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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 25173

FusionGeneSummary for NUMB_TTLL5

check button Fusion gene summary
Fusion gene informationFusion gene name: NUMB_TTLL5
Fusion gene ID: 25173
HgeneTgene
Gene symbol

NUMB

TTLL5

Gene ID

8650

254173

Gene nameNUMB, endocytic adaptor proteintubulin tyrosine ligase like 10
SynonymsC14orf41|S171|c14_5527TTLL5
Cytomap

14q24.2-q24.3

1p36.33

Type of geneprotein-codingprotein-coding
Descriptionprotein numb homologh-Numbnumb homologinactive polyglycylase TTLL10tubulin tyrosine ligase-like family, member 10tubulin tyrosine ligase-like family, member 5tubulin--tyrosine ligase-like protein 10
Modification date2018052220180519
UniProtAcc

P49757

Q6EMB2

Ensembl transtripts involved in fusion geneENST00000554546, ENST00000356296, 
ENST00000557597, ENST00000555238, 
ENST00000355058, ENST00000359560, 
ENST00000555394, ENST00000454166, 
ENST00000544991, ENST00000560335, 
ENST00000555738, ENST00000559312, 
ENST00000554521, ENST00000535282, 
ENST00000556600, ENST00000556772, 
ENST00000557636, ENST00000286650, 
ENST00000298832, ENST00000556893, 
ENST00000554510, ENST00000556977, 
ENST00000555422, 
Fusion gene scores* DoF score10 X 7 X 7=4907 X 6 X 6=252
# samples 117
** MAII scorelog2(11/490*10)=-2.15527822547791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUMB [Title/Abstract] AND TTLL5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTTLL5

GO:0018094

protein polyglycylation

19524510


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-YF-AA3L-01ANUMBchr14

73759442

-TTLL5chr14

76286350

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000554546ENST00000557636NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000554546ENST00000286650NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000554546ENST00000298832NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000554546ENST00000556893NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000554546ENST00000554510NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000554546ENST00000556977NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000554546ENST00000555422NUMBchr14

73759442

-TTLL5chr14

76286350

+
Frame-shiftENST00000356296ENST00000557636NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000356296ENST00000286650NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000356296ENST00000298832NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000356296ENST00000556893NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000356296ENST00000554510NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000356296ENST00000556977NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000356296ENST00000555422NUMBchr14

73759442

-TTLL5chr14

76286350

+
In-frameENST00000557597ENST00000557636NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000557597ENST00000286650NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000557597ENST00000298832NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000557597ENST00000556893NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000557597ENST00000554510NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000557597ENST00000556977NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000557597ENST00000555422NUMBchr14

73759442

-TTLL5chr14

76286350

+
In-frameENST00000555238ENST00000557636NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000555238ENST00000286650NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000555238ENST00000298832NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000555238ENST00000556893NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000555238ENST00000554510NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000555238ENST00000556977NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000555238ENST00000555422NUMBchr14

73759442

-TTLL5chr14

76286350

+
Frame-shiftENST00000355058ENST00000557636NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000355058ENST00000286650NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000355058ENST00000298832NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000355058ENST00000556893NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000355058ENST00000554510NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000355058ENST00000556977NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000355058ENST00000555422NUMBchr14

73759442

-TTLL5chr14

76286350

+
Frame-shiftENST00000359560ENST00000557636NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000359560ENST00000286650NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000359560ENST00000298832NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000359560ENST00000556893NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000359560ENST00000554510NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000359560ENST00000556977NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000359560ENST00000555422NUMBchr14

73759442

-TTLL5chr14

76286350

+
In-frameENST00000555394ENST00000557636NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000555394ENST00000286650NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000555394ENST00000298832NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000555394ENST00000556893NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000555394ENST00000554510NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000555394ENST00000556977NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000555394ENST00000555422NUMBchr14

73759442

-TTLL5chr14

76286350

+
In-frameENST00000454166ENST00000557636NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000454166ENST00000286650NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000454166ENST00000298832NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000454166ENST00000556893NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000454166ENST00000554510NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000454166ENST00000556977NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000454166ENST00000555422NUMBchr14

73759442

-TTLL5chr14

76286350

+
In-frameENST00000544991ENST00000557636NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000544991ENST00000286650NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000544991ENST00000298832NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000544991ENST00000556893NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000544991ENST00000554510NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000544991ENST00000556977NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000544991ENST00000555422NUMBchr14

73759442

-TTLL5chr14

76286350

+
In-frameENST00000560335ENST00000557636NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000560335ENST00000286650NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000560335ENST00000298832NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000560335ENST00000556893NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000560335ENST00000554510NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000560335ENST00000556977NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000560335ENST00000555422NUMBchr14

73759442

-TTLL5chr14

76286350

+
In-frameENST00000555738ENST00000557636NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000555738ENST00000286650NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000555738ENST00000298832NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000555738ENST00000556893NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000555738ENST00000554510NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000555738ENST00000556977NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000555738ENST00000555422NUMBchr14

73759442

-TTLL5chr14

76286350

+
In-frameENST00000559312ENST00000557636NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000559312ENST00000286650NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000559312ENST00000298832NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000559312ENST00000556893NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000559312ENST00000554510NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000559312ENST00000556977NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000559312ENST00000555422NUMBchr14

