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Fusion gene ID: 25232 |
FusionGeneSummary for NUP35_NCKAP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NUP35_NCKAP1 | Fusion gene ID: 25232 | Hgene | Tgene | Gene symbol | NUP35 | NCKAP1 | Gene ID | 129401 | 10787 |
| Gene name | nucleoporin 35 | NCK associated protein 1 | |
| Synonyms | MP-44|MP44|NP44|NUP53 | HEM2|NAP1|NAP125|p125Nap1 | |
| Cytomap | 2q32.1 | 2q32.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nucleoporin NUP35nucleoporin NUP53mitotic phosphoprotein 44nuclear pore complex protein Nup53nucleoporin 35kDa | nck-associated protein 1membrane-associated protein HEM-2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8NFH5 | Q9Y2A7 | |
| Ensembl transtripts involved in fusion gene | ENST00000409798, ENST00000295119, ENST00000541912, ENST00000497330, | ENST00000361354, ENST00000360982, ENST00000478449, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 8 X 7 X 5=280 |
| # samples | 2 | 8 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NUP35 [Title/Abstract] AND NCKAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NCKAP1 | GO:0016601 | Rac protein signal transduction | 21107423 |
| Tgene | NCKAP1 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation | 21107423 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-43-8115-01A | NUP35 | chr2 | 183989225 | + | NCKAP1 | chr2 | 183853914 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000409798 | ENST00000361354 | NUP35 | chr2 | 183989225 | + | NCKAP1 | chr2 | 183853914 | - |
| intron-3CDS | ENST00000409798 | ENST00000360982 | NUP35 | chr2 | 183989225 | + | NCKAP1 | chr2 | 183853914 | - |
| intron-intron | ENST00000409798 | ENST00000478449 | NUP35 | chr2 | 183989225 | + | NCKAP1 | chr2 | 183853914 | - |
| In-frame | ENST00000295119 | ENST00000361354 | NUP35 | chr2 | 183989225 | + | NCKAP1 | chr2 | 183853914 | - |
| In-frame | ENST00000295119 | ENST00000360982 | NUP35 | chr2 | 183989225 | + | NCKAP1 | chr2 | 183853914 | - |
| 5CDS-intron | ENST00000295119 | ENST00000478449 | NUP35 | chr2 | 183989225 | + | NCKAP1 | chr2 | 183853914 | - |
| 5UTR-3CDS | ENST00000541912 | ENST00000361354 | NUP35 | chr2 | 183989225 | + | NCKAP1 | chr2 | 183853914 | - |
| 5UTR-3CDS | ENST00000541912 | ENST00000360982 | NUP35 | chr2 | 183989225 | + | NCKAP1 | chr2 | 183853914 | - |
| 5UTR-intron | ENST00000541912 | ENST00000478449 | NUP35 | chr2 | 183989225 | + | NCKAP1 | chr2 | 183853914 | - |
| 3UTR-3CDS | ENST00000497330 | ENST00000361354 | NUP35 | chr2 | 183989225 | + | NCKAP1 | chr2 | 183853914 | - |
| 3UTR-3CDS | ENST00000497330 | ENST00000360982 | NUP35 | chr2 | 183989225 | + | NCKAP1 | chr2 | 183853914 | - |
| 3UTR-intron | ENST00000497330 | ENST00000478449 | NUP35 | chr2 | 183989225 | + | NCKAP1 | chr2 | 183853914 | - |
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FusionProtFeatures for NUP35_NCKAP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NUP35 | NCKAP1 |
| Functions as a component of the nuclear pore complex(NPC). NPC components, collectively referred to as nucleoporins(NUPs), can play the role of both NPC structural components and ofdocking or interaction partners for transiently associated nucleartransport factors. May play a role in the association of MAD1 withthe NPC. {ECO:0000269|PubMed:15703211}. | Part of the WAVE complex that regulates lamellipodiaformation. The WAVE complex regulates actin filamentreorganization via its interaction with the Arp2/3 complex. Actinremodeling activity is regulated by RAC1. As component of theWAVE1 complex, required for BDNF-NTRK2 endocytic trafficking andsignaling from early endosomes. {ECO:0000250|UniProtKB:P28660}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NUP35_NCKAP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NUP35_ENST00000295119_chr2_183989225_+_NCKAP1_ENST00000361354_chr2_183853914_-_879aa MAAFAVEPQGPALVGFILCHGILNTDATALNLWKLALQSSSCLSLFRDEVFHIHKAAEDLFVNIRGYNKRINDIRECKEAAVSHAGSMHR ERRKFLRSALKELATVLSDQPGLLGPKALFVFMALSFARDEIIWLLRHADNMPKKSADDFIDKHIAELIFYMEELRAHVRKYGPVMQRYY VQYLSGFDAVVLNELVQNLSVCPEDESIIMSSFVNTMTSLSVKQVEDGEVFDFRGMRLDWFRLQAYTSVSKASLGLADHRELGKMMNTII FHTKMVDSLVEMLVETSDLSIFCFYSRAFEKMFQQCLELPSQSRYSIAFPLLCTHFMSCTHELCPEERHHIGDRSLSLCNMFLDEMAKQA RNLITDICTEQCTLSDQLLPKHCAKTISQAVNKKSKKQTGKKGEPEREKPGVESMRKNRLVVTNLDKLHTALSELCFSINYVPNMVVWEH TFTPREYLTSHLEIRFTKSIVGMTMYNQATQEIAKPSELLTSVRAYMTVLQSIENYVQIDITRVFNNVLLQQTQHLDSHGEPTITSLYTN WYLETLLRQVSNGHIAYFPAMKAFVNLPTENELTFNAEEYSDISEMRSLSELLGPYGMKFLSESLMWHISSQVAELKKLVVENVDVLTQM