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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 25264

FusionGeneSummary for NUP98_RAP1GDS1

check button Fusion gene summary
Fusion gene informationFusion gene name: NUP98_RAP1GDS1
Fusion gene ID: 25264
HgeneTgene
Gene symbol

NUP98

RAP1GDS1

Gene ID

4928

5910

Gene namenucleoporin 98Rap1 GTPase-GDP dissociation stimulator 1
SynonymsADIR2|NUP196|NUP96GDS1|SmgGDS
Cytomap

11p15.4

4q23

Type of geneprotein-codingprotein-coding
Descriptionnuclear pore complex protein Nup98-Nup96nuclear pore complex protein Nup98GLFG-repeat containing nucleoporinNUP98/PHF23 fusion 2 proteinNup98-Nup96nucleoporin 98kDnucleoporin 98kDarap1 GTPase-GDP dissociation stimulator 1RAP1, GTP-GDP dissociation stimulator 1SMG GDS proteinSMG P21 stimulatory GDP/GTP exchange proteinexchange factor smgGDS
Modification date2018052320180523
UniProtAcc

P52948

P52306

Ensembl transtripts involved in fusion geneENST00000324932, ENST00000359171, 
ENST00000355260, ENST00000397004, 
ENST00000397007, ENST00000488828, 
ENST00000380158, ENST00000264572, 
ENST00000408927, ENST00000512857, 
ENST00000453712, ENST00000339360, 
ENST00000408900, 
Fusion gene scores* DoF score16 X 12 X 7=13443 X 5 X 1=15
# samples 215
** MAII scorelog2(21/1344*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/15*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NUP98 [Title/Abstract] AND RAP1GDS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AF133331NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
ChiTaRS3.1AF133334NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
ChiTaRS3.1AF133332NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000324932ENST00000380158NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
Frame-shitENST00000324932ENST00000264572NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
Frame-shitENST00000324932ENST00000408927NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
5CDS-3UTRENST00000324932ENST00000512857NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
5CDS-3UTRENST00000324932ENST00000453712NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
5CDS-3UTRENST00000324932ENST00000339360NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
5CDS-3UTRENST00000324932ENST00000408900NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
Frame-shitENST00000359171ENST00000380158NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
Frame-shitENST00000359171ENST00000264572NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
Frame-shitENST00000359171ENST00000408927NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
5CDS-3UTRENST00000359171ENST00000512857NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
5CDS-3UTRENST00000359171ENST00000453712NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
5CDS-3UTRENST00000359171ENST00000339360NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
5CDS-3UTRENST00000359171ENST00000408900NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
Frame-shitENST00000355260ENST00000380158NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
Frame-shitENST00000355260ENST00000264572NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
Frame-shitENST00000355260ENST00000408927NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
5CDS-3UTRENST00000355260ENST00000512857NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
5CDS-3UTRENST00000355260ENST00000453712NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
5CDS-3UTRENST00000355260ENST00000339360NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
5CDS-3UTRENST00000355260ENST00000408900NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
Frame-shitENST00000397004ENST00000380158NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
Frame-shitENST00000397004ENST00000264572NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
Frame-shitENST00000397004ENST00000408927NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
5CDS-3UTRENST00000397004ENST00000512857NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
5CDS-3UTRENST00000397004ENST00000453712NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
5CDS-3UTRENST00000397004ENST00000339360NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
5CDS-3UTRENST00000397004ENST00000408900NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
Frame-shitENST00000397007ENST00000380158NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
Frame-shitENST00000397007ENST00000264572NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
Frame-shitENST00000397007ENST00000408927NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
5CDS-3UTRENST00000397007ENST00000512857NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
5CDS-3UTRENST00000397007ENST00000453712NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
5CDS-3UTRENST00000397007ENST00000339360NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
5CDS-3UTRENST00000397007ENST00000408900NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
intron-3CDSENST00000488828ENST00000380158NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
intron-3CDSENST00000488828ENST00000264572NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
intron-3CDSENST00000488828ENST00000408927NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
intron-3UTRENST00000488828ENST00000512857NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
intron-3UTRENST00000488828ENST00000453712NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
intron-3UTRENST00000488828ENST00000339360NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
intron-3UTRENST00000488828ENST00000408900NUP98chr11

3765739

-RAP1GDS1chr4

99214557

+
5CDS-intronENST00000324932ENST00000380158NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000324932ENST00000264572NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000324932ENST00000408927NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000324932ENST00000512857NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000324932ENST00000453712NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000324932ENST00000339360NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000324932ENST00000408900NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000359171ENST00000380158NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000359171ENST00000264572NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000359171ENST00000408927NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000359171ENST00000512857NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000359171ENST00000453712NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000359171ENST00000339360NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000359171ENST00000408900NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000355260ENST00000380158NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000355260ENST00000264572NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000355260ENST00000408927NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000355260ENST00000512857NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000355260ENST00000453712NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000355260ENST00000339360NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000355260ENST00000408900NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000397004ENST00000380158NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000397004ENST00000264572NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000397004ENST00000408927NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000397004ENST00000512857NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000397004ENST00000453712NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000397004ENST00000339360NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
5CDS-intronENST00000397004ENST00000408900NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
intron-intronENST00000397007ENST00000380158NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
intron-intronENST00000397007ENST00000264572NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
intron-intronENST00000397007ENST00000408927NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
intron-intronENST00000397007ENST00000512857NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
intron-intronENST00000397007ENST00000453712NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
intron-intronENST00000397007ENST00000339360NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
intron-intronENST00000397007ENST00000408900NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
intron-intronENST00000488828ENST00000380158NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
intron-intronENST00000488828ENST00000264572NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
intron-intronENST00000488828ENST00000408927NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
intron-intronENST00000488828ENST00000512857NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
intron-intronENST00000488828ENST00000453712NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
intron-intronENST00000488828ENST00000339360NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
intron-intronENST00000488828ENST00000408900NUP98chr11

