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Fusion gene ID: 25209 |
FusionGeneSummary for NUP205_CCDC136 |
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Fusion gene information | Fusion gene name: NUP205_CCDC136 | Fusion gene ID: 25209 | Hgene | Tgene | Gene symbol | NUP205 | CCDC136 | Gene ID | 23165 | 64753 |
Gene name | nucleoporin 205 | coiled-coil domain containing 136 | |
Synonyms | C7orf14|NPHS13 | NAG6 | |
Cytomap | 7q33 | 7q32.1 | |
Type of gene | protein-coding | protein-coding | |
Description | nuclear pore complex protein Nup205205 kDa nucleoporinnucleoporin Nup205 | coiled-coil domain-containing protein 136nasopharyngeal carcinoma-associated gene 6 protein | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q92621 | Q96JN2 | |
Ensembl transtripts involved in fusion gene | ENST00000285968, ENST00000440390, ENST00000489493, | ENST00000378685, ENST00000464832, ENST00000487361, ENST00000297788, ENST00000471729, | |
Fusion gene scores | * DoF score | 6 X 7 X 5=210 | 2 X 2 X 2=8 |
# samples | 7 | 2 | |
** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: NUP205 [Title/Abstract] AND CCDC136 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-95-7944-01A | NUP205 | chr7 | 135310103 | + | CCDC136 | chr7 | 128441240 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000285968 | ENST00000378685 | NUP205 | chr7 | 135310103 | + | CCDC136 | chr7 | 128441240 | + |
Frame-shift | ENST00000285968 | ENST00000464832 | NUP205 | chr7 | 135310103 | + | CCDC136 | chr7 | 128441240 | + |
Frame-shift | ENST00000285968 | ENST00000487361 | NUP205 | chr7 | 135310103 | + | CCDC136 | chr7 | 128441240 | + |
Frame-shift | ENST00000285968 | ENST00000297788 | NUP205 | chr7 | 135310103 | + | CCDC136 | chr7 | 128441240 | + |
5CDS-intron | ENST00000285968 | ENST00000471729 | NUP205 | chr7 | 135310103 | + | CCDC136 | chr7 | 128441240 | + |
intron-3CDS | ENST00000440390 | ENST00000378685 | NUP205 | chr7 | 135310103 | + | CCDC136 | chr7 | 128441240 | + |
intron-3CDS | ENST00000440390 | ENST00000464832 | NUP205 | chr7 | 135310103 | + | CCDC136 | chr7 | 128441240 | + |
intron-3CDS | ENST00000440390 | ENST00000487361 | NUP205 | chr7 | 135310103 | + | CCDC136 | chr7 | 128441240 | + |
intron-3CDS | ENST00000440390 | ENST00000297788 | NUP205 | chr7 | 135310103 | + | CCDC136 | chr7 | 128441240 | + |
intron-intron | ENST00000440390 | ENST00000471729 | NUP205 | chr7 | 135310103 | + | CCDC136 | chr7 | 128441240 | + |
intron-3CDS | ENST00000489493 | ENST00000378685 | NUP205 | chr7 | 135310103 | + | CCDC136 | chr7 | 128441240 | + |
intron-3CDS | ENST00000489493 | ENST00000464832 | NUP205 | chr7 | 135310103 | + | CCDC136 | chr7 | 128441240 | + |
intron-3CDS | ENST00000489493 | ENST00000487361 | NUP205 | chr7 | 135310103 | + | CCDC136 | chr7 | 128441240 | + |
intron-3CDS | ENST00000489493 | ENST00000297788 | NUP205 | chr7 | 135310103 | + | CCDC136 | chr7 | 128441240 | + |
intron-intron | ENST00000489493 | ENST00000471729 | NUP205 | chr7 | 135310103 | + | CCDC136 | chr7 | 128441240 | + |
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FusionProtFeatures for NUP205_CCDC136 |
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Hgene | Tgene |
NUP205 | CCDC136 |
Plays a role in the nuclear pore complex (NPC) assemblyand/or maintenance (PubMed:9348540). May anchor NUP62 and othernucleoporins, but not NUP153 and TPR, to the NPC(PubMed:15229283). {ECO:0000269|PubMed:15229283,ECO:0000269|PubMed:9348540}. | May play a role in acrosome formation in spermatogenesisand in fertilization. {ECO:0000250|UniProtKB:Q3TVA9}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NUP205_CCDC136 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NUP205_CCDC136 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NUP205 | PHLDA3, PHB2, MAGED1, TTBK1, MYC, TPR, USP50, CLN3, SIRT7, HNRNPA1, RAPGEF3, CUL3, NXF1, TADA3, VCP, FN1, VCAM1, ITGA4, FBXW4, HOXC10, FBXO6, NUDCD3, LGR4, ENO1, SHMT2, MOV10, CUL7, OBSL1, CCDC8, EED, RNF2, HYOU1, NUP93, NTRK1, KRAS, IFI16, NUP35, TCTN3, CEP128, CEP164, CNTRL, TCTN1, KPNB1, UBE2I, NUPL1, NUP153, NUP107, SEH1L, FOXB1, FOXG1, FOXI2, FOXL1, FOXL2, FOXQ1, MTMR3, STOM, TRIM25, G3BP1, FBXL13 | CCDC136 | CDC5L, DISC1, PKN2, UBQLN4, ATXN1, COIL, GFI1B, ZNF408, NDN, AQP1, ATP5O, BARD1, BYSL, KIFC3, MAGEB4, MOS, PSMD9, SMARCE1, TCEA2, TNNT1, ZNF20, ZSCAN26, ZNF230, CDK2AP1, USP2, RAB33A, HDAC4, HMG20B, HMG20A, KAT5, NEBL, PDLIM5, FAM107A, PRPF31, BLOC1S6, ABT1, ZNF581, CCHCR1, C19orf66, CBX8, ZNF490, CCDC146, ZNF250, LENG1, ZC2HC1C, ENKD1, FAM161A, TBRG1, ZNF587, HAUS1, C1orf216, JMY, ZNF572, ASB7, CWF19L2, ZNF417, ZNF564, PPP1R18, TXLNA, ZBTB38, KANSL1, CEP57L1, STK11, SYNC, GCC2, CCDC77, COG5, ZNF197, NEURL4, HERC2, CCDC88A, CCDC85B, EXOC3, KXD1, CCDC85C, ZNF865, RGPD5, CTTNBP2, WT1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NUP205_CCDC136 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NUP205_CCDC136 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NUP205 | C0029401 | Osteitis Deformans | 1 | CTD_human |
Hgene | NUP205 | C1868672 | NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE | 1 | CTD_human |
Hgene | NUP205 | C4225165 | NEPHROTIC SYNDROME, TYPE 13 | 1 | UNIPROT |