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Fusion gene ID: 2531 |
FusionGeneSummary for ARHGEF17_EP300 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARHGEF17_EP300 | Fusion gene ID: 2531 | Hgene | Tgene | Gene symbol | ARHGEF17 | EP300 | Gene ID | 9828 | 2033 |
| Gene name | Rho guanine nucleotide exchange factor 17 | E1A binding protein p300 | |
| Synonyms | P164RHOGEF|RHOGEF17|TEM4|p164-RhoGEF | KAT3B|RSTS2|p300 | |
| Cytomap | 11q13.4 | 22q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho guanine nucleotide exchange factor 17164 kDa Rho-specific guanine-nucleotide exchange factorRho guanine nucleotide exchange factor (GEF) 17Rho-specific guanine-nucleotide exchange factor 164 kDatumor endothelial marker 4 | histone acetyltransferase p300E1A-associated protein p300E1A-binding protein, 300kDhistone butyryltransferase p300histone crotonyltransferase p300p300 HATprotein propionyltransferase p300 | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q96PE2 | Q09472 | |
| Ensembl transtripts involved in fusion gene | ENST00000263674, ENST00000536170, | ENST00000263253, | |
| Fusion gene scores | * DoF score | 7 X 2 X 5=70 | 13 X 13 X 6=1014 |
| # samples | 7 | 13 | |
| ** MAII score | log2(7/70*10)=0 | log2(13/1014*10)=-2.96347412397489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ARHGEF17 [Title/Abstract] AND EP300 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ARHGEF17 | GO:0030036 | actin cytoskeleton organization | 12071859 |
| Tgene | EP300 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10733570 |
| Tgene | EP300 | GO:0001666 | response to hypoxia | 9887100|15261140 |
| Tgene | EP300 | GO:0006355 | regulation of transcription, DNA-templated | 15261140 |
| Tgene | EP300 | GO:0006473 | protein acetylation | 21030595|24939902 |
| Tgene | EP300 | GO:0006475 | internal protein amino acid acetylation | 18722353 |
| Tgene | EP300 | GO:0010742 | macrophage derived foam cell differentiation | 26504087 |
| Tgene | EP300 | GO:0016573 | histone acetylation | 25818647 |
| Tgene | EP300 | GO:0018076 | N-terminal peptidyl-lysine acetylation | 12435739 |
| Tgene | EP300 | GO:0018393 | internal peptidyl-lysine acetylation | 17403783 |
| Tgene | EP300 | GO:0018394 | peptidyl-lysine acetylation | 23962722 |
| Tgene | EP300 | GO:0032460 | negative regulation of protein oligomerization | 23962722 |
| Tgene | EP300 | GO:0034644 | cellular response to UV | 24939902 |
| Tgene | EP300 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 17403783 |
| Tgene | EP300 | GO:0043627 | response to estrogen | 11581164 |
| Tgene | EP300 | GO:0043923 | positive regulation by host of viral transcription | 16687403 |
| Tgene | EP300 | GO:0043969 | histone H2B acetylation | 23415232 |
| Tgene | EP300 | GO:0045815 | positive regulation of gene expression, epigenetic | 25818647 |
| Tgene | EP300 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12586840|18722353 |
| Tgene | EP300 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 10518217|25818647 |
| Tgene | EP300 | GO:0060765 | regulation of androgen receptor signaling pathway | 18487222 |
| Tgene | EP300 | GO:0061921 | peptidyl-lysine propionylation | 17267393 |
| Tgene | EP300 | GO:0090043 | regulation of tubulin deacetylation | 18722353 |
| Tgene | EP300 | GO:0140066 | peptidyl-lysine crotonylation | 25818647 |
| Tgene | EP300 | GO:0140067 | peptidyl-lysine butyrylation | 17267393 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-BH-A0AU-01A | ARHGEF17 | chr11 | 73022875 | + | EP300 | chr22 | 41545042 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000263674 | ENST00000263253 | ARHGEF17 | chr11 | 73022875 | + | EP300 | chr22 | 41545042 | + |
| intron-3CDS | ENST00000536170 | ENST00000263253 | ARHGEF17 | chr11 | 73022875 | + | EP300 | chr22 | 41545042 | + |
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FusionProtFeatures for ARHGEF17_EP300 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARHGEF17 | EP300 |
| Acts as guanine nucleotide exchange factor (GEF) forRhoA GTPases. {ECO:0000269|PubMed:12071859}. | Functions as histone acetyltransferase and regulatestranscription via chromatin remodeling (PubMed:23415232,PubMed:23934153, PubMed:8945521). Acetylates all four corehistones in nucleosomes. Histone acetylation gives an epigenetictag for transcriptional activation (PubMed:23415232,PubMed:23934153, PubMed:8945521). Mediates cAMP-gene regulation bybinding specifically to phosphorylated CREB protein. Mediatesacetylation of histone H3 at 'Lys-122' (H3K122ac), a modificationthat localizes at the surface of the histone octamer andstimulates transcription, possibly by promoting nucleosomeinstability. Mediates acetylation of histone H3 at 'Lys-27'(H3K27ac) (PubMed:23911289). Also functions as acetyltransferasefor nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts asits coactivator (PubMed:12929931). Acetylates SIRT2 and isproposed to indirectly increase the transcriptional activity ofTP53 through acetylation and subsequent attenuation of SIRT2deacetylase function (PubMed:18722353). Acetylates HDAC1 leadingto its inactivation and modulation of transcription(PubMed:16762839). Acts as a TFAP2A-mediated transcriptionalcoactivator in presence of CITED2 (PubMed:12586840). Plays a roleas a coactivator of NEUROD1-dependent transcription of thesecretin and p21 genes and controls terminal differentiation ofcells in the intestinal epithelium. Promotes cardiac myocyteenlargement. Can also mediate transcriptional repression.Acetylates FOXO1 and enhances its transcriptional activity(PubMed:15890677). Acetylates BCL6 wich disrupts its ability torecruit histone deacetylases and hinders its transcriptionalrepressor activity (PubMed:12402037). Participates in CLOCK orNPAS2-regulated rhythmic gene transcription; exhibits a circadianassociation with CLOCK or NPAS2, correlating with increase inPER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter(PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essentialfor its transcriptional coactivator activity (PubMed:16617102).Acetylates XBP1 isoform 2; acetylation increases protein stabilityof XBP1 isoform 2 and enhances its transcriptional activity(PubMed:20955178). Acetylates PCNA; acetylation promotes removalof chromatin-bound PCNA and its degradation during nucleotideexcision repair (NER) (PubMed:24939902). Acetylates MEF2D(PubMed:21030595). Acetylates and stabilizes ZBTB7B protein byantagonizing ubiquitin conjugation and degragation, this mechanismmay be involved in CD4/CD8 lineage differentiation(PubMed:20810990). In addition to protein acetyltransferase, canuse different acyl-CoA substrates, such as (2E)-butenoyl-CoA(crotonyl-CoA), butanoyl-CoA (butyryl-CoA) or propanoyl-CoA(propionyl-CoA), and is able to mediate protein crotonylation,butyrylation or propionylation, respectively (PubMed:25818647,PubMed:17267393). Acts as a histone crotonyltransferase;crotonylation marks active promoters and enhancers and confersresistance to transcriptional repressors (PubMed:25818647).Histone crotonyltransferase activity is dependent on theconcentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate andsuch activity is weak when (E)-but-2-enoyl-CoA (crotonyl-CoA)concentration is low (PubMed:25818647). Also acts as a histonebutyryltransferase; butyrylation marks active promoters(PubMed:17267393). {ECO:0000250|UniProtKB:B2RWS6,ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825,ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037,ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931,ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:15186775,ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16617102,ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393,ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18995842,ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595,ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289,ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24939902,ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:8945521,ECO:0000305|PubMed:20955178}. (Microbial infection) In case of HIV-1 infection, it isrecruited by the viral protein Tat. Regulates Tat'stransactivating activity and may help inducing chromatinremodeling of proviral genes. Binds to and may be involved in thetransforming capacity of the adenovirus E1A protein.{ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ARHGEF17 | chr11:73022875 | chr22:41545042 | ENST00000263674 | + | 1 | 21 | 201_204 | 1064 | 2064 | Compositional bias | Note=Poly-Gln |
| Hgene | ARHGEF17 | chr11:73022875 | chr22:41545042 | ENST00000263674 | + | 1 | 21 | 230_235 | 1064 | 2064 | Compositional bias | Note=Poly-Ser |
| Hgene | ARHGEF17 | chr11:73022875 | chr22:41545042 | ENST00000263674 | + | 1 | 21 | 252_256 | 1064 | 2064 | Compositional bias | Note=Poly-Glu |
| Hgene | ARHGEF17 | chr11:73022875 | chr22:41545042 | ENST00000263674 | + | 1 | 21 | 566_569 | 1064 | 2064 | Compositional bias | Note=Poly-Ser |
| Hgene | ARHGEF17 | chr11:73022875 | chr22:41545042 | ENST00000263674 | + | 1 | 21 | 672_675 | 1064 | 2064 | Compositional bias | Note=Poly-Ser |
| Hgene | ARHGEF17 | chr11:73022875 | chr22:41545042 | ENST00000263674 | + | 1 | 21 | 707_710 | 1064 | 2064 | Compositional bias | Note=Poly-Arg |
| Hgene | ARHGEF17 | chr11:73022875 | chr22:41545042 | ENST00000263674 | + | 1 | 21 | 963_1054 | 1064 | 2064 | Compositional bias | Note=Pro-rich |
| Tgene | >EP300 | chr11:73022875 | chr22:41545042 | ENST00000263253 | + | 11 | 31 | 1519_1526 | 747 | 2415 | Compositional bias | Note=Poly-Glu |
| Tgene | >EP300 | chr11:73022875 | chr22:41545042 | ENST00000263253 | + | 11 | 31 | 2066_2069 | 747 | 2415 | Compositional bias | Note=Poly-Gln |