RTSFDKPDQMAALFKRLSSVDSVLKRMTIIGVILSFRSLAQEALRDVLSYHIPFLVSSIEDFKDHIPRETDMKVAMNVYELSSAAGLPCE IDPALVVALSSQKSENISPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIEGHCNNIHCLAKAINQIAAALFTIHKGSIEDRLKEFLA >In-frame_NUP35_ENST00000295119_chr2_183989225_+_NCKAP1_ENST00000360982_chr2_183853914_-_879aa MAAFAVEPQGPALVGFILCHGILNTDATALNLWKLALQSSSCLSLFRDEVFHIHKAAEDLFVNIRGYNKRINDIRECKEAAVSHAGSMHR ERRKFLRSALKELATVLSDQPGLLGPKALFVFMALSFARDEIIWLLRHADNMPKKSADDFIDKHIAELIFYMEELRAHVRKYGPVMQRYY VQYLSGFDAVVLNELVQNLSVCPEDESIIMSSFVNTMTSLSVKQVEDGEVFDFRGMRLDWFRLQAYTSVSKASLGLADHRELGKMMNTII FHTKMVDSLVEMLVETSDLSIFCFYSRAFEKMFQQCLELPSQSRYSIAFPLLCTHFMSCTHELCPEERHHIGDRSLSLCNMFLDEMAKQA RNLITDICTEQCTLSDQLLPKHCAKTISQAVNKKSKKQTGKKGEPEREKPGVESMRKNRLVVTNLDKLHTALSELCFSINYVPNMVVWEH TFTPREYLTSHLEIRFTKSIVGMTMYNQATQEIAKPSELLTSVRAYMTVLQSIENYVQIDITRVFNNVLLQQTQHLDSHGEPTITSLYTN WYLETLLRQVSNGHIAYFPAMKAFVNLPTENELTFNAEEYSDISEMRSLSELLGPYGMKFLSESLMWHISSQVAELKKLVVENVDVLTQM RTSFDKPDQMAALFKRLSSVDSVLKRMTIIGVILSFRSLAQEALRDVLSYHIPFLVSSIEDFKDHIPRETDMKVAMNVYELSSAAGLPCE IDPALVVALSSQKSENISPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIEGHCNNIHCLAKAINQIAAALFTIHKGSIEDRLKEFLA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NUP35_ENST00000295119_chr2_183989225_+_NCKAP1_ENST00000361354_chr2_183853914_-_2637nt ATGGCAGCCTTTGCAGTGGAACCTCAGGGGCCCGCGTTAGTTGGCTTTATTTTGTGCCATGGGATCCTAAATACTGACGCTACAGCACTG AACCTTTGGAAACTAGCTCTTCAAAGTAGCTCTTGCCTCTCTCTCTTTCGGGATGAAGTTTTCCACATTCACAAAGCTGCAGAAGACTTA TTTGTAAACATACGAGGCTATAATAAACGTATTAATGACATAAGAGAATGCAAGGAGGCAGCCGTGTCACATGCTGGTTCAATGCACAGA GAAAGACGCAAGTTTTTAAGATCTGCACTGAAGGAATTGGCTACTGTCCTCTCTGATCAACCTGGATTGCTAGGTCCCAAGGCACTTTTT GTTTTTATGGCATTATCCTTTGCCCGTGATGAAATCATCTGGCTACTTCGTCATGCAGATAACATGCCAAAGAAGAGTGCAGACGACTTT ATAGATAAGCACATTGCTGAATTAATATTTTACATGGAAGAACTTAGAGCACATGTGAGGAAATACGGACCTGTAATGCAGAGGTATTAC GTGCAGTACCTTTCTGGCTTTGATGCTGTTGTCCTCAATGAACTCGTGCAGAATCTTTCTGTTTGCCCTGAAGATGAATCAATCATCATG TCCTCTTTTGTTAACACTATGACTTCCCTAAGTGTAAAACAAGTTGAAGATGGGGAAGTATTTGATTTCAGAGGAATGAGATTAGATTGG TTTAGGTTACAGGCATATACTAGTGTCTCAAAGGCTTCACTTGGCCTTGCAGATCACAGAGAACTTGGAAAGATGATGAATACAATAATT TTTCATACAAAAATGGTAGATTCCTTGGTGGAAATGTTGGTGGAAACATCAGATCTCTCCATATTTTGTTTTTATAGTCGTGCTTTTGAG AAGATGTTTCAACAGTGTTTGGAGTTACCCTCTCAATCAAGATACTCAATTGCATTTCCACTACTTTGCACTCATTTTATGAGTTGCACG CATGAACTATGTCCAGAAGAGCGACATCATATTGGAGATCGCAGTCTTTCCTTATGTAATATGTTCCTAGATGAAATGGCCAAACAAGCT CGAAATCTCATCACTGATATTTGCACAGAACAGTGTACCCTTAGTGACCAGTTGCTACCCAAGCATTGTGCCAAAACTATCAGTCAAGCA GTGAATAAGAAATCAAAAAAGCAGACTGGTAAGAAAGGGGAACCTGAAAGGGAGAAACCAGGTGTTGAGAGCATGAGGAAAAACAGGCTG GTTGTGACCAACCTTGATAAATTGCACACTGCACTTTCTGAGTTATGCTTCTCTATAAATTATGTACCAAACATGGTGGTATGGGAACAT ACCTTTACCCCACGAGAATATTTGACTTCTCATCTGGAAATACGCTTTACCAAGTCAATTGTTGGGATGACTATGTATAATCAAGCCACA CAGGAAATTGCAAAACCTTCAGAACTTCTAACAAGTGTAAGAGCATACATGACCGTACTCCAGTCAATAGAAAACTATGTGCAGATTGAT ATTACAAGAGTATTTAATAATGTGCTTCTTCAACAAACACAACATTTAGACAGTCATGGAGAGCCAACCATTACAAGTCTATACACAAAT TGGTATTTGGAAACTTTGTTACGACAAGTCAGCAATGGCCATATAGCATATTTTCCTGCAATGAAAGCGTTTGTGAACTTACCTACAGAA AATGAATTAACATTCAATGCAGAGGAATATTCTGACATATCAGAAATGAGGTCATTATCAGAACTACTAGGCCCATATGGTATGAAGTTT CTAAGTGAAAGCCTTATGTGGCATATTTCATCACAAGTTGCTGAACTTAAGAAACTTGTGGTGGAGAATGTTGATGTGTTAACACAAATG AGGACCAGCTTTGACAAACCAGACCAGATGGCTGCACTGTTTAAAAGATTATCATCTGTTGACAGTGTCTTGAAGAGGATGACAATAATT GGTGTAATTTTATCCTTCCGATCATTGGCACAAGAAGCACTTAGAGATGTCTTATCCTACCACATTCCTTTTCTTGTAAGTTCAATTGAA GATTTTAAGGATCACATTCCAAGGGAAACTGATATGAAGGTTGCAATGAATGTGTATGAGTTATCATCAGCTGCCGGATTACCTTGTGAG ATTGATCCTGCATTGGTCGTAGCTCTTTCTTCACAAAAATCGGAAAACATTAGTCCAGAAGAAGAGTATAAAATTGCCTGCCTTCTCATG GTGTTTGTGGCAGTTTCTTTGCCAACACTGGCCAGTAATGTGATGTCTCAGTACAGCCCTGCTATAGAAGGGCATTGCAACAACATACAT TGCTTGGCCAAAGCCATCAACCAGATTGCTGCAGCTTTGTTTACAATTCACAAAGGAAGCATTGAAGACCGTCTTAAAGAATTTCTGGCG CTTGCATCCTCCAGTCTACTGAAAATTGGCCAGGAGACAGATAAAACTACAACAAGAAATAGAGAATCTGTTTATTTACTGCTAGATATG ATTGTACAAGAATCTCCATTCCTTACAATGGATCTTTTGGAATCTTGTTTTCCTTATGTCTTGCTGAGAAATGCATACCATGCTGTCTAC >In-frame_NUP35_ENST00000295119_chr2_183989225_+_NCKAP1_ENST00000360982_chr2_183853914_-_2637nt ATGGCAGCCTTTGCAGTGGAACCTCAGGGGCCCGCGTTAGTTGGCTTTATTTTGTGCCATGGGATCCTAAATACTGACGCTACAGCACTG AACCTTTGGAAACTAGCTCTTCAAAGTAGCTCTTGCCTCTCTCTCTTTCGGGATGAAGTTTTCCACATTCACAAAGCTGCAGAAGACTTA TTTGTAAACATACGAGGCTATAATAAACGTATTAATGACATAAGAGAATGCAAGGAGGCAGCCGTGTCACATGCTGGTTCAATGCACAGA GAAAGACGCAAGTTTTTAAGATCTGCACTGAAGGAATTGGCTACTGTCCTCTCTGATCAACCTGGATTGCTAGGTCCCAAGGCACTTTTT