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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25170

FusionGeneSummary for NUMB_SRP14

check button Fusion gene summary
Fusion gene informationFusion gene name: NUMB_SRP14
Fusion gene ID: 25170
HgeneTgene
Gene symbol

NUMB

SRP14

Gene ID

8650

6727

Gene nameNUMB, endocytic adaptor proteinsignal recognition particle 14
SynonymsC14orf41|S171|c14_5527ALURBP
Cytomap

14q24.2-q24.3

15q15.1

Type of geneprotein-codingprotein-coding
Descriptionprotein numb homologh-Numbnumb homologsignal recognition particle 14 kDa protein18 kDa Alu RNA-binding proteinhomologous Alu RNA binding protein
Modification date2018052220180523
UniProtAcc

P49757

P37108

Ensembl transtripts involved in fusion geneENST00000554546, ENST00000356296, 
ENST00000557597, ENST00000555238, 
ENST00000355058, ENST00000359560, 
ENST00000555394, ENST00000454166, 
ENST00000544991, ENST00000560335, 
ENST00000555738, ENST00000559312, 
ENST00000554521, ENST00000535282, 
ENST00000556600, ENST00000556772, 
ENST00000267884, ENST00000558527, 
ENST00000558720, ENST00000560773, 
ENST00000559081, 
Fusion gene scores* DoF score10 X 7 X 7=4902 X 2 X 2=8
# samples 112
** MAII scorelog2(11/490*10)=-2.15527822547791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: NUMB [Title/Abstract] AND SRP14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSRP14

GO:0042493

response to drug

18089836


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE836999NUMBchr14

73759574

+SRP14chr15

40331128

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000554546ENST00000267884NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000554546ENST00000558527NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000554546ENST00000558720NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000554546ENST00000560773NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000554546ENST00000559081NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-3CDSENST00000356296ENST00000267884NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000356296ENST00000558527NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000356296ENST00000558720NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000356296ENST00000560773NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000356296ENST00000559081NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-3CDSENST00000557597ENST00000267884NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000557597ENST00000558527NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000557597ENST00000558720NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000557597ENST00000560773NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000557597ENST00000559081NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-3CDSENST00000555238ENST00000267884NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000555238ENST00000558527NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000555238ENST00000558720NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000555238ENST00000560773NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000555238ENST00000559081NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-3CDSENST00000355058ENST00000267884NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000355058ENST00000558527NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000355058ENST00000558720NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000355058ENST00000560773NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000355058ENST00000559081NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-3CDSENST00000359560ENST00000267884NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000359560ENST00000558527NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000359560ENST00000558720NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000359560ENST00000560773NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000359560ENST00000559081NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-3CDSENST00000555394ENST00000267884NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000555394ENST00000558527NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000555394ENST00000558720NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000555394ENST00000560773NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000555394ENST00000559081NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-3CDSENST00000454166ENST00000267884NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000454166ENST00000558527NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000454166ENST00000558720NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000454166ENST00000560773NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000454166ENST00000559081NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-3CDSENST00000544991ENST00000267884NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000544991ENST00000558527NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000544991ENST00000558720NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000544991ENST00000560773NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000544991ENST00000559081NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-3CDSENST00000560335ENST00000267884NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000560335ENST00000558527NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000560335ENST00000558720NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000560335ENST00000560773NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000560335ENST00000559081NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-3CDSENST00000555738ENST00000267884NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000555738ENST00000558527NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000555738ENST00000558720NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000555738ENST00000560773NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000555738ENST00000559081NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-3CDSENST00000559312ENST00000267884NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000559312ENST00000558527NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000559312ENST00000558720NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000559312ENST00000560773NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000559312ENST00000559081NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-3CDSENST00000554521ENST00000267884NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000554521ENST00000558527NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000554521ENST00000558720NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000554521ENST00000560773NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000554521ENST00000559081NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-3CDSENST00000535282ENST00000267884NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000535282ENST00000558527NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000535282ENST00000558720NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000535282ENST00000560773NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000535282ENST00000559081NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-3CDSENST00000556600ENST00000267884NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000556600ENST00000558527NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000556600ENST00000558720NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000556600ENST00000560773NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000556600ENST00000559081NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-3CDSENST00000556772ENST00000267884NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000556772ENST00000558527NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-5UTRENST00000556772ENST00000558720NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000556772ENST00000560773NUMBchr14

73759574

+SRP14chr15

40331128

+
intron-intronENST00000556772ENST00000559081NUMBchr14

73759574

+SRP14chr15

40331128

+

Top

FusionProtFeatures for NUMB_SRP14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUMB

P49757

SRP14

P37108

Signal-recognition-particle assembly has a crucial rolein targeting secretory proteins to the rough endoplasmic reticulummembrane. SRP9 together with SRP14 and the Alu portion of the SRPRNA, constitutes the elongation arrest domain of SRP. The complexof SRP9 and SRP14 is required for SRP RNA binding.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NUMB_SRP14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NUMB_SRP14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NUMB_SRP14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSRP14P37108DB11638ArtenimolSignal recognition particle 14 kDa proteinsmall moleculeapproved|investigational

Top

RelatedDiseases for NUMB_SRP14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource