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Fusion gene ID: 25218 |
FusionGeneSummary for NUP210_MAST1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NUP210_MAST1 | Fusion gene ID: 25218 | Hgene | Tgene | Gene symbol | NUP210 | MAST1 | Gene ID | 23225 | 23332 |
| Gene name | nucleoporin 210 | cytoplasmic linker associated protein 1 | |
| Synonyms | GP210|POM210 | MAST1 | |
| Cytomap | 3p25.1 | 2q14.2-q14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear pore membrane glycoprotein 210nuclear envelope pore membrane protein POM 210nuclear pore protein gp210nucleoporin 210kDanucleoporin Nup210pore membrane protein of 210 kDa | CLIP-associating protein 1multiple asters 1multiple asters homolog 1protein Orbit homolog 1 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q8TEM1 | Q9Y2H9 | |
| Ensembl transtripts involved in fusion gene | ENST00000254508, ENST00000485755, | ENST00000251472, ENST00000591495, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 5 X 5 X 5=125 |
| # samples | 6 | 6 | |
| ** MAII score | log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/125*10)=-1.05889368905357 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NUP210 [Title/Abstract] AND MAST1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MAST1 | GO:0051294 | establishment of spindle orientation | 21822276 |
| Tgene | MAST1 | GO:0051301 | cell division | 21822276 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCS | TCGA-N5-A4RA-01A | NUP210 | chr3 | 13418956 | - | MAST1 | chr19 | 12962748 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000254508 | ENST00000251472 | NUP210 | chr3 | 13418956 | - | MAST1 | chr19 | 12962748 | + |
| In-frame | ENST00000254508 | ENST00000591495 | NUP210 | chr3 | 13418956 | - | MAST1 | chr19 | 12962748 | + |
| intron-3CDS | ENST00000485755 | ENST00000251472 | NUP210 | chr3 | 13418956 | - | MAST1 | chr19 | 12962748 | + |
| intron-3CDS | ENST00000485755 | ENST00000591495 | NUP210 | chr3 | 13418956 | - | MAST1 | chr19 | 12962748 | + |
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FusionProtFeatures for NUP210_MAST1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NUP210 | MAST1 |
| Nucleoporin essential for nuclear pore assembly andfusion, nuclear pore spacing, as well as structural integrity.{ECO:0000269|PubMed:14517331}. | Appears to link the dystrophin/utrophin network withmicrotubule filaments via the syntrophins. Phosphorylation of DMDor UTRN may modulate their affinities for associated proteins (Bysimilarity). {ECO:0000250|UniProtKB:Q9R1L5}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >MAST1 | chr3:13418956 | chr19:12962748 | ENST00000251472 | + | 6 | 26 | 374_647 | 258 | 1571 | Domain | Protein kinase |