GTTTTTATGGCATTATCCTTTGCCCGTGATGAAATCATCTGGCTACTTCGTCATGCAGATAACATGCCAAAGAAGAGTGCAGACGACTTT ATAGATAAGCACATTGCTGAATTAATATTTTACATGGAAGAACTTAGAGCACATGTGAGGAAATACGGACCTGTAATGCAGAGGTATTAC GTGCAGTACCTTTCTGGCTTTGATGCTGTTGTCCTCAATGAACTCGTGCAGAATCTTTCTGTTTGCCCTGAAGATGAATCAATCATCATG TCCTCTTTTGTTAACACTATGACTTCCCTAAGTGTAAAACAAGTTGAAGATGGGGAAGTATTTGATTTCAGAGGAATGAGATTAGATTGG TTTAGGTTACAGGCATATACTAGTGTCTCAAAGGCTTCACTTGGCCTTGCAGATCACAGAGAACTTGGAAAGATGATGAATACAATAATT TTTCATACAAAAATGGTAGATTCCTTGGTGGAAATGTTGGTGGAAACATCAGATCTCTCCATATTTTGTTTTTATAGTCGTGCTTTTGAG AAGATGTTTCAACAGTGTTTGGAGTTACCCTCTCAATCAAGATACTCAATTGCATTTCCACTACTTTGCACTCATTTTATGAGTTGCACG CATGAACTATGTCCAGAAGAGCGACATCATATTGGAGATCGCAGTCTTTCCTTATGTAATATGTTCCTAGATGAAATGGCCAAACAAGCT CGAAATCTCATCACTGATATTTGCACAGAACAGTGTACCCTTAGTGACCAGTTGCTACCCAAGCATTGTGCCAAAACTATCAGTCAAGCA GTGAATAAGAAATCAAAAAAGCAGACTGGTAAGAAAGGGGAACCTGAAAGGGAGAAACCAGGTGTTGAGAGCATGAGGAAAAACAGGCTG GTTGTGACCAACCTTGATAAATTGCACACTGCACTTTCTGAGTTATGCTTCTCTATAAATTATGTACCAAACATGGTGGTATGGGAACAT ACCTTTACCCCACGAGAATATTTGACTTCTCATCTGGAAATACGCTTTACCAAGTCAATTGTTGGGATGACTATGTATAATCAAGCCACA CAGGAAATTGCAAAACCTTCAGAACTTCTAACAAGTGTAAGAGCATACATGACCGTACTCCAGTCAATAGAAAACTATGTGCAGATTGAT ATTACAAGAGTATTTAATAATGTGCTTCTTCAACAAACACAACATTTAGACAGTCATGGAGAGCCAACCATTACAAGTCTATACACAAAT TGGTATTTGGAAACTTTGTTACGACAAGTCAGCAATGGCCATATAGCATATTTTCCTGCAATGAAAGCGTTTGTGAACTTACCTACAGAA AATGAATTAACATTCAATGCAGAGGAATATTCTGACATATCAGAAATGAGGTCATTATCAGAACTACTAGGCCCATATGGTATGAAGTTT CTAAGTGAAAGCCTTATGTGGCATATTTCATCACAAGTTGCTGAACTTAAGAAACTTGTGGTGGAGAATGTTGATGTGTTAACACAAATG AGGACCAGCTTTGACAAACCAGACCAGATGGCTGCACTGTTTAAAAGATTATCATCTGTTGACAGTGTCTTGAAGAGGATGACAATAATT GGTGTAATTTTATCCTTCCGATCATTGGCACAAGAAGCACTTAGAGATGTCTTATCCTACCACATTCCTTTTCTTGTAAGTTCAATTGAA GATTTTAAGGATCACATTCCAAGGGAAACTGATATGAAGGTTGCAATGAATGTGTATGAGTTATCATCAGCTGCCGGATTACCTTGTGAG ATTGATCCTGCATTGGTCGTAGCTCTTTCTTCACAAAAATCGGAAAACATTAGTCCAGAAGAAGAGTATAAAATTGCCTGCCTTCTCATG GTGTTTGTGGCAGTTTCTTTGCCAACACTGGCCAGTAATGTGATGTCTCAGTACAGCCCTGCTATAGAAGGGCATTGCAACAACATACAT TGCTTGGCCAAAGCCATCAACCAGATTGCTGCAGCTTTGTTTACAATTCACAAAGGAAGCATTGAAGACCGTCTTAAAGAATTTCTGGCG CTTGCATCCTCCAGTCTACTGAAAATTGGCCAGGAGACAGATAAAACTACAACAAGAAATAGAGAATCTGTTTATTTACTGCTAGATATG ATTGTACAAGAATCTCCATTCCTTACAATGGATCTTTTGGAATCTTGTTTTCCTTATGTCTTGCTGAGAAATGCATACCATGCTGTCTAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NUP35_ENST00000295119_chr2_183989225_+_NCKAP1_ENST00000361354_chr2_183853914_-_19327nt ACGCAACCCCATAAGGTAGCACGCCGTTACCCGTGGGGAGCGTTTCCGCCATTTTTGAAAATTAATTGGGAAGGTACTGGTTTTAAGTGT AGTTGCCGACGCAATGGCAGCCTTTGCAGTGGAACCTCAGGGGCCCGCGTTAGTTGGCTTTATTTTGTGCCATGGGATCCTAAATACTGA CGCTACAGCACTGAACCTTTGGAAACTAGCTCTTCAAAGTAGCTCTTGCCTCTCTCTCTTTCGGGATGAAGTTTTCCACATTCACAAAGC TGCAGAAGACTTATTTGTAAACATACGAGGCTATAATAAACGTATTAATGACATAAGAGAATGCAAGGAGGCAGCCGTGTCACATGCTGG TTCAATGCACAGAGAAAGACGCAAGTTTTTAAGATCTGCACTGAAGGAATTGGCTACTGTCCTCTCTGATCAACCTGGATTGCTAGGTCC CAAGGCACTTTTTGTTTTTATGGCATTATCCTTTGCCCGTGATGAAATCATCTGGCTACTTCGTCATGCAGATAACATGCCAAAGAAGAG TGCAGACGACTTTATAGATAAGCACATTGCTGAATTAATATTTTACATGGAAGAACTTAGAGCACATGTGAGGAAATACGGACCTGTAAT GCAGAGGTATTACGTGCAGTACCTTTCTGGCTTTGATGCTGTTGTCCTCAATGAACTCGTGCAGAATCTTTCTGTTTGCCCTGAAGATGA ATCAATCATCATGTCCTCTTTTGTTAACACTATGACTTCCCTAAGTGTAAAACAAGTTGAAGATGGGGAAGTATTTGATTTCAGAGGAAT GAGATTAGATTGGTTTAGGTTACAGGCATATACTAGTGTCTCAAAGGCTTCACTTGGCCTTGCAGATCACAGAGAACTTGGAAAGATGAT GAATACAATAATTTTTCATACAAAAATGGTAGATTCCTTGGTGGAAATGTTGGTGGAAACATCAGATCTCTCCATATTTTGTTTTTATAG TCGTGCTTTTGAGAAGATGTTTCAACAGTGTTTGGAGTTACCCTCTCAATCAAGATACTCAATTGCATTTCCACTACTTTGCACTCATTT TATGAGTTGCACGCATGAACTATGTCCAGAAGAGCGACATCATATTGGAGATCGCAGTCTTTCCTTATGTAATATGTTCCTAGATGAAAT GGCCAAACAAGCTCGAAATCTCATCACTGATATTTGCACAGAACAGTGTACCCTTAGTGACCAGTTGCTACCCAAGCATTGTGCCAAAAC TATCAGTCAAGCAGTGAATAAGAAATCAAAAAAGCAGACTGGTAAGAAAGGGGAACCTGAAAGGGAGAAACCAGGTGTTGAGAGCATGAG GAAAAACAGGCTGGTTGTGACCAACCTTGATAAATTGCACACTGCACTTTCTGAGTTATGCTTCTCTATAAATTATGTACCAAACATGGT GGTATGGGAACATACCTTTACCCCACGAGAATATTTGACTTCTCATCTGGAAATACGCTTTACCAAGTCAATTGTTGGGATGACTATGTA TAATCAAGCCACACAGGAAATTGCAAAACCTTCAGAACTTCTAACAAGTGTAAGAGCATACATGACCGTACTCCAGTCAATAGAAAACTA TGTGCAGATTGATATTACAAGAGTATTTAATAATGTGCTTCTTCAACAAACACAACATTTAGACAGTCATGGAGAGCCAACCATTACAAG TCTATACACAAATTGGTATTTGGAAACTTTGTTACGACAAGTCAGCAATGGCCATATAGCATATTTTCCTGCAATGAAAGCGTTTGTGAA CTTACCTACAGAAAATGAATTAACATTCAATGCAGAGGAATATTCTGACATATCAGAAATGAGGTCATTATCAGAACTACTAGGCCCATA TGGTATGAAGTTTCTAAGTGAAAGCCTTATGTGGCATATTTCATCACAAGTTGCTGAACTTAAGAAACTTGTGGTGGAGAATGTTGATGT GTTAACACAAATGAGGACCAGCTTTGACAAACCAGACCAGATGGCTGCACTGTTTAAAAGATTATCATCTGTTGACAGTGTCTTGAAGAG