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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25300

FusionGeneSummary for NXN_SLC43A2

check button Fusion gene summary
Fusion gene informationFusion gene name: NXN_SLC43A2
Fusion gene ID: 25300
HgeneTgene
Gene symbol

NXN

SLC43A2

Gene ID

64359

124935

Gene namenucleoredoxinsolute carrier family 43 member 2
SynonymsNRX|TRG-4LAT4
Cytomap

17p13.3

17p13.3

Type of geneprotein-codingprotein-coding
Descriptionnucleoredoxinnucleoredoxin 1large neutral amino acids transporter small subunit 4L-type amino acid transporter 4solute carrier family 43 (amino acid system L transporter), member 2
Modification date2018051920180523
UniProtAcc

Q6DKJ4

Q8N370

Ensembl transtripts involved in fusion geneENST00000336868, ENST00000577098, 
ENST00000575801, ENST00000538650, 
ENST00000537628, 		ENST00000301335, 
ENST00000571650, ENST00000382147, 
ENST00000412517, ENST00000574274, 
Fusion gene scores* DoF score9 X 5 X 7=3159 X 9 X 5=405
# samples 129
** MAII scorelog2(12/315*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/405*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NXN [Title/Abstract] AND SLC43A2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-A5-A7WK-01ANXNchr17

882559

-SLC43A2chr17

1518328

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000336868ENST00000301335NXNchr17

882559

-SLC43A2chr17

1518328

-
Frame-shiftENST00000336868ENST00000571650NXNchr17

882559

-SLC43A2chr17

1518328

-
Frame-shiftENST00000336868ENST00000382147NXNchr17

882559

-SLC43A2chr17

1518328

-
5CDS-intronENST00000336868ENST00000412517NXNchr17

882559

-SLC43A2chr17

1518328

-
5CDS-intronENST00000336868ENST00000574274NXNchr17

882559

-SLC43A2chr17

1518328

-
intron-3CDSENST00000577098ENST00000301335NXNchr17

882559

-SLC43A2chr17

1518328

-
intron-3CDSENST00000577098ENST00000571650NXNchr17

882559

-SLC43A2chr17

1518328

-
intron-3CDSENST00000577098ENST00000382147NXNchr17

882559

-SLC43A2chr17

1518328

-
intron-intronENST00000577098ENST00000412517NXNchr17

882559

-SLC43A2chr17

1518328

-
intron-intronENST00000577098ENST00000574274NXNchr17

882559

-SLC43A2chr17

1518328

-
intron-3CDSENST00000575801ENST00000301335NXNchr17

882559

-SLC43A2chr17

1518328

-
intron-3CDSENST00000575801ENST00000571650NXNchr17

882559

-SLC43A2chr17

1518328

-
intron-3CDSENST00000575801ENST00000382147NXNchr17

882559

-SLC43A2chr17

1518328

-
intron-intronENST00000575801ENST00000412517NXNchr17

882559

-SLC43A2chr17

1518328

-
intron-intronENST00000575801ENST00000574274NXNchr17

882559

-SLC43A2chr17

1518328

-
intron-3CDSENST00000538650ENST00000301335NXNchr17

882559

-SLC43A2chr17

1518328

-
intron-3CDSENST00000538650ENST00000571650NXNchr17

882559

-SLC43A2chr17

1518328

-
intron-3CDSENST00000538650ENST00000382147NXNchr17

882559

-SLC43A2chr17

1518328

-
intron-intronENST00000538650ENST00000412517NXNchr17

882559

-SLC43A2chr17

1518328

-
intron-intronENST00000538650ENST00000574274NXNchr17

882559

-SLC43A2chr17

1518328

-
intron-3CDSENST00000537628ENST00000301335NXNchr17

882559

-SLC43A2chr17

1518328

-
intron-3CDSENST00000537628ENST00000571650NXNchr17

882559

-SLC43A2chr17

1518328

-
intron-3CDSENST00000537628ENST00000382147NXNchr17

882559

-SLC43A2chr17

1518328

-
intron-intronENST00000537628ENST00000412517NXNchr17

882559

-SLC43A2chr17

1518328

-
intron-intronENST00000537628ENST00000574274NXNchr17

882559

-SLC43A2chr17

1518328

-

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FusionProtFeatures for NXN_SLC43A2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NXN

Q6DKJ4

SLC43A2

Q8N370

Functions as a redox-dependent negative regulator of theWnt signaling pathway, possibly by preventing ubiquitination ofDVL3 by the BCR(KLHL12) complex. May also function as atranscriptional regulator act as a regulator of proteinphosphatase 2A (PP2A) (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NXN_SLC43A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NXN_SLC43A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NXNCHMP6, USP3, ELAVL1, C9orf9, GAS2L1, ARRDC1, CRY2, DUSP4, DVL3, CGB2, GORASP1, CDH23, NCKAP1, ABI1, WASF1, TRIM25SLC43A2ELAVL1, KRTAP10-3, YIPF3, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NXN_SLC43A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NXN_SLC43A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNXNC0009404Colorectal Neoplasms1CTD_human
TgeneSLC43A2C0023893Liver Cirrhosis, Experimental1CTD_human