73759442

-TTLL5chr14

76286350

+
In-frameENST00000554521ENST00000557636NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000554521ENST00000286650NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000554521ENST00000298832NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000554521ENST00000556893NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000554521ENST00000554510NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000554521ENST00000556977NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000554521ENST00000555422NUMBchr14

73759442

-TTLL5chr14

76286350

+
Frame-shiftENST00000535282ENST00000557636NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000535282ENST00000286650NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000535282ENST00000298832NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000535282ENST00000556893NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000535282ENST00000554510NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000535282ENST00000556977NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000535282ENST00000555422NUMBchr14

73759442

-TTLL5chr14

76286350

+
intron-3CDSENST00000556600ENST00000557636NUMBchr14

73759442

-TTLL5chr14

76286350

+
intron-intronENST00000556600ENST00000286650NUMBchr14

73759442

-TTLL5chr14

76286350

+
intron-intronENST00000556600ENST00000298832NUMBchr14

73759442

-TTLL5chr14

76286350

+
intron-intronENST00000556600ENST00000556893NUMBchr14

73759442

-TTLL5chr14

76286350

+
intron-intronENST00000556600ENST00000554510NUMBchr14

73759442

-TTLL5chr14

76286350

+
intron-intronENST00000556600ENST00000556977NUMBchr14

73759442

-TTLL5chr14

76286350

+
intron-intronENST00000556600ENST00000555422NUMBchr14

73759442

-TTLL5chr14

76286350

+
Frame-shiftENST00000556772ENST00000557636NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000556772ENST00000286650NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000556772ENST00000298832NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000556772ENST00000556893NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000556772ENST00000554510NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000556772ENST00000556977NUMBchr14

73759442

-TTLL5chr14

76286350

+
5CDS-intronENST00000556772ENST00000555422NUMBchr14

73759442

-TTLL5chr14

76286350

+

Top

FusionProtFeatures for NUMB_TTLL5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUMB

P49757

TTLL5

Q6EMB2

Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain initiation step of thepolyglutamylation reaction rather than in the elongation step (Bysimilarity). Required for CCSAP localization to both spindle andcilia microtubules. Increases the effects of NCOA2 inglucocorticoid receptor-mediated repression and induction and inandrogen receptor-mediated induction (PubMed:17116691,PubMed:22493317). {ECO:0000250|UniProtKB:Q8CHB8,ECO:0000269|PubMed:17116691, ECO:0000269|PubMed:22493317}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTTLL5chr14:73759442chr14:76286350ENST00000286650+010552_557-69270Compositional biasNote=Poly-Arg
TgeneTTLL5chr14:73759442chr14:76286350ENST00000286650+010582_590-69270Compositional biasNote=Poly-Glu
TgeneTTLL5chr14:73759442chr14:76286350ENST00000286650+010776_780-69270Compositional biasNote=Poly-Glu
TgeneTTLL5chr14:73759442chr14:76286350ENST00000286650+010827_830-69270Compositional biasNote=Poly-Asn
TgeneTTLL5chr14:73759442chr14:76286350ENST00000556893+1217776_780608818Compositional biasNote=Poly-Glu
TgeneTTLL5chr14:73759442chr14:76286350ENST00000556893+1217827_830608818Compositional biasNote=Poly-Asn
TgeneTTLL5chr14:73759442chr14:76286350ENST00000286650+01062_407-69270DomainTTL
TgeneTTLL5chr14:73759442chr14:76286350ENST00000286650+010208_211-69270Nucleotide bindingATP binding
TgeneTTLL5chr14:73759442chr14:76286350ENST00000286650+010378_488-69270Regionc-MTBD region

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNUMBchr14:73759442chr14:76286350ENST00000355058-81333_193150652DomainPID
HgeneNUMBchr14:73759442chr14:76286350ENST00000356296-81233_193150604DomainPID
HgeneNUMBchr14:73759442chr14:76286350ENST00000359560-71233_193139641DomainPID
HgeneNUMBchr14:73759442chr14:76286350ENST00000454166-5833_193150506DomainPID
HgeneNUMBchr14:73759442chr14:76286350ENST00000535282-61133_193139641DomainPID
HgeneNUMBchr14:73759442chr14:76286350ENST00000554546-71133_193139593DomainPID
HgeneNUMBchr14:73759442chr14:76286350ENST00000555238-81333_193150652DomainPID
HgeneNUMBchr14:73759442chr14:76286350ENST00000555394-81233_193150604DomainPID
HgeneNUMBchr14:73759442chr14:76286350ENST00000555738-5833_193139495DomainPID
HgeneNUMBchr14:73759442chr14:76286350ENST00000557597-71233_193139641DomainPID
HgeneNUMBchr14:73759442chr14:76286350ENST00000560335-6933_193150506DomainPID
TgeneTTLL5chr14:73759442chr14:76286350ENST00000298832+2632552_55710571282Compositional biasNote=Poly-Arg
TgeneTTLL5chr14:73759442chr14:76286350ENST00000298832+2632582_59010571282Compositional biasNote=Poly-Glu
TgeneTTLL5chr14:73759442chr14:76286350ENST00000298832+2632776_78010571282Compositional biasNote=Poly-Glu
TgeneTTLL5chr14:73759442chr14:76286350ENST00000298832+2632827_83010571282Compositional biasNote=Poly-Asn
TgeneTTLL5chr14:73759442chr14:76286350ENST00000556893+1217552_557608818Compositional biasNote=Poly-Arg
TgeneTTLL5chr14:73759442chr14:76286350ENST00000556893+1217582_590608818Compositional biasNote=Poly-Glu
TgeneTTLL5chr14:73759442chr14:76286350ENST00000298832+263262_40710571282DomainTTL
TgeneTTLL5chr14:73759442chr14:76286350ENST00000556893+121762_407608818DomainTTL
TgeneTTLL5chr14:73759442chr14:76286350ENST00000298832+2632208_21110571282Nucleotide bindingATP binding
TgeneTTLL5chr14:73759442chr14:76286350ENST00000556893+1217208_211608818Nucleotide bindingATP binding
TgeneTTLL5chr14:73759442chr14:76286350ENST00000298832+2632378_48810571282Regionc-MTBD region
TgeneTTLL5chr14:73759442chr14:76286350ENST00000556893+1217378_488608818Regionc-MTBD region