GATGACAATAATTGGTGTAATTTTATCCTTCCGATCATTGGCACAAGAAGCACTTAGAGATGTCTTATCCTACCACATTCCTTTTCTTGT AAGTTCAATTGAAGATTTTAAGGATCACATTCCAAGGGAAACTGATATGAAGGTTGCAATGAATGTGTATGAGTTATCATCAGCTGCCGG ATTACCTTGTGAGATTGATCCTGCATTGGTCGTAGCTCTTTCTTCACAAAAATCGGAAAACATTAGTCCAGAAGAAGAGTATAAAATTGC CTGCCTTCTCATGGTGTTTGTGGCAGTTTCTTTGCCAACACTGGCCAGTAATGTGATGTCTCAGTACAGCCCTGCTATAGAAGGGCATTG CAACAACATACATTGCTTGGCCAAAGCCATCAACCAGATTGCTGCAGCTTTGTTTACAATTCACAAAGGAAGCATTGAAGACCGTCTTAA AGAATTTCTGGCGCTTGCATCCTCCAGTCTACTGAAAATTGGCCAGGAGACAGATAAAACTACAACAAGAAATAGAGAATCTGTTTATTT ACTGCTAGATATGATTGTACAAGAATCTCCATTCCTTACAATGGATCTTTTGGAATCTTGTTTTCCTTATGTCTTGCTGAGAAATGCATA CCATGCTGTCTACAAACAAAGTGTTACATCTTCTGCATAAAATTACCTACTTAATCAAGATAAGCACGCATTTTTGTTGCCTTGGTTTTA CCTGTAGACTGTGGAACTATTTTACCTTAAGACCTGAAAAAGTTTTGTGGATTATAAATTTCTTTCATACGGTTGTATTTTCTGATCATT GGTTTCTTAATATGGTTGTACTACAGTATACTTGGTTGATTTAGGTTGCACATTCACTGAATTCACTGAGATTATTCCTATAATTTTAAA GTATCATTTATTTGAAAAACATACATTATCAACATGTTTTTGATATTTGATAATGAAAAAAATCTTTGCTTGTTTATTTCTGAAAAAGAA CTGTATTTAGTGATTATTTTAGATAGTGATATTATAGTATTCATCTGTGTGTAAATTATTTCATATAGGGAAGAGTTCTGATCTGTACCT ATGGTTCTTATTGAAAACAACATTGGATGTGCATTTCTGTGATGTTATGAATACATTTCTACTTTATTTTGAAACATTTGCCAAACTAAA TACTGTAACACTGTATAACATTTAAAAATGTTAAAGAACTGCTTAGTATTAGAAGCAGATCATTTCCCAAAATTCTAAGAGCAGCAGCAT ATGTTGTTGCTTGTATAAAGCCTAGCGATAATTTTTAGACTAACTTCCATGGTGCCCTGTTGGCATTAGCACTACCATTGTACCCTGCTG TATAATAAACAATCTTAGACATTTATCAACTGTTGATACAAATGTTAGTCCCTAACCACTTTTTATATATGTTTTAAATTTTTGAAATTC AAGTGTACCTGCCATAACATAAAATAAACACTAGACTGTATCACACTTCGATTGATTTCTTTAAGATCCTTGGATATTCGTTCAATAATA ATAAAGTTTTTGTTTAAACTTAGTTTGAAATATAAAAAATAATGGTTTAGGAATGTCTAAGTACAGCATTCGATACCAGGTCAGCTATTA TATGATTTGTTTAAATGTTTTAAAAAACATTTTATTGAAAAAAATACCAAAATTAGAAAATAAAATTACACAATACTTCTTAAAAATTAA GAACTTAAAGAAAACTTGTATGCTGTCAACTTGCTCATTTTATCTGTAACCAAATAGAGTTATTTAAAAGAATAGGGAAAAAAAATTGAG TGATCATGGGACTAGTGAGAATGTTGAGAACTGCTGCATTAGTCAGTAATGAATGGGAAAGACATAAAAGGGCCTATTGCTTAATAGTTG GCATGGAGGGCAAAGCAGCTCATTTAGTTTGAAAACTAACCCAATGTTTTGCTCTTTGATTGGCATTGTTGAGGCTGTTTCTCAGCAGCT TTGTATATGAATATCATAAAGAGCTTCTGTTCACAGCTTCTTATGTATACACTGGTAACTTGTGTTAAGATAAAAGAAGGCTGCTGTGAA CTCAGTTATAATGTTTTTCTTTCTTCAAACATAGAGAGTAGAATGAAATTGAAGTACTATGAGATTATGCTATTATTTTGTGTATGATTT GTCCAGCCTATATTTAAAGTAGGGAGTAGTTGTCACTATCTGTCGAAAAATTGTACTTGTTCCATAAAGATTTTTTAAAAAGGGAAATTT TAAAATGGCATAGTTCAGACCTGAAATAGTCTGATTTACACAGTGAGCAGTCAAAACTAAGATTTAATGCCGTTTGTTTTGAAATATTAG GATCTTAGAGAGGTAATAACTTTGTTGGCAGTGATCTCTGGAGAGGTAAAGTAGGAATTTGGATATGTACACTTTGGAATCATATGTGAA AGGGCATAAGGATGAAAATAAGGCATTCTCTACCACTGCTAGGCTGAGAAAAAAATCGCTCCTCATAGTCACCTGAAGTTTTTGTCCAAA TTTTTTCTCATACAGCAAAGGCGGGGGAGGAGGCGTGGCAAAGGTAACTTGGAGGAAAAAGTTAAAAGTAAATTGACAACTACTATTTTT AATATCTTGTTTGTTTTATTTTCTTCTAAACTTACACAACAACATACTATTTTTGTTGTTTTCTCTACATTAATGTGATCATACCATACA TACTGGCCTGTAATCTGCTTATTTCACTCAGTAGTAGAAAAAATGTCTTTAATATTCTTTTTAATACCTTTATAGATACCATAACTAATT TAACAATTTCATGGCCAGGCGTAGTGGCACACGCCTATTTCAGCACTTTGGGAGGCCAAGGCGGATGGATCACTTGAGGTCAGGAGTTCA ACACCAGCCTGGCCAACATGGCAAAACCCTGACACTACTAAAAATACAAAAATTACCCAGGTATGATGGTGCACACCTATCATCCTGGCT ACATGGGAGGCTGAGGTGGAAGAATTGTTTGAACCCGGAAGGAGGAGGTTGCTGTGAGCTGAGATCACACCACTGCACTCCAGCCTGGAT GACAGAATGAGACTGTCTCAAAAAAAAAAAGAAAATACTCATTTGGATAGATTGGATAGATTTTTAGACAATTTCTTTTCATTATTATAA ATGTATATCTATATCTTGGTAAAGTTGACCTGTTATTTTTTTAGAATAATTTTTCAGAAGTAAAATTGCTTCCTTTCTGCTGCTTTTTCA TTCACTTATTTAAGCAAGTATTTTTAGATGCCTGCATGTAATGGTGAGCAAAAAGGTGACCCTTTTATAGTTGAGCTTGGATTTTAGTGA TGGTATACAATAAACAAACCAGCTTCTTGAGACGGAGTTTCACTCTTGTTGCCCAGGAAATGGGCAATGGCCTGATCTCGGCTCACTGTA ACCTCCGCCTCCCGGGTTCAAGCAATTCTCCCATCTCAGCCTCCTGAGTAGCTGAGATTACAGGCGCCCGCCACTACGCCCAGTTAATTT TTGGTATTTTTAGTAGAGATGGGGTTTTACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCACCTCAGCCTCC CAAAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCATGAGCAAACTTCTGATGGTGACTGGAAAGTATACAGGATAATGTGGGG AGGCAGTGGTGAAACTACTTTAGAAGAAAGTGTTAGAAGAAAGTGTCATCTGTGTAAGAGAAAACATTTGAGCTGGTACGTGAAGGATTA GAAGGAACCACAAGTGGGCTGAGGGGAGGAATAATAAAGGCAAAGACCCAGAAGGCAAGCACAAACTTGGCATGTTTGAGAAGTTAGAAG TGTGTCATCTGTGTCTCTGTCATGAGGAGTGCTCAAGTTCCCTCTAGGAGCCTTATGGGCTATCTAGCTCTTTTTCTCTTCTGATCATGT GCTTGCTTGCTTTCTTCTTTGCTTATATAGCAGAGTTCACAAATTAAATCTAATGTAGGCTGGTTAATAAAGGAAATGAACATGAATTCA CTGATAGGCTCTTGCATTAATGTGAAAATGTAAAGTCTGTTGTACACCATCAGGCCTTCTAAATGAAGCCCAAATTCTGTAAGGTAGTGA ATTGTAACCTACTGATTAGTACATGATCCATGCCCATTCTGTTATAAGGACTTGCCTTTCTGAGACTTCACCTGTATTATTCCTAAGACT TTTGTGAATAATCCTTAAAGTAGTGACTCCTTACATCTTTCTTTCATTTCTTCTTTGTAGTCACTTGAAATGACAGCATGAACCATCATT TCATTTGAAGGCCTGAGCCTGAATTTTCAAATAGACAAAATGCTCTCTTTCTCCGAAGATTTGCCATGACCTCTGCCTTTGGGAAAAAAT