| Tgene | >MAST1 | chr3:13418956 | chr19:12962748 | ENST00000251472 | + | 6 | 26 | 648_719 | 258 | 1571 | Domain | Note=AGC-kinase C-terminal |
| Tgene | >MAST1 | chr3:13418956 | chr19:12962748 | ENST00000251472 | + | 6 | 26 | 967_1055 | 258 | 1571 | Domain | PDZ |
| Tgene | >MAST1 | chr3:13418956 | chr19:12962748 | ENST00000251472 | + | 6 | 26 | 380_388 | 258 | 1571 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NUP210 | chr3:13418956 | chr19:12962748 | ENST00000254508 | - | 9 | 40 | 486_491 | 384 | 1888 | Compositional bias | Note=Poly-Ser |
| Hgene | >NUP210 | chr3:13418956 | chr19:12962748 | ENST00000254508 | - | 9 | 40 | 1830_1887 | 384 | 1888 | Topological domain | Cytoplasmic |
| Hgene | >NUP210 | chr3:13418956 | chr19:12962748 | ENST00000254508 | - | 9 | 40 | 27_1808 | 384 | 1888 | Topological domain | Lumenal |
| Hgene | >NUP210 | chr3:13418956 | chr19:12962748 | ENST00000254508 | - | 9 | 40 | 1809_1829 | 384 | 1888 | Transmembrane | Helical |
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FusionGeneSequence for NUP210_MAST1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NUP210_ENST00000254508_chr3_13418956_-_MAST1_ENST00000251472_chr19_12962748_+_1697aa MAARGRGLLLLTLSVLLAAGPSAAAAKLNIPKVLLPFTRATRVNFTLEASEGCYRWLSTRPEVASIEPLGLDEQQCSQKAVVQARLTQPA RLTSIIFAEDITTGQVLRCDAIVDLIHDIQIVSTTRELYLEDSPLELKIQALDSEGNTFSTLAGLVFEWTIVKDSEADRFSDSHNALRIL TFLESTYIPPSYISEMEKAAKQGDTILVSGMKTGSSKLKARIQEAVYKNVRPAEVRLLILENILLNPAYDVYLMVGTSIHYKVQKIRQGK ITELSMPSDQYELQLQNSIPGPEGDPARPVAVLAQDTSMVTALQLGQSSLVLGHRSIRMQGASRLPNSTIYVVEPGYLGFTVHPGDRWVL ETGRLYEITIEVFDKFSNKVYVSDAYERSESLEVAFVTQLVKKLLIIISRPARLLECLEFNPEEFYHLLEAAEGHAKEGHLVKTDIPRYI IRQLGLTRDPFPDVVHLEEQDSGGSNTPEQDDLSEGRSSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRN QIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLL ITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEE LFGQVISDDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAEFIPHLESEDDTSYFDTRSDRYHH VNSYDEDDTTEEEPVEIRQFSSCSPRFSKVYSSMEQLSQHEPKTPVAAAGSSKREPSTKGPEEKVAGKREGLGGLTLREKTWRGGSPEIK RFSASEASFLEGEASPPLGARRRFSALLEPSRFSAPQEDEDEARLRRPPRPSSDPAGSLDARAPKEETQGEGTSSAGDSEATDRPRPGDL CPPSKDGDASGPRATNDLVLRRARHQQMSGDVAVEKRPSRTGGKVIKSASATALSVMIPAVDPHGSSPLASPMSPRSLSSNPSSRDSSPS RDYSPAVSGLRSPITIQRSGKKYGFTLRAIRVYMGDTDVYSVHHIVWHVEEGGPAQEAGLCAGDLITHVNGEPVHGMVHPEVVELILKSG NKVAVTTTPFENTSIRIGPARRSSYKAKMARRNKRPSAKEGQESKKRSSLFRKITKQSNLLHTSRSLSSLNRSLSSSDSLPGSPTHGLPA RSPTHSYRSTPDSAYLGASSQSSSPASSTPNSPASSASHHIRPSTLHGLSPKLHRQYRSARCKSAGNIPLSPLAHTPSPTQASPPPLPGH TVGSSHTTQSFPAKLHSSPPVVRPRPKSAEPPRSPLLKRVQSAEKLGASLSADKKGALRKHSLEVGHPDFRKDFHGELALHSLAESDGET PPVEGLGAPRQVAVRRLGRQESPLSLGADPLLPEGASRPPVSSKEKESPGGAEACTPPRATTPGGRTLERDVGCTRHQSVQTEDGTGGMA RAVAKAALSPVQEHETGRRSSSGEAGTPLVPIVVEPARPGAKAVVPQPLGADSKGLQEPAPLAPSVPEAPRGRERWVLEVVEERTTLSGP >In-frame_NUP210_ENST00000254508_chr3_13418956_-_MAST1_ENST00000591495_chr19_12962748_+_606aa MAARGRGLLLLTLSVLLAAGPSAAAAKLNIPKVLLPFTRATRVNFTLEASEGCYRWLSTRPEVASIEPLGLDEQQCSQKAVVQARLTQPA RLTSIIFAEDITTGQVLRCDAIVDLIHDIQIVSTTRELYLEDSPLELKIQALDSEGNTFSTLAGLVFEWTIVKDSEADRFSDSHNALRIL TFLESTYIPPSYISEMEKAAKQGDTILVSGMKTGSSKLKARIQEAVYKNVRPAEVRLLILENILLNPAYDVYLMVGTSIHYKVQKIRQGK ITELSMPSDQYELQLQNSIPGPEGDPARPVAVLAQDTSMVTALQLGQSSLVLGHRSIRMQGASRLPNSTIYVVEPGYLGFTVHPGDRWVL ETGRLYEITIEVFDKFSNKVYVSDAYERSESLEVAFVTQLVKKLLIIISRPARLLECLEFNPEEFYHLLEAAEGHAKEGHLVKTDIPRYI IRQLGLTRDPFPDVVHLEEQDSGGSNTPEQDDLSEGRSSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NUP210_ENST00000254508_chr3_13418956_-_MAST1_ENST00000251472_chr19_12962748_+_5091nt ATGGCGGCGCGGGGCCGGGGGCTGCTGCTGCTGACGCTGTCGGTGCTGTTGGCGGCGGGCCCCTCCGCCGCTGCGGCCAAGCTCAACATC CCCAAAGTGCTGCTGCCCTTCACGCGGGCCACGCGCGTTAACTTCACGCTGGAGGCCTCGGAGGGCTGCTACCGCTGGTTGTCCACCCGG CCGGAGGTGGCCAGCATCGAGCCGCTGGGCCTGGACGAGCAGCAGTGCTCCCAGAAGGCAGTGGTGCAGGCCCGCCTGACCCAGCCTGCC CGCCTCACCAGCATCATCTTCGCAGAGGACATCACCACAGGCCAGGTCCTGCGCTGTGATGCCATTGTGGACCTCATCCATGACATCCAG ATCGTCTCCACCACCCGCGAGCTCTACCTGGAGGACTCCCCCCTGGAGCTGAAGATCCAGGCCCTGGACTCCGAAGGGAACACCTTCAGC ACTCTGGCTGGACTGGTCTTCGAGTGGACGATTGTGAAGGACTCCGAGGCGGACAGGTTCTCAGACTCCCACAATGCGCTGCGAATCCTC ACTTTCTTGGAGTCTACGTACATCCCTCCTTCTTACATCTCAGAGATGGAGAAGGCTGCCAAGCAAGGGGACACCATCCTGGTGTCTGGG ATGAAGACCGGGAGCTCCAAGCTCAAGGCTCGCATCCAGGAGGCTGTCTACAAGAATGTACGCCCTGCAGAAGTCAGGCTGCTGATTTTG GAAAACATCCTTCTGAACCCGGCCTATGACGTCTACCTGATGGTGGGAACCTCCATTCACTACAAGGTGCAGAAGATCAGGCAAGGGAAA ATTACAGAACTCTCCATGCCTTCCGATCAGTACGAGTTGCAGCTTCAGAACAGCATCCCGGGCCCCGAAGGAGACCCAGCCCGGCCGGTG GCTGTCTTGGCCCAGGACACGTCGATGGTCACTGCACTGCAGCTGGGACAGAGCAGCCTCGTCCTTGGCCACAGGAGTATTCGCATGCAA GGTGCTTCTAGGTTACCCAACAGCACTATCTACGTGGTCGAACCTGGATACCTAGGGTTCACTGTTCACCCTGGTGACAGGTGGGTGCTG GAGACCGGCCGCCTGTATGAAATCACCATCGAAGTTTTTGACAAGTTCAGCAACAAGGTCTATGTATCTGACGCCTATGAACGCTCTGAG AGCTTGGAGGTGGCCTTCGTTACTCAGCTGGTGAAGAAGTTGCTTATTATCATCTCACGCCCTGCGAGGCTGCTGGAGTGCCTGGAATTC AACCCCGAGGAGTTCTACCACCTGCTGGAGGCGGCCGAAGGACACGCCAAGGAGGGCCACCTTGTGAAGACGGACATCCCCCGCTACATC ATCCGCCAGCTGGGCCTCACCCGTGACCCCTTTCCAGATGTGGTGCATCTGGAGGAACAGGACAGTGGTGGTTCCAACACCCCTGAGCAA GACGATCTCTCTGAGGGCCGCAGCAGCAAGGCCAAGAAACCGCCGGGGGAGAATGACTTCGATACCATCAAGCTCATAAGCAACGGTGCC TACGGCGCTGTCTACCTGGTGCGGCACCGCGACACGCGGCAGCGCTTTGCCATGAAAAAGATCAACAAGCAGAACTTGATCCTCCGCAAC CAGATCCAGCAGGCCTTTGTGGAGCGCGATATCCTCACCTTCGCCGAGAACCCGTTTGTGGTCGGCATGTTCTGCTCCTTTGAGACTCGG CGCCACCTCTGCATGGTCATGGAATATGTGGAAGGCGGCGACTGTGCCACCCTGCTGAAGAATATTGGAGCGCTGCCCGTAGAGATGGCC