| Tgene | >EP300 | chr11:73022875 | chr22:41545042 | ENST00000263253 | + | 11 | 31 | 2190_2195 | 747 | 2415 | Compositional bias | Note=Poly-Gln |
| Tgene | >EP300 | chr11:73022875 | chr22:41545042 | ENST00000263253 | + | 11 | 31 | 797_800 | 747 | 2415 | Compositional bias | Note=Poly-Ser |
| Tgene | >EP300 | chr11:73022875 | chr22:41545042 | ENST00000263253 | + | 11 | 31 | 1067_1139 | 747 | 2415 | Domain | Bromo |
| Tgene | >EP300 | chr11:73022875 | chr22:41545042 | ENST00000263253 | + | 11 | 31 | 1287_1663 | 747 | 2415 | Domain | CBP/p300-type HAT |
| Tgene | >EP300 | chr11:73022875 | chr22:41545042 | ENST00000263253 | + | 11 | 31 | 1017_1029 | 747 | 2415 | Region | Note=CRD1%3B mediates transcriptional repression |
| Tgene | >EP300 | chr11:73022875 | chr22:41545042 | ENST00000263253 | + | 11 | 31 | 1398_1400 | 747 | 2415 | Region | Acetyl-CoA binding |
| Tgene | >EP300 | chr11:73022875 | chr22:41545042 | ENST00000263253 | + | 11 | 31 | 1410_1411 | 747 | 2415 | Region | Acetyl-CoA binding |
| Tgene | >EP300 | chr11:73022875 | chr22:41545042 | ENST00000263253 | + | 11 | 31 | 1572_1818 | 747 | 2415 | Region | Note=Binding region for E1A adenovirus |
| Tgene | >EP300 | chr11:73022875 | chr22:41545042 | ENST00000263253 | + | 11 | 31 | 1664_1707 | 747 | 2415 | Zinc finger | ZZ-type |
| Tgene | >EP300 | chr11:73022875 | chr22:41545042 | ENST00000263253 | + | 11 | 31 | 1728_1809 | 747 | 2415 | Zinc finger | TAZ-type 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ARHGEF17 | chr11:73022875 | chr22:41545042 | ENST00000263674 | + | 1 | 21 | 1990_1996 | 1064 | 2064 | Compositional bias | Note=Poly-Pro |
| Hgene | >ARHGEF17 | chr11:73022875 | chr22:41545042 | ENST00000263674 | + | 1 | 21 | 1066_1254 | 1064 | 2064 | Domain | DH |
| Tgene | EP300 | chr11:73022875 | chr22:41545042 | ENST00000263253 | + | 11 | 31 | 566_645 | 747 | 2415 | Domain | KIX |
| Tgene | EP300 | chr11:73022875 | chr22:41545042 | ENST00000263253 | + | 11 | 31 | 11_17 | 747 | 2415 | Motif | Nuclear localization signal |
| Tgene | EP300 | chr11:73022875 | chr22:41545042 | ENST00000263253 | + | 11 | 31 | 331_417 | 747 | 2415 | Zinc finger | TAZ-type 1 |
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FusionGeneSequence for ARHGEF17_EP300 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ARHGEF17_ENST00000263674_chr11_73022875_+_EP300_ENST00000263253_chr22_41545042_+_2732aa MADGAPRPQLYRSVSFKLLERWSGGPGLREEDTDTPGLRRRASCRPTTAARGQPSRRVSKLASGPLAAPAQPRPLRSLSPSVRQLSRRFD APRLDDGSAGTRDGGVLPAAAEEAAEGPARGAWPSVTEMRKLFGGPGSRRPSADSESPGTPSPDGAAWEPPARESRQPPTPPPRTCFPLA GLRSARPLTGPETEGRLRRPQQQQERAQRPADGLHSWHIFSQPQAGARASCSSSSIAASYPVSRSRAASSSEEEEEGPPQLPGAQSPAYH GGHSSGSDDDRDGEGGHRWGGRPGLRPGSSLLDQDCRPDSDGLNLSSMNSAGVSGSPEPPTSPRAPREEGLREWGSGSPPCVPGPQEGLR PMSDSVGGAFRVAKVSFPSYLASPAGSRGSSRYSSTETLKDDDLWSSRGSGGWGVYRSPSFGAGEGLLRSQARTRAKGPGGTSRALRDGG FEPEKSRQRKSLSNPDIASETLTLLSFLRSDLSELRVRKPGGSSGDRGSNPLDGRDSPSAGGPVGQLEPIPIPAPASPGTRPTLKDLTAT LRRAKSFTCSEKPMARRLPRTSALKSSSSELLLTGPGAEEDPLPLIVQDQYVQEARQVFEKIQRMGAQQDDGSDAPPGSPDWAGDVTRGQ RSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSSSSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGS ELSNGEAGEAYRSLSDPIPQRHRAATSEEPTGFSVDSNLLGSLSPKTGLPATSAMDEGLTSGHSDWSVGSEESKGYQEVIQSIVQGPGTL GRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIREVEPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAH RNFHLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHASVPATFMPIVVPEPPTSVGPPVAVPEPIGF PTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLAAPPSAEAKPPEAARPADEPTPASKCCSKPQVPMGYGPRMQQPSNQGQ FLPQTQFPSQGMNVTNIPLAPSSGQAPVSQAQMSSSSCPVNSPIMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHHTPPSIGAQQ PPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPSLPAAPSADQPQQQPRSQQSTAASVPTPTAPLLPPQPATPLSQP AVSIEGQVSNPPSTSSTEVNSQAIAEKQPSQEVKMEAKMEVDQPEPADTQPEDISESKVEDCKMESTETEERSTELKTEIKEEEDQPSTS ATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWL MFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYHFCEKCFNEIQGESV SLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICVLHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLE NRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRV YISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDY KDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDVTKGDSKNAKKKNNKKTSKNKSSLSRGNKKKPGM PNVSNDLSQKLYATMEKHKEVFFVIRLIAGPAANSLPPIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQ DRFVYTCNECKHHVETRWHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLDDESNNQQAAATQSPGDSRRLSIQRCIQSLVHACQCRNANC SLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENKCPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVVGQ QQGLPSPTPATPTTPTGQQPTTPQTPQPTSQPQPTPPNSMPPYLPRTQAAGPVSQGKAAGQVTPPTPPQTAQPPLPGPPPAAVEMAMQIQ RAAETQRQMAHVQIFQRPIQHQMPPMTPMAPMGMNPPPMTRGPSGHLEPGMGPTGMQQQPPWSQGGLPQPQQLQSGMPRPAMMSVAQHGQ PLNMAPQPGLGQVGISPLKPGTVSQQALQNLLRTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYANSNPQPIPGQPGMPQGQPGL QPPTMPGQQGVHSNPAMQNMNPMQAGVQRAGLPQQQPQQQLQPPMGGMSPQAQQMNMNHNTMPSQFRDILRRQQMMQQQQQQGAGPGIGP GMANHNQFQQPQGVGYPPQQQQRMQHHMQQMQQGNMGQIGQLPQALGAEAGASLQAYQQRLLQQQMGSPVQPNPMSPQQHMLPNQAQSPH LQGQQIPNSLSNQVRSPQPVPSPRPQSQPPHSSPSPRMQPQPSPHHVSPQTSSPHPGLVAAQANPMEQGHFASPDQNSMLSQLASNPGMA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ARHGEF17_ENST00000263674_chr11_73022875_+_EP300_ENST00000263253_chr22_41545042_+_8196nt ATGGCGGACGGGGCACCCCGGCCCCAGCTTTACCGCAGCGTCTCGTTCAAGCTGCTGGAGCGCTGGAGCGGCGGCCCCGGGCTGAGGGAG GAGGACACGGACACCCCCGGCTTGAGGCGACGCGCCTCGTGCCGGCCGACCACGGCTGCCCGGGGCCAGCCCTCTCGGCGCGTGTCCAAG CTGGCGTCTGGGCCCCTGGCCGCCCCCGCGCAGCCGCGCCCGCTCCGCAGCCTCTCGCCGTCGGTTCGCCAGCTCTCCCGGCGCTTCGAC GCGCCGCGTCTGGACGACGGCTCCGCTGGGACCCGAGACGGAGGCGTCTTACCCGCGGCCGCGGAAGAAGCGGCCGAGGGCCCAGCGCGA GGAGCCTGGCCCAGCGTCACCGAGATGCGCAAGCTCTTCGGCGGTCCTGGCTCCAGGAGGCCCAGCGCCGACTCTGAATCCCCAGGAACG CCCAGCCCCGACGGTGCCGCGTGGGAGCCTCCGGCTCGGGAGTCGCGGCAGCCACCGACGCCACCCCCTCGGACATGCTTCCCCCTGGCG GGTCTGCGTTCGGCGCGGCCCCTGACCGGGCCGGAGACCGAAGGGAGGCTGCGCCGGCCGCAGCAGCAACAGGAGCGGGCGCAGCGTCCA GCGGATGGTTTACATTCTTGGCATATCTTCTCCCAACCGCAGGCCGGGGCCCGGGCCTCCTGCTCCTCCTCCTCCATCGCCGCCTCCTAT CCTGTCAGCCGCAGTCGTGCTGCCAGCTCCAGCGAGGAGGAAGAGGAGGGCCCGCCGCAGCTGCCTGGAGCCCAGAGTCCGGCCTACCAC GGCGGCCACTCCTCGGGCAGTGACGACGACCGAGACGGTGAGGGCGGCCACCGCTGGGGAGGGAGGCCCGGGCTCAGGCCTGGAAGCTCC CTATTGGATCAGGACTGCAGGCCTGACAGTGATGGGTTAAATCTAAGCAGCATGAACTCAGCAGGGGTTTCTGGGAGCCCTGAGCCCCCA ACATCTCCAAGAGCCCCTAGAGAAGAAGGACTCCGGGAGTGGGGTAGTGGCTCTCCGCCCTGCGTCCCAGGTCCCCAGGAGGGACTTCGG CCTATGTCTGACTCTGTGGGAGGAGCTTTCCGTGTGGCCAAGGTGAGCTTTCCCTCGTACCTGGCCAGCCCCGCAGGCTCCCGCGGTAGC AGCCGTTATTCCAGCACGGAGACCCTCAAGGACGACGACCTATGGTCTAGTAGGGGTTCTGGGGGCTGGGGCGTGTACCGCTCCCCTAGC TTTGGAGCTGGGGAAGGGCTCCTGCGGTCCCAGGCTCGAACCCGTGCCAAAGGACCTGGAGGCACCTCTAGGGCATTGAGGGATGGAGGA TTTGAGCCTGAAAAGAGTCGACAGCGGAAGTCCCTGTCAAATCCAGATATCGCCTCAGAGACCCTGACGCTTCTCAGTTTCCTGCGCTCA GACCTTTCAGAGCTGAGGGTCCGAAAACCTGGTGGGAGCTCCGGGGACCGTGGAAGCAACCCCCTAGATGGCAGAGACTCACCATCCGCA GGTGGCCCTGTGGGGCAACTTGAACCCATACCCATCCCAGCCCCAGCATCACCTGGCACGCGCCCCACACTCAAGGACTTGACAGCCACT CTGCGGAGAGCAAAGTCATTCACCTGCTCTGAGAAGCCCATGGCCCGCCGCCTGCCCCGCACCAGTGCTCTGAAGTCCAGCTCCTCCGAG CTCCTGCTCACAGGCCCTGGTGCCGAGGAGGATCCGCTGCCCCTCATCGTCCAGGACCAATATGTGCAGGAGGCCCGCCAGGTTTTTGAG AAGATCCAGCGCATGGGTGCCCAACAAGATGATGGAAGCGATGCCCCCCCTGGAAGCCCTGACTGGGCAGGGGATGTGACCCGAGGGCAG CGGTCCCAGGAGGAGCTCTCAGGCCCTGAGTCCAGTCTGACAGATGAAGGCATTGGGGCAGACCCTGAGCCTCCTGTTGCAGCATTTTGC GGCCTGGGTACCACAGGGATGTGGCGACCTCTTTCCTCATCCTCGGCCCAGACGAACCACCATGGCCCTGGGACTGAGGACAGTCTGGGC GGGTGGGCCCTGGTGTCGCCTGAGACCCCTCCCACACCAGGTGCCCTCCGCCGACGACGCAAAGTCCCACCTTCAGGTTCTGGTGGGAGC GAATTGAGCAATGGGGAGGCAGGGGAGGCCTACAGGTCCCTGAGTGACCCAATTCCTCAGCGCCACCGGGCTGCCACCTCTGAAGAGCCT ACTGGGTTCTCTGTGGACAGCAACCTCCTGGGCTCACTGAGCCCCAAGACAGGGCTCCCTGCCACCTCAGCCATGGATGAGGGCTTGACC AGTGGTCACAGTGACTGGTCTGTGGGCAGTGAAGAGAGCAAGGGATATCAGGAGGTTATTCAGAGCATAGTTCAGGGGCCTGGCACCCTG GGGCGTGTGGTGGACGACAGGATTGCTGGCAAAGCCCCCAAGAAGAAATCCCTGAGTGACCCCAGCCGCCGTGGGGAGCTGGCTGGGCCT GGATTCGAGGGCCCTGGAGGGGAGCCCATCCGAGAAGTTGAGCCCATGCTGCCTCCATCCAGCAGCGAGCCCATCCTTGTAGAGCAGCGG GCAGAGCCAGAAGAACCTGGTGCCACCAGGAGCCGGGCACAGTCTGAAAGGGCCCTACCTGAGGCTCTGCCTCCCCCTGCCACTGCCCAC CGAAACTTTCACCTTGACCCCAAGCTGGCTGACATTCTGTCCCCGAGGCTAATCCGCCGAGGCTCCAAGAAGCGCCCAGCTCGGAGTAGT CACCAGGAGCTTCGGAGAGACGAGGGCAGTCAGGACCAGACTGGCAGCCTGTCTCGGGCCCGGCCCTCCTCCAGACACGTTCGCCATGCC AGTGTGCCCGCCACATTTATGCCTATTGTGGTGCCTGAGCCACCAACTTCTGTTGGTCCCCCTGTGGCTGTGCCAGAACCCATAGGCTTC CCTACCCGAGCCCATCCCACGTTGCAGGCACCATCGCTCGAGGACGTCACCAAGCAGTACATGCTGAACCTGCACTCCGGTGAGGTCCCT GCCCCAGTGCCAGTGGACATGCCCTGCTTGCCTCTGGCTGCACCGCCCTCTGCTGAGGCCAAGCCCCCTGAGGCAGCTCGGCCTGCAGAT GAGCCTACCCCTGCCAGCAAGTGCTGCAGCAAGCCACAGGTGCCTATGGGCTATGGGCCTCGTATGCAACAGCCTTCCAACCAGGGCCAG TTCCTTCCTCAGACTCAGTTCCCATCACAGGGAATGAATGTAACAAATATCCCTTTGGCTCCGTCCAGCGGTCAAGCTCCAGTGTCTCAA GCACAAATGTCTAGTTCTTCCTGCCCGGTGAACTCTCCTATAATGCCTCCAGGGTCTCAGGGGAGCCACATTCACTGTCCCCAGCTTCCT CAACCAGCTCTTCATCAGAATTCACCCTCGCCTGTACCTAGTCGTACCCCCACCCCTCACCATACTCCCCCAAGCATAGGGGCTCAGCAG CCACCAGCAACAACAATTCCAGCCCCTGTTCCTACACCTCCTGCCATGCCACCTGGGCCACAGTCCCAGGCTCTACATCCCCCTCCAAGG CAGACACCTACACCACCAACAACACAACTTCCCCAACAAGTGCAGCCTTCACTTCCTGCTGCACCTTCTGCTGACCAGCCCCAGCAGCAG CCTCGCTCACAGCAGAGCACAGCAGCGTCTGTTCCTACCCCAACAGCACCGCTGCTTCCTCCGCAGCCTGCAACTCCACTTTCCCAGCCA GCTGTAAGCATTGAAGGACAGGTATCAAATCCTCCATCTACTAGTAGCACAGAAGTGAATTCTCAGGCCATTGCTGAGAAGCAGCCTTCC CAGGAAGTGAAGATGGAGGCCAAAATGGAAGTGGATCAACCAGAACCAGCAGATACTCAGCCGGAGGATATTTCAGAGTCTAAAGTGGAA GACTGTAAAATGGAATCTACCGAAACAGAAGAGAGAAGCACTGAGTTAAAAACTGAAATAAAAGAGGAGGAAGACCAGCCAAGTACTTCA GCTACCCAGTCATCTCCGGCTCCAGGACAGTCAAAGAAAAAGATTTTCAAACCAGAAGAACTACGACAGGCACTGATGCCAACTTTGGAG GCACTTTACCGTCAGGATCCAGAATCCCTTCCCTTTCGTCAACCTGTGGACCCTCAGCTTTTAGGAATCCCTGATTACTTTGATATTGTG