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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25322

FusionGeneSummary for OASL_BOLA2

check button Fusion gene summary
Fusion gene informationFusion gene name: OASL_BOLA2
Fusion gene ID: 25322
HgeneTgene
Gene symbol

OASL

BOLA2

Gene ID

8638

654483

Gene name2'-5'-oligoadenylate synthetase likebolA family member 2B
SynonymsOASL1|OASLd|TRIP-14|TRIP14|p59 OASL|p59-OASL|p59OASLBOLA2
Cytomap

12q24.31

16p11.2

Type of geneprotein-codingprotein-coding
Description2'-5'-oligoadenylate synthase-like protein2'-5'-OAS-RP2'-5'-OAS-related protein59 kDa 2'-5'-oligoadenylate synthase-like protein59 kDa 2'-5'-oligoadenylate synthetase-like proteinTR-interacting protein 14thyroid receptor-interacting protein 14bolA-like protein 2BolA-like protein 2 member BbolA homolog 2BbolA-like protein 2B
Modification date2018052320180519
UniProtAcc

Q15646

Q9H3K6

Ensembl transtripts involved in fusion geneENST00000257570, ENST00000339275, 
ENST00000330978, 
Fusion gene scores* DoF score2 X 2 X 2=819 X 26 X 1=494
# samples 228
** MAII scorelog2(2/8*10)=1.32192809488736log2(28/494*10)=-0.819084214639711
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OASL [Title/Abstract] AND BOLA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOASL

GO:0009615

response to virus

18931074|20074559

HgeneOASL

GO:0045071

negative regulation of viral genome replication

18931074|20074559

HgeneOASL

GO:0051607

defense response to virus

21478870

TgeneBOLA2

GO:0044571

[2Fe-2S] cluster assembly

27519415

TgeneBOLA2

GO:0097428

protein maturation by iron-sulfur cluster transfer

27519415


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC064330OASLchr12

121476622

+BOLA2chr16

30194946

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000257570ENST00000330978OASLchr12

121476622

+BOLA2chr16

30194946

+
intron-intronENST00000339275ENST00000330978OASLchr12

121476622

+BOLA2chr16

30194946

+

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FusionProtFeatures for OASL_BOLA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OASL

Q15646

BOLA2

Q9H3K6

Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity againstencephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) viaan alternative antiviral pathway independent of RNase L.{ECO:0000269|PubMed:18931074, ECO:0000269|PubMed:20074559,ECO:0000269|PubMed:9826176}. Acts as a cytosolic iron-sulfur (Fe-S) cluster assemblyfactor that facilitates [2Fe-2S] cluster insertion into a subsetof cytosolic proteins (PubMed:26613676, PubMed:27519415). Actstogether with the monothiol glutaredoxin GLRX3 (PubMed:26613676,PubMed:27519415). {ECO:0000269|PubMed:26613676,ECO:0000269|PubMed:27519415}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OASL_BOLA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OASL_BOLA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OASL_BOLA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for OASL_BOLA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneOASLC0021400Influenza1CTD_human