CGCATGTACTTTGCTGAGACGGTGCTAGCCCTGGAGTATTTGCACAACTATGGCATCGTGCACCGCGACCTCAAGCCTGACAACCTCCTT ATCACCTCCATGGGTCACATCAAGCTCACAGATTTCGGCCTCTCCAAGATGGGGCTCATGAGCCTCACCACCAACTTATATGAAGGCCAC ATCGAGAAGGACGCCCGAGAGTTCCTGGACAAACAGGTGTGTGGGACCCCAGAGTACATCGCGCCCGAGGTCATCCTGCGTCAAGGCTAC GGCAAGCCAGTGGACTGGTGGGCTATGGGGATCATCCTCTACGAGTTCCTGGTGGGCTGTGTGCCCTTCTTCGGAGACACACCAGAGGAG CTATTTGGACAGGTCATCAGTGATGACATCCTGTGGCCCGAGGGGGATGAGGCCCTACCTACGGAGGCCCAACTCCTCATATCCAGCCTC CTGCAGACCAACCCTCTGGTCAGGCTTGGGGCAGGCGGCGCTTTTGAGGTGAAGCAGCACAGTTTCTTTCGAGACCTGGACTGGACAGGG CTGCTGAGGCAGAAGGCCGAGTTCATCCCCCACCTAGAGTCGGAAGATGACACTAGCTACTTTGACACCCGCTCAGACAGGTATCACCAC GTGAACTCCTATGACGAGGATGACACGACGGAGGAGGAGCCCGTGGAAATCCGCCAGTTCTCTTCCTGCTCTCCGCGCTTCAGCAAGGTG TATAGCAGCATGGAGCAGCTGTCGCAGCACGAGCCCAAGACCCCAGTAGCAGCTGCAGGGAGCAGCAAGCGGGAGCCGAGCACCAAGGGC CCCGAGGAGAAGGTGGCCGGCAAGCGGGAGGGGCTGGGCGGCCTGACCCTGCGTGAGAAGACCTGGAGAGGGGGCTCTCCGGAGATCAAG CGATTCTCCGCGTCCGAGGCCAGTTTCCTGGAGGGAGAGGCCAGTCCCCCTTTGGGCGCCCGCCGCCGTTTCTCGGCGCTGCTGGAGCCC AGCCGCTTCAGCGCCCCCCAAGAGGACGAGGATGAGGCCCGGCTGCGCAGGCCTCCCCGGCCCAGCTCCGACCCCGCGGGATCCCTGGAT GCACGGGCCCCCAAAGAGGAGACTCAAGGGGAAGGCACCTCCAGCGCCGGGGACTCCGAGGCCACTGACCGTCCACGCCCAGGTGACCTC TGCCCACCCTCGAAGGATGGGGATGCATCAGGCCCAAGGGCTACCAATGACTTGGTTCTGCGCCGGGCGCGGCACCAGCAGATGTCAGGG GATGTGGCAGTAGAGAAGAGGCCTTCTCGAACTGGGGGCAAAGTCATCAAATCAGCCTCAGCCACTGCCTTATCTGTCATGATTCCTGCA GTGGACCCACATGGAAGTTCACCCCTTGCTAGTCCCATGTCTCCACGATCTCTGTCCTCCAACCCATCCTCACGGGACTCCTCACCCAGC CGGGACTACTCACCAGCTGTCAGTGGGCTCCGCTCCCCCATCACCATCCAGCGCTCGGGCAAGAAGTATGGCTTCACACTGCGTGCCATC CGTGTCTACATGGGTGACACGGATGTCTATAGTGTCCACCACATTGTCTGGCATGTGGAGGAAGGAGGCCCAGCCCAGGAGGCAGGACTC TGTGCTGGGGACCTCATCACCCACGTGAATGGGGAGCCTGTGCATGGCATGGTGCATCCTGAGGTCGTGGAGCTGATCCTTAAGAGTGGC AACAAGGTAGCAGTGACCACAACGCCCTTCGAAAATACCTCTATCCGCATTGGTCCCGCAAGGCGCAGCAGCTACAAGGCTAAAATGGCT CGGAGGAACAAGCGACCCTCCGCCAAGGAGGGCCAGGAGAGCAAGAAGCGCAGCTCCCTCTTCCGGAAGATCACGAAGCAGTCGAACCTG CTGCATACTAGCCGCTCGCTGTCGTCGCTGAACCGCTCGCTGTCATCCAGCGATAGTCTCCCGGGCTCGCCTACGCACGGGCTGCCGGCG CGCTCGCCCACGCACAGCTACCGCTCCACGCCTGACTCCGCCTACCTAGGCGCCTCATCCCAGAGCAGCTCCCCAGCCTCGAGCACGCCC AACTCGCCTGCGTCGTCGGCGTCGCACCACATTCGGCCCAGCACGCTGCACGGACTGTCGCCAAAGCTCCATCGCCAGTACCGCTCTGCG CGATGCAAGTCGGCCGGCAACATCCCTCTATCGCCGCTGGCACACACGCCGTCCCCCACGCAGGCGTCACCGCCGCCACTGCCGGGCCAC ACGGTGGGCAGCTCGCACACTACTCAGAGCTTCCCGGCCAAACTGCACTCATCGCCTCCCGTCGTGCGCCCGCGCCCCAAGAGTGCCGAG CCCCCTCGCTCGCCGCTCCTCAAGCGCGTGCAGTCGGCCGAGAAGCTGGGAGCCTCTTTGAGTGCGGACAAGAAGGGCGCGCTGCGCAAA CACAGCCTCGAGGTGGGCCACCCGGATTTCCGCAAGGACTTCCATGGCGAGCTGGCGCTGCATAGCCTTGCCGAGTCCGACGGTGAGACG CCCCCAGTCGAGGGCCTTGGCGCGCCCCGGCAGGTCGCCGTCCGCCGCCTGGGCCGACAGGAGTCACCTTTGAGCCTGGGCGCGGACCCG TTGCTGCCCGAGGGTGCCTCCAGGCCACCAGTGTCGAGCAAGGAGAAGGAATCCCCGGGGGGCGCCGAGGCGTGCACCCCACCCCGCGCG