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Fusion gene ID: 25161 |
FusionGeneSummary for NUMA1_YAP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NUMA1_YAP1 | Fusion gene ID: 25161 | Hgene | Tgene | Gene symbol | NUMA1 | YAP1 | Gene ID | 4926 | 10413 |
| Gene name | nuclear mitotic apparatus protein 1 | Yes associated protein 1 | |
| Synonyms | NMP-22|NUMA | COB1|YAP|YAP2|YAP65|YKI | |
| Cytomap | 11q13.4 | 11q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear mitotic apparatus protein 1SP-H antigencentrophilin stabilizes mitotic spindle in mitotic cellsnuclear matrix protein-22structural nuclear protein | transcriptional coactivator YAP165 kDa Yes-associated proteinprotein yorkie homologyes-associated protein 1yes-associated protein 2yes-associated protein YAP65 homologyorkie homolog | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q14980 | P46937 | |
| Ensembl transtripts involved in fusion gene | ENST00000351960, ENST00000358965, ENST00000393695, ENST00000543450, | ENST00000526343, ENST00000282441, ENST00000537274, ENST00000345877, ENST00000531439, ENST00000524575, ENST00000528834, | |
| Fusion gene scores | * DoF score | 29 X 14 X 14=5684 | 13 X 7 X 11=1001 |
| # samples | 31 | 13 | |
| ** MAII score | log2(31/5684*10)=-4.19656643396854 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/1001*10)=-2.94485844580754 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NUMA1 [Title/Abstract] AND YAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NUMA1 | GO:0000132 | establishment of mitotic spindle orientation | 21816348 |
| Hgene | NUMA1 | GO:0030953 | astral microtubule organization | 12445386 |
| Hgene | NUMA1 | GO:0060236 | regulation of mitotic spindle organization | 26195665 |
| Hgene | NUMA1 | GO:1902365 | positive regulation of protein localization to spindle pole body | 16076287 |
| Tgene | YAP1 | GO:0006974 | cellular response to DNA damage stimulus | 18280240 |
| Tgene | YAP1 | GO:0008283 | cell proliferation | 17974916 |
| Tgene | YAP1 | GO:0032570 | response to progesterone | 16772533 |
| Tgene | YAP1 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway | 16772533 |
| Tgene | YAP1 | GO:0045893 | positive regulation of transcription, DNA-templated | 20368466 |
| Tgene | YAP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 25796446 |
| Tgene | YAP1 | GO:0050767 | regulation of neurogenesis | 25433207 |
| Tgene | YAP1 | GO:0050847 | progesterone receptor signaling pathway | 16772533 |
| Tgene | YAP1 | GO:0060242 | contact inhibition | 17974916 |
| Tgene | YAP1 | GO:0065003 | protein-containing complex assembly | 20368466 |
| Tgene | YAP1 | GO:0071480 | cellular response to gamma radiation | 18280240 |
| Tgene | YAP1 | GO:0072091 | regulation of stem cell proliferation | 25433207 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-GN-A4U7-06A | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000351960 | ENST00000526343 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| In-frame | ENST00000351960 | ENST00000282441 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| In-frame | ENST00000351960 | ENST00000537274 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| In-frame | ENST00000351960 | ENST00000345877 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| In-frame | ENST00000351960 | ENST00000531439 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| In-frame | ENST00000351960 | ENST00000524575 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| 5CDS-intron | ENST00000351960 | ENST00000528834 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| Frame-shift | ENST00000358965 | ENST00000526343 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| Frame-shift | ENST00000358965 | ENST00000282441 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| Frame-shift | ENST00000358965 | ENST00000537274 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| Frame-shift | ENST00000358965 | ENST00000345877 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| Frame-shift | ENST00000358965 | ENST00000531439 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| Frame-shift | ENST00000358965 | ENST00000524575 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| 5CDS-intron | ENST00000358965 | ENST00000528834 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| In-frame | ENST00000393695 | ENST00000526343 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| In-frame | ENST00000393695 | ENST00000282441 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| In-frame | ENST00000393695 | ENST00000537274 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| In-frame | ENST00000393695 | ENST00000345877 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| In-frame | ENST00000393695 | ENST00000531439 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| In-frame | ENST00000393695 | ENST00000524575 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| 5CDS-intron | ENST00000393695 | ENST00000528834 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| intron-3CDS | ENST00000543450 | ENST00000526343 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| intron-3CDS | ENST00000543450 | ENST00000282441 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| intron-3CDS | ENST00000543450 | ENST00000537274 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| intron-3CDS | ENST00000543450 | ENST00000345877 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| intron-3CDS | ENST00000543450 | ENST00000531439 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| intron-3CDS | ENST00000543450 | ENST00000524575 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
| intron-intron | ENST00000543450 | ENST00000528834 | NUMA1 | chr11 | 71746948 | - | YAP1 | chr11 | 102094353 | + |
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FusionProtFeatures for NUMA1_YAP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NUMA1 | YAP1 |
| Microtubule (MT)-binding protein that plays a role inthe formation and maintenance of the spindle poles and thealignement and the segregation of chromosomes during mitotic celldivision (PubMed:7769006, PubMed:17172455, PubMed:19255246,PubMed:24996901, PubMed:26195665, PubMed:27462074). Functions totether the minus ends of MTs at the spindle poles, which iscritical for the establishment and maintenance of the spindlepoles (PubMed:12445386, PubMed:11956313). Plays a role in theestablishment of the mitotic spindle orientation during metaphaseand elongation during anaphase in a dynein-dynactin-dependentmanner (PubMed:23870127, PubMed:24109598, PubMed:24996901,PubMed:26765568). In metaphase, part of a ternary complex composedof GPSM2 and G(i) alpha proteins, that regulates the recruitmentand anchorage of the dynein-dynactin complex in the mitotic cellcortex regions situated above the two spindle poles, and henceregulates the correct oritentation of the mitotic spindle(PubMed:23027904, PubMed:22327364, PubMed:23921553). Duringanaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical regionthrough direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulationof the spindle elongation and chromosome segregation(PubMed:22327364, PubMed:23921553, PubMed:24996901,PubMed:24371089). Binds also to other polyanionicphosphoinositides, such as phosphatidylinositol 3-phosphate (PIP),lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate(PIP3), in vitro (PubMed:24996901, PubMed:24371089). Also requiredfor proper orientation of the mitotic spindle during asymmetriccell divisions (PubMed:21816348). Plays a role in mitotic MT asterassembly (PubMed:11163243, PubMed:11229403, PubMed:12445386).Involved in anastral spindle assembly (PubMed:25657325).Positively regulates TNKS protein localization to spindle poles inmitosis (PubMed:16076287). Highly abundant component of thenuclear matrix where it may serve a non-mitotic structural role,occupies the majority of the nuclear volume (PubMed:10075938).Required for epidermal differentiation and hair folliclemorphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0,ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403,ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386,ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455,ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364,ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127,ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598,ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901,ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665,ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074,ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938,ECO:0000305|PubMed:21816348}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >YAP1 | chr11:71746948 | chr11:102094353 | ENST00000345877 | + | 3 | 7 | 298_359 | 294 | 455 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >YAP1 | chr11:71746948 | chr11:102094353 | ENST00000524575 | + | 5 | 9 | 298_359 | 166 | 327 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >YAP1 | chr11:71746948 | chr11:102094353 | ENST00000526343 | + | 3 | 7 | 298_359 | 290 | 451 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >YAP1 | chr11:71746948 | chr11:102094353 | ENST00000524575 | + | 5 | 9 | 171_204 | 166 | 327 | Domain | WW 1 |
| Tgene | >YAP1 | chr11:71746948 | chr11:102094353 | ENST00000524575 | + | 5 | 9 | 230_263 | 166 | 327 | Domain | WW 2 |
| Tgene | >YAP1 | chr11:71746948 | chr11:102094353 | ENST00000345877 | + | 3 | 7 | 291_504 | 294 | 455 | Region | Note=Transactivation domain |
