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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25268

FusionGeneSummary for NUP98_TMEM117

check button Fusion gene summary
Fusion gene informationFusion gene name: NUP98_TMEM117
Fusion gene ID: 25268
HgeneTgene
Gene symbol

NUP98

TMEM117

Gene ID

4928

84216

Gene namenucleoporin 98transmembrane protein 117
SynonymsADIR2|NUP196|NUP96-
Cytomap

11p15.4

12q12

Type of geneprotein-codingprotein-coding
Descriptionnuclear pore complex protein Nup98-Nup96nuclear pore complex protein Nup98GLFG-repeat containing nucleoporinNUP98/PHF23 fusion 2 proteinNup98-Nup96nucleoporin 98kDnucleoporin 98kDatransmembrane protein 117
Modification date2018052320180329
UniProtAcc

P52948

Q9H0C3

Ensembl transtripts involved in fusion geneENST00000324932, ENST00000359171, 
ENST00000355260, ENST00000397004, 
ENST00000397007, ENST00000488828, 
ENST00000551577, ENST00000266534, 
ENST00000536799, ENST00000546978, 
Fusion gene scores* DoF score16 X 12 X 7=13446 X 5 X 3=90
# samples 216
** MAII scorelog2(21/1344*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUP98 [Title/Abstract] AND TMEM117 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A8-A06U-01ANUP98chr11

3774546

-TMEM117chr12

44770378

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000324932ENST00000551577NUP98chr11

3774546

-TMEM117chr12

44770378

+
5CDS-intronENST00000324932ENST00000266534NUP98chr11

3774546

-TMEM117chr12

44770378

+
5CDS-intronENST00000324932ENST00000536799NUP98chr11

3774546

-TMEM117chr12

44770378

+
5CDS-3UTRENST00000324932ENST00000546978NUP98chr11

3774546

-TMEM117chr12

44770378

+
5CDS-intronENST00000359171ENST00000551577NUP98chr11

3774546

-TMEM117chr12

44770378

+
5CDS-intronENST00000359171ENST00000266534NUP98chr11

3774546

-TMEM117chr12

44770378

+
5CDS-intronENST00000359171ENST00000536799NUP98chr11

3774546

-TMEM117chr12

44770378

+
5CDS-3UTRENST00000359171ENST00000546978NUP98chr11

3774546

-TMEM117chr12

44770378

+
5CDS-intronENST00000355260ENST00000551577NUP98chr11

3774546

-TMEM117chr12

44770378

+
5CDS-intronENST00000355260ENST00000266534NUP98chr11

3774546

-TMEM117chr12

44770378

+
5CDS-intronENST00000355260ENST00000536799NUP98chr11

3774546

-TMEM117chr12

44770378

+
5CDS-3UTRENST00000355260ENST00000546978NUP98chr11

3774546

-TMEM117chr12

44770378

+
5CDS-intronENST00000397004ENST00000551577NUP98chr11

3774546

-TMEM117chr12

44770378

+
5CDS-intronENST00000397004ENST00000266534NUP98chr11

3774546

-TMEM117chr12

44770378

+
5CDS-intronENST00000397004ENST00000536799NUP98chr11

3774546

-TMEM117chr12

44770378

+
5CDS-3UTRENST00000397004ENST00000546978NUP98chr11

3774546

-TMEM117chr12

44770378

+
5CDS-intronENST00000397007ENST00000551577NUP98chr11

3774546

-TMEM117chr12

44770378

+
5CDS-intronENST00000397007ENST00000266534NUP98chr11

3774546

-TMEM117chr12

44770378

+
5CDS-intronENST00000397007ENST00000536799NUP98chr11

3774546

-TMEM117chr12

44770378

+
5CDS-3UTRENST00000397007ENST00000546978NUP98chr11

3774546

-TMEM117chr12

44770378

+
intron-intronENST00000488828ENST00000551577NUP98chr11

3774546

-TMEM117chr12

44770378

+
intron-intronENST00000488828ENST00000266534NUP98chr11

3774546

-TMEM117chr12

44770378

+
intron-intronENST00000488828ENST00000536799NUP98chr11

3774546

-TMEM117chr12

44770378

+
intron-3UTRENST00000488828ENST00000546978NUP98chr11

3774546

-TMEM117chr12

44770378

+

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FusionProtFeatures for NUP98_TMEM117


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUP98

P52948

TMEM117

Q9H0C3

Involved in endoplasmic reticulum (ER) stress-inducedcell death pathway. {ECO:0000269|PubMed:28285135}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NUP98_TMEM117


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NUP98_TMEM117


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NUP98MOB1A, PARP11, QRICH2, TPR, NUP88, CREBBP, EP300, NUP133, KPNB1, RAE1, TNPO2, NXF1, TNPO1, USP7, NPM1, PTTG1, APC, HDAC1, SIRT7, NUP107, CTNNB1, RAPGEF3, NUMA1, ECT2, CSNK2A1, HNRNPUL1, LMNA, HDAC8, HDAC11, FBXO6, ARFGEF2, CDC73, PAF1, CDC37, CUL7, OBSL1, EED, MAPK8, COMTD1, SEC13, PNKD, NUP43, CLEC11A, RNF166, UNK, NUP54, NUP85, SEH1L, XPO5, KRAS, IFI16, NUP160, NUP35, B9D2, UBE2I, NUPL1, NUP153, PIM2, NUDT21, NCBP2, CHMP4B, GTF2H5, FOXI2, FOXL1, FOXQ1, FAF1, C11orf30, DUSP13, SPAST, FAM136A, UXS1, CD70, VASN, TRIM25, G3BP1, CDC27, ANAPC4, ANAPC10, MAD2L1, CDC20, FZR1, PIN1TMEM117


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NUP98_TMEM117


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NUP98_TMEM117


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNUP98C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneTMEM117C0008370Cholestasis1CTD_human
TgeneTMEM117C4277682Chemical and Drug Induced Liver Injury1CTD_human