AAGAGCCCCATGGATCTTTCTACCATTAAGAGGAAGTTAGACACTGGACAGTATCAGGAGCCCTGGCAGTATGTCGATGATATTTGGCTT ATGTTCAATAATGCCTGGTTATATAACCGGAAAACATCACGGGTATACAAATACTGCTCCAAGCTCTCTGAGGTCTTTGAACAAGAAATT GACCCAGTGATGCAAAGCCTTGGATACTGTTGTGGCAGAAAGTTGGAGTTCTCTCCACAGACACTGTGTTGCTACGGCAAACAGTTGTGC ACAATACCTCGTGATGCCACTTATTACAGTTACCAGAACAGGTATCATTTCTGTGAGAAGTGTTTCAATGAGATCCAAGGGGAGAGCGTT TCTTTGGGGGATGACCCTTCCCAGCCTCAAACTACAATAAATAAAGAACAATTTTCCAAGAGAAAAAATGACACACTGGATCCTGAACTG TTTGTTGAATGTACAGAGTGCGGAAGAAAGATGCATCAGATCTGTGTCCTTCACCATGAGATCATCTGGCCTGCTGGATTCGTCTGTGAT GGCTGTTTAAAGAAAAGTGCACGAACTAGGAAAGAAAATAAGTTTTCTGCTAAAAGGTTGCCATCTACCAGACTTGGCACCTTTCTAGAG AATCGTGTGAATGACTTTCTGAGGCGACAGAATCACCCTGAGTCAGGAGAGGTCACTGTTAGAGTAGTTCATGCTTCTGACAAAACCGTG GAAGTAAAACCAGGCATGAAAGCAAGGTTTGTGGACAGTGGAGAGATGGCAGAATCCTTTCCATACCGAACCAAAGCCCTCTTTGCCTTT GAAGAAATTGATGGTGTTGACCTGTGCTTCTTTGGCATGCATGTTCAAGAGTATGGCTCTGACTGCCCTCCACCCAACCAGAGGAGAGTA TACATATCTTACCTCGATAGTGTTCATTTCTTCCGTCCTAAATGCTTGAGGACTGCAGTCTATCATGAAATCCTAATTGGATATTTAGAA TATGTCAAGAAATTAGGTTACACAACAGGGCATATTTGGGCATGTCCACCAAGTGAGGGAGATGATTATATCTTCCATTGCCATCCTCCT GACCAGAAGATACCCAAGCCCAAGCGACTGCAGGAATGGTACAAAAAAATGCTTGACAAGGCTGTATCAGAGCGTATTGTCCATGACTAC AAGGATATTTTTAAACAAGCTACTGAAGATAGATTAACAAGTGCAAAGGAATTGCCTTATTTCGAGGGTGATTTCTGGCCCAATGTTCTG GAAGAAAGCATTAAGGAACTGGAACAGGAGGAAGAAGAGAGAAAACGAGAGGAAAACACCAGCAATGAAAGCACAGATGTGACCAAGGGA GACAGCAAAAATGCTAAAAAGAAGAATAATAAGAAAACCAGCAAAAATAAGAGCAGCCTGAGTAGGGGCAACAAGAAGAAACCCGGGATG CCCAATGTATCTAACGACCTCTCACAGAAACTATATGCCACCATGGAGAAGCATAAAGAGGTCTTCTTTGTGATCCGCCTCATTGCTGGC CCTGCTGCCAACTCCCTGCCTCCCATTGTTGATCCTGATCCTCTCATCCCCTGCGATCTGATGGATGGTCGGGATGCGTTTCTCACGCTG GCAAGGGACAAGCACCTGGAGTTCTCTTCACTCCGAAGAGCCCAGTGGTCCACCATGTGCATGCTGGTGGAGCTGCACACGCAGAGCCAG GACCGCTTTGTCTACACCTGCAATGAATGCAAGCACCATGTGGAGACACGCTGGCACTGTACTGTCTGTGAGGATTATGACTTGTGTATC ACCTGCTATAACACTAAAAACCATGACCACAAAATGGAGAAACTAGGCCTTGGCTTAGATGATGAGAGCAACAACCAGCAGGCTGCAGCC ACCCAGAGCCCAGGCGATTCTCGCCGCCTGAGTATCCAGCGCTGCATCCAGTCTCTGGTCCATGCTTGCCAGTGTCGGAATGCCAATTGC TCACTGCCATCCTGCCAGAAGATGAAGCGGGTTGTGCAGCATACCAAGGGTTGCAAACGGAAAACCAATGGCGGGTGCCCCATCTGCAAG CAGCTCATTGCCCTCTGCTGCTACCATGCCAAGCACTGCCAGGAGAACAAATGCCCGGTGCCGTTCTGCCTAAACATCAAGCAGAAGCTC CGGCAGCAACAGCTGCAGCACCGACTACAGCAGGCCCAAATGCTTCGCAGGAGGATGGCCAGCATGCAGCGGACTGGTGTGGTTGGGCAG CAACAGGGCCTCCCTTCCCCCACTCCTGCCACTCCAACGACACCAACTGGCCAACAGCCAACCACCCCGCAGACGCCCCAGCCCACTTCT CAGCCTCAGCCTACCCCTCCCAATAGCATGCCACCCTACTTGCCCAGGACTCAAGCTGCTGGCCCTGTGTCCCAGGGTAAGGCAGCAGGC CAGGTGACCCCTCCAACCCCTCCTCAGACTGCTCAGCCACCCCTTCCAGGGCCCCCACCTGCAGCAGTGGAAATGGCAATGCAGATTCAG AGAGCAGCGGAGACGCAGCGCCAGATGGCCCACGTGCAAATTTTTCAAAGGCCAATCCAACACCAGATGCCCCCGATGACTCCCATGGCC CCCATGGGTATGAACCCACCTCCCATGACCAGAGGTCCCAGTGGGCATTTGGAGCCAGGGATGGGACCGACAGGGATGCAGCAACAGCCA CCCTGGAGCCAAGGAGGATTGCCTCAGCCCCAGCAACTACAGTCTGGGATGCCAAGGCCAGCCATGATGTCAGTGGCCCAGCATGGTCAA CCTTTGAACATGGCTCCACAACCAGGATTGGGCCAGGTAGGTATCAGCCCACTCAAACCAGGCACTGTGTCTCAACAAGCCTTACAAAAC CTTTTGCGGACTCTCAGGTCTCCCAGCTCTCCCCTGCAGCAGCAACAGGTGCTTAGTATCCTTCACGCCAACCCCCAGCTGTTGGCTGCA TTCATCAAGCAGCGGGCTGCCAAGTATGCCAACTCTAATCCACAACCCATCCCTGGGCAGCCTGGCATGCCCCAGGGGCAGCCAGGGCTA CAGCCACCTACCATGCCAGGTCAGCAGGGGGTCCACTCCAATCCAGCCATGCAGAACATGAATCCAATGCAGGCGGGCGTTCAGAGGGCT GGCCTGCCCCAGCAGCAACCACAGCAGCAACTCCAGCCACCCATGGGAGGGATGAGCCCCCAGGCTCAGCAGATGAACATGAACCACAAC ACCATGCCTTCACAATTCCGAGACATCTTGAGACGACAGCAAATGATGCAACAGCAGCAGCAACAGGGAGCAGGGCCAGGAATAGGCCCT GGAATGGCCAACCATAACCAGTTCCAGCAACCCCAAGGAGTTGGCTACCCACCACAGCAGCAGCAGCGGATGCAGCATCACATGCAACAG ATGCAACAAGGAAATATGGGACAGATAGGCCAGCTTCCCCAGGCCTTGGGAGCAGAGGCAGGTGCCAGTCTACAGGCCTATCAGCAGCGA CTCCTTCAGCAACAGATGGGGTCCCCTGTTCAGCCCAACCCCATGAGCCCCCAGCAGCATATGCTCCCAAATCAGGCCCAGTCCCCACAC CTACAAGGCCAGCAGATCCCTAATTCTCTCTCCAATCAAGTGCGCTCTCCCCAGCCTGTCCCTTCTCCACGGCCACAGTCCCAGCCCCCC CACTCCAGTCCTTCCCCAAGGATGCAGCCTCAGCCTTCTCCACACCACGTTTCCCCACAGACAAGTTCCCCACATCCTGGACTGGTAGCT GCCCAGGCCAACCCCATGGAACAAGGGCATTTTGCCAGCCCGGACCAGAATTCAATGCTTTCTCAGCTTGCTAGCAATCCAGGCATGGCA AACCTCCATGGTGCAAGCGCCACGGACCTGGGACTCAGCACCGATAACTCAGACTTGAATTCAAACCTCTCACAGAGTACACTAGACATA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ARHGEF17_ENST00000263674_chr11_73022875_+_EP300_ENST00000263253_chr22_41545042_+_9667nt GAGCGAGCAGCCAAGGGCGTTGGGCAGGCGGACGCAGAGTCGAGGAACCAAGCGCTGGGATCCCGCCCAGGCGGTGCCGCGGTGCCCCTG GTCGCTCCAGCCGCGGCGGGGGCTGGGCCTGGGGGTCGGCGCTGAGGCGGGAGGGGCCGCCCGGGATGGAGACGTTGCGGCCGGTGGCCA CAGAAACTTGAGCCGCGGCAGAGAAACCTCTGCTCCGGTCTCTGCGTCCTCTTCCCACACTCCCGTGCGCTGCTTTCGGCGTGGGCCGCT GCGCTCCTAGGGAGTGGGGGCGCAGGGGGGGTTGGCCGCGGCTGCCCGAGGCCAGCCCCCCCGGAGTGAGTTACGCCACTATGGCGGACG GGGCACCCCGGCCCCAGCTTTACCGCAGCGTCTCGTTCAAGCTGCTGGAGCGCTGGAGCGGCGGCCCCGGGCTGAGGGAGGAGGACACGG ACACCCCCGGCTTGAGGCGACGCGCCTCGTGCCGGCCGACCACGGCTGCCCGGGGCCAGCCCTCTCGGCGCGTGTCCAAGCTGGCGTCTG GGCCCCTGGCCGCCCCCGCGCAGCCGCGCCCGCTCCGCAGCCTCTCGCCGTCGGTTCGCCAGCTCTCCCGGCGCTTCGACGCGCCGCGTC