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Fusion gene ID: 25236 |
FusionGeneSummary for NUP54_CXCL9 |
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Fusion gene information | Fusion gene name: NUP54_CXCL9 | Fusion gene ID: 25236 | Hgene | Tgene | Gene symbol | NUP54 | CXCL9 | Gene ID | 53371 | 4283 |
Gene name | nucleoporin 54 | C-X-C motif chemokine ligand 9 | |
Synonyms | - | CMK|Humig|MIG|SCYB9|crg-10 | |
Cytomap | 4q21.1 | 4q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | nucleoporin p5454 kDa nucleoporinnucleoporin 54kDnucleoporin 54kDa | C-X-C motif chemokine 9chemokine (C-X-C motif) ligand 9gamma-interferon-induced monokinemonokine induced by gamma interferonmonokine induced by interferon-gammasmall-inducible cytokine B9 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q7Z3B4 | Q07325 | |
Ensembl transtripts involved in fusion gene | ENST00000264883, ENST00000342467, ENST00000514987, ENST00000458189, ENST00000515460, | ENST00000264888, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 2 X 3=18 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: NUP54 [Title/Abstract] AND CXCL9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CXCL9 | GO:0006935 | chemotaxis | 12782716 |
Tgene | CXCL9 | GO:0030816 | positive regulation of cAMP metabolic process | 12782716 |
Tgene | CXCL9 | GO:0042127 | regulation of cell proliferation | 12782716 |
Tgene | CXCL9 | GO:0043950 | positive regulation of cAMP-mediated signaling | 12782716 |
Tgene | CXCL9 | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | 12782716 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-69-8255-01A | NUP54 | chr4 | 77045802 | - | CXCL9 | chr4 | 76927427 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000264883 | ENST00000264888 | NUP54 | chr4 | 77045802 | - | CXCL9 | chr4 | 76927427 | - |
intron-3CDS | ENST00000342467 | ENST00000264888 | NUP54 | chr4 | 77045802 | - | CXCL9 | chr4 | 76927427 | - |
Frame-shift | ENST00000514987 | ENST00000264888 | NUP54 | chr4 | 77045802 | - | CXCL9 | chr4 | 76927427 | - |
Frame-shift | ENST00000458189 | ENST00000264888 | NUP54 | chr4 | 77045802 | - | CXCL9 | chr4 | 76927427 | - |
intron-3CDS | ENST00000515460 | ENST00000264888 | NUP54 | chr4 | 77045802 | - | CXCL9 | chr4 | 76927427 | - |
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FusionProtFeatures for NUP54_CXCL9 |
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Hgene | Tgene |
NUP54 | CXCL9 |
Component of the nuclear pore complex, a complexrequired for the trafficking across the nuclear membrane.{ECO:0000250|UniProtKB:P70582}. | Cytokine that affects the growth, movement, oractivation state of cells that participate in immune andinflammatory response. Chemotactic for activated T-cells. Binds toCXCR3. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NUP54_CXCL9 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NUP54_CXCL9 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NUP54 | NUP62, AP2B1, CCDC85B, NUTF2, KPNA1, KPNB1, APC, HDAC1, NUP153, SPEN, DGCR6, VCP, KRT15, HGS, NUPL1, IFT20, HAUS1, OBSL1, WDFY2, RNF166, NUP98, RAE1, NTRK1, IFI16, NUP35, SCLT1, ADD1, NUP107, TIGD6, NEDD1, NUP62CL, BFSP1, NDEL1, CEP250, LPXN, HOMER1, NDE1, CDK16, COG4, WDR59, HOMER3, EXOC1, CPNE2, CRNN | CXCL9 | CXCR3, PAX8, BMF, SFTPC, PTPN5, CCDC155, SYNE4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NUP54_CXCL9 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NUP54_CXCL9 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CXCL9 | C0002171 | Alopecia Areata | 1 | CTD_human |
Tgene | CXCL9 | C0020517 | Hypersensitivity | 1 | CTD_human |
Tgene | CXCL9 | C0023892 | Biliary cirrhosis | 1 | CTD_human |
Tgene | CXCL9 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | CXCL9 | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
Tgene | CXCL9 | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
Tgene | CXCL9 | C0032285 | Pneumonia | 1 | CTD_human |
Tgene | CXCL9 | C0282488 | Interstitial Cystitis | 1 | CTD_human |
Tgene | CXCL9 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Tgene | CXCL9 | C1458155 | Mammary Neoplasms | 1 | CTD_human |