ATTTGAGATTTTAAAATTTTTATTCTGTAGTACAAAAATTATGTTTTTCGTTAATTGGTCCTGTGGAATTGGAAGGAAATTTAATATTTA TTGACTCTACTTTGGTATTATTTTCAGAGTGAGAAGTAACTTTAAGTGTATTAAAATTTCATTCATTTTTGCATGAACCAAACTTTCCCT ACACATCGCTGTCCTTGACTGTCCAGAGTAAACATGTCTAACTCTGGAATGTTTCATTTCCAATAAAAGTATTCAGCCTGTCATTTTGGG CCTAAGTAAAATGGGATAAATTAGCAATCTGAAGTTAGGATCCTAGCCACAGAGGGCCATGTCTCATTTCTGGTTTAAGTGCACCCCTCA TCCCCAGCCCTTACCTTCTTCTTTCTCTTAAGGATTGAGACAATCCTCTTGGTGCTCTTGGTGCAGGTGCATCTTGGTCACCTCTTACAT GAGGGCCACAAACTTGGTAAATGGGTGGCCTGGAGATGGGGTTGTACTAGGTATGTGACCTTGGTGATTGCCTTGTCTCAGTTGTAGTAT ATGGCTGAGTCACATTCATAGTACACTACATACACATACTGACCAAATGCCAATGGCTAAGGCTTGAAATTATTTCACCAAGACCTAAAC TGAAGATTACCATCATAAAATAAGCTTCTAGAATCCATGAATAAGTAGGAAATCATATTTAAAATTTACTGTAATTTTATTAAAGCTCAT TTTTTAAATTTAATGCAGTGCAGAGTCATTAATTTCTCAGCAGTATCAGGTGCTAAATTGCTCACTCATTAAACTACTAATTTAAGATAG TTATTTTAAATTATAGAACAGGAAGCAACTTACGAGGTTGCAACCAAATTATATTTATTTTTTCTCCATTAGTAACTGACTAAAAGTGTT TTCTTCAACTCTGGGATTTGAAGATTTTGTGGTCAGTGGTGATATAATTTCACTGAAGCGTGCTCACAGACTAAAACTGTGCACTACTCA GTGATGCGTCCTGAATGTTTTCAGAGACAAACCTAAGATAATGTTGCCCTTGTTTACTTTCATTATTTCTGATTTTTTTTTTATGCATGT GTTTGCTGCATCACACAATTACTTAAGAAGTTGTCCCTAACCTTTGTGCTGTGGTCTGAATGTTTGTGTCCCCCTGGCCACAAAATTCAT ATGTTGAAATCTGATCATCAGTGTGACAGGATGTGGGGCCTTTGGGAGGTGATTAGGTCATGAGAGTGGAGCCTTCATGAATGGGATTAA TGCCCTCGTAAAAGGGGCCCCAGACAGCCGACTTGCCCCAACCACCACGTGAGGACAAAGCAAGAAGCCACTGTTCATGAACCAGAAAGC AGACCCTCCACAAACACCAAATATGCCAGCACACTGATTGGCTTCCCAGCCTCCAGAACTATAAGCAAGAAGTTTTTTTATAGTAACAAA TTTATTGTTCACAGTTCTTGCTTATAAACTTTATAAACCAGACTAAGGCATTTCGTTATAGCAGCCCACACGGACTCATATTTTGGTTCT AGAAATGTGACACTGGAATGATGTGGCTCTCAAGATGACAGTGTTGCTTCTGAATGTCTATGTTCATGTCATCTTTAATTGCATGAACAC CAGTTTTAGCATCTTCCCTTGAGTAGAAAGAGATTCTCTACAGCAAGTATTACGTAAGAAGTACTGGTGGCCAGGCACAGTGGTTCACGC CTGTAATCCCAACACTTTGAGAGGCGGAGCCAGAGGTATCATTTGAGCCTAGAAGTTCGAGAGCAGCCTGGGCAATATGTCTAAACCCCA TCTCTACAAAAAAAATACAAAAATGAAAAAGCCGGGTGTGATTGTGTACACCTGTAGTCCCAGCAACTTGAGAAGCTGAGGTGGCAGGAT TGCTTGAGCCCAAGGGGAGGGTTGGCGGCAGTGGGTGGTTCGAGGCTGCAGTGAGCCATGATTATACCAGTGCGCTCCAGCCTAGGTGAC AGAGCAAGAGCCGGTCTCGATAATAATTAAGGCCAGACGCGGTGGCTCACTCCTGTGATCCCAGCACTTTGGGAGGCCAAGGTGGATGGA TCACCTGAGGTCAAGAGATTGAGACCAACCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGCTTTGTGG CTCGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCGGGAGAATCGCTTGAACCCAGGAGGCGGAGATTGCAGTGAGCCGAGATCATG CCACTGCACTCCAGCCTGGGCAACAGAACAAGACTCTGTCTCAAAAAAAAAAAAAATTATAATACATTAAAAAAAAAAAGCACTTGCATT CTGAAGGCATATTCACCCTTGAACTGATAGCATTCAATGTATAAAACACATGAGTTTCACTCCAAGTTACATATAGAATGTTTATCTTTA TTTGAGAGGAAATATCCAGTTAATAATCAGAATGTCATACTAATTAGGTATGACCATAACTTACGTTAGTCACATGGTCATTGATTGCAT GCAGATTCTGGCTGCCAGAAAGCACATTGAAGTAGGTAGTCATTTAACCATTTAACTGTTAGATCTTGCAAAGGTTGAAGCTGAAGCTGA GGAGCAGGTAGTACACAACTTTACAGGTTAATGCTGAATGTCAGTTCATTCTGAATTCTTACCTTCAGCCAAAAGGTACAAGGGTCTTTG CAGTCTGAAGCAAGGCCCAGATGGCAGAACTTGTGATGGCTAGGAGGGGAAAATTTGACCTTAACTGGTAGTTGTGGTTTTATCAAGCCA AAAATGCTGACTAGAATAATAATGAGAGCTAATGTTTATTGAAAGCCCATTGTGTACCAGATACTCTGTTTTCTCTAATTCAAACCTCTA AATATTGCTCTTTTAGTCTTCACAGTAATCCTATATCATGATGACCCCCATTTATTGATATGGAAACTGAAGCTCAGGAAAGACAAAGCA ATTTTTACAAACTCACACTACAAGGAAGTAGCAGAGGCCAACATTTAAATCTGGCCCCAGAGTTGTGTTCTTCTCATTAAACTGTGTCTC AGATCTCTCAAATGTGAGTGTGGACTTTTCTAACCAATAGCATTTTTTAATTAATGTTTTAAAAATTTGAATAGCTTTTAGGGTACAGTG GGTTTTTGTTTACATGGATGAATCATACATTGGTGAAGTCTGAGGTTTTAGTGTACCTGTCACCCAGGTAGTATGCATTGTACCCAATGT GTAGTTTTTTATCCCTAGACCCGTTCCCATCCTCCCACTTCTGAGTCTCCAAAGTCCATGATATCACTCTGTATGCCTTTGCATACACAT AGCTTAGCTCCCACTTACAAGTGAGAACATACGGTATTTGGTTTTCTGTTCCTGAGTTACTTTGCTTAGAATAATGGCCTCTGGCTCCAT CATAGTTGCTGCAAAAAGACATTGTTTCTTTTTTTATGGCTGAACAGTATTCCGTGGTGTGTATATATACCACACTTTCTTTGTCCACTC ATTGGTCAGTGGGCACTTAGGTTGGTTCCATATCTTTGCAGTTATGAATTGTGCTGCAATAAATATACACATGCAGATTTTTTTTGATAT ATTGACTTCCTTTGGGTAGATACCCAGTAGTAGGATTGCTGGATCAAATTCTATCCAGTAGCATTTGAAACTGCTTTACATTAACAATGA GGGACAAAAAAAATAACAATGAGGGCTTACATTATGCTACTCTTGATACTAGACATTTTCATATCCATTACTTCATTTAAACTCCACAAC CAAATTACTCAATAGGGATTGTTTTCTTTATTTTTGTAAATGAATGTGGAAACCAGCTCATAAAACTTTAAATTCCTTGCCCCAGTGTCA TAAAATTACTGAGTTTGAGTGGCAGTGCTGAGATTAAAACCTAAGGCTCTAGGATTTCCAGCCCATATTTTTTCTACTGTATCATGTTCT TTCCCAAAGCACTAAAAAACATTTCCTGGGTAAATGACTGTGGGCTTGGGGACACTATGCCCACTTTCTGGCCTTCATGGGTCTAAGTTG CTTCTTTGCTTCTTCACTTTTTCTCTCTGATCCTGCTCAGATTAATCTCTAGTAAATCAGATTTCTTTCCTAGGCTGTCTTATCCCACAT ATATAGTAGATAATATGTCACATATTTGTGAATGTTAAAAATATTTGTTTTAGTTTTAAATCTCAAGCTCACACAGTACTTACTCTCTAT GTTAACAAAAATGGTTTTTACTATTTTCTGAAGGTAACGCAGCTGTTGAAGTGAGATCCTACACTGGAACATACAACACTTGGTCTAATA