TGGACGACGGCTCCGCTGGGACCCGAGACGGAGGCGTCTTACCCGCGGCCGCGGAAGAAGCGGCCGAGGGCCCAGCGCGAGGAGCCTGGC CCAGCGTCACCGAGATGCGCAAGCTCTTCGGCGGTCCTGGCTCCAGGAGGCCCAGCGCCGACTCTGAATCCCCAGGAACGCCCAGCCCCG ACGGTGCCGCGTGGGAGCCTCCGGCTCGGGAGTCGCGGCAGCCACCGACGCCACCCCCTCGGACATGCTTCCCCCTGGCGGGTCTGCGTT CGGCGCGGCCCCTGACCGGGCCGGAGACCGAAGGGAGGCTGCGCCGGCCGCAGCAGCAACAGGAGCGGGCGCAGCGTCCAGCGGATGGTT TACATTCTTGGCATATCTTCTCCCAACCGCAGGCCGGGGCCCGGGCCTCCTGCTCCTCCTCCTCCATCGCCGCCTCCTATCCTGTCAGCC GCAGTCGTGCTGCCAGCTCCAGCGAGGAGGAAGAGGAGGGCCCGCCGCAGCTGCCTGGAGCCCAGAGTCCGGCCTACCACGGCGGCCACT CCTCGGGCAGTGACGACGACCGAGACGGTGAGGGCGGCCACCGCTGGGGAGGGAGGCCCGGGCTCAGGCCTGGAAGCTCCCTATTGGATC AGGACTGCAGGCCTGACAGTGATGGGTTAAATCTAAGCAGCATGAACTCAGCAGGGGTTTCTGGGAGCCCTGAGCCCCCAACATCTCCAA GAGCCCCTAGAGAAGAAGGACTCCGGGAGTGGGGTAGTGGCTCTCCGCCCTGCGTCCCAGGTCCCCAGGAGGGACTTCGGCCTATGTCTG ACTCTGTGGGAGGAGCTTTCCGTGTGGCCAAGGTGAGCTTTCCCTCGTACCTGGCCAGCCCCGCAGGCTCCCGCGGTAGCAGCCGTTATT CCAGCACGGAGACCCTCAAGGACGACGACCTATGGTCTAGTAGGGGTTCTGGGGGCTGGGGCGTGTACCGCTCCCCTAGCTTTGGAGCTG GGGAAGGGCTCCTGCGGTCCCAGGCTCGAACCCGTGCCAAAGGACCTGGAGGCACCTCTAGGGCATTGAGGGATGGAGGATTTGAGCCTG AAAAGAGTCGACAGCGGAAGTCCCTGTCAAATCCAGATATCGCCTCAGAGACCCTGACGCTTCTCAGTTTCCTGCGCTCAGACCTTTCAG AGCTGAGGGTCCGAAAACCTGGTGGGAGCTCCGGGGACCGTGGAAGCAACCCCCTAGATGGCAGAGACTCACCATCCGCAGGTGGCCCTG TGGGGCAACTTGAACCCATACCCATCCCAGCCCCAGCATCACCTGGCACGCGCCCCACACTCAAGGACTTGACAGCCACTCTGCGGAGAG CAAAGTCATTCACCTGCTCTGAGAAGCCCATGGCCCGCCGCCTGCCCCGCACCAGTGCTCTGAAGTCCAGCTCCTCCGAGCTCCTGCTCA CAGGCCCTGGTGCCGAGGAGGATCCGCTGCCCCTCATCGTCCAGGACCAATATGTGCAGGAGGCCCGCCAGGTTTTTGAGAAGATCCAGC GCATGGGTGCCCAACAAGATGATGGAAGCGATGCCCCCCCTGGAAGCCCTGACTGGGCAGGGGATGTGACCCGAGGGCAGCGGTCCCAGG AGGAGCTCTCAGGCCCTGAGTCCAGTCTGACAGATGAAGGCATTGGGGCAGACCCTGAGCCTCCTGTTGCAGCATTTTGCGGCCTGGGTA CCACAGGGATGTGGCGACCTCTTTCCTCATCCTCGGCCCAGACGAACCACCATGGCCCTGGGACTGAGGACAGTCTGGGCGGGTGGGCCC TGGTGTCGCCTGAGACCCCTCCCACACCAGGTGCCCTCCGCCGACGACGCAAAGTCCCACCTTCAGGTTCTGGTGGGAGCGAATTGAGCA ATGGGGAGGCAGGGGAGGCCTACAGGTCCCTGAGTGACCCAATTCCTCAGCGCCACCGGGCTGCCACCTCTGAAGAGCCTACTGGGTTCT CTGTGGACAGCAACCTCCTGGGCTCACTGAGCCCCAAGACAGGGCTCCCTGCCACCTCAGCCATGGATGAGGGCTTGACCAGTGGTCACA GTGACTGGTCTGTGGGCAGTGAAGAGAGCAAGGGATATCAGGAGGTTATTCAGAGCATAGTTCAGGGGCCTGGCACCCTGGGGCGTGTGG TGGACGACAGGATTGCTGGCAAAGCCCCCAAGAAGAAATCCCTGAGTGACCCCAGCCGCCGTGGGGAGCTGGCTGGGCCTGGATTCGAGG GCCCTGGAGGGGAGCCCATCCGAGAAGTTGAGCCCATGCTGCCTCCATCCAGCAGCGAGCCCATCCTTGTAGAGCAGCGGGCAGAGCCAG AAGAACCTGGTGCCACCAGGAGCCGGGCACAGTCTGAAAGGGCCCTACCTGAGGCTCTGCCTCCCCCTGCCACTGCCCACCGAAACTTTC ACCTTGACCCCAAGCTGGCTGACATTCTGTCCCCGAGGCTAATCCGCCGAGGCTCCAAGAAGCGCCCAGCTCGGAGTAGTCACCAGGAGC TTCGGAGAGACGAGGGCAGTCAGGACCAGACTGGCAGCCTGTCTCGGGCCCGGCCCTCCTCCAGACACGTTCGCCATGCCAGTGTGCCCG CCACATTTATGCCTATTGTGGTGCCTGAGCCACCAACTTCTGTTGGTCCCCCTGTGGCTGTGCCAGAACCCATAGGCTTCCCTACCCGAG CCCATCCCACGTTGCAGGCACCATCGCTCGAGGACGTCACCAAGCAGTACATGCTGAACCTGCACTCCGGTGAGGTCCCTGCCCCAGTGC CAGTGGACATGCCCTGCTTGCCTCTGGCTGCACCGCCCTCTGCTGAGGCCAAGCCCCCTGAGGCAGCTCGGCCTGCAGATGAGCCTACCC CTGCCAGCAAGTGCTGCAGCAAGCCACAGGTGCCTATGGGCTATGGGCCTCGTATGCAACAGCCTTCCAACCAGGGCCAGTTCCTTCCTC AGACTCAGTTCCCATCACAGGGAATGAATGTAACAAATATCCCTTTGGCTCCGTCCAGCGGTCAAGCTCCAGTGTCTCAAGCACAAATGT CTAGTTCTTCCTGCCCGGTGAACTCTCCTATAATGCCTCCAGGGTCTCAGGGGAGCCACATTCACTGTCCCCAGCTTCCTCAACCAGCTC TTCATCAGAATTCACCCTCGCCTGTACCTAGTCGTACCCCCACCCCTCACCATACTCCCCCAAGCATAGGGGCTCAGCAGCCACCAGCAA CAACAATTCCAGCCCCTGTTCCTACACCTCCTGCCATGCCACCTGGGCCACAGTCCCAGGCTCTACATCCCCCTCCAAGGCAGACACCTA CACCACCAACAACACAACTTCCCCAACAAGTGCAGCCTTCACTTCCTGCTGCACCTTCTGCTGACCAGCCCCAGCAGCAGCCTCGCTCAC AGCAGAGCACAGCAGCGTCTGTTCCTACCCCAACAGCACCGCTGCTTCCTCCGCAGCCTGCAACTCCACTTTCCCAGCCAGCTGTAAGCA TTGAAGGACAGGTATCAAATCCTCCATCTACTAGTAGCACAGAAGTGAATTCTCAGGCCATTGCTGAGAAGCAGCCTTCCCAGGAAGTGA AGATGGAGGCCAAAATGGAAGTGGATCAACCAGAACCAGCAGATACTCAGCCGGAGGATATTTCAGAGTCTAAAGTGGAAGACTGTAAAA TGGAATCTACCGAAACAGAAGAGAGAAGCACTGAGTTAAAAACTGAAATAAAAGAGGAGGAAGACCAGCCAAGTACTTCAGCTACCCAGT CATCTCCGGCTCCAGGACAGTCAAAGAAAAAGATTTTCAAACCAGAAGAACTACGACAGGCACTGATGCCAACTTTGGAGGCACTTTACC GTCAGGATCCAGAATCCCTTCCCTTTCGTCAACCTGTGGACCCTCAGCTTTTAGGAATCCCTGATTACTTTGATATTGTGAAGAGCCCCA TGGATCTTTCTACCATTAAGAGGAAGTTAGACACTGGACAGTATCAGGAGCCCTGGCAGTATGTCGATGATATTTGGCTTATGTTCAATA ATGCCTGGTTATATAACCGGAAAACATCACGGGTATACAAATACTGCTCCAAGCTCTCTGAGGTCTTTGAACAAGAAATTGACCCAGTGA TGCAAAGCCTTGGATACTGTTGTGGCAGAAAGTTGGAGTTCTCTCCACAGACACTGTGTTGCTACGGCAAACAGTTGTGCACAATACCTC GTGATGCCACTTATTACAGTTACCAGAACAGGTATCATTTCTGTGAGAAGTGTTTCAATGAGATCCAAGGGGAGAGCGTTTCTTTGGGGG ATGACCCTTCCCAGCCTCAAACTACAATAAATAAAGAACAATTTTCCAAGAGAAAAAATGACACACTGGATCCTGAACTGTTTGTTGAAT GTACAGAGTGCGGAAGAAAGATGCATCAGATCTGTGTCCTTCACCATGAGATCATCTGGCCTGCTGGATTCGTCTGTGATGGCTGTTTAA AGAAAAGTGCACGAACTAGGAAAGAAAATAAGTTTTCTGCTAAAAGGTTGCCATCTACCAGACTTGGCACCTTTCTAGAGAATCGTGTGA ATGACTTTCTGAGGCGACAGAATCACCCTGAGTCAGGAGAGGTCACTGTTAGAGTAGTTCATGCTTCTGACAAAACCGTGGAAGTAAAAC CAGGCATGAAAGCAAGGTTTGTGGACAGTGGAGAGATGGCAGAATCCTTTCCATACCGAACCAAAGCCCTCTTTGCCTTTGAAGAAATTG