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Fusion gene ID: 25281 |
FusionGeneSummary for NVL_LARS2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NVL_LARS2 | Fusion gene ID: 25281 | Hgene | Tgene | Gene symbol | NVL | LARS2 | Gene ID | 4931 | 23395 |
| Gene name | nuclear VCP-like | leucyl-tRNA synthetase 2, mitochondrial | |
| Synonyms | NVL2 | HLASA|LEURS|PRLTS4|mtLeuRS | |
| Cytomap | 1q42.11 | 3p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear valosin-containing protein-likeNVLp | probable leucine--tRNA ligase, mitochondrialleucine tRNA ligase 2, mitochondrialleucine tRNA ligase 2, mitocondrialleucine translaseprobable leucyl-tRNA synthetase, mitochondrial | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O15381 | Q15031 | |
| Ensembl transtripts involved in fusion gene | ENST00000391875, ENST00000281701, ENST00000469075, ENST00000482491, ENST00000340871, ENST00000361463, ENST00000468673, | ENST00000265537, ENST00000415258, ENST00000414984, ENST00000467936, | |
| Fusion gene scores | * DoF score | 8 X 6 X 6=288 | 3 X 5 X 5=75 |
| # samples | 7 | 5 | |
| ** MAII score | log2(7/288*10)=-2.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NVL [Title/Abstract] AND LARS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | LARS2 | GO:0006429 | leucyl-tRNA aminoacylation | 10684970 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-BL-A0C8-01A | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000391875 | ENST00000265537 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| In-frame | ENST00000391875 | ENST00000415258 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| In-frame | ENST00000391875 | ENST00000414984 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| 5CDS-intron | ENST00000391875 | ENST00000467936 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| In-frame | ENST00000281701 | ENST00000265537 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| In-frame | ENST00000281701 | ENST00000415258 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| In-frame | ENST00000281701 | ENST00000414984 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| 5CDS-intron | ENST00000281701 | ENST00000467936 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| In-frame | ENST00000469075 | ENST00000265537 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| In-frame | ENST00000469075 | ENST00000415258 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| In-frame | ENST00000469075 | ENST00000414984 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| 5CDS-intron | ENST00000469075 | ENST00000467936 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| 5UTR-3CDS | ENST00000482491 | ENST00000265537 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| 5UTR-3CDS | ENST00000482491 | ENST00000415258 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| 5UTR-3CDS | ENST00000482491 | ENST00000414984 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| 5UTR-intron | ENST00000482491 | ENST00000467936 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| Frame-shift | ENST00000340871 | ENST00000265537 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| Frame-shift | ENST00000340871 | ENST00000415258 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| Frame-shift | ENST00000340871 | ENST00000414984 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| 5CDS-intron | ENST00000340871 | ENST00000467936 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| Frame-shift | ENST00000361463 | ENST00000265537 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| Frame-shift | ENST00000361463 | ENST00000415258 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| Frame-shift | ENST00000361463 | ENST00000414984 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| 5CDS-intron | ENST00000361463 | ENST00000467936 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| intron-3CDS | ENST00000468673 | ENST00000265537 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| intron-3CDS | ENST00000468673 | ENST00000415258 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| intron-3CDS | ENST00000468673 | ENST00000414984 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
| intron-intron | ENST00000468673 | ENST00000467936 | NVL | chr1 | 224492736 | - | LARS2 | chr3 | 45583321 | + |
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FusionProtFeatures for NVL_LARS2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NVL | LARS2 |
| Participates in the assembly of the telomeraseholoenzyme and effecting of telomerase activity via itsinteraction with TERT (PubMed:22226966). May play a role in 60Sribosomal subunit biogenesis (PubMed:15469983, PubMed:16782053).{ECO:0000269|PubMed:15469983, ECO:0000269|PubMed:16782053,ECO:0000269|PubMed:22226966}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NVL | chr1:224492736 | chr3:45583321 | ENST00000281701 | - | 7 | 23 | 218_232 | 249 | 857 | Motif | Nuclear localization signal |
| Hgene | NVL | chr1:224492736 | chr3:45583321 | ENST00000281701 | - | 7 | 23 | 49_52 | 249 | 857 | Motif | Nucleolar localization signal |