TTAAAGTTCGTGCCAAGAGCTCTCTAAATGTGATTGATGGATTAATTCTGCCTTTATGAAAGATGAACTTATTTTCAAGATAATAGCTAA TTCTTGAATGGGCAACCTATTATGTATCAATGATTGTAATGATGGAGCATTTTAGTCATTTGTAGCTGGAAGAGCCTTAGAGATTATCTG GTTCAACCTATTCAAGAGTTAGGTAATTTAACCAAATTAACATATGTGGCGATGTGCTCATATAGTGTTCCTTCCACTGTGCTGTGTTGC CGCATATATGCTGATCTTATGTTTATGCAGTAATAGTCTTCATAATGATAAACAGCTACTGGTTCCTGGTAGGATTTTGGACGTGGATAT GACTTGAAGTATGATGCCACAGCCTCAAACAAATCTGGGGTTTGAATCCCAGCTCTGTCACTTATGGACAAATTACTTAACTTCTCCAAG TTTGTTTCCCTAAGTGTAGAATGTGGATAATATCTACTTTAAAGGGCTATTGTAAGCATTAAAATAAGATCATGCGTATAAATTGATGAG ATGGTGGGGAAGAAGAGGCTACCACAAAGTAGGCATTCAGTGTAAATGGTGGTAGTTTCTCCAGTATTATTAGGCTATTTGGTTTCACTT ATAAAATTGCCTTCAAAGAGTTTTTTCATGGCTTTTATGAGTATTATAATATCAGAACTTCCACTCATGCAAATGTAACATTTGTGTGTT AGTCTATTCTATAGCTCTGATCGGAGTCTTTATCTTAAATGGGAAAGATTATTTTCCCTGTCATGTAACTTTAACAGAAAACGATGCTAA AATTAATTTTAAGACTGCTCTATACTATATGTATGTTATACTATATTTTTATATACTATACACAAAAATGTATAAGATGTAAAGCTTGTA TTTTCAAATGTTATTGCAGTATCCAGAACAATTGCGACAATTGCTCTTGGAAGCTTCTGTGCTTTTCCACATGCTGTTCCCTGTCTCTGG AATGGAATGTTCTCTTATTCTGGCTGGCAAACTCCTGAACATAATGTAAACAGTAAGCTCAAACATCACTTGCCCTTTCCTTACCATGCC ATCCTGTTTCTTCTAAACCTTATAAATGCCTTTATTATAGTACATATTGAATCATAATGTAATTATTATTTATCTCTGACTCCTTTGATT CTGGGACTGCCTTGAGGTCACGGTCTAGGTTTATTTCATCTTTCTGTCTGTTTAGTCAAATTTCCTACCCTGTGTAACTCTCAGAATCTT ACTTTAAGTTAGGAAAGGCCAGTGGCTGGACAGATGCTACAGACCTCCATTGGTACAGATGCCCTTAGCTTCATGTTGGGAACAAGTGGT TCTGTTTCTTTTTGTTCCTGTGGAGAAGCATCAGAGATACAGGCAGCTGGGGATTTCTACACCTGTAATAGCAGCAGCTCAGTGATGACA CAGAGACATGTTTTTTTTTTTTTTTTTTTTTTGACAGAAGGCGAAGGGGAAGCAAGGTACTTCTTACATGGCAGAGGGAAAAGGAGAGTT GGAGTGGGGGAGGGGGAGAGGGAGGAGCAGGAGCAGGGAGACGGGGAGGGAGAGGAAACTGCCCCGAAGACATGGTTTCTAAGATTTCTC CCAATGAGACAAATCACTTGTCTGGGATGTCAGGGGGAGAAGATGCAGAATCTGAGCCCCTTGTATAAATAGACAAAAGGTGAAAGCATT GGCAATAGATCAAAAAGGCATTCCACGTAGCAAAAAAATTATTTTTAAATCTGAAAATTTAAGTGAAATGCCAAGAGCAAAGAAGAGAGG CCATCAGAAAAATTTCAAAGTGACTACTCAGGTCATTGTCCTGAAATAAATGATCATTTTATTCTGGTGACTCACCCCTAGCTAGAGTCA GTACTTCATAGAAAAGACAGGAGCTGTGAGACACTTAACTGTAATCTTACCCCTTTACAGAAATGCCTCCTATAGTCAAGCTGGTCTGAT GATCTCATGTCATCATGCACAAGGATTAGCAAGCCTTGAAATTTTATCCTGTCAGTGTAACTCCTCATCTAGTCTCAAGATTGCACTGGC AGTTCTTTCGCAGCTGATCGTACAGGGAGGACCAATAAGGCTCATAGAACACCCTTGGAGAATGAATGCCTCTGCTGCTGGAGGTCACAG CACCCAGAAAGTGACTAGAGGGAGCAGCTGATACCTGCTCTAGTGAGTTGTGCTATTCCTGTCACATCCTTGCAGAGGTCCAAGGGTTGC TGGCAAGTGAAGGAATATCATGCCTGTAGTTTGAAGGATAGATCACTCAACTCTCAACTATTCTCTCTTCAGCTGTGAACCATACAACGT TTTTGAAAAGCAAAGTCTGAACATTTGCATTCTATACAGAATATTACAGTTGGAAAATAGGTGTGGTGTCTAGAGAAATGCTTCTAAATG CTGCAAGCCACCCTATGTGAAGCCTAGTCTAGAAATCTGCTTTGCTTCATTTATTAACTTCATTGTATCTTTGGAAGTAGAAGTTCTTAA AAGTGTGTACAGAAGATGAGTCCTCAGCATGAGTTTCACTGCCTGTCTGTGTGAGAGGAAGTGACCTTGAGAGCAGCTGTAGCCCTAGGG GGACACCCAGGTAGAGGTGCTCACAACATGCTCTGACACCCGGTATGGCTGCATTCCCAGCTTAAATGATCACATCTGCTCTTGGTTTTT TCACTGTTTACAAAATCTGATTTCTTTAAAGGGAAGGGATGGAAAAGGTAGTCAATGCTCCTCTGAGCACCCAAAGCATCCCTCCACAAG AACAAAGAGGAAAAATCATTACTTGCTCCCAACATTACACAAAGCGCATCTCTACCAATGGAACTCTGCAGTGTCGGTCTAGCCATCAGC CTTTCCCACCTCACAGCATATTTTCTGTGGGGGTAATTTATTAGAGGGGAATTTGTTCCTTTTTACTCTTTTTACTCTTCAAATTAGTAA TAGAACCCCTCATGTCATTCTAAGTGACTTAAGTTTTAAAGGGAACCAGAAAAGGAGAGAATATGCTATTGTGGCACTTCTAAAATGCAG AGTGTCCTCAAAGATGGTTATAGTGGGTAATGGGTTTCATATAAATTGCATACTAGAGTATCTCCATTTCCTCTTTTAATTTTTTAATTG GTTTTTTAAAGCTTGATATGCTGAGTTAGTTTTCATTTAAAAACAATGCTTGAGTAGGAAAGTTAAAGAAATAGAAATTGCCTGTTTTAA TCTATTCATCCTGGCAGCAGGTATGTATTGTATCTGTCCAGAGTCCAAAACGTCAGCTCCCTCCACTTGCCTTCCCCATTTCACATAAAC TATAAAAGTTAGAAATAATATATTATGTCATATCCTAACATCAGTTCAATGAATATAGTTTTTAAAATACCTACTATGTGCTAGATACTG AGGACAGAATGATAAAATACAAAACAAAGCTAACTAAAAACACAGTTTAACTAGTCTTGTCTACGATTACCTGCCCTAACTATAACTTCA TTTAAGGGGAGATACTGCTAAAGGGAGTTCCTTCTGTGACTGCACACTCTGATACCAATATGTGACTTCTCCCTGGCTACAACTGATTAA ATGAGGGAAGAAAACTGATCCAAGGGGAGTTAGTCCAATAGCTTGTAAATGGTGGGTTCTTATCAGAGTTTTCTCACTAAGTTAGAACCA AGAGGCTGAGGGTTGTGGGGGCTACTTAAGCAGAAAGTTTCATGGAGTATGGACTGTGCACCATTGTGAAGTTTCCTGTATTTCCACAGG CTGTGGGGGCAGAGAGCATCAGAGTGCTGATCAGGAAAAAAGAATGAGGCAGATGCAGACAGAGAAGCAAAGAAGCATGAGAGGATGAGA ATTAGGAAGTAGACTCTTTTTTCATTTTAATTAATTTGACTAGATTATATTTCTTGCAATCAAAAGGGCCCTGTGCAGAGAAGGTCCTTA TCTTCGTTCATTTTTTGTTGCTATAGCTGAATACCCGAGACTGGGTAATTTATAAAGTAAAGAAATTTATTGCTTACCATTTTAGATGCT GGGAAGTACAAGGTCAAGGGTTCTCATCTAGTGAGGGCCTTCTTGCTAGTGGGGTCTCTGTAGAGTCCTGAGGTAACACAGAGCATCACA TGGTGTGGGGGTGGGATTCACCAGAGAGAGCCAAACTGACTTTTATAACAGACTCACTTTTGTGGTAACTAACCCACTCCCTTGATAGCC CATCAATCCATTAATCTAGAAATAAATTCATTCACTCATGAGGGCAGAGCTCTTGTGAACCAATCACCTCCCAGAAGTCCCACCTCTCAA CACTGCTGCACTGGGGACCAAATTTCCAACACATGAACTTTTCGGGGACACATTCAAGCCACAACAGTCCTCAATAAATATTTGTTGAAT CAATAAATACACAGGACATAGTGTCCTAAATGCTTGGCATGTACATGAACCAGATTTGGTCCTTGATGTCACAGAGCTTATAATATAGTG