ATGGTGTTGACCTGTGCTTCTTTGGCATGCATGTTCAAGAGTATGGCTCTGACTGCCCTCCACCCAACCAGAGGAGAGTATACATATCTT ACCTCGATAGTGTTCATTTCTTCCGTCCTAAATGCTTGAGGACTGCAGTCTATCATGAAATCCTAATTGGATATTTAGAATATGTCAAGA AATTAGGTTACACAACAGGGCATATTTGGGCATGTCCACCAAGTGAGGGAGATGATTATATCTTCCATTGCCATCCTCCTGACCAGAAGA TACCCAAGCCCAAGCGACTGCAGGAATGGTACAAAAAAATGCTTGACAAGGCTGTATCAGAGCGTATTGTCCATGACTACAAGGATATTT TTAAACAAGCTACTGAAGATAGATTAACAAGTGCAAAGGAATTGCCTTATTTCGAGGGTGATTTCTGGCCCAATGTTCTGGAAGAAAGCA TTAAGGAACTGGAACAGGAGGAAGAAGAGAGAAAACGAGAGGAAAACACCAGCAATGAAAGCACAGATGTGACCAAGGGAGACAGCAAAA ATGCTAAAAAGAAGAATAATAAGAAAACCAGCAAAAATAAGAGCAGCCTGAGTAGGGGCAACAAGAAGAAACCCGGGATGCCCAATGTAT CTAACGACCTCTCACAGAAACTATATGCCACCATGGAGAAGCATAAAGAGGTCTTCTTTGTGATCCGCCTCATTGCTGGCCCTGCTGCCA ACTCCCTGCCTCCCATTGTTGATCCTGATCCTCTCATCCCCTGCGATCTGATGGATGGTCGGGATGCGTTTCTCACGCTGGCAAGGGACA AGCACCTGGAGTTCTCTTCACTCCGAAGAGCCCAGTGGTCCACCATGTGCATGCTGGTGGAGCTGCACACGCAGAGCCAGGACCGCTTTG TCTACACCTGCAATGAATGCAAGCACCATGTGGAGACACGCTGGCACTGTACTGTCTGTGAGGATTATGACTTGTGTATCACCTGCTATA ACACTAAAAACCATGACCACAAAATGGAGAAACTAGGCCTTGGCTTAGATGATGAGAGCAACAACCAGCAGGCTGCAGCCACCCAGAGCC CAGGCGATTCTCGCCGCCTGAGTATCCAGCGCTGCATCCAGTCTCTGGTCCATGCTTGCCAGTGTCGGAATGCCAATTGCTCACTGCCAT CCTGCCAGAAGATGAAGCGGGTTGTGCAGCATACCAAGGGTTGCAAACGGAAAACCAATGGCGGGTGCCCCATCTGCAAGCAGCTCATTG CCCTCTGCTGCTACCATGCCAAGCACTGCCAGGAGAACAAATGCCCGGTGCCGTTCTGCCTAAACATCAAGCAGAAGCTCCGGCAGCAAC AGCTGCAGCACCGACTACAGCAGGCCCAAATGCTTCGCAGGAGGATGGCCAGCATGCAGCGGACTGGTGTGGTTGGGCAGCAACAGGGCC TCCCTTCCCCCACTCCTGCCACTCCAACGACACCAACTGGCCAACAGCCAACCACCCCGCAGACGCCCCAGCCCACTTCTCAGCCTCAGC CTACCCCTCCCAATAGCATGCCACCCTACTTGCCCAGGACTCAAGCTGCTGGCCCTGTGTCCCAGGGTAAGGCAGCAGGCCAGGTGACCC CTCCAACCCCTCCTCAGACTGCTCAGCCACCCCTTCCAGGGCCCCCACCTGCAGCAGTGGAAATGGCAATGCAGATTCAGAGAGCAGCGG AGACGCAGCGCCAGATGGCCCACGTGCAAATTTTTCAAAGGCCAATCCAACACCAGATGCCCCCGATGACTCCCATGGCCCCCATGGGTA TGAACCCACCTCCCATGACCAGAGGTCCCAGTGGGCATTTGGAGCCAGGGATGGGACCGACAGGGATGCAGCAACAGCCACCCTGGAGCC AAGGAGGATTGCCTCAGCCCCAGCAACTACAGTCTGGGATGCCAAGGCCAGCCATGATGTCAGTGGCCCAGCATGGTCAACCTTTGAACA TGGCTCCACAACCAGGATTGGGCCAGGTAGGTATCAGCCCACTCAAACCAGGCACTGTGTCTCAACAAGCCTTACAAAACCTTTTGCGGA CTCTCAGGTCTCCCAGCTCTCCCCTGCAGCAGCAACAGGTGCTTAGTATCCTTCACGCCAACCCCCAGCTGTTGGCTGCATTCATCAAGC AGCGGGCTGCCAAGTATGCCAACTCTAATCCACAACCCATCCCTGGGCAGCCTGGCATGCCCCAGGGGCAGCCAGGGCTACAGCCACCTA CCATGCCAGGTCAGCAGGGGGTCCACTCCAATCCAGCCATGCAGAACATGAATCCAATGCAGGCGGGCGTTCAGAGGGCTGGCCTGCCCC AGCAGCAACCACAGCAGCAACTCCAGCCACCCATGGGAGGGATGAGCCCCCAGGCTCAGCAGATGAACATGAACCACAACACCATGCCTT CACAATTCCGAGACATCTTGAGACGACAGCAAATGATGCAACAGCAGCAGCAACAGGGAGCAGGGCCAGGAATAGGCCCTGGAATGGCCA ACCATAACCAGTTCCAGCAACCCCAAGGAGTTGGCTACCCACCACAGCAGCAGCAGCGGATGCAGCATCACATGCAACAGATGCAACAAG GAAATATGGGACAGATAGGCCAGCTTCCCCAGGCCTTGGGAGCAGAGGCAGGTGCCAGTCTACAGGCCTATCAGCAGCGACTCCTTCAGC AACAGATGGGGTCCCCTGTTCAGCCCAACCCCATGAGCCCCCAGCAGCATATGCTCCCAAATCAGGCCCAGTCCCCACACCTACAAGGCC AGCAGATCCCTAATTCTCTCTCCAATCAAGTGCGCTCTCCCCAGCCTGTCCCTTCTCCACGGCCACAGTCCCAGCCCCCCCACTCCAGTC CTTCCCCAAGGATGCAGCCTCAGCCTTCTCCACACCACGTTTCCCCACAGACAAGTTCCCCACATCCTGGACTGGTAGCTGCCCAGGCCA ACCCCATGGAACAAGGGCATTTTGCCAGCCCGGACCAGAATTCAATGCTTTCTCAGCTTGCTAGCAATCCAGGCATGGCAAACCTCCATG GTGCAAGCGCCACGGACCTGGGACTCAGCACCGATAACTCAGACTTGAATTCAAACCTCTCACAGAGTACACTAGACATACACTAGAGAC ACCTTGTAGTATTTTGGGAGCAAAAAAATTATTTTCTCTTAACAAGACTTTTTGTACTGAAAACAATTTTTTTGAATCTTTCGTAGCCTA AAAGACAATTTTCCTTGGAACACATAAGAACTGTGCAGTAGCCGTTTGTGGTTTAAAGCAAACATGCAAGATGAACCTGAGGGATGATAG AATACAAAGAATATATTTTTGTTATGGCTGGTTACCACCAGCCTTTCTTCCCCTTTGTGTGTGTGGTTCAAGTGTGCACTGGGAGGAGGC TGAGGCCTGTGAAGCCAAACAATATGCTCCTGCCTTGCACCTCCAATAGGTTTTATTATTTTTTTTAAATTAATGAACATATGTAATATT AATAGTTATTATTTACTGGTGCAGATGGTTGACATTTTTCCCTATTTTCCTCACTTTATGGAAGAGTTAAAACATTTCTAAACCAGAGGA CAAAAGGGGTTAATGTTACTTTAAAATTACATTCTATATATATATAAATATATATAAATATATATTAAAATACCAGTTTTTTTTCTCTGG GTGCAAAGATGTTCATTCTTTTAAAAAATGTTTAAAAAAAAAAAAAAACTGCCTTTCTTCCCCTCAAGTCAACTTTTGTGCTCCAGAAAA TTTTCTATTCTGTAAGTCTGAGCGTAAAACTTCAAGTATTAAAATAATTTGTACATGTAGAGAGAAAAATGACTTTTTCAAAAATATACA GGGGCAGCTGCCAAATTGATGTATTATATATTGTGGTTTCTGTTTCTTGAAAGAATTTTTTTCGTTATTTTTACATCTAACAAAGTAAAA AAATTAAAAAGAGGGTAAGAAACGATTCCGGTGGGATGATTTTAACATGCAAAATGTCCCTGGGGGTTTCTTCTTTGCTTGCTTTCTTCC TCCTTACCCTACCCCCCACTCACACACACACACACACACACACACACACACACACACACACACTTTCTATAAAACTTGAAAATAGCAAAA ACCCTCAACTGTTGTAAATCATGCAATTAAAGTTGATTACTTATAAATATGAACTTTGGATCACTGTATAGACTGTTAAATTTGATTTCT |
Top |