ACGACCCCCGGTGGCCGGACCCTGGAGCGGGACGTCGGCTGCACGCGGCATCAGAGCGTGCAGACGGAGGATGGCACTGGCGGGATGGCC AGGGCTGTGGCCAAGGCGGCGCTGAGCCCGGTGCAGGAACACGAGACAGGCCGGCGCAGCAGCTCTGGCGAGGCGGGCACACCCCTGGTA CCCATTGTCGTAGAGCCTGCGCGGCCCGGGGCTAAGGCTGTGGTGCCTCAGCCTCTGGGCGCGGACTCCAAGGGGTTGCAGGAACCCGCA CCCCTGGCGCCTTCCGTGCCCGAGGCCCCCCGGGGCCGGGAGCGCTGGGTGTTGGAGGTGGTGGAGGAGCGCACCACGCTGAGCGGTCCT CGCTCCAAGCCCGCCTCCCCAAAGCTCTCCCCGGAGCCCCAGACACCCTCCCTAGCCCCAGCGAAGTGCAGTGCACCCAGCAGTGCAGTG ACCCCAGTCCCACCCGCATCCCTCTTGGGCTCAGGCACCAAGCCTCAAGTGGGGCTGACCTCCCGGTGCCCTGCTGAAGCTGTGCCCCCA >In-frame_NUP210_ENST00000254508_chr3_13418956_-_MAST1_ENST00000591495_chr19_12962748_+_1818nt ATGGCGGCGCGGGGCCGGGGGCTGCTGCTGCTGACGCTGTCGGTGCTGTTGGCGGCGGGCCCCTCCGCCGCTGCGGCCAAGCTCAACATC CCCAAAGTGCTGCTGCCCTTCACGCGGGCCACGCGCGTTAACTTCACGCTGGAGGCCTCGGAGGGCTGCTACCGCTGGTTGTCCACCCGG CCGGAGGTGGCCAGCATCGAGCCGCTGGGCCTGGACGAGCAGCAGTGCTCCCAGAAGGCAGTGGTGCAGGCCCGCCTGACCCAGCCTGCC CGCCTCACCAGCATCATCTTCGCAGAGGACATCACCACAGGCCAGGTCCTGCGCTGTGATGCCATTGTGGACCTCATCCATGACATCCAG ATCGTCTCCACCACCCGCGAGCTCTACCTGGAGGACTCCCCCCTGGAGCTGAAGATCCAGGCCCTGGACTCCGAAGGGAACACCTTCAGC ACTCTGGCTGGACTGGTCTTCGAGTGGACGATTGTGAAGGACTCCGAGGCGGACAGGTTCTCAGACTCCCACAATGCGCTGCGAATCCTC ACTTTCTTGGAGTCTACGTACATCCCTCCTTCTTACATCTCAGAGATGGAGAAGGCTGCCAAGCAAGGGGACACCATCCTGGTGTCTGGG ATGAAGACCGGGAGCTCCAAGCTCAAGGCTCGCATCCAGGAGGCTGTCTACAAGAATGTACGCCCTGCAGAAGTCAGGCTGCTGATTTTG GAAAACATCCTTCTGAACCCGGCCTATGACGTCTACCTGATGGTGGGAACCTCCATTCACTACAAGGTGCAGAAGATCAGGCAAGGGAAA ATTACAGAACTCTCCATGCCTTCCGATCAGTACGAGTTGCAGCTTCAGAACAGCATCCCGGGCCCCGAAGGAGACCCAGCCCGGCCGGTG GCTGTCTTGGCCCAGGACACGTCGATGGTCACTGCACTGCAGCTGGGACAGAGCAGCCTCGTCCTTGGCCACAGGAGTATTCGCATGCAA GGTGCTTCTAGGTTACCCAACAGCACTATCTACGTGGTCGAACCTGGATACCTAGGGTTCACTGTTCACCCTGGTGACAGGTGGGTGCTG GAGACCGGCCGCCTGTATGAAATCACCATCGAAGTTTTTGACAAGTTCAGCAACAAGGTCTATGTATCTGACGCCTATGAACGCTCTGAG AGCTTGGAGGTGGCCTTCGTTACTCAGCTGGTGAAGAAGTTGCTTATTATCATCTCACGCCCTGCGAGGCTGCTGGAGTGCCTGGAATTC AACCCCGAGGAGTTCTACCACCTGCTGGAGGCGGCCGAAGGACACGCCAAGGAGGGCCACCTTGTGAAGACGGACATCCCCCGCTACATC ATCCGCCAGCTGGGCCTCACCCGTGACCCCTTTCCAGATGTGGTGCATCTGGAGGAACAGGACAGTGGTGGTTCCAACACCCCTGAGCAA GACGATCTCTCTGAGGGCCGCAGCAGCAAGGCCAAGAAACCGCCGGGGGAGAATGACTTCGATACCATCAAGCTCATAAGCAACGGTGCC TACGGCGCTGTCTACCTGGTGCGGCACCGCGACACGCGGCAGCGCTTTGCCATGAAAAAGATCAACAAGCAGAACTTGATCCTCCGCAAC CAGATCCAGCAGGCCTTTGTGGAGCGCGATATCCTCACCTTCGCCGAGAACCCGTTTGTGGTCGGCATGTTCTGCTCCTTTGAGACTCGG CGCCACCTCTGCATGGTCATGGAATATGTGGAAGGTGTGGCTGCCTGCGGGGCTGCAGGGAAGATGGGGCCGTGCTCACTGGTCAGGGCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NUP210_ENST00000254508_chr3_13418956_-_MAST1_ENST00000251472_chr19_12962748_+_5255nt GCGCGCGCGCGGGCGGGAGCGGAGGGCAACGGGGCGGCGCGGGCGGCCGGGCGCAGGGTCGCGGGAGGTGACGCGCGGCGAGGATGGCGG