| Hgene | NVL | chr1:224492736 | chr3:45583321 | ENST00000281701 | - | 7 | 23 | 85_88 | 249 | 857 | Motif | Nuclear localization signal |
| Hgene | NVL | chr1:224492736 | chr3:45583321 | ENST00000391875 | - | 6 | 22 | 49_52 | 143 | 751 | Motif | Nucleolar localization signal |
| Hgene | NVL | chr1:224492736 | chr3:45583321 | ENST00000391875 | - | 6 | 22 | 85_88 | 143 | 751 | Motif | Nuclear localization signal |
| Hgene | NVL | chr1:224492736 | chr3:45583321 | ENST00000469075 | - | 6 | 22 | 49_52 | 158 | 766 | Motif | Nucleolar localization signal |
| Hgene | NVL | chr1:224492736 | chr3:45583321 | ENST00000469075 | - | 6 | 22 | 85_88 | 158 | 766 | Motif | Nuclear localization signal |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NVL | chr1:224492736 | chr3:45583321 | ENST00000340871 | - | 4 | 21 | 218_232 | 33 | 668 | Motif | Nuclear localization signal |
| Hgene | >NVL | chr1:224492736 | chr3:45583321 | ENST00000340871 | - | 4 | 21 | 49_52 | 33 | 668 | Motif | Nucleolar localization signal |
| Hgene | >NVL | chr1:224492736 | chr3:45583321 | ENST00000340871 | - | 4 | 21 | 85_88 | 33 | 668 | Motif | Nuclear localization signal |
| Hgene | >NVL | chr1:224492736 | chr3:45583321 | ENST00000391875 | - | 6 | 22 | 218_232 | 143 | 751 | Motif | Nuclear localization signal |
| Hgene | >NVL | chr1:224492736 | chr3:45583321 | ENST00000469075 | - | 6 | 22 | 218_232 | 158 | 766 | Motif | Nuclear localization signal |
| Hgene | >NVL | chr1:224492736 | chr3:45583321 | ENST00000281701 | - | 7 | 23 | 305_312 | 249 | 857 | Nucleotide binding | ATP |
| Hgene | >NVL | chr1:224492736 | chr3:45583321 | ENST00000281701 | - | 7 | 23 | 622_629 | 249 | 857 | Nucleotide binding | ATP |
| Hgene | >NVL | chr1:224492736 | chr3:45583321 | ENST00000340871 | - | 4 | 21 | 305_312 | 33 | 668 | Nucleotide binding | ATP |
| Hgene | >NVL | chr1:224492736 | chr3:45583321 | ENST00000340871 | - | 4 | 21 | 622_629 | 33 | 668 | Nucleotide binding | ATP |
| Hgene | >NVL | chr1:224492736 | chr3:45583321 | ENST00000391875 | - | 6 | 22 | 305_312 | 143 | 751 | Nucleotide binding | ATP |
| Hgene | >NVL | chr1:224492736 | chr3:45583321 | ENST00000391875 | - | 6 | 22 | 622_629 | 143 | 751 | Nucleotide binding | ATP |
| Hgene | >NVL | chr1:224492736 | chr3:45583321 | ENST00000469075 | - | 6 | 22 | 305_312 | 158 | 766 | Nucleotide binding | ATP |
| Hgene | >NVL | chr1:224492736 | chr3:45583321 | ENST00000469075 | - | 6 | 22 | 622_629 | 158 | 766 | Nucleotide binding | ATP |
| Tgene | LARS2 | chr1:224492736 | chr3:45583321 | ENST00000265537 | + | 19 | 22 | 639_643 | 801 | 904 | Motif | Note="KMSKS" region |
| Tgene | LARS2 | chr1:224492736 | chr3:45583321 | ENST00000265537 | + | 19 | 22 | 92_102 | 801 | 904 | Motif | Note="HIGH" region |
| Tgene | LARS2 | chr1:224492736 | chr3:45583321 | ENST00000415258 | + | 18 | 21 | 639_643 | 801 | 904 | Motif | Note="KMSKS" region |
| Tgene | LARS2 | chr1:224492736 | chr3:45583321 | ENST00000415258 | + | 18 | 21 | 92_102 | 801 | 904 | Motif | Note="HIGH" region |
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FusionGeneSequence for NVL_LARS2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NVL_ENST00000391875_chr1_224492736_-_LARS2_ENST00000265537_chr3_45583321_+_246aa MEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSCEKSN PKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEV >In-frame_NVL_ENST00000391875_chr1_224492736_-_LARS2_ENST00000415258_chr3_45583321_+_246aa MEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSCEKSN PKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEV >In-frame_NVL_ENST00000391875_chr1_224492736_-_LARS2_ENST00000414984_chr3_45583321_+_246aa MEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSCEKSN PKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEV >In-frame_NVL_ENST00000281701_chr1_224492736_-_LARS2_ENST00000265537_chr3_45583321_+_352aa MKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQG EEDNEYTESYSDDDSSMEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPS VKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKGLALVPRKLCAHYTWDASVLL >In-frame_NVL_ENST00000281701_chr1_224492736_-_LARS2_ENST00000415258_chr3_45583321_+_352aa MKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQG EEDNEYTESYSDDDSSMEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPS VKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKGLALVPRKLCAHYTWDASVLL >In-frame_NVL_ENST00000281701_chr1_224492736_-_LARS2_ENST00000414984_chr3_45583321_+_352aa MKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQG EEDNEYTESYSDDDSSMEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPS VKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKGLALVPRKLCAHYTWDASVLL >In-frame_NVL_ENST00000469075_chr1_224492736_-_LARS2_ENST00000265537_chr3_45583321_+_261aa MKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQG EEDNEYTESYSDDDSSMEDYPDPQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKGLALVPRKLCAHYTWDASVLLQ >In-frame_NVL_ENST00000469075_chr1_224492736_-_LARS2_ENST00000415258_chr3_45583321_+_261aa MKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQG EEDNEYTESYSDDDSSMEDYPDPQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKGLALVPRKLCAHYTWDASVLLQ >In-frame_NVL_ENST00000469075_chr1_224492736_-_LARS2_ENST00000414984_chr3_45583321_+_261aa MKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQG EEDNEYTESYSDDDSSMEDYPDPQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKGLALVPRKLCAHYTWDASVLLQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NVL_ENST00000391875_chr1_224492736_-_LARS2_ENST00000265537_chr3_45583321_+_738nt ATGGAAGACTACCCAGATCCACAGTCAGCAAATCACATGAACAGTTCCCTGCTGTCTTTATATCGGAAAGGAAATCCTGATTCTGTTTCA AATACTCCTGAGATGGAGCAAAGAGAAACCACCTCTTCAACACCACGGATAAGTTCCAAAACAGGCTCCATTCCCTTGAAGACCCCTGCC AAAGATTCTGAAGGAGGATGGTTTATTGACAAAACCCCAAGTGTAAAGAAAGACAGTTTTTTCTTGGACCTGTCATGTGAGAAAAGTAAT CCTAAGAAGCCAATAACTGAGATACAGGATTCAAAAGATTCTTCTCTTTTGGAGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAA GGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGAGAAATTGAAGCTGTCCTGCAAAAGAAAGGCCTGGCGCTGGTGCCGAGG AAGCTCTGTGCCCACTACACTTGGGATGCCAGTGTGCTGCTCCAGGCATGGCCTGCTGTGGACCCGGAGTTCCTGCAGCAGCCTGAGGTT GTCCAGATGGCAGTTCTGATCAACAATAAAGCTTGTGGCAAAATTCCTGTGCCCCAACAAGTTGCCCGGGACCAGGACAAAGTCCACGAA TTTGTTCTTCAAAGCGAGCTGGGTGTCAGGCTTTTGCAAGGACGAAGCATCAAGAAGTCCTTCCTTTCCCCGAGAACTGCCCTCATCAAC >In-frame_NVL_ENST00000391875_chr1_224492736_-_LARS2_ENST00000415258_chr3_45583321_+_738nt ATGGAAGACTACCCAGATCCACAGTCAGCAAATCACATGAACAGTTCCCTGCTGTCTTTATATCGGAAAGGAAATCCTGATTCTGTTTCA AATACTCCTGAGATGGAGCAAAGAGAAACCACCTCTTCAACACCACGGATAAGTTCCAAAACAGGCTCCATTCCCTTGAAGACCCCTGCC AAAGATTCTGAAGGAGGATGGTTTATTGACAAAACCCCAAGTGTAAAGAAAGACAGTTTTTTCTTGGACCTGTCATGTGAGAAAAGTAAT CCTAAGAAGCCAATAACTGAGATACAGGATTCAAAAGATTCTTCTCTTTTGGAGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAA GGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGAGAAATTGAAGCTGTCCTGCAAAAGAAAGGCCTGGCGCTGGTGCCGAGG AAGCTCTGTGCCCACTACACTTGGGATGCCAGTGTGCTGCTCCAGGCATGGCCTGCTGTGGACCCGGAGTTCCTGCAGCAGCCTGAGGTT GTCCAGATGGCAGTTCTGATCAACAATAAAGCTTGTGGCAAAATTCCTGTGCCCCAACAAGTTGCCCGGGACCAGGACAAAGTCCACGAA TTTGTTCTTCAAAGCGAGCTGGGTGTCAGGCTTTTGCAAGGACGAAGCATCAAGAAGTCCTTCCTTTCCCCGAGAACTGCCCTCATCAAC >In-frame_NVL_ENST00000391875_chr1_224492736_-_LARS2_ENST00000414984_chr3_45583321_+_738nt ATGGAAGACTACCCAGATCCACAGTCAGCAAATCACATGAACAGTTCCCTGCTGTCTTTATATCGGAAAGGAAATCCTGATTCTGTTTCA AATACTCCTGAGATGGAGCAAAGAGAAACCACCTCTTCAACACCACGGATAAGTTCCAAAACAGGCTCCATTCCCTTGAAGACCCCTGCC AAAGATTCTGAAGGAGGATGGTTTATTGACAAAACCCCAAGTGTAAAGAAAGACAGTTTTTTCTTGGACCTGTCATGTGAGAAAAGTAAT CCTAAGAAGCCAATAACTGAGATACAGGATTCAAAAGATTCTTCTCTTTTGGAGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAA GGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGAGAAATTGAAGCTGTCCTGCAAAAGAAAGGCCTGGCGCTGGTGCCGAGG AAGCTCTGTGCCCACTACACTTGGGATGCCAGTGTGCTGCTCCAGGCATGGCCTGCTGTGGACCCGGAGTTCCTGCAGCAGCCTGAGGTT GTCCAGATGGCAGTTCTGATCAACAATAAAGCTTGTGGCAAAATTCCTGTGCCCCAACAAGTTGCCCGGGACCAGGACAAAGTCCACGAA TTTGTTCTTCAAAGCGAGCTGGGTGTCAGGCTTTTGCAAGGACGAAGCATCAAGAAGTCCTTCCTTTCCCCGAGAACTGCCCTCATCAAC >In-frame_NVL_ENST00000281701_chr1_224492736_-_LARS2_ENST00000265537_chr3_45583321_+_1056nt ATGAAGCCCAGACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCGAGTCATCCAGTACCTTACCAGTAACAAATGTGGCAAATATGTG GACATTGGAGTCTTAGCGTCTGATTTACAAAGAGTGTACAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGATTCAGGTAGAA AAAGTATTTAGCATAATTAGTAGTGAGAAGGAACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGGCAAGACAAGGT GAAGAGGATAATGAGTATACTGAAAGCTATTCTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGTCAGCAAATCACATGAAC AGTTCCCTGCTGTCTTTATATCGGAAAGGAAATCCTGATTCTGTTTCAAATACTCCTGAGATGGAGCAAAGAGAAACCACCTCTTCAACA CCACGGATAAGTTCCAAAACAGGCTCCATTCCCTTGAAGACCCCTGCCAAAGATTCTGAAGGAGGATGGTTTATTGACAAAACCCCAAGT GTAAAGAAAGACAGTTTTTTCTTGGACCTGTCATGTGAGAAAAGTAATCCTAAGAAGCCAATAACTGAGATACAGGATTCAAAAGATTCT TCTCTTTTGGAGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGA GAAATTGAAGCTGTCCTGCAAAAGAAAGGCCTGGCGCTGGTGCCGAGGAAGCTCTGTGCCCACTACACTTGGGATGCCAGTGTGCTGCTC CAGGCATGGCCTGCTGTGGACCCGGAGTTCCTGCAGCAGCCTGAGGTTGTCCAGATGGCAGTTCTGATCAACAATAAAGCTTGTGGCAAA ATTCCTGTGCCCCAACAAGTTGCCCGGGACCAGGACAAAGTCCACGAATTTGTTCTTCAAAGCGAGCTGGGTGTCAGGCTTTTGCAAGGA >In-frame_NVL_ENST00000281701_chr1_224492736_-_LARS2_ENST00000415258_chr3_45583321_+_1056nt ATGAAGCCCAGACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCGAGTCATCCAGTACCTTACCAGTAACAAATGTGGCAAATATGTG GACATTGGAGTCTTAGCGTCTGATTTACAAAGAGTGTACAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGATTCAGGTAGAA AAAGTATTTAGCATAATTAGTAGTGAGAAGGAACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGGCAAGACAAGGT GAAGAGGATAATGAGTATACTGAAAGCTATTCTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGTCAGCAAATCACATGAAC AGTTCCCTGCTGTCTTTATATCGGAAAGGAAATCCTGATTCTGTTTCAAATACTCCTGAGATGGAGCAAAGAGAAACCACCTCTTCAACA CCACGGATAAGTTCCAAAACAGGCTCCATTCCCTTGAAGACCCCTGCCAAAGATTCTGAAGGAGGATGGTTTATTGACAAAACCCCAAGT GTAAAGAAAGACAGTTTTTTCTTGGACCTGTCATGTGAGAAAAGTAATCCTAAGAAGCCAATAACTGAGATACAGGATTCAAAAGATTCT TCTCTTTTGGAGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGA GAAATTGAAGCTGTCCTGCAAAAGAAAGGCCTGGCGCTGGTGCCGAGGAAGCTCTGTGCCCACTACACTTGGGATGCCAGTGTGCTGCTC CAGGCATGGCCTGCTGTGGACCCGGAGTTCCTGCAGCAGCCTGAGGTTGTCCAGATGGCAGTTCTGATCAACAATAAAGCTTGTGGCAAA