Top

FusionGeneSequence for NUMB_TTLL5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NUMB_ENST00000554546_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_349aa
MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKATGKKAVKAVLWVSADGLRVVDEK
TKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTVTNLNLATGIINRSSASAPPTLRPIISPSGPTWSTQSDPQA
PENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKLQSRQLLDQSRARHQAIFGSQTLPNSNLW

>In-frame_NUMB_ENST00000557597_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_349aa
MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKATGKKAVKAVLWVSADGLRVVDEK
TKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTVTNLNLATGIINRSSASAPPTLRPIISPSGPTWSTQSDPQA
PENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKLQSRQLLDQSRARHQAIFGSQTLPNSNLW

>In-frame_NUMB_ENST00000555238_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_360aa
MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWV
SADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTVTNLNLATGIINRSSASAPPTLRPIISPSG
PTWSTQSDPQAPENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKLQSRQLLDQSRARHQAIF
GSQTLPNSNLWTMNNGAGCRISSATASGQKPTTLPQKVVPPPSSCASLVPKPPPNHEQVLRRATSQKASNTRFRSSFQNYLWYFFQAVSX

>In-frame_NUMB_ENST00000555394_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_360aa
MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWV
SADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTVTNLNLATGIINRSSASAPPTLRPIISPSG
PTWSTQSDPQAPENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKLQSRQLLDQSRARHQAIF
GSQTLPNSNLWTMNNGAGCRISSATASGQKPTTLPQKVVPPPSSCASLVPKPPPNHEQVLRRATSQKASNTRFRSSFQNYLWYFFQAVSX

>In-frame_NUMB_ENST00000454166_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_360aa
MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWV
SADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTVTNLNLATGIINRSSASAPPTLRPIISPSG
PTWSTQSDPQAPENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKLQSRQLLDQSRARHQAIF
GSQTLPNSNLWTMNNGAGCRISSATASGQKPTTLPQKVVPPPSSCASLVPKPPPNHEQVLRRATSQKASNTRFRSSFQNYLWYFFQAVSX

>In-frame_NUMB_ENST00000544991_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_360aa
MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWV
SADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTVTNLNLATGIINRSSASAPPTLRPIISPSG
PTWSTQSDPQAPENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKLQSRQLLDQSRARHQAIF
GSQTLPNSNLWTMNNGAGCRISSATASGQKPTTLPQKVVPPPSSCASLVPKPPPNHEQVLRRATSQKASNTRFRSSFQNYLWYFFQAVSX

>In-frame_NUMB_ENST00000560335_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_360aa
MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWV
SADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTVTNLNLATGIINRSSASAPPTLRPIISPSG
PTWSTQSDPQAPENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKLQSRQLLDQSRARHQAIF
GSQTLPNSNLWTMNNGAGCRISSATASGQKPTTLPQKVVPPPSSCASLVPKPPPNHEQVLRRATSQKASNTRFRSSFQNYLWYFFQAVSX

>In-frame_NUMB_ENST00000555738_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_349aa
MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKATGKKAVKAVLWVSADGLRVVDEK
TKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTVTNLNLATGIINRSSASAPPTLRPIISPSGPTWSTQSDPQA
PENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKLQSRQLLDQSRARHQAIFGSQTLPNSNLW

>In-frame_NUMB_ENST00000559312_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_360aa
MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWV
SADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTVTNLNLATGIINRSSASAPPTLRPIISPSG
PTWSTQSDPQAPENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKLQSRQLLDQSRARHQAIF
GSQTLPNSNLWTMNNGAGCRISSATASGQKPTTLPQKVVPPPSSCASLVPKPPPNHEQVLRRATSQKASNTRFRSSFQNYLWYFFQAVSX

>In-frame_NUMB_ENST00000554521_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_349aa
MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKATGKKAVKAVLWVSADGLRVVDEK
TKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTVTNLNLATGIINRSSASAPPTLRPIISPSGPTWSTQSDPQA
PENHSSSPGSRSLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKLQSRQLLDQSRARHQAIFGSQTLPNSNLW