CGCGGGGCCGGGGGCTGCTGCTGCTGACGCTGTCGGTGCTGTTGGCGGCGGGCCCCTCCGCCGCTGCGGCCAAGCTCAACATCCCCAAAG TGCTGCTGCCCTTCACGCGGGCCACGCGCGTTAACTTCACGCTGGAGGCCTCGGAGGGCTGCTACCGCTGGTTGTCCACCCGGCCGGAGG TGGCCAGCATCGAGCCGCTGGGCCTGGACGAGCAGCAGTGCTCCCAGAAGGCAGTGGTGCAGGCCCGCCTGACCCAGCCTGCCCGCCTCA CCAGCATCATCTTCGCAGAGGACATCACCACAGGCCAGGTCCTGCGCTGTGATGCCATTGTGGACCTCATCCATGACATCCAGATCGTCT CCACCACCCGCGAGCTCTACCTGGAGGACTCCCCCCTGGAGCTGAAGATCCAGGCCCTGGACTCCGAAGGGAACACCTTCAGCACTCTGG CTGGACTGGTCTTCGAGTGGACGATTGTGAAGGACTCCGAGGCGGACAGGTTCTCAGACTCCCACAATGCGCTGCGAATCCTCACTTTCT TGGAGTCTACGTACATCCCTCCTTCTTACATCTCAGAGATGGAGAAGGCTGCCAAGCAAGGGGACACCATCCTGGTGTCTGGGATGAAGA CCGGGAGCTCCAAGCTCAAGGCTCGCATCCAGGAGGCTGTCTACAAGAATGTACGCCCTGCAGAAGTCAGGCTGCTGATTTTGGAAAACA TCCTTCTGAACCCGGCCTATGACGTCTACCTGATGGTGGGAACCTCCATTCACTACAAGGTGCAGAAGATCAGGCAAGGGAAAATTACAG AACTCTCCATGCCTTCCGATCAGTACGAGTTGCAGCTTCAGAACAGCATCCCGGGCCCCGAAGGAGACCCAGCCCGGCCGGTGGCTGTCT TGGCCCAGGACACGTCGATGGTCACTGCACTGCAGCTGGGACAGAGCAGCCTCGTCCTTGGCCACAGGAGTATTCGCATGCAAGGTGCTT CTAGGTTACCCAACAGCACTATCTACGTGGTCGAACCTGGATACCTAGGGTTCACTGTTCACCCTGGTGACAGGTGGGTGCTGGAGACCG GCCGCCTGTATGAAATCACCATCGAAGTTTTTGACAAGTTCAGCAACAAGGTCTATGTATCTGACGCCTATGAACGCTCTGAGAGCTTGG AGGTGGCCTTCGTTACTCAGCTGGTGAAGAAGTTGCTTATTATCATCTCACGCCCTGCGAGGCTGCTGGAGTGCCTGGAATTCAACCCCG AGGAGTTCTACCACCTGCTGGAGGCGGCCGAAGGACACGCCAAGGAGGGCCACCTTGTGAAGACGGACATCCCCCGCTACATCATCCGCC AGCTGGGCCTCACCCGTGACCCCTTTCCAGATGTGGTGCATCTGGAGGAACAGGACAGTGGTGGTTCCAACACCCCTGAGCAAGACGATC TCTCTGAGGGCCGCAGCAGCAAGGCCAAGAAACCGCCGGGGGAGAATGACTTCGATACCATCAAGCTCATAAGCAACGGTGCCTACGGCG CTGTCTACCTGGTGCGGCACCGCGACACGCGGCAGCGCTTTGCCATGAAAAAGATCAACAAGCAGAACTTGATCCTCCGCAACCAGATCC AGCAGGCCTTTGTGGAGCGCGATATCCTCACCTTCGCCGAGAACCCGTTTGTGGTCGGCATGTTCTGCTCCTTTGAGACTCGGCGCCACC TCTGCATGGTCATGGAATATGTGGAAGGCGGCGACTGTGCCACCCTGCTGAAGAATATTGGAGCGCTGCCCGTAGAGATGGCCCGCATGT ACTTTGCTGAGACGGTGCTAGCCCTGGAGTATTTGCACAACTATGGCATCGTGCACCGCGACCTCAAGCCTGACAACCTCCTTATCACCT CCATGGGTCACATCAAGCTCACAGATTTCGGCCTCTCCAAGATGGGGCTCATGAGCCTCACCACCAACTTATATGAAGGCCACATCGAGA AGGACGCCCGAGAGTTCCTGGACAAACAGGTGTGTGGGACCCCAGAGTACATCGCGCCCGAGGTCATCCTGCGTCAAGGCTACGGCAAGC CAGTGGACTGGTGGGCTATGGGGATCATCCTCTACGAGTTCCTGGTGGGCTGTGTGCCCTTCTTCGGAGACACACCAGAGGAGCTATTTG GACAGGTCATCAGTGATGACATCCTGTGGCCCGAGGGGGATGAGGCCCTACCTACGGAGGCCCAACTCCTCATATCCAGCCTCCTGCAGA CCAACCCTCTGGTCAGGCTTGGGGCAGGCGGCGCTTTTGAGGTGAAGCAGCACAGTTTCTTTCGAGACCTGGACTGGACAGGGCTGCTGA GGCAGAAGGCCGAGTTCATCCCCCACCTAGAGTCGGAAGATGACACTAGCTACTTTGACACCCGCTCAGACAGGTATCACCACGTGAACT CCTATGACGAGGATGACACGACGGAGGAGGAGCCCGTGGAAATCCGCCAGTTCTCTTCCTGCTCTCCGCGCTTCAGCAAGGTGTATAGCA GCATGGAGCAGCTGTCGCAGCACGAGCCCAAGACCCCAGTAGCAGCTGCAGGGAGCAGCAAGCGGGAGCCGAGCACCAAGGGCCCCGAGG AGAAGGTGGCCGGCAAGCGGGAGGGGCTGGGCGGCCTGACCCTGCGTGAGAAGACCTGGAGAGGGGGCTCTCCGGAGATCAAGCGATTCT