3781769

-RAP1GDS1chr4

99214548

+
Frame-shitENST00000324932ENST00000380158NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
Frame-shitENST00000324932ENST00000264572NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
Frame-shitENST00000324932ENST00000408927NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
5CDS-3UTRENST00000324932ENST00000512857NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
5CDS-3UTRENST00000324932ENST00000453712NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
5CDS-3UTRENST00000324932ENST00000339360NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
5CDS-3UTRENST00000324932ENST00000408900NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
Frame-shitENST00000359171ENST00000380158NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
Frame-shitENST00000359171ENST00000264572NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
Frame-shitENST00000359171ENST00000408927NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
5CDS-3UTRENST00000359171ENST00000512857NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
5CDS-3UTRENST00000359171ENST00000453712NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
5CDS-3UTRENST00000359171ENST00000339360NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
5CDS-3UTRENST00000359171ENST00000408900NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
Frame-shitENST00000355260ENST00000380158NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
Frame-shitENST00000355260ENST00000264572NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
Frame-shitENST00000355260ENST00000408927NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
5CDS-3UTRENST00000355260ENST00000512857NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
5CDS-3UTRENST00000355260ENST00000453712NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
5CDS-3UTRENST00000355260ENST00000339360NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
5CDS-3UTRENST00000355260ENST00000408900NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
Frame-shitENST00000397004ENST00000380158NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
Frame-shitENST00000397004ENST00000264572NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
Frame-shitENST00000397004ENST00000408927NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
5CDS-3UTRENST00000397004ENST00000512857NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
5CDS-3UTRENST00000397004ENST00000453712NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
5CDS-3UTRENST00000397004ENST00000339360NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
5CDS-3UTRENST00000397004ENST00000408900NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
Frame-shitENST00000397007ENST00000380158NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
Frame-shitENST00000397007ENST00000264572NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
Frame-shitENST00000397007ENST00000408927NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
5CDS-3UTRENST00000397007ENST00000512857NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
5CDS-3UTRENST00000397007ENST00000453712NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
5CDS-3UTRENST00000397007ENST00000339360NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
5CDS-3UTRENST00000397007ENST00000408900NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
intron-3CDSENST00000488828ENST00000380158NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
intron-3CDSENST00000488828ENST00000264572NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
intron-3CDSENST00000488828ENST00000408927NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
intron-3UTRENST00000488828ENST00000512857NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
intron-3UTRENST00000488828ENST00000453712NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
intron-3UTRENST00000488828ENST00000339360NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+
intron-3UTRENST00000488828ENST00000408900NUP98chr11

3765739

-RAP1GDS1chr4

99214554

+

Top

FusionProtFeatures for NUP98_RAP1GDS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUP98

P52948

RAP1GDS1

P52306


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NUP98_RAP1GDS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NUP98_RAP1GDS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NUP98MOB1A, PARP11, QRICH2, TPR, NUP88, CREBBP, EP300, NUP133, KPNB1, RAE1, TNPO2, NXF1, TNPO1, USP7, NPM1, PTTG1, APC, HDAC1, SIRT7, NUP107, CTNNB1, RAPGEF3, NUMA1, ECT2, CSNK2A1, HNRNPUL1, LMNA, HDAC8, HDAC11, FBXO6, ARFGEF2, CDC73, PAF1, CDC37, CUL7, OBSL1, EED, MAPK8, COMTD1, SEC13, PNKD, NUP43, CLEC11A, RNF166, UNK, NUP54, NUP85, SEH1L, XPO5, KRAS, IFI16, NUP160, NUP35, B9D2, UBE2I, NUPL1, NUP153, PIM2, NUDT21, NCBP2, CHMP4B, GTF2H5, FOXI2, FOXL1, FOXQ1, FAF1, C11orf30, DUSP13, SPAST, FAM136A, UXS1, CD70, VASN, TRIM25, G3BP1, CDC27, ANAPC4, ANAPC10, MAD2L1, CDC20, FZR1, PIN1RAP1GDS1NRAS, RHOA, RAP1A, HRAS, KRAS, RAC1, MBIP, ZNF451, KIFAP3, EGFR, CDC42, DCPS, GAPDH, GINS3, HSPA1L, NAE1, OLA1, PAFAH1B2, PPP1R2, PTMA, ABHD14A, ASNS, CAPN1, ECHS1, GMDS, GSS, HSPA5, HSPA9, MSN, PDIA4, PFAS, PPP5C, TATDN1, UBQLN1, USP14, VCL, YWHAE, DOC2A, PLEKHB1, MOV10, DIRAS3, RAB34, RASD2, HDAC7, APBB2, RAB1B, SNX24, GNAI1, GNAZ, SEPT12, TSC22D4, RAB31, RASL10A, SEPT6, BAIAP2, HSPB9, C2orf48, UNC45A, NTRK1, PUF60, CDK2, DUSP23, DIRAS1, UBTF, DIRAS2, RAC3, PRDM10, RAP2C, RAP1B, DNAL1, RHOF, RHOC, RAB15, RABL3, RBM42, IRGC, VASH1, NKIRAS2, IL13RA1, RAC2, ARL4C, NT5C, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NUP98_RAP1GDS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NUP98_RAP1GDS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNUP98C0023467Leukemia, Myelocytic, Acute1CTD_human