ATTCCTGTGCCCCAACAAGTTGCCCGGGACCAGGACAAAGTCCACGAATTTGTTCTTCAAAGCGAGCTGGGTGTCAGGCTTTTGCAAGGA >In-frame_NVL_ENST00000281701_chr1_224492736_-_LARS2_ENST00000414984_chr3_45583321_+_1056nt ATGAAGCCCAGACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCGAGTCATCCAGTACCTTACCAGTAACAAATGTGGCAAATATGTG GACATTGGAGTCTTAGCGTCTGATTTACAAAGAGTGTACAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGATTCAGGTAGAA AAAGTATTTAGCATAATTAGTAGTGAGAAGGAACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGGCAAGACAAGGT GAAGAGGATAATGAGTATACTGAAAGCTATTCTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGTCAGCAAATCACATGAAC AGTTCCCTGCTGTCTTTATATCGGAAAGGAAATCCTGATTCTGTTTCAAATACTCCTGAGATGGAGCAAAGAGAAACCACCTCTTCAACA CCACGGATAAGTTCCAAAACAGGCTCCATTCCCTTGAAGACCCCTGCCAAAGATTCTGAAGGAGGATGGTTTATTGACAAAACCCCAAGT GTAAAGAAAGACAGTTTTTTCTTGGACCTGTCATGTGAGAAAAGTAATCCTAAGAAGCCAATAACTGAGATACAGGATTCAAAAGATTCT TCTCTTTTGGAGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGA GAAATTGAAGCTGTCCTGCAAAAGAAAGGCCTGGCGCTGGTGCCGAGGAAGCTCTGTGCCCACTACACTTGGGATGCCAGTGTGCTGCTC CAGGCATGGCCTGCTGTGGACCCGGAGTTCCTGCAGCAGCCTGAGGTTGTCCAGATGGCAGTTCTGATCAACAATAAAGCTTGTGGCAAA ATTCCTGTGCCCCAACAAGTTGCCCGGGACCAGGACAAAGTCCACGAATTTGTTCTTCAAAGCGAGCTGGGTGTCAGGCTTTTGCAAGGA >In-frame_NVL_ENST00000469075_chr1_224492736_-_LARS2_ENST00000265537_chr3_45583321_+_783nt ATGAAGCCCAGACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCGAGTCATCCAGTACCTTACCAGTAACAAATGTGGCAAATATGTG GACATTGGAGTCTTAGCGTCTGATTTACAAAGAGTGTACAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGATTCAGGTAGAA AAAGTATTTAGCATAATTAGTAGTGAGAAGGAACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGGCAAGACAAGGT GAAGAGGATAATGAGTATACTGAAAGCTATTCTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGGATTCAAAAGATTCTTCT CTTTTGGAGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGAGAA ATTGAAGCTGTCCTGCAAAAGAAAGGCCTGGCGCTGGTGCCGAGGAAGCTCTGTGCCCACTACACTTGGGATGCCAGTGTGCTGCTCCAG GCATGGCCTGCTGTGGACCCGGAGTTCCTGCAGCAGCCTGAGGTTGTCCAGATGGCAGTTCTGATCAACAATAAAGCTTGTGGCAAAATT CCTGTGCCCCAACAAGTTGCCCGGGACCAGGACAAAGTCCACGAATTTGTTCTTCAAAGCGAGCTGGGTGTCAGGCTTTTGCAAGGACGA >In-frame_NVL_ENST00000469075_chr1_224492736_-_LARS2_ENST00000415258_chr3_45583321_+_783nt ATGAAGCCCAGACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCGAGTCATCCAGTACCTTACCAGTAACAAATGTGGCAAATATGTG GACATTGGAGTCTTAGCGTCTGATTTACAAAGAGTGTACAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGATTCAGGTAGAA AAAGTATTTAGCATAATTAGTAGTGAGAAGGAACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGGCAAGACAAGGT GAAGAGGATAATGAGTATACTGAAAGCTATTCTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGGATTCAAAAGATTCTTCT CTTTTGGAGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGAGAA ATTGAAGCTGTCCTGCAAAAGAAAGGCCTGGCGCTGGTGCCGAGGAAGCTCTGTGCCCACTACACTTGGGATGCCAGTGTGCTGCTCCAG GCATGGCCTGCTGTGGACCCGGAGTTCCTGCAGCAGCCTGAGGTTGTCCAGATGGCAGTTCTGATCAACAATAAAGCTTGTGGCAAAATT CCTGTGCCCCAACAAGTTGCCCGGGACCAGGACAAAGTCCACGAATTTGTTCTTCAAAGCGAGCTGGGTGTCAGGCTTTTGCAAGGACGA >In-frame_NVL_ENST00000469075_chr1_224492736_-_LARS2_ENST00000414984_chr3_45583321_+_783nt ATGAAGCCCAGACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCGAGTCATCCAGTACCTTACCAGTAACAAATGTGGCAAATATGTG GACATTGGAGTCTTAGCGTCTGATTTACAAAGAGTGTACAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGATTCAGGTAGAA AAAGTATTTAGCATAATTAGTAGTGAGAAGGAACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGGCAAGACAAGGT GAAGAGGATAATGAGTATACTGAAAGCTATTCTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGGATTCAAAAGATTCTTCT CTTTTGGAGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGAGAA ATTGAAGCTGTCCTGCAAAAGAAAGGCCTGGCGCTGGTGCCGAGGAAGCTCTGTGCCCACTACACTTGGGATGCCAGTGTGCTGCTCCAG GCATGGCCTGCTGTGGACCCGGAGTTCCTGCAGCAGCCTGAGGTTGTCCAGATGGCAGTTCTGATCAACAATAAAGCTTGTGGCAAAATT CCTGTGCCCCAACAAGTTGCCCGGGACCAGGACAAAGTCCACGAATTTGTTCTTCAAAGCGAGCTGGGTGTCAGGCTTTTGCAAGGACGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NVL_ENST00000391875_chr1_224492736_-_LARS2_ENST00000265537_chr3_45583321_+_2332nt CTAGGAGCTGGCGGTCCGAGCTGTGGCTTGGAAGACCGACGCGATGAAGCCCAGACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCG AGTCATCCAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGATTCAGGTAGAAAAAGTATTTAGCATAATTAGTAGTGAGAAGG AACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGGCAAGACAAGGTGAAGAGGATAATGAGTATACTGAAAGCTATT CTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGTCAGCAAATCACATGAACAGTTCCCTGCTGTCTTTATATCGGAAAGGAA ATCCTGATTCTGTTTCAAATACTCCTGAGATGGAGCAAAGAGAAACCACCTCTTCAACACCACGGATAAGTTCCAAAACAGGCTCCATTC CCTTGAAGACCCCTGCCAAAGATTCTGAAGGAGGATGGTTTATTGACAAAACCCCAAGTGTAAAGAAAGACAGTTTTTTCTTGGACCTGT CATGTGAGAAAAGTAATCCTAAGAAGCCAATAACTGAGATACAGGATTCAAAAGATTCTTCTCTTTTGGAGAGTGATATGAAACGGAAAG GCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGAGAAATTGAAGCTGTCCTGCAAAAGAAAGGCC TGGCGCTGGTGCCGAGGAAGCTCTGTGCCCACTACACTTGGGATGCCAGTGTGCTGCTCCAGGCATGGCCTGCTGTGGACCCGGAGTTCC TGCAGCAGCCTGAGGTTGTCCAGATGGCAGTTCTGATCAACAATAAAGCTTGTGGCAAAATTCCTGTGCCCCAACAAGTTGCCCGGGACC AGGACAAAGTCCACGAATTTGTTCTTCAAAGCGAGCTGGGTGTCAGGCTTTTGCAAGGACGAAGCATCAAGAAGTCCTTCCTTTCCCCGA GAACTGCCCTCATCAACTTCCTGGTGCAAGATTGACAGCCAGGAGGCTGCAGCTACCACGAGGGCCTCTGAGGAACCTCCTTCCAGGCCT