCCTCCTCCCACAGAGCACTGGAGGGCAGCTGAGG
AGGAGCTACCTTAAAAAAGGAGGTGTGTGCCAGGGAGCTGGGTAGGAGCCTGGCTATATATCTGCCCAGCAGCGGTACTCTCGGGACAGA
GATGGCACTGATGCAGGAACTGTATAGCACACCAGCCTCCAGGCTGGACTCCTTCGTGGCTCAGTGGCTGCAGCCCCACCGGGAGTGGAA
GGAAGAGGTGCTAGACGCTGTGCGGACCGTGGAGGAGTTTCTGAGGCAGGAGCATTTCCAGGGGAAGCGTGGGCTGGACCAGGATGTGCG
GGTGCTGAAGGTAGTCAAGCTCTCTGATGTAAAGGATGGAGTAAATCAAGCAGCACCTGCATTTGGATTTGGCAGCAGTCAAGCAGCAAC
ATTTATGTCGCCAGGCTTTCCAGTCAATAACAGCAGCAGTGATAATGCTCAGAACTTTAGTTTTAAAACAAACTCTGGATTTGCTGCTGC
CTCTTCTGGAAGCCCTGCTGGTTTTGGGAGTTCCCCAGCATTTGGAGCTGCAGCCTCTACCAGTTCAGGTATCTCTACTTCTGCTCCAGC
TTTTGGATTTGGGAAGCCTGAAGTCACATCGGCTGCATCATTTTCATTCAAAAGCCCTGCAGCTTCCAGTTTTGGATCACCTGGATTTTC
AGGACTTCCAGCTTCCTTGGCAACAGGTCCTGTCAGAGCTCCAGTGGCCCCAGCCTTTGGAGGTGGCAGTTCTGTGGCTGGTTTTGGTAG
TCCGGGCTCACATTCTCACACTGCTTTTTCTAAGCCATCCAGTGACACTTTTGGAAATAGCAGCATATCCACTTCTCTGTCAGCCTCAAG
CAGCATCATTGCAACAGATAATGTGTTATTCACACCCAGAGATAAACTAACAGTAGAAGAACTGGAACAATTTCAATCCAAGAAATTTAC
TCTGGGAAAAATTCCATTAAAGCCTCCACCTCTGGAACTTCTAAATGTTTAAAAGGGCAATTTTAAATACAAAAAAGAATGATGTTTAAA
ATTGCTTTGAGTGATTCATACAGAGATGTATATATGCATACATGTATATATTCATAAGGAATATAAGCTTCCATCAATAGTGATTTTAAA
TTTGATTTTTTTCTTAACTCTAAATATTTAAGTAAAAAGTAACAAAAACTCTGCAAGCAAGGGAATTTTTTTGTACTGTAATTTTGAATG

>In-frame_OASL_ENST00000339275_chr12_121476577_-_NUPL2_ENST00000258742_chr7_23239077_+_1310nt
TCTCCAAGAAGGGGGACCTGGAGTCAGCCCGTCACACCTGGTTTCCTCTCTGCTAGGGTCCCTCCTCCCACAGAGCACTGGAGGGCAGCT
GAGGAGGAGCTACCTTAAAAAAGGAGGTGTGTGCCAGGGAGCTGGGTAGGAGCCTGGCTATATATCTGCCCAGCAGCGGTACTCTCGGGA
CAGAGATGGCACTGATGCAGGAACTGTATAGCACACCAGCCTCCAGGCTGGACTCCTTCGTGGCTCAGTGGCTGCAGCCCCACCGGGAGT
GGAAGGAAGAGGTGCTAGACGCTGTGCGGACCGTGGAGGAGTTTCTGAGGCAGGAGCATTTCCAGGGGAAGCGTGGGCTGGACCAGGATG
TGCGGGTGCTGAAGGTAGTCAAGCTCTCTGATGTAAAGGATGGAGTAAATCAAGCAGCACCTGCATTTGGATTTGGCAGCAGTCAAGCAG
CAACATTTATGTCGCCAGGCTTTCCAGTCAATAACAGCAGCAGTGATAATGCTCAGAACTTTAGTTTTAAAACAAACTCTGGATTTGCTG
CTGCCTCTTCTGGAAGCCCTGCTGGTTTTGGGAGTTCCCCAGCATTTGGAGCTGCAGCCTCTACCAGTTCAGGTATCTCTACTTCTGCTC
CAGCTTTTGGATTTGGGAAGCCTGAAGTCACATCGGCTGCATCATTTTCATTCAAAAGCCCTGCAGCTTCCAGTTTTGGATCACCTGGAT
TTTCAGGACTTCCAGCTTCCTTGGCAACAGGTCCTGTCAGAGCTCCAGTGGCCCCAGCCTTTGGAGGTGGCAGTTCTGTGGCTGGTTTTG
GTAGTCCGGGCTCACATTCTCACACTGCTTTTTCTAAGCCATCCAGTGACACTTTTGGAAATAGCAGCATATCCACTTCTCTGTCAGCCT
CAAGCAGCATCATTGCAACAGATAATGTGTTATTCACACCCAGAGATAAACTAACAGTAGAAGAACTGGAACAATTTCAATCCAAGAAAT
TTACTCTGGGAAAAATTCCATTAAAGCCTCCACCTCTGGAACTTCTAAATGTTTAAAAGGGCAATTTTAAATACAAAAAAGAATGATGTT
TAAAATTGCTTTGAGTGATTCATACAGAGATGTATATATGCATACATGTATATATTCATAAGGAATATAAGCTTCCATCAATAGTGATTT
TAAATTTGATTTTTTTCTTAACTCTAAATATTTAAGTAAAAAGTAACAAAAACTCTGCAAGCAAGGGAATTTTTTTGTACTGTAATTTTG


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FusionGenePPI for OASL_NUPL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
OASLSIRT7, SEZ6L2, CD14, SORT1, TM9SF4, TMEM63BNUPL2RAE1, APC, COPS5, NUP214, C9orf41, NUP35, MARK2, KPNB1, NCBP1, NUPL1, NUP153, CNOT1, NUP107, NXF2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneNUPL2chr12:121476577chr7:23239077ENST00000258742+47365_423203424GLE1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneNUPL2chr12:121476577chr7:23239077ENST00000258742+4794_170203424HIV-1 Vpr


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OASL_NUPL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for OASL_NUPL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneOASLC0021400Influenza1CTD_human