FusionGenePPI for ARHGEF17_EP300 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ARHGEF17 | SFN, TP53, NXF1, RASL12, WDR83, CAPZA2, MYH9, IQGAP1, SYNPO, ANLN, MYO18A, RERG | EP300 | TFAP2A, EGR1, MAF, PROX1, CITED2, JMY, BRCA1, NCOA3, TP53, SS18L1, PIAS3, CLOCK, ARNTL, NPAS2, KLF5, ING4, ING5, N4BP2, MEF2D, PPARG, ESR1, KAT2B, RELA, YY1, SMAD2, ETS1, ETS2, ELK1, SS18, CDX2, PAX6, CREB1, USF2, FEN1, EP300, MEF2A, THRA, RORA, MYOD1, TSG101, MYBL2, ING1, SMAD1, TWIST1, NEUROD1, HAND2, DTX1, ASCL1, GPS2, HNRNPU, SMAD7, MAML1, EID1, RBM14, CITED4, HIF1A, MDM4, NCOA6, TADA3, GATA6, BCL3, TCF3, MGMT, DDX5, CITED1, PELP1, SREBF2, NFATC2, TRIP4, STAT2, STAT1, TDG, NUP98, TRERF1, TGS1, NEUROG1, SNIP1, SMAD4, IRF2, STAT3, NR4A1, HNF1A, LEF1, MEF2C, MDM2, CCND1, PPARA, PCNA, XPA, TAL1, PTMA, CEBPB, POLR2A, COPS6, SUB1, STAT6, ZBTB17, HIST3H3, HIST4H4, TAF1B, NAP1L1, NAP1L4, CREBBP, USF1, HDAC6, RECQL4, BTRC, ANAPC7, ANAPC5, CDC16, ANAPC2, CDH1, CDC20, HDAC3, CDT1, ATF4, REL, DDX17, MAX, SP1, MAP3K5, PAK2, GRB2, CHUK, NOTCH1, ELSPBP1, SOX9, HIST1H3A, CTBP2, KAT6A, TBX21, SIRT2, NCOR1, NCOR2, PARP1, PPARGC1A, CTTN, PPARD, CARM1, RUNX1, HIPK2, ESR2, SMAD3, PLAGL1, HDAC1, ING2, SP3, RUNX2, CALCOCO1, GTF3C1, GTF3C3, GTF3C2, GTF3C5, MTA1, SMAD5, VHL, RUNX3, HSP90AA2P, NFKB1, IRF1, HIST2H2AC, HIST1H4A, MYC, JUND, ETV1, KLF13, PGR, PTMS, JUN, BCL6, AR, ATXN3, CTBP1, MTF1, NPM1, GRIP1, RARA, HIST1H2AB, HIST1H2BB, SREBF1, DEK, ATXN7, YAP1, TP73, HIST1H1D, HIST2H2AB, VDR, MYB, SRCAP, PRMT1, CDKN1A, GATA4, NFYB, TCF12, JUNB, SRY, PRDM2, CTF1, KPNA2, HIST2H2BE, AKT1, XRCC6, GATA2, SNW1, NCOA1, KLF4, NR3C1, FOSL1, CTNNB1, NFATC1, MAPK1, PAX5, GABPA, KDM1A, ATR, NUTM1, BRD4, KLF8, TGFBR1, IRF5, ZBTB7B, MAPT, RPS6KB1, RPS6KB2, NR1H4, FOXO3, SOX4, HOXD10, HOXD4, SMARCA2, MDC1, DDX24, ACTA1, ANXA2, HERC1, TP53BP1, MSH6, RAD50, NBN, MRE11A, NEDD1, ACTA2, CRTC2, IRF3, ATF2, POU3F2, TBP, GTF2B, CDK2, CRX, HMGN1, HMGN2, AHR, ARNT, RPS6KA5, NUPR1, PAXIP1, CXCL8, MAGEA11, NCOA2, IRF7, PCK1, BAG6, SPHK1, NFYA, KLF16, KAT5, MAPK14, HBP1, TACC2, FOS, FOSB, FOSL2, RXRA, TCF4, PIN1, MAP9, STAT5A, KLF11, ZNF148, DDB2, DDB1, CD44, GAPDH, ERCC8, FBXO3, TNK2, ZBTB16, SKP2, HIST2H3C, HIST2H4A, ZNF76, EPAS1, HIST1H1A, PIK3R1, NABP2, PKM, APEX1, ASCL2, YBX1, CBX8, STRAP, TCL1A, ATG7, KLF1, MYBBP1A, RPS26, TNIP2, GOLGA2, CFH, DECR2, PLG, MAGED1, TINAGL1, KRT18, IMMT, MSTO1, WDR59, EWSR1, EPO, GAA, ITIH3, PCK2, PLSCR1, POLD2, RPL27, SEPP1, THPO, TRAF2, MCM3AP, NOXA1, HNRNPUL1, FBXL5, SERTAD1, UBQLN1, KCTD5, PLSCR2, VPS18, SAV1, HPS6, ZC3H12A, ARSF, C1R, CLTC, DAO, CNOT4, BCAS2, ATF5, ACSM5, ACTB, DYRK1B, DYRK1A, PTGS2, DDIT3, COPS2, ZBTB48, SIRT1, ZBTB8A, E2F1, AURKB, COMMD1, PRDM6, ELF3, FOXO1, KLF2, HSPA5, FBXW8, FBXW2, UBE2D1, SENP3, BANP, ASCC1, TERF2, TERF1, CEBPD, PRKCB, PRKCA, PRKCD, PAX8, ZEB1, FOXP3, FHL1, RB1, NANOG, BRMS1, PPP1R13B, TP53BP2, PPP1R13L, CCNB1, TP63, SATB1, UBC, MITF, EID2, CDK1, SPIB, MAPK8, CRTC1, MAML2, POLB, PPP2R5C, PPP2CA, DNA2, PDHX, FHL2, ASH2L, CXXC1, SETD1A, WDR82, WDR5, RBBP5, PRKAA1, NEIL2, MN1, DYNC1I1, BMI1, SUMO2, FLII, ILF2, CCNA2, C3orf62, BRD7, ZBTB33, RERE, KLF15, ZBTB49, ORC2, MCM2, PRKDC, MCM4, MCM3, ILF3, MCM5, EEF2, EEF1A1, MORF4L1, RUVBL2, AUTS2, TCF7L2, UBE2I, MED23, COBL, SDC1, PSMD10, SNAI1, ZNF350, SMC1A, HEMGN, GATA1, NR3C2, GCKR, CIITA, YWHAZ, ITGAV, MKL1, ZEB2, GLUL, CHD4, HSF1, RORC, SRC, HNRNPA2B1, CTGF, SPATA1, HSPA8, JUP, LAMP2, TRIM25, XRCC5, MTDH, PIAS1, ARHGDIA, RPTOR, MTOR |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | EP300 | chr11:73022875 | chr22:41545042 | ENST00000263253 | + | 11 | 31 | 1397_1399 | 747 | 2415 | histone |
| Tgene | EP300 | chr11:73022875 | chr22:41545042 | ENST00000263253 | + | 11 | 31 | 2003_2212 | 747 | 2415 | HTLV-1 Tax |
| Tgene | EP300 | chr11:73022875 | chr22:41545042 | ENST00000263253 | + | 11 | 31 | 2041_2240 | 747 | 2415 | NCOA2 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | EP300 | chr11:73022875 | chr22:41545042 | ENST00000263253 | + | 11 | 31 | 2_139 | 747 | 2415 | ALX1 |
| Tgene | EP300 | chr11:73022875 | chr22:41545042 | ENST00000263253 | + | 11 | 31 | 2_149 | 747 | 2415 | RORA |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARHGEF17_EP300 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARHGEF17_EP300 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | EP300 | C0279626 | Squamous cell carcinoma of esophagus | 2 | CTD_human |
| Tgene | EP300 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Tgene | EP300 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Tgene | EP300 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Tgene | EP300 | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
| Tgene | EP300 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Tgene | EP300 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
| Tgene | EP300 | C0025202 | melanoma | 1 | CTD_human |
| Tgene | EP300 | C0028754 | Obesity | 1 | CTD_human |
| Tgene | EP300 | C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human |
| Tgene | EP300 | C0079772 | T-Cell Lymphoma | 1 | CTD_human |
| Tgene | EP300 | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
| Tgene | EP300 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| Tgene | EP300 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
| Tgene | EP300 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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