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NUMB_ENST00000554546_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_1047nt
ATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAA
GGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTAGAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGAT
GCTGTAAAAAGATTGAAAGCTACTGGAAAGAAAGCAGTTAAAGCAGTTCTGTGGGTCTCAGCAGATGGACTCAGAGTTGTGGATGAAAAA
ACTAAGGACCTCATAGTTGACCAGACGATAGAGAAAGTTTCTTTCTGTGCCCCAGACAGGAACTTTGATAGAGCCTTTTCTTACATATGC
CGTGATGGCACCACTCGTCGCTGGATCTGTCACTGCTTCATGGCTGTCAAGGACACAGTAACAAACCTGAATTTGGCAACTGGCATCATA
AACAGAAGCAGTGCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCCTAGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCT
CCCGAGAATCACTCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGATTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGC
CAGGCTACAGGGGTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAGCTATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAA
AAACTTCAGTCCCGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGCAATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGG
ACAATGAATAATGGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGGCCAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCT
CCAAGTTCTTGCGCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACAAGTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACC

>In-frame_NUMB_ENST00000557597_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_1047nt
ATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAA
GGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTAGAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGAT
GCTGTAAAAAGATTGAAAGCTACTGGAAAGAAAGCAGTTAAAGCAGTTCTGTGGGTCTCAGCAGATGGACTCAGAGTTGTGGATGAAAAA
ACTAAGGACCTCATAGTTGACCAGACGATAGAGAAAGTTTCTTTCTGTGCCCCAGACAGGAACTTTGATAGAGCCTTTTCTTACATATGC
CGTGATGGCACCACTCGTCGCTGGATCTGTCACTGCTTCATGGCTGTCAAGGACACAGTAACAAACCTGAATTTGGCAACTGGCATCATA
AACAGAAGCAGTGCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCCTAGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCT
CCCGAGAATCACTCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGATTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGC
CAGGCTACAGGGGTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAGCTATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAA
AAACTTCAGTCCCGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGCAATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGG
ACAATGAATAATGGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGGCCAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCT
CCAAGTTCTTGCGCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACAAGTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACC

>In-frame_NUMB_ENST00000555238_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_1080nt
ATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAA
GGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTAGAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGAT
GCTGTAAAAAGATTGAAAGCTGAAAGGAAGTTCTTCAAAGGCTTCTTTGGAAAAACTGGAAAGAAAGCAGTTAAAGCAGTTCTGTGGGTC
TCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGGACCTCATAGTTGACCAGACGATAGAGAAAGTTTCTTTCTGTGCCCCAGAC
AGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATGGCACCACTCGTCGCTGGATCTGTCACTGCTTCATGGCTGTCAAGGACACA
GTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGTGCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCCTAGTGGC
CCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCACTCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGATTTGCC
TGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGGGTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAGCTATCAG
CTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCCCGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGCAATCTTT
GGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAATGGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGGCCAGAAG
CCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGCGCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACAAGTGCTC
AGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCCTCCTTTCAAAACTATTTGTGGTATTTCTTCCAAGCAGTCAGCTGA

>In-frame_NUMB_ENST00000555394_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_1080nt
ATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAA
GGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTAGAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGAT
GCTGTAAAAAGATTGAAAGCTGAAAGGAAGTTCTTCAAAGGCTTCTTTGGAAAAACTGGAAAGAAAGCAGTTAAAGCAGTTCTGTGGGTC
TCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGGACCTCATAGTTGACCAGACGATAGAGAAAGTTTCTTTCTGTGCCCCAGAC
AGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATGGCACCACTCGTCGCTGGATCTGTCACTGCTTCATGGCTGTCAAGGACACA
GTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGTGCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCCTAGTGGC
CCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCACTCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGATTTGCC
TGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGGGTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAGCTATCAG
CTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCCCGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGCAATCTTT
GGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAATGGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGGCCAGAAG
CCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGCGCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACAAGTGCTC
AGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCCTCCTTTCAAAACTATTTGTGGTATTTCTTCCAAGCAGTCAGCTGA

>In-frame_NUMB_ENST00000454166_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_1080nt
ATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAA
GGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTAGAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGAT
GCTGTAAAAAGATTGAAAGCTGAAAGGAAGTTCTTCAAAGGCTTCTTTGGAAAAACTGGAAAGAAAGCAGTTAAAGCAGTTCTGTGGGTC
TCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGGACCTCATAGTTGACCAGACGATAGAGAAAGTTTCTTTCTGTGCCCCAGAC
AGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATGGCACCACTCGTCGCTGGATCTGTCACTGCTTCATGGCTGTCAAGGACACA
GTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGTGCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCCTAGTGGC
CCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCACTCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGATTTGCC
TGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGGGTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAGCTATCAG
CTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCCCGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGCAATCTTT
GGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAATGGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGGCCAGAAG
CCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGCGCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACAAGTGCTC
AGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCCTCCTTTCAAAACTATTTGTGGTATTTCTTCCAAGCAGTCAGCTGA