CCGCGTCCGAGGCCAGTTTCCTGGAGGGAGAGGCCAGTCCCCCTTTGGGCGCCCGCCGCCGTTTCTCGGCGCTGCTGGAGCCCAGCCGCT TCAGCGCCCCCCAAGAGGACGAGGATGAGGCCCGGCTGCGCAGGCCTCCCCGGCCCAGCTCCGACCCCGCGGGATCCCTGGATGCACGGG CCCCCAAAGAGGAGACTCAAGGGGAAGGCACCTCCAGCGCCGGGGACTCCGAGGCCACTGACCGTCCACGCCCAGGTGACCTCTGCCCAC CCTCGAAGGATGGGGATGCATCAGGCCCAAGGGCTACCAATGACTTGGTTCTGCGCCGGGCGCGGCACCAGCAGATGTCAGGGGATGTGG CAGTAGAGAAGAGGCCTTCTCGAACTGGGGGCAAAGTCATCAAATCAGCCTCAGCCACTGCCTTATCTGTCATGATTCCTGCAGTGGACC CACATGGAAGTTCACCCCTTGCTAGTCCCATGTCTCCACGATCTCTGTCCTCCAACCCATCCTCACGGGACTCCTCACCCAGCCGGGACT ACTCACCAGCTGTCAGTGGGCTCCGCTCCCCCATCACCATCCAGCGCTCGGGCAAGAAGTATGGCTTCACACTGCGTGCCATCCGTGTCT ACATGGGTGACACGGATGTCTATAGTGTCCACCACATTGTCTGGCATGTGGAGGAAGGAGGCCCAGCCCAGGAGGCAGGACTCTGTGCTG GGGACCTCATCACCCACGTGAATGGGGAGCCTGTGCATGGCATGGTGCATCCTGAGGTCGTGGAGCTGATCCTTAAGAGTGGCAACAAGG TAGCAGTGACCACAACGCCCTTCGAAAATACCTCTATCCGCATTGGTCCCGCAAGGCGCAGCAGCTACAAGGCTAAAATGGCTCGGAGGA ACAAGCGACCCTCCGCCAAGGAGGGCCAGGAGAGCAAGAAGCGCAGCTCCCTCTTCCGGAAGATCACGAAGCAGTCGAACCTGCTGCATA CTAGCCGCTCGCTGTCGTCGCTGAACCGCTCGCTGTCATCCAGCGATAGTCTCCCGGGCTCGCCTACGCACGGGCTGCCGGCGCGCTCGC CCACGCACAGCTACCGCTCCACGCCTGACTCCGCCTACCTAGGCGCCTCATCCCAGAGCAGCTCCCCAGCCTCGAGCACGCCCAACTCGC CTGCGTCGTCGGCGTCGCACCACATTCGGCCCAGCACGCTGCACGGACTGTCGCCAAAGCTCCATCGCCAGTACCGCTCTGCGCGATGCA AGTCGGCCGGCAACATCCCTCTATCGCCGCTGGCACACACGCCGTCCCCCACGCAGGCGTCACCGCCGCCACTGCCGGGCCACACGGTGG GCAGCTCGCACACTACTCAGAGCTTCCCGGCCAAACTGCACTCATCGCCTCCCGTCGTGCGCCCGCGCCCCAAGAGTGCCGAGCCCCCTC GCTCGCCGCTCCTCAAGCGCGTGCAGTCGGCCGAGAAGCTGGGAGCCTCTTTGAGTGCGGACAAGAAGGGCGCGCTGCGCAAACACAGCC TCGAGGTGGGCCACCCGGATTTCCGCAAGGACTTCCATGGCGAGCTGGCGCTGCATAGCCTTGCCGAGTCCGACGGTGAGACGCCCCCAG TCGAGGGCCTTGGCGCGCCCCGGCAGGTCGCCGTCCGCCGCCTGGGCCGACAGGAGTCACCTTTGAGCCTGGGCGCGGACCCGTTGCTGC CCGAGGGTGCCTCCAGGCCACCAGTGTCGAGCAAGGAGAAGGAATCCCCGGGGGGCGCCGAGGCGTGCACCCCACCCCGCGCGACGACCC CCGGTGGCCGGACCCTGGAGCGGGACGTCGGCTGCACGCGGCATCAGAGCGTGCAGACGGAGGATGGCACTGGCGGGATGGCCAGGGCTG TGGCCAAGGCGGCGCTGAGCCCGGTGCAGGAACACGAGACAGGCCGGCGCAGCAGCTCTGGCGAGGCGGGCACACCCCTGGTACCCATTG TCGTAGAGCCTGCGCGGCCCGGGGCTAAGGCTGTGGTGCCTCAGCCTCTGGGCGCGGACTCCAAGGGGTTGCAGGAACCCGCACCCCTGG CGCCTTCCGTGCCCGAGGCCCCCCGGGGCCGGGAGCGCTGGGTGTTGGAGGTGGTGGAGGAGCGCACCACGCTGAGCGGTCCTCGCTCCA AGCCCGCCTCCCCAAAGCTCTCCCCGGAGCCCCAGACACCCTCCCTAGCCCCAGCGAAGTGCAGTGCACCCAGCAGTGCAGTGACCCCAG TCCCACCCGCATCCCTCTTGGGCTCAGGCACCAAGCCTCAAGTGGGGCTGACCTCCCGGTGCCCTGCTGAAGCTGTGCCCCCAGCAGGCC TGACCAAAAAAGGAGTGTCCAGTCCCGCACCCCCGGGACCATAGCCAAGGGGGTCATCGGCCCCGCGCTGTACAGCCTCCGTATACATAT >In-frame_NUP210_ENST00000254508_chr3_13418956_-_MAST1_ENST00000591495_chr19_12962748_+_1952nt GCGCGCGCGCGGGCGGGAGCGGAGGGCAACGGGGCGGCGCGGGCGGCCGGGCGCAGGGTCGCGGGAGGTGACGCGCGGCGAGGATGGCGG