GAGGAGACAGACTTTACATGTTTGATCTTGACTGTAAAACTAGGGTCACTACTCATCATCTGATGAAGGAGGCAGACAGTAAAACAAATA ACAACTATTCAACATGGTAACGTCAAAACTGAACAGAGGCTCAAGTGAAAGTTTCAATGATAGTAACCATGGCCAATGGATAGGTGAATG CATTGGAAAATTAGTATGATGCCATTAGCAAAAACATAAATTGCACTTAACTAAAGTTCATCTGGCTGAATTCTTTCCTTCCTTCCTTCC TTCCTTCCTTCCTTCCTTCCTTTCTTCCTCTATCTTTCTTTGGTTTTGAGATCTGTCTATAGTATTGTGCTAGTGCACATATTTTAATTT GGTGCAAGGCATGCTTAACAGAGTAAGTGAAAAGCTATAAAGGTTAGAGCGTGTATTAGTTTCAATGACGAAGGAGTAATAAATCATTTT GTCAGGTTGCACTCTAACATTCAAATTCCATTTTTATTATGGCTAACTAGCCAAGCATTTATAATTCTGAACTCCACAGAATGGGGAAAA AGTGTATTAACTTATAATAGATCATTGAGCTTGTTAAATGTACCTTTCCTAATTCGTACTTTTTCCCTTTTGCTGAGAAAAATGCCTTTC TGAATATATAATTTTTACAGGTCATTGGAAAGGAGTACTGCACAACAGGATTATTATAATGTGCTAAAAGATGGCACTTGTATCTCATTG CCACATAGAGAGCTCATGTGAAAACTCTTTGATCTTTGCTGGCTTTTTAGCTGAAAAGATTTGGAAATCTTTTTGGCACTGGCAAAAACA GAACTGTGGTAACTGTTTATAGTTGGTTGATTTTTAGCAATGGGTAAGAATGTCTTTGTTGAATCCAGTTTATTAATACGTAATGGGCAA CATGTTGCCTTAAAGGCAAAAGCATATTTTTCTCATATCAAAAAGCTCCCTAAATTTTTGCCAATATCCAAAGATATTTTAAGATGGTCT TCATTTTCTTTTTCAGTCTGTCCTATGCTGAGAAAAAAAAATTACAACCTCTGAACTTCAGCAGTTTTTTAGGTAAAAGGAATTTTTCAT GATGTGATTGATATAACTACTCAGCTGGACATAAGCTTTCAAGGGCTAAGTCCATTTGCCGATTTGTTTGCATTTCCTACTCCAACTAAA ATAATTCAAAGACATGAAGTGTCTATTGTGGAAAATGCATGAATAATGCAAAAGTCATTCTCAAGTGACCTATCAGAAAGGCCTACCAGA AATGCAGTTACTGCTTTCTAATAAAATCATGAAAAACTTTTTTAAAAAGTATAACCATCTTGAATTTGTTGAGGCAATTATAAGAGAGTA TATAAGGGCAAGTTTCTCCAAAAGCGGTTCTGTTTGTTTTGTTTTTTTTTAATAATTCCCATCAACAGCAATCTGTTTTCTCATTGTAGT AGTATAGGTGTTAACATAAAAGCTCAAACAGCTTGGGAGAAAAAAAAGGATATAGCAAACCTAACTGATAACTTTGCTAGTTTCAAATCA TTATGATGGCCATTCATAGATGACTGAAATATTTAACATTTGAAGTAACAGAATTTTGACTTATGTTTTCATGGTTTAAGAGTTTATATT TCAAATTTTTTCACATAGTCTGTTTATAACAGTATATAAAACATGTATTAACTATATAAGTTAATAAAGTCATGAACTGATGGCCATTTT TTGGTCTTATTCATATAGTATAGGCTGTTTTGTGAATTAATCCCCTTCCCATGTGTTTGAATTCCCCACTATGTAAGGCTTAGTGGTGTT AGCATGATCCAAGGGTGGGATTTTCAGCCCTCTGACATCAAAAGGTGAAGCAGAGGACACAAAAACCCTCACTGCATCTTCCCTAGACTG GCCAGAACCACTCCATGGTCAGTGGACTCCCTTAATAGGAAGGAATGCTGGTCAGTTGTCAAAGAGCAAAAAGGGAGGGGTAGTCATGAG GTTGGTTGTAATCAGAGGTGCAACAGGTCTTTCCAAAGGGCTGGTTTCTGTTTAACTCTTAGGAAAGAACACCTAATGGTAGTTAGTGAG GAGGGGGTATAATGAGATGTGCCCAACCTCCCATCCCATCATGGCCGGGAACTCAGTTTTTAAGGTTTCCCTGAAGTCCTCTTGGCCAGG AGAGGGTCTGTTTAGTCAAATGTGGGGGGGGAGCTTAGGATTTTATTTTTATTTCCAAGTTATAATGTTGGACCATCAGAGCATGAATAC AGGTTGAGTCTTTAATCTGTAAATACTTAGCAATCACCTTCTTCTCAGTAACTTTCTCTGAAGGTTGCTGATAAGCCAGTGTTCTTGATG TTTGCCCACTTACCCCTCAAGATGAGGAGTGAAGAAATTAGATTGCATTGCCAGGAATTTCCTAGAAGAAAAGGTTTTGAGGATGCATGA CCTATGAGGGTGCTGAGGACCCCTTTCCACCAAACATGGACTAACTTCTGGGTTGCTCTTTCACATCTATTGTCTTGTTCGACGTACACA GAAGTGCAGAGCACAGCCGCAGCCCTCACAGCATCATCTATCTAGGTTCTGAATCCTGAATGGTCTGAGGCTCTCCTAGAGCTGAGATTC TCCTTTGCAGTTCCAGTGGAGAAAAGCACTTTCTTTGCCGAGGCAGTGTAACTTCCTTGTTCCCAAGGCTCCAACTGTTGTGGGCACATA TGAGTATACATTAACATCCATGCCCAATTTATAATCACTGTTTTCCCCACATGTGTACTCAGACCTCCAAGCTTCTGAAAAATATTTCCT CTCATCTCTCAAAGAATTTTAGTACATTTGCCTGGATGCAGAAACACAAATCATGCTGGCTTTCCTACTCAATCAAAAACTGTAGCTTGA GTGGGGTGGCAAGGGTTGTCCCACAGCAGGTTTACTTGGACTCCAAAATGATGTAGAGTTTAGTGAGGCAGCTCCTTGAGTTTGAACTTA GAGCCCTTTTGGCTACCAGGGCACCTGCAGTCCTCCAAGATAGTAGAGTCTGAACCAGTTAAAGAGCCAGCTACCACAGCTTTGCAGAAA CCACTGTTTCTCCTTAACTCTAGGGCTCAGCGGTTGAACTCCTTAGAATAAAACTTTCTGTCTGCGACCCTATCATTTTCTTTTGTATTT TGGCCTTCACTGAATTCCCACCCCATCCATTCCAACAGACTTGGTTATACGTGTCTGAACACCAAATGTGACAGAATTTGTGGCCTTGGA TCAGGAGGCTATTTGGCCCTTATCTAAATCGGTGGCTGAGAATGGATTCCAGGGAAGTGTTTTTCTTAGGAGTACCCAAGAAGCTCAGCT CAGGTTGGGCTCCCTGTTCTATTCTGAGAACTACAAATCAAATTCAAAATGGAGCACAGAAAATTCTCATTTCTAGTTGACTTATTTGTA TTTTGGTGTCCTGTGCCCTAAATATCTTCTCAAGGAAACCTTGGCTTTAAAAGTGATTGTTTACTTAAACAAATAAAACAACAACATACA AGAAAAGGCAGTAAATCCGAGCGTCCATCAACAAATGAATCAAAAAACAAATGAGATATATATGTACGGTGGCATATTATTCAGCCTTAA AAAGGAAAGAAATTTTGACACATGAGACAATATGAATGAACCTTGAAGACATTAATTATGCTGAGTGAAATAAGCCAGCCACAAAAGAAC AGATATTGTATAATTCCTCTTATATTAGGTACCTAAAATAGTCAAATTGATAGAAAGTAGAATGTTGGTTGGCAGGGGCTGGCAAGGAGA GGGAAATGAAGAGAAGGTGTATGAAGGGAACAGAGTTTCAGTTGGGGAAGACGAAAAAGTTCTGACAGTGGATGATGGTGGTTGTTGCAC AGCAACATGAATGTACTTAATGCCACAGAACTGTATGCTTAAAAATGGTTGAAACGGTAAATTTGATATAATGTGTATTGAACCTATTTC >In-frame_NUP35_ENST00000295119_chr2_183989225_+_NCKAP1_ENST00000360982_chr2_183853914_-_3565nt ACGCAACCCCATAAGGTAGCACGCCGTTACCCGTGGGGAGCGTTTCCGCCATTTTTGAAAATTAATTGGGAAGGTACTGGTTTTAAGTGT AGTTGCCGACGCAATGGCAGCCTTTGCAGTGGAACCTCAGGGGCCCGCGTTAGTTGGCTTTATTTTGTGCCATGGGATCCTAAATACTGA CGCTACAGCACTGAACCTTTGGAAACTAGCTCTTCAAAGTAGCTCTTGCCTCTCTCTCTTTCGGGATGAAGTTTTCCACATTCACAAAGC