>In-frame_NUMB_ENST00000544991_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_1080nt
ATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAA
GGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTAGAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGAT
GCTGTAAAAAGATTGAAAGCTGAAAGGAAGTTCTTCAAAGGCTTCTTTGGAAAAACTGGAAAGAAAGCAGTTAAAGCAGTTCTGTGGGTC
TCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGGACCTCATAGTTGACCAGACGATAGAGAAAGTTTCTTTCTGTGCCCCAGAC
AGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATGGCACCACTCGTCGCTGGATCTGTCACTGCTTCATGGCTGTCAAGGACACA
GTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGTGCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCCTAGTGGC
CCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCACTCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGATTTGCC
TGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGGGTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAGCTATCAG
CTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCCCGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGCAATCTTT
GGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAATGGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGGCCAGAAG
CCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGCGCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACAAGTGCTC
AGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCCTCCTTTCAAAACTATTTGTGGTATTTCTTCCAAGCAGTCAGCTGA

>In-frame_NUMB_ENST00000560335_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_1080nt
ATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAA
GGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTAGAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGAT
GCTGTAAAAAGATTGAAAGCTGAAAGGAAGTTCTTCAAAGGCTTCTTTGGAAAAACTGGAAAGAAAGCAGTTAAAGCAGTTCTGTGGGTC
TCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGGACCTCATAGTTGACCAGACGATAGAGAAAGTTTCTTTCTGTGCCCCAGAC
AGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATGGCACCACTCGTCGCTGGATCTGTCACTGCTTCATGGCTGTCAAGGACACA
GTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGTGCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCCTAGTGGC
CCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCACTCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGATTTGCC
TGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGGGTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAGCTATCAG
CTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCCCGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGCAATCTTT
GGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAATGGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGGCCAGAAG
CCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGCGCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACAAGTGCTC
AGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCCTCCTTTCAAAACTATTTGTGGTATTTCTTCCAAGCAGTCAGCTGA

>In-frame_NUMB_ENST00000555738_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_1047nt
ATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAA
GGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTAGAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGAT
GCTGTAAAAAGATTGAAAGCTACTGGAAAGAAAGCAGTTAAAGCAGTTCTGTGGGTCTCAGCAGATGGACTCAGAGTTGTGGATGAAAAA
ACTAAGGACCTCATAGTTGACCAGACGATAGAGAAAGTTTCTTTCTGTGCCCCAGACAGGAACTTTGATAGAGCCTTTTCTTACATATGC
CGTGATGGCACCACTCGTCGCTGGATCTGTCACTGCTTCATGGCTGTCAAGGACACAGTAACAAACCTGAATTTGGCAACTGGCATCATA
AACAGAAGCAGTGCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCCTAGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCT
CCCGAGAATCACTCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGATTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGC
CAGGCTACAGGGGTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAGCTATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAA
AAACTTCAGTCCCGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGCAATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGG
ACAATGAATAATGGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGGCCAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCT
CCAAGTTCTTGCGCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACAAGTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACC

>In-frame_NUMB_ENST00000559312_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_1080nt
ATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAA
GGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTAGAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGAT
GCTGTAAAAAGATTGAAAGCTGAAAGGAAGTTCTTCAAAGGCTTCTTTGGAAAAACTGGAAAGAAAGCAGTTAAAGCAGTTCTGTGGGTC
TCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGGACCTCATAGTTGACCAGACGATAGAGAAAGTTTCTTTCTGTGCCCCAGAC
AGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATGGCACCACTCGTCGCTGGATCTGTCACTGCTTCATGGCTGTCAAGGACACA
GTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGTGCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCCTAGTGGC
CCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCACTCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGATTTGCC
TGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGGGTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAGCTATCAG
CTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCCCGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGCAATCTTT
GGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAATGGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGGCCAGAAG
CCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGCGCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACAAGTGCTC
AGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCCTCCTTTCAAAACTATTTGTGGTATTTCTTCCAAGCAGTCAGCTGA

>In-frame_NUMB_ENST00000554521_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_1047nt
ATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAA
GGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTAGAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGAT
GCTGTAAAAAGATTGAAAGCTACTGGAAAGAAAGCAGTTAAAGCAGTTCTGTGGGTCTCAGCAGATGGACTCAGAGTTGTGGATGAAAAA
ACTAAGGACCTCATAGTTGACCAGACGATAGAGAAAGTTTCTTTCTGTGCCCCAGACAGGAACTTTGATAGAGCCTTTTCTTACATATGC
CGTGATGGCACCACTCGTCGCTGGATCTGTCACTGCTTCATGGCTGTCAAGGACACAGTAACAAACCTGAATTTGGCAACTGGCATCATA
AACAGAAGCAGTGCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCCTAGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCT
CCCGAGAATCACTCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGATTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGC
CAGGCTACAGGGGTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAGCTATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAA
AAACTTCAGTCCCGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGCAATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGG
ACAATGAATAATGGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGGCCAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCT
CCAAGTTCTTGCGCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACAAGTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACC


* Fusion transcript sequences (Full-length transcript).
>In-frame_NUMB_ENST00000554546_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_1511nt
CAATGGATAGGTTAGAAGTATGAAAGAGGGTGGGCCTGTTGTCATGGGGGAGGTGGTGGCGCTTGGTGGCCACTGGCGGCCGAGGTAGAG
GCAGTGGCGCTTGAGTTGGTCGGGGGCAGCGGCAGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCACTGTTAC
AATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTAGGACAAATGAGGAAACTGA
GGCTTGGTGAAGTTACGAAACTTGTCCAAAATCACACAACTTGTAAAGGGCACAGCCAAGATTCAGAGCCAGGCTGTAAAAATTAAAATG
AACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAAGGC
GTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTAGAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGATGCT
GTAAAAAGATTGAAAGCTACTGGAAAGAAAGCAGTTAAAGCAGTTCTGTGGGTCTCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACT
AAGGACCTCATAGTTGACCAGACGATAGAGAAAGTTTCTTTCTGTGCCCCAGACAGGAACTTTGATAGAGCCTTTTCTTACATATGCCGT
GATGGCACCACTCGTCGCTGGATCTGTCACTGCTTCATGGCTGTCAAGGACACAGTAACAAACCTGAATTTGGCAACTGGCATCATAAAC
AGAAGCAGTGCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCCTAGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCTCCC
GAGAATCACTCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGATTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAG
GCTACAGGGGTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAGCTATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAA
CTTCAGTCCCGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGCAATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGGACA
ATGAATAATGGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGGCCAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCTCCA
AGTTCTTGCGCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACAAGTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGC
TTCAGATCCTCCTTTCAAAACTATTTGTGGTATTTCTTCCAAGCAGTCAGCTGAACTGAGGACGACAGCCTACAAACAACTACATGCATC

>In-frame_NUMB_ENST00000557597_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_1416nt
GGCGCTTGAGTTGGTCGGGGGCAGCGGCAGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCACTGTTACAATTC
AAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTAGGACAAATGAGGAAACTGAGGCTT
GGTGAAGTTACGAAACTTGTCCAAAATCACACAACTTGTAAAGGGCACAGCCAAGATTCAGAGCCAGGCTGTAAAAATTAAAATGAACAA
ATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAAGGCGTTCG
CACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTAGAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGATGCTGTAAA
AAGATTGAAAGCTACTGGAAAGAAAGCAGTTAAAGCAGTTCTGTGGGTCTCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGGA
CCTCATAGTTGACCAGACGATAGAGAAAGTTTCTTTCTGTGCCCCAGACAGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATGG
CACCACTCGTCGCTGGATCTGTCACTGCTTCATGGCTGTCAAGGACACAGTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAG
CAGTGCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCCTAGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAA
TCACTCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGATTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTAC
AGGGGTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAGCTATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCA
GTCCCGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGCAATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAA
TAATGGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGGCCAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTC
TTGCGCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACAAGTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAG
ATCCTCCTTTCAAAACTATTTGTGGTATTTCTTCCAAGCAGTCAGCTGAACTGAGGACGACAGCCTACAAACAACTACATGCATCTGAAC

>In-frame_NUMB_ENST00000555238_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_1457nt
GAGGCAGTGGCGCTTGAGTTGGTCGGGGGCAGCGGCAGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCACTGT
TACAATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTAGGACAAATGAGGAAAC
TGAGGCTTGGTGAAGTTACGAAACTTGTCCAAAATCACACAACTTGTAAAGGGCACAGCCAAGATTCAGAGCCAGGCTGTAAAAATTAAA
ATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAA
GGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTAGAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGAT
GCTGTAAAAAGATTGAAAGCTGAAAGGAAGTTCTTCAAAGGCTTCTTTGGAAAAACTGGAAAGAAAGCAGTTAAAGCAGTTCTGTGGGTC
TCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGGACCTCATAGTTGACCAGACGATAGAGAAAGTTTCTTTCTGTGCCCCAGAC
AGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATGGCACCACTCGTCGCTGGATCTGTCACTGCTTCATGGCTGTCAAGGACACA
GTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGTGCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCCTAGTGGC
CCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCACTCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGATTTGCC
TGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGGGTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAGCTATCAG
CTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCCCGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGCAATCTTT
GGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAATGGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGGCCAGAAG
CCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGCGCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACAAGTGCTC
AGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCCTCCTTTCAAAACTATTTGTGGTATTTCTTCCAAGCAGTCAGCTGA
ACTGAGGACGACAGCCTACAAACAACTACATGCATCTGAACTGTCTCTTGTAAATGAGCTTTTTTCAGAGCCAGAATCATACTCTCCAGG

>In-frame_NUMB_ENST00000555394_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_1507nt
GTTGTCATGGGGGAGGTGGTGGCGCTTGGTGGCCACTGGCGGCCGAGGTAGAGGCAGTGGCGCTTGAGTTGGTCGGGGGCAGCGGCAGAT
TTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCACTGTTACAATTCAAGATCTTGATCTATATCCATAGATTGGAATA
TTGGTGGGCCAGCAATCCTCAGACGCCTCACTTAGGACAAATGAGGAAACTGAGGCTTGGTGAAGTTACGAAACTTGTCCAAAATCACAC
AACTTGTAAAGGGCACAGCCAAGATTCAGAGCCAGGCTGTAAAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATG
TTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACC
TTGGCCATGTAGAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGATGCTGTAAAAAGATTGAAAGCTGAAAGGAAGTTCTTCAAAG
GCTTCTTTGGAAAAACTGGAAAGAAAGCAGTTAAAGCAGTTCTGTGGGTCTCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGG
ACCTCATAGTTGACCAGACGATAGAGAAAGTTTCTTTCTGTGCCCCAGACAGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATG
GCACCACTCGTCGCTGGATCTGTCACTGCTTCATGGCTGTCAAGGACACAGTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAA
GCAGTGCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCCTAGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGA
ATCACTCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGATTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTA
CAGGGGTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAGCTATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTC
AGTCCCGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGCAATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGA
ATAATGGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGGCCAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTT
CTTGCGCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACAAGTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCA
GATCCTCCTTTCAAAACTATTTGTGGTATTTCTTCCAAGCAGTCAGCTGAACTGAGGACGACAGCCTACAAACAACTACATGCATCTGAA