GGGATGAGGGGGCGATGTCTGCTGGCCCAGGGGAAGGGAAAAGACAAATGTCTTGACTGTTGACCTCGGTCCTGTGGCAGACTGCAGTCA ACAGTGTGCCTCTGTAGTGTGGCCTGGTGCTGGGGTGAAGGTGAGCTGGGCAAAGGAGAAATATGAGCTACTGAGGAGGGGGTTGGACAT CCTGCCCCTCACCCCCCACCCACACTGCAGGTAGAGGAGGCCATCTGATCCCATGGGAAGCCATCAGAGACACTGCTGGTGGGAGCAGGA AGGAGCAGTGCCCCTCGAGCAGCCAGGAAGCCTGCGGATCTGGGAAATGGCTCTGCCTTAGGCACTTCTCGGGAATTTGAGGCCAGCCTG AGGAACTGCAGGACTCAGGTGCAATGTGCCAGCCACTTGGAACTGCTAACTGAGCCTCCAGATGGTAGTGAATGGTCTCTTTGCCTTCAG GCTGGATGAGGAAGTCATTTAGGAAATGTTCAAATAACCAATATGTGGAAATGGACACAGGGATCTTCTGAAGTTGCTTTGAATCAAAAG GCAGGCAGTGCTGGTTCCTCTGCCTGTGTCCCCACCACTCCCCAGCTCTGTCATGCAGGCCTGTCCTCCCCAACCCCAGCTGGATGTGCC TCCCAGGCCTGCTGTGGTTCTGACACACAGGATCCCAGGCAAGGCACCACTTCCTCACATGAATGAGGAGCAGCAAGTCATAACCACTCC CTTGGGTATACAATTTGCTGTGTAGTGAAGTGGAACCAGGCTCAGGCTGCTGGTCCCAACCTCAGAGCCCCACCGCAGCCCAGTAGGGAT GCAGCACGCCCCAGAGGGCTCATGTGGGCCCCAGATGGCAATGCCACCATTGTTGATGTGACTCCAGAGCCAGTTATTAGGAAGAGCAAG CTCACCACAGAGGAGTGGAACTGAGGCCCCCCAGATGTTGCCTCCGGTGTCCAAGCCACAGCGGTCTGGCTGTTGGGAAGATGGCCAGGA ATGGACTCATACCATTGGCACATTAGGCTAATCCTGGTTTTATGTGAAGTCAGCAATTAAGTGTTCCCACTAGAACTGACCTAAGCCACT GATTAATATTTAATGAGGGAAGGTAGGGGAGAATCTAGCCATTTTATAATGCCAGAAATCTATATATGTTATCTGATGCCATTTTTCTGA >In-frame_NVL_ENST00000391875_chr1_224492736_-_LARS2_ENST00000415258_chr3_45583321_+_2916nt CTAGGAGCTGGCGGTCCGAGCTGTGGCTTGGAAGACCGACGCGATGAAGCCCAGACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCG AGTCATCCAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGATTCAGGTAGAAAAAGTATTTAGCATAATTAGTAGTGAGAAGG AACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGGCAAGACAAGGTGAAGAGGATAATGAGTATACTGAAAGCTATT CTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGTCAGCAAATCACATGAACAGTTCCCTGCTGTCTTTATATCGGAAAGGAA ATCCTGATTCTGTTTCAAATACTCCTGAGATGGAGCAAAGAGAAACCACCTCTTCAACACCACGGATAAGTTCCAAAACAGGCTCCATTC CCTTGAAGACCCCTGCCAAAGATTCTGAAGGAGGATGGTTTATTGACAAAACCCCAAGTGTAAAGAAAGACAGTTTTTTCTTGGACCTGT CATGTGAGAAAAGTAATCCTAAGAAGCCAATAACTGAGATACAGGATTCAAAAGATTCTTCTCTTTTGGAGAGTGATATGAAACGGAAAG GCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGAGAAATTGAAGCTGTCCTGCAAAAGAAAGGCC TGGCGCTGGTGCCGAGGAAGCTCTGTGCCCACTACACTTGGGATGCCAGTGTGCTGCTCCAGGCATGGCCTGCTGTGGACCCGGAGTTCC TGCAGCAGCCTGAGGTTGTCCAGATGGCAGTTCTGATCAACAATAAAGCTTGTGGCAAAATTCCTGTGCCCCAACAAGTTGCCCGGGACC AGGACAAAGTCCACGAATTTGTTCTTCAAAGCGAGCTGGGTGTCAGGCTTTTGCAAGGACGAAGCATCAAGAAGTCCTTCCTTTCCCCGA GAACTGCCCTCATCAACTTCCTGGTGCAAGATTGACAGCCAGGAGGCTGCAGCTACCACGAGGGCCTCTGAGGAACCTCCTTCCAGGCCT GGGATGAGGGGGCGATGTCTGCTGGCCCAGGGGAAGGGAAAAGACAAATGTCTTGACTGTTGACCTCGGTCCTGTGGCAGACTGCAGTCA ACAGTGTGCCTCTGTAGTGTGGCCTGGTGCTGGGGTGAAGGTGAGCTGGGCAAAGGAGAAATATGAGCTACTGAGGAGGGGGTTGGACAT CCTGCCCCTCACCCCCCACCCACACTGCAGGTAGAGGAGGCCATCTGATCCCATGGGAAGCCATCAGAGACACTGCTGGTGGGAGCAGGA AGGAGCAGTGCCCCTCGAGCAGCCAGGAAGCCTGCGGATCTGGGAAATGGCTCTGCCTTAGGCACTTCTCGGGAATTTGAGGCCAGCCTG AGGAACTGCAGGACTCAGGTGCAATGTGCCAGCCACTTGGAACTGCTAACTGAGCCTCCAGATGGTAGTGAATGGTCTCTTTGCCTTCAG GCTGGATGAGGAAGTCATTTAGGAAATGTTCAAATAACCAATATGTGGAAATGGACACAGGGATCTTCTGAAGTTGCTTTGAATCAAAAG GCAGGCAGTGCTGGTTCCTCTGCCTGTGTCCCCACCACTCCCCAGCTCTGTCATGCAGGCCTGTCCTCCCCAACCCCAGCTGGATGTGCC TCCCAGGCCTGCTGTGGTTCTGACACACAGGATCCCAGGCAAGGCACCACTTCCTCACATGAATGAGGAGCAGCAAGTCATAACCACTCC CTTGGGTATACAATTTGCTGTGTAGTGAAGTGGAACCAGGCTCAGGCTGCTGGTCCCAACCTCAGAGCCCCACCGCAGCCCAGTAGGGAT GCAGCACGCCCCAGAGGGCTCATGTGGGCCCCAGATGGCAATGCCACCATTGTTGATGTGACTCCAGAGCCAGTTATTAGGAAGAGCAAG CTCACCACAGAGGAGTGGAACTGAGGCCCCCCAGATGTTGCCTCCGGTGTCCAAGCCACAGCGGTCTGGCTGTTGGGAAGATGGCCAGGA ATGGACTCATACCATTGGCACATTAGGCTAATCCTGGTTTTATGTGAAGTCAGCAATTAAGTGTTCCCACTAGAACTGACCTAAGCCACT GATTAATATTTAATGAGGGAAGGTAGGGGAGAATCTAGCCATTTTATAATGCCAGAAATCTATATATGTTATCTGATGCCATTTTTCTGA AGTAGCCTCACATGTGGTCCCCCTGCAGTTCAGCAGTTAACAGATGACTTTTTTAGTGTAATAAAATGTTTATCATCTATGACTTCAGGA CATATGTGTGATCCTGGAATACACCATATTCCAATTTCAGAGTTAATTACAAACAGATTGAGGTATTCCATCATCATCGGAAGCATTGGC TGTGTGTCTGACTCCACATGGAATGCTATAAAGTGGGATACATGTGGTTCTTCTTGTTCCAGAACTTACAGTCCATGGTAGACAACACTG ATACAGGCAAACTAGCAACAGCAATTAAGTCACTGGTTCTCAGACTTAATACTCTGCCTGGTCCTCATGCCCAGATATTCCAATTTAATT GGTCCATGGTGTGGCTTGAACACCAGGAATCTTTAAAACTCCACAAGTGATTCTAATGGGCAGCAAAGTTTGAGAATCACTGGACACATT GATGCACTTGAGCCATCATTTCTATCTAGTTCTTCCTCTTCCTAATCTTCAGGTTAGCGGGGATAAGTTTGGTCCAGGACCAAGAGTTGG ACCAAAAGGGAAGACAGGGGCCAGAAGTCTAGAGTGCTAGAGCCGACTTGAATGTACTCAGTCTCATTGCACATGGCAGTGAATATGGAT >In-frame_NVL_ENST00000391875_chr1_224492736_-_LARS2_ENST00000414984_chr3_45583321_+_1104nt CTAGGAGCTGGCGGTCCGAGCTGTGGCTTGGAAGACCGACGCGATGAAGCCCAGACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCG AGTCATCCAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGATTCAGGTAGAAAAAGTATTTAGCATAATTAGTAGTGAGAAGG AACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGGCAAGACAAGGTGAAGAGGATAATGAGTATACTGAAAGCTATT CTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGTCAGCAAATCACATGAACAGTTCCCTGCTGTCTTTATATCGGAAAGGAA ATCCTGATTCTGTTTCAAATACTCCTGAGATGGAGCAAAGAGAAACCACCTCTTCAACACCACGGATAAGTTCCAAAACAGGCTCCATTC CCTTGAAGACCCCTGCCAAAGATTCTGAAGGAGGATGGTTTATTGACAAAACCCCAAGTGTAAAGAAAGACAGTTTTTTCTTGGACCTGT CATGTGAGAAAAGTAATCCTAAGAAGCCAATAACTGAGATACAGGATTCAAAAGATTCTTCTCTTTTGGAGAGTGATATGAAACGGAAAG GCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGAGAAATTGAAGCTGTCCTGCAAAAGAAAGGCC