TGCAGAAGACTTATTTGTAAACATACGAGGCTATAATAAACGTATTAATGACATAAGAGAATGCAAGGAGGCAGCCGTGTCACATGCTGG TTCAATGCACAGAGAAAGACGCAAGTTTTTAAGATCTGCACTGAAGGAATTGGCTACTGTCCTCTCTGATCAACCTGGATTGCTAGGTCC CAAGGCACTTTTTGTTTTTATGGCATTATCCTTTGCCCGTGATGAAATCATCTGGCTACTTCGTCATGCAGATAACATGCCAAAGAAGAG TGCAGACGACTTTATAGATAAGCACATTGCTGAATTAATATTTTACATGGAAGAACTTAGAGCACATGTGAGGAAATACGGACCTGTAAT GCAGAGGTATTACGTGCAGTACCTTTCTGGCTTTGATGCTGTTGTCCTCAATGAACTCGTGCAGAATCTTTCTGTTTGCCCTGAAGATGA ATCAATCATCATGTCCTCTTTTGTTAACACTATGACTTCCCTAAGTGTAAAACAAGTTGAAGATGGGGAAGTATTTGATTTCAGAGGAAT GAGATTAGATTGGTTTAGGTTACAGGCATATACTAGTGTCTCAAAGGCTTCACTTGGCCTTGCAGATCACAGAGAACTTGGAAAGATGAT GAATACAATAATTTTTCATACAAAAATGGTAGATTCCTTGGTGGAAATGTTGGTGGAAACATCAGATCTCTCCATATTTTGTTTTTATAG TCGTGCTTTTGAGAAGATGTTTCAACAGTGTTTGGAGTTACCCTCTCAATCAAGATACTCAATTGCATTTCCACTACTTTGCACTCATTT TATGAGTTGCACGCATGAACTATGTCCAGAAGAGCGACATCATATTGGAGATCGCAGTCTTTCCTTATGTAATATGTTCCTAGATGAAAT GGCCAAACAAGCTCGAAATCTCATCACTGATATTTGCACAGAACAGTGTACCCTTAGTGACCAGTTGCTACCCAAGCATTGTGCCAAAAC TATCAGTCAAGCAGTGAATAAGAAATCAAAAAAGCAGACTGGTAAGAAAGGGGAACCTGAAAGGGAGAAACCAGGTGTTGAGAGCATGAG GAAAAACAGGCTGGTTGTGACCAACCTTGATAAATTGCACACTGCACTTTCTGAGTTATGCTTCTCTATAAATTATGTACCAAACATGGT GGTATGGGAACATACCTTTACCCCACGAGAATATTTGACTTCTCATCTGGAAATACGCTTTACCAAGTCAATTGTTGGGATGACTATGTA TAATCAAGCCACACAGGAAATTGCAAAACCTTCAGAACTTCTAACAAGTGTAAGAGCATACATGACCGTACTCCAGTCAATAGAAAACTA TGTGCAGATTGATATTACAAGAGTATTTAATAATGTGCTTCTTCAACAAACACAACATTTAGACAGTCATGGAGAGCCAACCATTACAAG TCTATACACAAATTGGTATTTGGAAACTTTGTTACGACAAGTCAGCAATGGCCATATAGCATATTTTCCTGCAATGAAAGCGTTTGTGAA CTTACCTACAGAAAATGAATTAACATTCAATGCAGAGGAATATTCTGACATATCAGAAATGAGGTCATTATCAGAACTACTAGGCCCATA TGGTATGAAGTTTCTAAGTGAAAGCCTTATGTGGCATATTTCATCACAAGTTGCTGAACTTAAGAAACTTGTGGTGGAGAATGTTGATGT GTTAACACAAATGAGGACCAGCTTTGACAAACCAGACCAGATGGCTGCACTGTTTAAAAGATTATCATCTGTTGACAGTGTCTTGAAGAG GATGACAATAATTGGTGTAATTTTATCCTTCCGATCATTGGCACAAGAAGCACTTAGAGATGTCTTATCCTACCACATTCCTTTTCTTGT AAGTTCAATTGAAGATTTTAAGGATCACATTCCAAGGGAAACTGATATGAAGGTTGCAATGAATGTGTATGAGTTATCATCAGCTGCCGG ATTACCTTGTGAGATTGATCCTGCATTGGTCGTAGCTCTTTCTTCACAAAAATCGGAAAACATTAGTCCAGAAGAAGAGTATAAAATTGC CTGCCTTCTCATGGTGTTTGTGGCAGTTTCTTTGCCAACACTGGCCAGTAATGTGATGTCTCAGTACAGCCCTGCTATAGAAGGGCATTG CAACAACATACATTGCTTGGCCAAAGCCATCAACCAGATTGCTGCAGCTTTGTTTACAATTCACAAAGGAAGCATTGAAGACCGTCTTAA AGAATTTCTGGCGCTTGCATCCTCCAGTCTACTGAAAATTGGCCAGGAGACAGATAAAACTACAACAAGAAATAGAGAATCTGTTTATTT ACTGCTAGATATGATTGTACAAGAATCTCCATTCCTTACAATGGATCTTTTGGAATCTTGTTTTCCTTATGTCTTGCTGAGAAATGCATA CCATGCTGTCTACAAACAAAGTGTTACATCTTCTGCATAAAATTACCTACTTAATCAAGATAAGCACGCATTTTTGTTGCCTTGGTTTTA CCTGTAGACTGTGGAACTATTTTACCTTAAGACCTGAAAAAGTTTTGTGGATTATAAATTTCTTTCATACGGTTGTATTTTCTGATCATT GGTTTCTTAATATGGTTGTACTACAGTATACTTGGTTGATTTAGGTTGCACATTCACTGAATTCACTGAGATTATTCCTATAATTTTAAA GTATCATTTATTTGAAAAACATACATTATCAACATGTTTTTGATATTTGATAATGAAAAAAATCTTTGCTTGTTTATTTCTGAAAAAGAA CTGTATTTAGTGATTATTTTAGATAGTGATATTATAGTATTCATCTGTGTGTAAATTATTTCATATAGGGAAGAGTTCTGATCTGTACCT ATGGTTCTTATTGAAAACAACATTGGATGTGCATTTCTGTGATGTTATGAATACATTTCTACTTTATTTTGAAACATTTGCCAAACTAAA TACTGTAACACTGTATAACATTTAAAAATGTTAAAGAACTGCTTAGTATTAGAAGCAGATCATTTCCCAAAATTCTAAGAGCAGCAGCAT ATGTTGTTGCTTGTATAAAGCCTAGCGATAATTTTTAGACTAACTTCCATGGTGCCCTGTTGGCATTAGCACTACCATTGTACCCTGCTG TATAATAAACAATCTTAGACATTTATCAACTGTTGATACAAATGTTAGTCCCTAACCACTTTTTATATATGTTTTAAATTTTTGAAATTC |
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FusionGenePPI for NUP35_NCKAP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NUP35 | ILF3, MMS19, FAM96B, CIAO1, KCTD9, CUL7, OBSL1, HOXB5, XRCC6BP1, TRPV5, C16orf70, RNF166, GLRA2, CYP1A1, IFI16, PRKDC, SYNE1, PDZD2, HIVEP3, ESYT1, NUP93, RANGAP1, EPB41L2, PEX14, AHCTF1, MLLT4, TMEM201, NUP205, GLE1, TMEM214, ACBD3, LEMD3, DDX19B, GOLGB1, NDC1, NUP50, EMD, MAVS, NUP88, NUP54, PGRMC2, POM121, NUP155, TMPO, RANBP2, NUP188, NUPL2, NUP98, NUPL1, NUP153, NUP214, NUP62, TMEM216, KPNB1, UBE2I, NUP107, SEH1L, FAM136A, WDYHV1, KCNJ5, USP47, SNRNP27, ALG12 | NCKAP1 | ABI1, YWHAB, YWHAZ, DNMBP, RAC1, RYK, SIRT7, SPP1, GRB2, GAS7, BRK1, ACTA1, CAP2, CDKN2A, CYFIP1, CLUH, MCM4, HUWE1, ZNF511, UBXN11, DTNBP1, NCK2, BAIAP2, HSPB9, CYFIP2, ETF1, ACTG1, WASF1, WASF2, NTRK1, CEP152, CEP128, TMEM17, TCF4, ZNF746, ABI2, AMZ1, IKBIP, TIMM50, WASF3, NHSL2, CBLC, KIAA0355, C10orf88, HOMER3, CGB2, COG6, GJB7, NYAP1, NYAP2, MYO16, CDH23, NXN |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NUP35_NCKAP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NUP35_NCKAP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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