>In-frame_NUMB_ENST00000454166_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_1205nt
CAGGCTGTAAAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAG
TGGCAGACAGATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTAGAAGTTGATGAATCAAGAGGA
ATGCACATCTGTGAAGATGCTGTAAAAAGATTGAAAGCTGAAAGGAAGTTCTTCAAAGGCTTCTTTGGAAAAACTGGAAAGAAAGCAGTT
AAAGCAGTTCTGTGGGTCTCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGGACCTCATAGTTGACCAGACGATAGAGAAAGTT
TCTTTCTGTGCCCCAGACAGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATGGCACCACTCGTCGCTGGATCTGTCACTGCTTC
ATGGCTGTCAAGGACACAGTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGTGCTTCAGCTCCCCCAACCCTCCGACCC
ATCATCAGTCCTAGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCACTCCAGCTCTCCTGGAAGCAGGAGCCTG
CAGACAGGGGGATTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGGGTGGTCCCCCAGCACAAGTATCACCCC
ACAGCAGGCAGCTATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCCCGGCAGCTCCTGGACCAGAGTCGAGCC
CGGCACCAGGCAATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAATGGTGCAGGTTGTAGAATTTCCAGTGCC
ACAGCTAGTGGCCAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGCGCCTCCCTGGTTCCCAAACCCCCACCC
AACCACGAACAAGTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCCTCCTTTCAAAACTATTTGTGGTATTTC
TTCCAAGCAGTCAGCTGAACTGAGGACGACAGCCTACAAACAACTACATGCATCTGAACTGTCTCTTGTAAATGAGCTTTTTTCAGAGCC

>In-frame_NUMB_ENST00000544991_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_1205nt
CAGGCTGTAAAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAG
TGGCAGACAGATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTAGAAGTTGATGAATCAAGAGGA
ATGCACATCTGTGAAGATGCTGTAAAAAGATTGAAAGCTGAAAGGAAGTTCTTCAAAGGCTTCTTTGGAAAAACTGGAAAGAAAGCAGTT
AAAGCAGTTCTGTGGGTCTCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGGACCTCATAGTTGACCAGACGATAGAGAAAGTT
TCTTTCTGTGCCCCAGACAGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATGGCACCACTCGTCGCTGGATCTGTCACTGCTTC
ATGGCTGTCAAGGACACAGTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGTGCTTCAGCTCCCCCAACCCTCCGACCC
ATCATCAGTCCTAGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCACTCCAGCTCTCCTGGAAGCAGGAGCCTG
CAGACAGGGGGATTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGGGTGGTCCCCCAGCACAAGTATCACCCC
ACAGCAGGCAGCTATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCCCGGCAGCTCCTGGACCAGAGTCGAGCC
CGGCACCAGGCAATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAATGGTGCAGGTTGTAGAATTTCCAGTGCC
ACAGCTAGTGGCCAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGCGCCTCCCTGGTTCCCAAACCCCCACCC
AACCACGAACAAGTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCCTCCTTTCAAAACTATTTGTGGTATTTC
TTCCAAGCAGTCAGCTGAACTGAGGACGACAGCCTACAAACAACTACATGCATCTGAACTGTCTCTTGTAAATGAGCTTTTTTCAGAGCC

>In-frame_NUMB_ENST00000560335_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_1226nt
GGCACAGCCAAGATTCAGAGCCAGGCTGTAAAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCA
GAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTA
GAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGATGCTGTAAAAAGATTGAAAGCTGAAAGGAAGTTCTTCAAAGGCTTCTTTGGA
AAAACTGGAAAGAAAGCAGTTAAAGCAGTTCTGTGGGTCTCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGGACCTCATAGTT
GACCAGACGATAGAGAAAGTTTCTTTCTGTGCCCCAGACAGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATGGCACCACTCGT
CGCTGGATCTGTCACTGCTTCATGGCTGTCAAGGACACAGTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGTGCTTCA
GCTCCCCCAACCCTCCGACCCATCATCAGTCCTAGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCACTCCAGC
TCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGATTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGGGTGGTC
CCCCAGCACAAGTATCACCCCACAGCAGGCAGCTATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCCCGGCAG
CTCCTGGACCAGAGTCGAGCCCGGCACCAGGCAATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAATGGTGCA
GGTTGTAGAATTTCCAGTGCCACAGCTAGTGGCCAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGCGCCTCC
CTGGTTCCCAAACCCCCACCCAACCACGAACAAGTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCCTCCTTT
CAAAACTATTTGTGGTATTTCTTCCAAGCAGTCAGCTGAACTGAGGACGACAGCCTACAAACAACTACATGCATCTGAACTGTCTCTTGT