TGGCGCTGGTGCCGAGGAAGCTCTGTGCCCACTACACTTGGGATGCCAGTGTGCTGCTCCAGGCATGGCCTGCTGTGGACCCGGAGTTCC TGCAGCAGCCTGAGGTTGTCCAGATGGCAGTTCTGATCAACAATAAAGCTTGTGGCAAAATTCCTGTGCCCCAACAAGTTGCCCGGGACC AGGACAAAGTCCACGAATTTGTTCTTCAAAGCGAGCTGGGTGTCAGGCTTTTGCAAGGACGAAGCATCAAGAAGTCCTTCCTTTCCCCGA GAACTGCCCTCATCAACTTCCTGGTGCAAGATTGACAGCCAGGAGGCTGCAGCTACCACGAGGGCCTCTGAGGAACCTCCTTCCAGGCCT >In-frame_NVL_ENST00000281701_chr1_224492736_-_LARS2_ENST00000265537_chr3_45583321_+_2623nt AATCTTCCAGGGTCCACTGGGCAGGCCTGCAAAATAAGGCCCCTAGAAACTCCCTGAGGTTTTCAAGTCTTCTCCCTCTCCTCGGAATTT TTTCCCCTTCATTCGCATTACTTTTATTCTGACGGAAACGGCGCGGGCTAGGCCCCAGGAGGGGCGCATTTCAGGTGCAACTGGCCCGGC GATCGCGGCGGGCAACCCCTACGAGGCCCCCGGTTGACTAGGAGCTGGCGGTCCGAGCTGTGGCTTGGAAGACCGACGCGATGAAGCCCA GACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCGAGTCATCCAGTACCTTACCAGTAACAAATGTGGCAAATATGTGGACATTGGAG TCTTAGCGTCTGATTTACAAAGAGTGTACAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGATTCAGGTAGAAAAAGTATTTA GCATAATTAGTAGTGAGAAGGAACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGGCAAGACAAGGTGAAGAGGATA ATGAGTATACTGAAAGCTATTCTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGTCAGCAAATCACATGAACAGTTCCCTGC TGTCTTTATATCGGAAAGGAAATCCTGATTCTGTTTCAAATACTCCTGAGATGGAGCAAAGAGAAACCACCTCTTCAACACCACGGATAA GTTCCAAAACAGGCTCCATTCCCTTGAAGACCCCTGCCAAAGATTCTGAAGGAGGATGGTTTATTGACAAAACCCCAAGTGTAAAGAAAG ACAGTTTTTTCTTGGACCTGTCATGTGAGAAAAGTAATCCTAAGAAGCCAATAACTGAGATACAGGATTCAAAAGATTCTTCTCTTTTGG AGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGAGAAATTGAAG CTGTCCTGCAAAAGAAAGGCCTGGCGCTGGTGCCGAGGAAGCTCTGTGCCCACTACACTTGGGATGCCAGTGTGCTGCTCCAGGCATGGC CTGCTGTGGACCCGGAGTTCCTGCAGCAGCCTGAGGTTGTCCAGATGGCAGTTCTGATCAACAATAAAGCTTGTGGCAAAATTCCTGTGC CCCAACAAGTTGCCCGGGACCAGGACAAAGTCCACGAATTTGTTCTTCAAAGCGAGCTGGGTGTCAGGCTTTTGCAAGGACGAAGCATCA AGAAGTCCTTCCTTTCCCCGAGAACTGCCCTCATCAACTTCCTGGTGCAAGATTGACAGCCAGGAGGCTGCAGCTACCACGAGGGCCTCT GAGGAACCTCCTTCCAGGCCTGGGATGAGGGGGCGATGTCTGCTGGCCCAGGGGAAGGGAAAAGACAAATGTCTTGACTGTTGACCTCGG TCCTGTGGCAGACTGCAGTCAACAGTGTGCCTCTGTAGTGTGGCCTGGTGCTGGGGTGAAGGTGAGCTGGGCAAAGGAGAAATATGAGCT ACTGAGGAGGGGGTTGGACATCCTGCCCCTCACCCCCCACCCACACTGCAGGTAGAGGAGGCCATCTGATCCCATGGGAAGCCATCAGAG ACACTGCTGGTGGGAGCAGGAAGGAGCAGTGCCCCTCGAGCAGCCAGGAAGCCTGCGGATCTGGGAAATGGCTCTGCCTTAGGCACTTCT CGGGAATTTGAGGCCAGCCTGAGGAACTGCAGGACTCAGGTGCAATGTGCCAGCCACTTGGAACTGCTAACTGAGCCTCCAGATGGTAGT GAATGGTCTCTTTGCCTTCAGGCTGGATGAGGAAGTCATTTAGGAAATGTTCAAATAACCAATATGTGGAAATGGACACAGGGATCTTCT GAAGTTGCTTTGAATCAAAAGGCAGGCAGTGCTGGTTCCTCTGCCTGTGTCCCCACCACTCCCCAGCTCTGTCATGCAGGCCTGTCCTCC CCAACCCCAGCTGGATGTGCCTCCCAGGCCTGCTGTGGTTCTGACACACAGGATCCCAGGCAAGGCACCACTTCCTCACATGAATGAGGA GCAGCAAGTCATAACCACTCCCTTGGGTATACAATTTGCTGTGTAGTGAAGTGGAACCAGGCTCAGGCTGCTGGTCCCAACCTCAGAGCC CCACCGCAGCCCAGTAGGGATGCAGCACGCCCCAGAGGGCTCATGTGGGCCCCAGATGGCAATGCCACCATTGTTGATGTGACTCCAGAG CCAGTTATTAGGAAGAGCAAGCTCACCACAGAGGAGTGGAACTGAGGCCCCCCAGATGTTGCCTCCGGTGTCCAAGCCACAGCGGTCTGG CTGTTGGGAAGATGGCCAGGAATGGACTCATACCATTGGCACATTAGGCTAATCCTGGTTTTATGTGAAGTCAGCAATTAAGTGTTCCCA CTAGAACTGACCTAAGCCACTGATTAATATTTAATGAGGGAAGGTAGGGGAGAATCTAGCCATTTTATAATGCCAGAAATCTATATATGT TATCTGATGCCATTTTTCTGAAGTAGCCTCACATGTGGTCCCCCTGCAGTTCAGCAGTTAACAGATGACTTTTTTAGTGTAATAAAATGT >In-frame_NVL_ENST00000281701_chr1_224492736_-_LARS2_ENST00000415258_chr3_45583321_+_3207nt AATCTTCCAGGGTCCACTGGGCAGGCCTGCAAAATAAGGCCCCTAGAAACTCCCTGAGGTTTTCAAGTCTTCTCCCTCTCCTCGGAATTT TTTCCCCTTCATTCGCATTACTTTTATTCTGACGGAAACGGCGCGGGCTAGGCCCCAGGAGGGGCGCATTTCAGGTGCAACTGGCCCGGC GATCGCGGCGGGCAACCCCTACGAGGCCCCCGGTTGACTAGGAGCTGGCGGTCCGAGCTGTGGCTTGGAAGACCGACGCGATGAAGCCCA GACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCGAGTCATCCAGTACCTTACCAGTAACAAATGTGGCAAATATGTGGACATTGGAG TCTTAGCGTCTGATTTACAAAGAGTGTACAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGATTCAGGTAGAAAAAGTATTTA GCATAATTAGTAGTGAGAAGGAACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGGCAAGACAAGGTGAAGAGGATA ATGAGTATACTGAAAGCTATTCTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGTCAGCAAATCACATGAACAGTTCCCTGC TGTCTTTATATCGGAAAGGAAATCCTGATTCTGTTTCAAATACTCCTGAGATGGAGCAAAGAGAAACCACCTCTTCAACACCACGGATAA GTTCCAAAACAGGCTCCATTCCCTTGAAGACCCCTGCCAAAGATTCTGAAGGAGGATGGTTTATTGACAAAACCCCAAGTGTAAAGAAAG ACAGTTTTTTCTTGGACCTGTCATGTGAGAAAAGTAATCCTAAGAAGCCAATAACTGAGATACAGGATTCAAAAGATTCTTCTCTTTTGG AGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGAGAAATTGAAG CTGTCCTGCAAAAGAAAGGCCTGGCGCTGGTGCCGAGGAAGCTCTGTGCCCACTACACTTGGGATGCCAGTGTGCTGCTCCAGGCATGGC CTGCTGTGGACCCGGAGTTCCTGCAGCAGCCTGAGGTTGTCCAGATGGCAGTTCTGATCAACAATAAAGCTTGTGGCAAAATTCCTGTGC CCCAACAAGTTGCCCGGGACCAGGACAAAGTCCACGAATTTGTTCTTCAAAGCGAGCTGGGTGTCAGGCTTTTGCAAGGACGAAGCATCA AGAAGTCCTTCCTTTCCCCGAGAACTGCCCTCATCAACTTCCTGGTGCAAGATTGACAGCCAGGAGGCTGCAGCTACCACGAGGGCCTCT GAGGAACCTCCTTCCAGGCCTGGGATGAGGGGGCGATGTCTGCTGGCCCAGGGGAAGGGAAAAGACAAATGTCTTGACTGTTGACCTCGG TCCTGTGGCAGACTGCAGTCAACAGTGTGCCTCTGTAGTGTGGCCTGGTGCTGGGGTGAAGGTGAGCTGGGCAAAGGAGAAATATGAGCT ACTGAGGAGGGGGTTGGACATCCTGCCCCTCACCCCCCACCCACACTGCAGGTAGAGGAGGCCATCTGATCCCATGGGAAGCCATCAGAG ACACTGCTGGTGGGAGCAGGAAGGAGCAGTGCCCCTCGAGCAGCCAGGAAGCCTGCGGATCTGGGAAATGGCTCTGCCTTAGGCACTTCT CGGGAATTTGAGGCCAGCCTGAGGAACTGCAGGACTCAGGTGCAATGTGCCAGCCACTTGGAACTGCTAACTGAGCCTCCAGATGGTAGT