CGCGGGGCCGGGGGCTGCTGCTGCTGACGCTGTCGGTGCTGTTGGCGGCGGGCCCCTCCGCCGCTGCGGCCAAGCTCAACATCCCCAAAG TGCTGCTGCCCTTCACGCGGGCCACGCGCGTTAACTTCACGCTGGAGGCCTCGGAGGGCTGCTACCGCTGGTTGTCCACCCGGCCGGAGG TGGCCAGCATCGAGCCGCTGGGCCTGGACGAGCAGCAGTGCTCCCAGAAGGCAGTGGTGCAGGCCCGCCTGACCCAGCCTGCCCGCCTCA CCAGCATCATCTTCGCAGAGGACATCACCACAGGCCAGGTCCTGCGCTGTGATGCCATTGTGGACCTCATCCATGACATCCAGATCGTCT CCACCACCCGCGAGCTCTACCTGGAGGACTCCCCCCTGGAGCTGAAGATCCAGGCCCTGGACTCCGAAGGGAACACCTTCAGCACTCTGG CTGGACTGGTCTTCGAGTGGACGATTGTGAAGGACTCCGAGGCGGACAGGTTCTCAGACTCCCACAATGCGCTGCGAATCCTCACTTTCT TGGAGTCTACGTACATCCCTCCTTCTTACATCTCAGAGATGGAGAAGGCTGCCAAGCAAGGGGACACCATCCTGGTGTCTGGGATGAAGA CCGGGAGCTCCAAGCTCAAGGCTCGCATCCAGGAGGCTGTCTACAAGAATGTACGCCCTGCAGAAGTCAGGCTGCTGATTTTGGAAAACA TCCTTCTGAACCCGGCCTATGACGTCTACCTGATGGTGGGAACCTCCATTCACTACAAGGTGCAGAAGATCAGGCAAGGGAAAATTACAG AACTCTCCATGCCTTCCGATCAGTACGAGTTGCAGCTTCAGAACAGCATCCCGGGCCCCGAAGGAGACCCAGCCCGGCCGGTGGCTGTCT TGGCCCAGGACACGTCGATGGTCACTGCACTGCAGCTGGGACAGAGCAGCCTCGTCCTTGGCCACAGGAGTATTCGCATGCAAGGTGCTT CTAGGTTACCCAACAGCACTATCTACGTGGTCGAACCTGGATACCTAGGGTTCACTGTTCACCCTGGTGACAGGTGGGTGCTGGAGACCG GCCGCCTGTATGAAATCACCATCGAAGTTTTTGACAAGTTCAGCAACAAGGTCTATGTATCTGACGCCTATGAACGCTCTGAGAGCTTGG AGGTGGCCTTCGTTACTCAGCTGGTGAAGAAGTTGCTTATTATCATCTCACGCCCTGCGAGGCTGCTGGAGTGCCTGGAATTCAACCCCG AGGAGTTCTACCACCTGCTGGAGGCGGCCGAAGGACACGCCAAGGAGGGCCACCTTGTGAAGACGGACATCCCCCGCTACATCATCCGCC AGCTGGGCCTCACCCGTGACCCCTTTCCAGATGTGGTGCATCTGGAGGAACAGGACAGTGGTGGTTCCAACACCCCTGAGCAAGACGATC TCTCTGAGGGCCGCAGCAGCAAGGCCAAGAAACCGCCGGGGGAGAATGACTTCGATACCATCAAGCTCATAAGCAACGGTGCCTACGGCG CTGTCTACCTGGTGCGGCACCGCGACACGCGGCAGCGCTTTGCCATGAAAAAGATCAACAAGCAGAACTTGATCCTCCGCAACCAGATCC AGCAGGCCTTTGTGGAGCGCGATATCCTCACCTTCGCCGAGAACCCGTTTGTGGTCGGCATGTTCTGCTCCTTTGAGACTCGGCGCCACC TCTGCATGGTCATGGAATATGTGGAAGGTGTGGCTGCCTGCGGGGCTGCAGGGAAGATGGGGCCGTGCTCACTGGTCAGGGCTGCGGGGT |
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FusionGenePPI for NUP210_MAST1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NUP210 | TRIP6, SIRT7, FBXO6, KYNU, LACTB2, FLNB, NUDCD2, OS9, FN1, ITGA4, ADRB2, EXOSC5, LGR4, CUL7, OBSL1, EED, ETFA, NONO, SARS, SFPQ, NTRK1, EWSR1, CEP162, TCTN1, KPNB1, UBE2I, NUP153, NUP107, SEH1L, NFATC1, PTPRN, CCRN4L, RHOBTB3, NR3C1 | MAST1 | SNTB2, EGFR, PAXIP1, APP, PSEN2, A2M, BLMH, APOE, NOS3, AP1M2, CDK5, CYP2C8, DNAJB1, ECSIT, ELAVL3, EXOC6, EXOSC1, FBXL12, IFIT3, IFIT5, LONP1, LOXL4, MGEA5, PRAM1, PRDX2, RAD23A, RPP30, STAMBPL1, FBXW4, RAB3A, RAB3D, CYP2C9, RNLS, GCDH, RNF32, YWHAB, YWHAE, YWHAH, YWHAZ |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NUP210_MAST1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NUP210_MAST1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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