>In-frame_NUMB_ENST00000555738_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_1193nt
GGCACAGCCAAGATTCAGAGCCAGGCTGTAAAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCA
GAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTA
GAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGATGCTGTAAAAAGATTGAAAGCTACTGGAAAGAAAGCAGTTAAAGCAGTTCTG
TGGGTCTCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGGACCTCATAGTTGACCAGACGATAGAGAAAGTTTCTTTCTGTGCC
CCAGACAGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATGGCACCACTCGTCGCTGGATCTGTCACTGCTTCATGGCTGTCAAG
GACACAGTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGTGCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCCT
AGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCACTCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGA
TTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGGGTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAGC
TATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCCCGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGCA
ATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAATGGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGGC
CAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGCGCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACAA
GTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCCTCCTTTCAAAACTATTTGTGGTATTTCTTCCAAGCAGTC
AGCTGAACTGAGGACGACAGCCTACAAACAACTACATGCATCTGAACTGTCTCTTGTAAATGAGCTTTTTTCAGAGCCAGAATCATACTC

>In-frame_NUMB_ENST00000559312_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_1226nt
GGCACAGCCAAGATTCAGAGCCAGGCTGTAAAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCA
GAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTA
GAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGATGCTGTAAAAAGATTGAAAGCTGAAAGGAAGTTCTTCAAAGGCTTCTTTGGA
AAAACTGGAAAGAAAGCAGTTAAAGCAGTTCTGTGGGTCTCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGGACCTCATAGTT
GACCAGACGATAGAGAAAGTTTCTTTCTGTGCCCCAGACAGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATGGCACCACTCGT
CGCTGGATCTGTCACTGCTTCATGGCTGTCAAGGACACAGTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGTGCTTCA
GCTCCCCCAACCCTCCGACCCATCATCAGTCCTAGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCACTCCAGC
TCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGATTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGGGTGGTC
CCCCAGCACAAGTATCACCCCACAGCAGGCAGCTATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCCCGGCAG
CTCCTGGACCAGAGTCGAGCCCGGCACCAGGCAATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAATGGTGCA
GGTTGTAGAATTTCCAGTGCCACAGCTAGTGGCCAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGCGCCTCC
CTGGTTCCCAAACCCCCACCCAACCACGAACAAGTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCCTCCTTT
CAAAACTATTTGTGGTATTTCTTCCAAGCAGTCAGCTGAACTGAGGACGACAGCCTACAAACAACTACATGCATCTGAACTGTCTCTTGT

>In-frame_NUMB_ENST00000554521_chr14_73759442_-_TTLL5_ENST00000557636_chr14_76286350_+_1193nt
GGCACAGCCAAGATTCAGAGCCAGGCTGTAAAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCA
GAGGCCAGTCGTCCACATCAGTGGCAGACAGATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACCTTGGCCATGTA
GAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGATGCTGTAAAAAGATTGAAAGCTACTGGAAAGAAAGCAGTTAAAGCAGTTCTG
TGGGTCTCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGGACCTCATAGTTGACCAGACGATAGAGAAAGTTTCTTTCTGTGCC
CCAGACAGGAACTTTGATAGAGCCTTTTCTTACATATGCCGTGATGGCACCACTCGTCGCTGGATCTGTCACTGCTTCATGGCTGTCAAG
GACACAGTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGTGCTTCAGCTCCCCCAACCCTCCGACCCATCATCAGTCCT
AGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCACTCCAGCTCTCCTGGAAGCAGGAGCCTGCAGACAGGGGGA
TTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGGGTGGTCCCCCAGCACAAGTATCACCCCACAGCAGGCAGC
TATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCCCGGCAGCTCCTGGACCAGAGTCGAGCCCGGCACCAGGCA
ATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAATGGTGCAGGTTGTAGAATTTCCAGTGCCACAGCTAGTGGC
CAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGCGCCTCCCTGGTTCCCAAACCCCCACCCAACCACGAACAA
GTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCCTCCTTTCAAAACTATTTGTGGTATTTCTTCCAAGCAGTC
AGCTGAACTGAGGACGACAGCCTACAAACAACTACATGCATCTGAACTGTCTCTTGTAAATGAGCTTTTTTCAGAGCCAGAATCATACTC


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FusionGenePPI for NUMB_TTLL5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NUMBAP2A1, DPYSL2, L1CAM, RALBP1, ITCH, MDM2, NOTCH1, LNX1, SIAH1, TP53, GLI1, EPS15, APP, EGFR, PRKCA, PRKCZ, PRKCE, PRKCB, RPL3, AP2M1, IRS1, OLIG1, FRS3, LNX2, MAPK8IP2, TERF2, TMEM17, XPO1, CAPZA2, CLTB, CLTC, DBN1, GAK, IGBP1, ATP6AP2, KIAA1107, GTSE1, ANLN, CDH1, CTDSPL, KBTBD7, UNC5CL, TULP3, STAMBPL1, COL10A1, DCAF7TTLL5TP53, TP73, CREB3, THBS3, MED4, PCM1, CEP128, OFD1, PTTG1, CEP135, FGFR1OP, GAR1, CCDC14, VWCE, TTC25, CACNG5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NUMB_TTLL5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NUMB_TTLL5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTTLL5C3495559Juvenile arthritis1CTD_human
TgeneTTLL5C4014501CONE-ROD DYSTROPHY 191UNIPROT