GAATGGTCTCTTTGCCTTCAGGCTGGATGAGGAAGTCATTTAGGAAATGTTCAAATAACCAATATGTGGAAATGGACACAGGGATCTTCT GAAGTTGCTTTGAATCAAAAGGCAGGCAGTGCTGGTTCCTCTGCCTGTGTCCCCACCACTCCCCAGCTCTGTCATGCAGGCCTGTCCTCC CCAACCCCAGCTGGATGTGCCTCCCAGGCCTGCTGTGGTTCTGACACACAGGATCCCAGGCAAGGCACCACTTCCTCACATGAATGAGGA GCAGCAAGTCATAACCACTCCCTTGGGTATACAATTTGCTGTGTAGTGAAGTGGAACCAGGCTCAGGCTGCTGGTCCCAACCTCAGAGCC CCACCGCAGCCCAGTAGGGATGCAGCACGCCCCAGAGGGCTCATGTGGGCCCCAGATGGCAATGCCACCATTGTTGATGTGACTCCAGAG CCAGTTATTAGGAAGAGCAAGCTCACCACAGAGGAGTGGAACTGAGGCCCCCCAGATGTTGCCTCCGGTGTCCAAGCCACAGCGGTCTGG CTGTTGGGAAGATGGCCAGGAATGGACTCATACCATTGGCACATTAGGCTAATCCTGGTTTTATGTGAAGTCAGCAATTAAGTGTTCCCA CTAGAACTGACCTAAGCCACTGATTAATATTTAATGAGGGAAGGTAGGGGAGAATCTAGCCATTTTATAATGCCAGAAATCTATATATGT TATCTGATGCCATTTTTCTGAAGTAGCCTCACATGTGGTCCCCCTGCAGTTCAGCAGTTAACAGATGACTTTTTTAGTGTAATAAAATGT TTATCATCTATGACTTCAGGACATATGTGTGATCCTGGAATACACCATATTCCAATTTCAGAGTTAATTACAAACAGATTGAGGTATTCC ATCATCATCGGAAGCATTGGCTGTGTGTCTGACTCCACATGGAATGCTATAAAGTGGGATACATGTGGTTCTTCTTGTTCCAGAACTTAC AGTCCATGGTAGACAACACTGATACAGGCAAACTAGCAACAGCAATTAAGTCACTGGTTCTCAGACTTAATACTCTGCCTGGTCCTCATG CCCAGATATTCCAATTTAATTGGTCCATGGTGTGGCTTGAACACCAGGAATCTTTAAAACTCCACAAGTGATTCTAATGGGCAGCAAAGT TTGAGAATCACTGGACACATTGATGCACTTGAGCCATCATTTCTATCTAGTTCTTCCTCTTCCTAATCTTCAGGTTAGCGGGGATAAGTT TGGTCCAGGACCAAGAGTTGGACCAAAAGGGAAGACAGGGGCCAGAAGTCTAGAGTGCTAGAGCCGACTTGAATGTACTCAGTCTCATTG >In-frame_NVL_ENST00000281701_chr1_224492736_-_LARS2_ENST00000414984_chr3_45583321_+_1395nt AATCTTCCAGGGTCCACTGGGCAGGCCTGCAAAATAAGGCCCCTAGAAACTCCCTGAGGTTTTCAAGTCTTCTCCCTCTCCTCGGAATTT TTTCCCCTTCATTCGCATTACTTTTATTCTGACGGAAACGGCGCGGGCTAGGCCCCAGGAGGGGCGCATTTCAGGTGCAACTGGCCCGGC GATCGCGGCGGGCAACCCCTACGAGGCCCCCGGTTGACTAGGAGCTGGCGGTCCGAGCTGTGGCTTGGAAGACCGACGCGATGAAGCCCA GACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCGAGTCATCCAGTACCTTACCAGTAACAAATGTGGCAAATATGTGGACATTGGAG TCTTAGCGTCTGATTTACAAAGAGTGTACAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGATTCAGGTAGAAAAAGTATTTA GCATAATTAGTAGTGAGAAGGAACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGGCAAGACAAGGTGAAGAGGATA ATGAGTATACTGAAAGCTATTCTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGTCAGCAAATCACATGAACAGTTCCCTGC TGTCTTTATATCGGAAAGGAAATCCTGATTCTGTTTCAAATACTCCTGAGATGGAGCAAAGAGAAACCACCTCTTCAACACCACGGATAA GTTCCAAAACAGGCTCCATTCCCTTGAAGACCCCTGCCAAAGATTCTGAAGGAGGATGGTTTATTGACAAAACCCCAAGTGTAAAGAAAG ACAGTTTTTTCTTGGACCTGTCATGTGAGAAAAGTAATCCTAAGAAGCCAATAACTGAGATACAGGATTCAAAAGATTCTTCTCTTTTGG AGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAGTAGATGGAGAAATTGAAG CTGTCCTGCAAAAGAAAGGCCTGGCGCTGGTGCCGAGGAAGCTCTGTGCCCACTACACTTGGGATGCCAGTGTGCTGCTCCAGGCATGGC CTGCTGTGGACCCGGAGTTCCTGCAGCAGCCTGAGGTTGTCCAGATGGCAGTTCTGATCAACAATAAAGCTTGTGGCAAAATTCCTGTGC CCCAACAAGTTGCCCGGGACCAGGACAAAGTCCACGAATTTGTTCTTCAAAGCGAGCTGGGTGTCAGGCTTTTGCAAGGACGAAGCATCA AGAAGTCCTTCCTTTCCCCGAGAACTGCCCTCATCAACTTCCTGGTGCAAGATTGACAGCCAGGAGGCTGCAGCTACCACGAGGGCCTCT >In-frame_NVL_ENST00000469075_chr1_224492736_-_LARS2_ENST00000265537_chr3_45583321_+_2101nt AGACCGACGCGATGAAGCCCAGACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCGAGTCATCCAGTACCTTACCAGTAACAAATGTG GCAAATATGTGGACATTGGAGTCTTAGCGTCTGATTTACAAAGAGTGTACAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGA TTCAGGTAGAAAAAGTATTTAGCATAATTAGTAGTGAGAAGGAACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGG CAAGACAAGGTGAAGAGGATAATGAGTATACTGAAAGCTATTCTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGGATTCAA AAGATTCTTCTCTTTTGGAGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAG TAGATGGAGAAATTGAAGCTGTCCTGCAAAAGAAAGGCCTGGCGCTGGTGCCGAGGAAGCTCTGTGCCCACTACACTTGGGATGCCAGTG TGCTGCTCCAGGCATGGCCTGCTGTGGACCCGGAGTTCCTGCAGCAGCCTGAGGTTGTCCAGATGGCAGTTCTGATCAACAATAAAGCTT GTGGCAAAATTCCTGTGCCCCAACAAGTTGCCCGGGACCAGGACAAAGTCCACGAATTTGTTCTTCAAAGCGAGCTGGGTGTCAGGCTTT TGCAAGGACGAAGCATCAAGAAGTCCTTCCTTTCCCCGAGAACTGCCCTCATCAACTTCCTGGTGCAAGATTGACAGCCAGGAGGCTGCA GCTACCACGAGGGCCTCTGAGGAACCTCCTTCCAGGCCTGGGATGAGGGGGCGATGTCTGCTGGCCCAGGGGAAGGGAAAAGACAAATGT CTTGACTGTTGACCTCGGTCCTGTGGCAGACTGCAGTCAACAGTGTGCCTCTGTAGTGTGGCCTGGTGCTGGGGTGAAGGTGAGCTGGGC AAAGGAGAAATATGAGCTACTGAGGAGGGGGTTGGACATCCTGCCCCTCACCCCCCACCCACACTGCAGGTAGAGGAGGCCATCTGATCC CATGGGAAGCCATCAGAGACACTGCTGGTGGGAGCAGGAAGGAGCAGTGCCCCTCGAGCAGCCAGGAAGCCTGCGGATCTGGGAAATGGC TCTGCCTTAGGCACTTCTCGGGAATTTGAGGCCAGCCTGAGGAACTGCAGGACTCAGGTGCAATGTGCCAGCCACTTGGAACTGCTAACT GAGCCTCCAGATGGTAGTGAATGGTCTCTTTGCCTTCAGGCTGGATGAGGAAGTCATTTAGGAAATGTTCAAATAACCAATATGTGGAAA TGGACACAGGGATCTTCTGAAGTTGCTTTGAATCAAAAGGCAGGCAGTGCTGGTTCCTCTGCCTGTGTCCCCACCACTCCCCAGCTCTGT CATGCAGGCCTGTCCTCCCCAACCCCAGCTGGATGTGCCTCCCAGGCCTGCTGTGGTTCTGACACACAGGATCCCAGGCAAGGCACCACT TCCTCACATGAATGAGGAGCAGCAAGTCATAACCACTCCCTTGGGTATACAATTTGCTGTGTAGTGAAGTGGAACCAGGCTCAGGCTGCT GGTCCCAACCTCAGAGCCCCACCGCAGCCCAGTAGGGATGCAGCACGCCCCAGAGGGCTCATGTGGGCCCCAGATGGCAATGCCACCATT GTTGATGTGACTCCAGAGCCAGTTATTAGGAAGAGCAAGCTCACCACAGAGGAGTGGAACTGAGGCCCCCCAGATGTTGCCTCCGGTGTC CAAGCCACAGCGGTCTGGCTGTTGGGAAGATGGCCAGGAATGGACTCATACCATTGGCACATTAGGCTAATCCTGGTTTTATGTGAAGTC AGCAATTAAGTGTTCCCACTAGAACTGACCTAAGCCACTGATTAATATTTAATGAGGGAAGGTAGGGGAGAATCTAGCCATTTTATAATG CCAGAAATCTATATATGTTATCTGATGCCATTTTTCTGAAGTAGCCTCACATGTGGTCCCCCTGCAGTTCAGCAGTTAACAGATGACTTT >In-frame_NVL_ENST00000469075_chr1_224492736_-_LARS2_ENST00000415258_chr3_45583321_+_2685nt AGACCGACGCGATGAAGCCCAGACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCGAGTCATCCAGTACCTTACCAGTAACAAATGTG GCAAATATGTGGACATTGGAGTCTTAGCGTCTGATTTACAAAGAGTGTACAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGA TTCAGGTAGAAAAAGTATTTAGCATAATTAGTAGTGAGAAGGAACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGG CAAGACAAGGTGAAGAGGATAATGAGTATACTGAAAGCTATTCTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGGATTCAA AAGATTCTTCTCTTTTGGAGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAG TAGATGGAGAAATTGAAGCTGTCCTGCAAAAGAAAGGCCTGGCGCTGGTGCCGAGGAAGCTCTGTGCCCACTACACTTGGGATGCCAGTG TGCTGCTCCAGGCATGGCCTGCTGTGGACCCGGAGTTCCTGCAGCAGCCTGAGGTTGTCCAGATGGCAGTTCTGATCAACAATAAAGCTT GTGGCAAAATTCCTGTGCCCCAACAAGTTGCCCGGGACCAGGACAAAGTCCACGAATTTGTTCTTCAAAGCGAGCTGGGTGTCAGGCTTT TGCAAGGACGAAGCATCAAGAAGTCCTTCCTTTCCCCGAGAACTGCCCTCATCAACTTCCTGGTGCAAGATTGACAGCCAGGAGGCTGCA GCTACCACGAGGGCCTCTGAGGAACCTCCTTCCAGGCCTGGGATGAGGGGGCGATGTCTGCTGGCCCAGGGGAAGGGAAAAGACAAATGT CTTGACTGTTGACCTCGGTCCTGTGGCAGACTGCAGTCAACAGTGTGCCTCTGTAGTGTGGCCTGGTGCTGGGGTGAAGGTGAGCTGGGC AAAGGAGAAATATGAGCTACTGAGGAGGGGGTTGGACATCCTGCCCCTCACCCCCCACCCACACTGCAGGTAGAGGAGGCCATCTGATCC CATGGGAAGCCATCAGAGACACTGCTGGTGGGAGCAGGAAGGAGCAGTGCCCCTCGAGCAGCCAGGAAGCCTGCGGATCTGGGAAATGGC TCTGCCTTAGGCACTTCTCGGGAATTTGAGGCCAGCCTGAGGAACTGCAGGACTCAGGTGCAATGTGCCAGCCACTTGGAACTGCTAACT GAGCCTCCAGATGGTAGTGAATGGTCTCTTTGCCTTCAGGCTGGATGAGGAAGTCATTTAGGAAATGTTCAAATAACCAATATGTGGAAA TGGACACAGGGATCTTCTGAAGTTGCTTTGAATCAAAAGGCAGGCAGTGCTGGTTCCTCTGCCTGTGTCCCCACCACTCCCCAGCTCTGT CATGCAGGCCTGTCCTCCCCAACCCCAGCTGGATGTGCCTCCCAGGCCTGCTGTGGTTCTGACACACAGGATCCCAGGCAAGGCACCACT TCCTCACATGAATGAGGAGCAGCAAGTCATAACCACTCCCTTGGGTATACAATTTGCTGTGTAGTGAAGTGGAACCAGGCTCAGGCTGCT GGTCCCAACCTCAGAGCCCCACCGCAGCCCAGTAGGGATGCAGCACGCCCCAGAGGGCTCATGTGGGCCCCAGATGGCAATGCCACCATT GTTGATGTGACTCCAGAGCCAGTTATTAGGAAGAGCAAGCTCACCACAGAGGAGTGGAACTGAGGCCCCCCAGATGTTGCCTCCGGTGTC CAAGCCACAGCGGTCTGGCTGTTGGGAAGATGGCCAGGAATGGACTCATACCATTGGCACATTAGGCTAATCCTGGTTTTATGTGAAGTC AGCAATTAAGTGTTCCCACTAGAACTGACCTAAGCCACTGATTAATATTTAATGAGGGAAGGTAGGGGAGAATCTAGCCATTTTATAATG CCAGAAATCTATATATGTTATCTGATGCCATTTTTCTGAAGTAGCCTCACATGTGGTCCCCCTGCAGTTCAGCAGTTAACAGATGACTTT TTTAGTGTAATAAAATGTTTATCATCTATGACTTCAGGACATATGTGTGATCCTGGAATACACCATATTCCAATTTCAGAGTTAATTACA AACAGATTGAGGTATTCCATCATCATCGGAAGCATTGGCTGTGTGTCTGACTCCACATGGAATGCTATAAAGTGGGATACATGTGGTTCT TCTTGTTCCAGAACTTACAGTCCATGGTAGACAACACTGATACAGGCAAACTAGCAACAGCAATTAAGTCACTGGTTCTCAGACTTAATA CTCTGCCTGGTCCTCATGCCCAGATATTCCAATTTAATTGGTCCATGGTGTGGCTTGAACACCAGGAATCTTTAAAACTCCACAAGTGAT TCTAATGGGCAGCAAAGTTTGAGAATCACTGGACACATTGATGCACTTGAGCCATCATTTCTATCTAGTTCTTCCTCTTCCTAATCTTCA GGTTAGCGGGGATAAGTTTGGTCCAGGACCAAGAGTTGGACCAAAAGGGAAGACAGGGGCCAGAAGTCTAGAGTGCTAGAGCCGACTTGA >In-frame_NVL_ENST00000469075_chr1_224492736_-_LARS2_ENST00000414984_chr3_45583321_+_873nt AGACCGACGCGATGAAGCCCAGACCTGCAGGGTTCGTGGATAATAAACTCAAGCAGCGAGTCATCCAGTACCTTACCAGTAACAAATGTG GCAAATATGTGGACATTGGAGTCTTAGCGTCTGATTTACAAAGAGTGTACAGTATAGACTATGGTCGAAGAAAAAGAAATGCTTTTAGGA TTCAGGTAGAAAAAGTATTTAGCATAATTAGTAGTGAGAAGGAACTTAAGAATTTAACAGAATTAGAAGATGAACATTTGGCAAAAAGGG CAAGACAAGGTGAAGAGGATAATGAGTATACTGAAAGCTATTCTGATGATGATTCAAGTATGGAAGACTACCCAGATCCACAGGATTCAA AAGATTCTTCTCTTTTGGAGAGTGATATGAAACGGAAAGGCAAGCTAAAGAATAAAGGAAGCAAAAGGAAGAAAGAAGATCTTCAGGAAG TAGATGGAGAAATTGAAGCTGTCCTGCAAAAGAAAGGCCTGGCGCTGGTGCCGAGGAAGCTCTGTGCCCACTACACTTGGGATGCCAGTG TGCTGCTCCAGGCATGGCCTGCTGTGGACCCGGAGTTCCTGCAGCAGCCTGAGGTTGTCCAGATGGCAGTTCTGATCAACAATAAAGCTT GTGGCAAAATTCCTGTGCCCCAACAAGTTGCCCGGGACCAGGACAAAGTCCACGAATTTGTTCTTCAAAGCGAGCTGGGTGTCAGGCTTT TGCAAGGACGAAGCATCAAGAAGTCCTTCCTTTCCCCGAGAACTGCCCTCATCAACTTCCTGGTGCAAGATTGACAGCCAGGAGGCTGCA |
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FusionGenePPI for NVL_LARS2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NVL | TTF2, CRMP1, OSGEP, SIRT7, CUL3, MOV10, RPL14, NPM1, PRR11, ILF2, HSPB1, IFI16, CEP164, CEP19, UBE2I, RHOA, CLCN2, HNRNPU, RPL10, UBA1, KIF21A, GPATCH4, RRP8, PES1, MAK16, ZNF512, PLEKHO1, FGF8, MECP2, RBM34, DGCR8, ZNF71, RBM4, PPAN | LARS2 | YWHAQ, BSG, TGOLN2, FBXW11, NTRK1, RHOU, DUSP22, NIT1, NDUFS7, YBEY, ACSM5, BPNT1, MRPL21, C1orf85, ATP5D, SUCLG1, BCKDHB, ACAA2, LIG3, SDHB |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | NVL | chr1:224492736 | chr3:45583321 | ENST00000281701 | - | 7 | 23 | 1_220 | 249 | 857 | RPL5 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | NVL | chr1:224492736 | chr3:45583321 | ENST00000340871 | - | 4 | 21 | 1_220 | 33 | 668 | RPL5 |
| Hgene | NVL | chr1:224492736 | chr3:45583321 | ENST00000391875 | - | 6 | 22 | 1_220 | 143 | 751 | RPL5 |
| Hgene | NVL | chr1:224492736 | chr3:45583321 | ENST00000469075 | - | 6 | 22 | 1_220 | 158 | 766 | RPL5 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NVL_LARS2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NVL_LARS2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | LARS2 | C3809105 | PERRAULT SYNDROME 4 | 2 | UNIPROT |
| Tgene | LARS2 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | LARS2 | C0036341 | Schizophrenia | 1 | PSYGENET |
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