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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25236

FusionGeneSummary for NUP54_CXCL9

check button Fusion gene summary
Fusion gene informationFusion gene name: NUP54_CXCL9
Fusion gene ID: 25236
HgeneTgene
Gene symbol

NUP54

CXCL9

Gene ID

53371

4283

Gene namenucleoporin 54C-X-C motif chemokine ligand 9
Synonyms-CMK|Humig|MIG|SCYB9|crg-10
Cytomap

4q21.1

4q21.1

Type of geneprotein-codingprotein-coding
Descriptionnucleoporin p5454 kDa nucleoporinnucleoporin 54kDnucleoporin 54kDaC-X-C motif chemokine 9chemokine (C-X-C motif) ligand 9gamma-interferon-induced monokinemonokine induced by gamma interferonmonokine induced by interferon-gammasmall-inducible cytokine B9
Modification date2018052320180523
UniProtAcc

Q7Z3B4

Q07325

Ensembl transtripts involved in fusion geneENST00000264883, ENST00000342467, 
ENST00000514987, ENST00000458189, 
ENST00000515460, 
ENST00000264888, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 2 X 3=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NUP54 [Title/Abstract] AND CXCL9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCXCL9

GO:0006935

chemotaxis

12782716

TgeneCXCL9

GO:0030816

positive regulation of cAMP metabolic process

12782716

TgeneCXCL9

GO:0042127

regulation of cell proliferation

12782716

TgeneCXCL9

GO:0043950

positive regulation of cAMP-mediated signaling

12782716

TgeneCXCL9

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

12782716


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-69-8255-01ANUP54chr4

77045802

-CXCL9chr4

76927427

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000264883ENST00000264888NUP54chr4

77045802

-CXCL9chr4

76927427

-
intron-3CDSENST00000342467ENST00000264888NUP54chr4

77045802

-CXCL9chr4

76927427

-
Frame-shiftENST00000514987ENST00000264888NUP54chr4

77045802

-CXCL9chr4

76927427

-
Frame-shiftENST00000458189ENST00000264888NUP54chr4

77045802

-CXCL9chr4

76927427

-
intron-3CDSENST00000515460ENST00000264888NUP54chr4

77045802

-CXCL9chr4

76927427

-

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FusionProtFeatures for NUP54_CXCL9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUP54

Q7Z3B4

CXCL9

Q07325

Component of the nuclear pore complex, a complexrequired for the trafficking across the nuclear membrane.{ECO:0000250|UniProtKB:P70582}. Cytokine that affects the growth, movement, oractivation state of cells that participate in immune andinflammatory response. Chemotactic for activated T-cells. Binds toCXCR3.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NUP54_CXCL9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NUP54_CXCL9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NUP54NUP62, AP2B1, CCDC85B, NUTF2, KPNA1, KPNB1, APC, HDAC1, NUP153, SPEN, DGCR6, VCP, KRT15, HGS, NUPL1, IFT20, HAUS1, OBSL1, WDFY2, RNF166, NUP98, RAE1, NTRK1, IFI16, NUP35, SCLT1, ADD1, NUP107, TIGD6, NEDD1, NUP62CL, BFSP1, NDEL1, CEP250, LPXN, HOMER1, NDE1, CDK16, COG4, WDR59, HOMER3, EXOC1, CPNE2, CRNNCXCL9CXCR3, PAX8, BMF, SFTPC, PTPN5, CCDC155, SYNE4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NUP54_CXCL9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NUP54_CXCL9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCXCL9C0002171Alopecia Areata1CTD_human
TgeneCXCL9C0020517Hypersensitivity1CTD_human
TgeneCXCL9C0023892Biliary cirrhosis1CTD_human
TgeneCXCL9C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCXCL9C0023904Liver Neoplasms, Experimental1CTD_human
TgeneCXCL9C0027643Neoplasm Recurrence, Local1CTD_human
TgeneCXCL9C0032285Pneumonia1CTD_human
TgeneCXCL9C0282488Interstitial Cystitis1CTD_human
TgeneCXCL9C0345967Malignant mesothelioma1CTD_human
TgeneCXCL9C1458155Mammary Neoplasms1CTD_human