| Tgene | >YAP1 | chr11:71746948 | chr11:102094353 | ENST00000524575 | + | 5 | 9 | 291_504 | 166 | 327 | Region | Note=Transactivation domain |
| Tgene | >YAP1 | chr11:71746948 | chr11:102094353 | ENST00000526343 | + | 3 | 7 | 291_504 | 290 | 451 | Region | Note=Transactivation domain |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000358965 | - | 4 | 27 | 213_1699 | 14 | 2102 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000393695 | - | 3 | 27 | 213_1699 | 14 | 2116 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000358965 | - | 4 | 27 | 1742_1748 | 14 | 2102 | Motif | Tankyrase-binding domain |
| Hgene | >NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000358965 | - | 4 | 27 | 1984_1989 | 14 | 2102 | Motif | Nuclear localization signal |
| Hgene | >NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000393695 | - | 3 | 27 | 1742_1748 | 14 | 2116 | Motif | Tankyrase-binding domain |
| Hgene | >NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000393695 | - | 3 | 27 | 1984_1989 | 14 | 2116 | Motif | Nuclear localization signal |
| Hgene | >NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000358965 | - | 4 | 27 | 1699_1876 | 14 | 2102 | Region | Membrane-binding domain 1 |
| Hgene | >NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000358965 | - | 4 | 27 | 1700_2115 | 14 | 2102 | Region | Note=Tail (Globular) |
| Hgene | >NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000358965 | - | 4 | 27 | 1788_1810 | 14 | 2102 | Region | 4.1-binding domain |
| Hgene | >NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000358965 | - | 4 | 27 | 1882_1985 | 14 | 2102 | Region | Tubulin-binding domain |
| Hgene | >NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000358965 | - | 4 | 27 | 1892_1926 | 14 | 2102 | Region | GPSM2-binding domain |
| Hgene | >NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000358965 | - | 4 | 27 | 1981_2060 | 14 | 2102 | Region | Membrane-binding domain 2 |
| Hgene | >NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000358965 | - | 4 | 27 | 1_212 | 14 | 2102 | Region | Note=Head (Globular) |
| Hgene | >NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000393695 | - | 3 | 27 | 1699_1876 | 14 | 2116 | Region | Membrane-binding domain 1 |
| Hgene | >NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000393695 | - | 3 | 27 | 1700_2115 | 14 | 2116 | Region | Note=Tail (Globular) |
| Hgene | >NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000393695 | - | 3 | 27 | 1788_1810 | 14 | 2116 | Region | 4.1-binding domain |
| Hgene | >NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000393695 | - | 3 | 27 | 1882_1985 | 14 | 2116 | Region | Tubulin-binding domain |
| Hgene | >NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000393695 | - | 3 | 27 | 1892_1926 | 14 | 2116 | Region | GPSM2-binding domain |
| Hgene | >NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000393695 | - | 3 | 27 | 1981_2060 | 14 | 2116 | Region | Membrane-binding domain 2 |
| Hgene | >NUMA1 | chr11:71746948 | chr11:102094353 | ENST00000393695 | - | 3 | 27 | 1_212 | 14 | 2116 | Region | Note=Head (Globular) |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000282441 | + | 5 | 9 | 298_359 | 344 | 505 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000282441 | + | 5 | 9 | 86_100 | 344 | 505 | Coiled coil | Ontology_term=ECO:0000269 |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000345877 | + | 3 | 7 | 86_100 | 294 | 455 | Coiled coil | Ontology_term=ECO:0000269 |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000524575 | + | 5 | 9 | 86_100 | 166 | 327 | Coiled coil | Ontology_term=ECO:0000269 |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000526343 | + | 3 | 7 | 86_100 | 290 | 451 | Coiled coil | Ontology_term=ECO:0000269 |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000531439 | + | 4 | 8 | 298_359 | 328 | 489 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000531439 | + | 4 | 8 | 86_100 | 328 | 489 | Coiled coil | Ontology_term=ECO:0000269 |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000537274 | + | 4 | 8 | 298_359 | 332 | 493 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000537274 | + | 4 | 8 | 86_100 | 332 | 493 | Coiled coil | Ontology_term=ECO:0000269 |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000282441 | + | 5 | 9 | 3_49 | 344 | 505 | Compositional bias | Note=Pro-rich |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000345877 | + | 3 | 7 | 3_49 | 294 | 455 | Compositional bias | Note=Pro-rich |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000524575 | + | 5 | 9 | 3_49 | 166 | 327 | Compositional bias | Note=Pro-rich |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000526343 | + | 3 | 7 | 3_49 | 290 | 451 | Compositional bias | Note=Pro-rich |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000531439 | + | 4 | 8 | 3_49 | 328 | 489 | Compositional bias | Note=Pro-rich |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000537274 | + | 4 | 8 | 3_49 | 332 | 493 | Compositional bias | Note=Pro-rich |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000282441 | + | 5 | 9 | 171_204 | 344 | 505 | Domain | WW 1 |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000282441 | + | 5 | 9 | 230_263 | 344 | 505 | Domain | WW 2 |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000345877 | + | 3 | 7 | 171_204 | 294 | 455 | Domain | WW 1 |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000345877 | + | 3 | 7 | 230_263 | 294 | 455 | Domain | WW 2 |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000526343 | + | 3 | 7 | 171_204 | 290 | 451 | Domain | WW 1 |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000526343 | + | 3 | 7 | 230_263 | 290 | 451 | Domain | WW 2 |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000531439 | + | 4 | 8 | 171_204 | 328 | 489 | Domain | WW 1 |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000531439 | + | 4 | 8 | 230_263 | 328 | 489 | Domain | WW 2 |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000537274 | + | 4 | 8 | 171_204 | 332 | 493 | Domain | WW 1 |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000537274 | + | 4 | 8 | 230_263 | 332 | 493 | Domain | WW 2 |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000282441 | + | 5 | 9 | 291_504 | 344 | 505 | Region | Note=Transactivation domain |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000531439 | + | 4 | 8 | 291_504 | 328 | 489 | Region | Note=Transactivation domain |
| Tgene | YAP1 | chr11:71746948 | chr11:102094353 | ENST00000537274 | + | 4 | 8 | 291_504 | 332 | 493 | Region | Note=Transactivation domain |
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FusionGeneSequence for NUMA1_YAP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NUMA1_ENST00000351960_chr11_71746948_-_YAP1_ENST00000526343_chr11_102094353_+_175aa MTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV >In-frame_NUMA1_ENST00000351960_chr11_71746948_-_YAP1_ENST00000282441_chr11_102094353_+_175aa MTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV >In-frame_NUMA1_ENST00000351960_chr11_71746948_-_YAP1_ENST00000537274_chr11_102094353_+_175aa MTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV >In-frame_NUMA1_ENST00000351960_chr11_71746948_-_YAP1_ENST00000345877_chr11_102094353_+_175aa MTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV >In-frame_NUMA1_ENST00000351960_chr11_71746948_-_YAP1_ENST00000531439_chr11_102094353_+_175aa MTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV >In-frame_NUMA1_ENST00000351960_chr11_71746948_-_YAP1_ENST00000524575_chr11_102094353_+_175aa MTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV >In-frame_NUMA1_ENST00000393695_chr11_71746948_-_YAP1_ENST00000526343_chr11_102094353_+_175aa MTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV >In-frame_NUMA1_ENST00000393695_chr11_71746948_-_YAP1_ENST00000282441_chr11_102094353_+_175aa MTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV >In-frame_NUMA1_ENST00000393695_chr11_71746948_-_YAP1_ENST00000537274_chr11_102094353_+_175aa MTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV >In-frame_NUMA1_ENST00000393695_chr11_71746948_-_YAP1_ENST00000345877_chr11_102094353_+_175aa MTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV >In-frame_NUMA1_ENST00000393695_chr11_71746948_-_YAP1_ENST00000531439_chr11_102094353_+_175aa MTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV >In-frame_NUMA1_ENST00000393695_chr11_71746948_-_YAP1_ENST00000524575_chr11_102094353_+_175aa MTLHATRGAALLSWELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NUMA1_ENST00000351960_chr11_71746948_-_YAP1_ENST00000526343_chr11_102094353_+_525nt ATGACACTCCACGCCACCCGGGGGGCTGCACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGG ACTCAAAATCCAGTGTCTTCTCCCGGGATGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACC TATCACTCTCGAGATGAGAGTACAGACAGTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTG GATGAGATGGATACAGGTGATACTATCAACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGG ACAAATGTGGACCTTGGAACACTGGAAGGAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCT >In-frame_NUMA1_ENST00000351960_chr11_71746948_-_YAP1_ENST00000282441_chr11_102094353_+_525nt ATGACACTCCACGCCACCCGGGGGGCTGCACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGG ACTCAAAATCCAGTGTCTTCTCCCGGGATGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACC TATCACTCTCGAGATGAGAGTACAGACAGTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTG GATGAGATGGATACAGGTGATACTATCAACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGG ACAAATGTGGACCTTGGAACACTGGAAGGAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCT >In-frame_NUMA1_ENST00000351960_chr11_71746948_-_YAP1_ENST00000537274_chr11_102094353_+_525nt ATGACACTCCACGCCACCCGGGGGGCTGCACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGG ACTCAAAATCCAGTGTCTTCTCCCGGGATGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACC TATCACTCTCGAGATGAGAGTACAGACAGTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTG GATGAGATGGATACAGGTGATACTATCAACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGG ACAAATGTGGACCTTGGAACACTGGAAGGAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCT >In-frame_NUMA1_ENST00000351960_chr11_71746948_-_YAP1_ENST00000345877_chr11_102094353_+_525nt ATGACACTCCACGCCACCCGGGGGGCTGCACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGG ACTCAAAATCCAGTGTCTTCTCCCGGGATGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACC TATCACTCTCGAGATGAGAGTACAGACAGTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTG GATGAGATGGATACAGGTGATACTATCAACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGG ACAAATGTGGACCTTGGAACACTGGAAGGAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCT >In-frame_NUMA1_ENST00000351960_chr11_71746948_-_YAP1_ENST00000531439_chr11_102094353_+_525nt ATGACACTCCACGCCACCCGGGGGGCTGCACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGG ACTCAAAATCCAGTGTCTTCTCCCGGGATGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACC TATCACTCTCGAGATGAGAGTACAGACAGTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTG GATGAGATGGATACAGGTGATACTATCAACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGG ACAAATGTGGACCTTGGAACACTGGAAGGAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCT >In-frame_NUMA1_ENST00000351960_chr11_71746948_-_YAP1_ENST00000524575_chr11_102094353_+_525nt ATGACACTCCACGCCACCCGGGGGGCTGCACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGG ACTCAAAATCCAGTGTCTTCTCCCGGGATGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACC TATCACTCTCGAGATGAGAGTACAGACAGTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTG GATGAGATGGATACAGGTGATACTATCAACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGG ACAAATGTGGACCTTGGAACACTGGAAGGAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCT >In-frame_NUMA1_ENST00000393695_chr11_71746948_-_YAP1_ENST00000526343_chr11_102094353_+_525nt ATGACACTCCACGCCACCCGGGGGGCTGCACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGG ACTCAAAATCCAGTGTCTTCTCCCGGGATGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACC TATCACTCTCGAGATGAGAGTACAGACAGTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTG GATGAGATGGATACAGGTGATACTATCAACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGG ACAAATGTGGACCTTGGAACACTGGAAGGAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCT >In-frame_NUMA1_ENST00000393695_chr11_71746948_-_YAP1_ENST00000282441_chr11_102094353_+_525nt ATGACACTCCACGCCACCCGGGGGGCTGCACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGG ACTCAAAATCCAGTGTCTTCTCCCGGGATGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACC TATCACTCTCGAGATGAGAGTACAGACAGTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTG GATGAGATGGATACAGGTGATACTATCAACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGG ACAAATGTGGACCTTGGAACACTGGAAGGAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCT >In-frame_NUMA1_ENST00000393695_chr11_71746948_-_YAP1_ENST00000537274_chr11_102094353_+_525nt ATGACACTCCACGCCACCCGGGGGGCTGCACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGG ACTCAAAATCCAGTGTCTTCTCCCGGGATGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACC TATCACTCTCGAGATGAGAGTACAGACAGTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTG GATGAGATGGATACAGGTGATACTATCAACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGG ACAAATGTGGACCTTGGAACACTGGAAGGAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCT >In-frame_NUMA1_ENST00000393695_chr11_71746948_-_YAP1_ENST00000345877_chr11_102094353_+_525nt ATGACACTCCACGCCACCCGGGGGGCTGCACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGG ACTCAAAATCCAGTGTCTTCTCCCGGGATGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACC TATCACTCTCGAGATGAGAGTACAGACAGTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTG GATGAGATGGATACAGGTGATACTATCAACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGG ACAAATGTGGACCTTGGAACACTGGAAGGAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCT >In-frame_NUMA1_ENST00000393695_chr11_71746948_-_YAP1_ENST00000531439_chr11_102094353_+_525nt ATGACACTCCACGCCACCCGGGGGGCTGCACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGG ACTCAAAATCCAGTGTCTTCTCCCGGGATGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACC TATCACTCTCGAGATGAGAGTACAGACAGTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTG GATGAGATGGATACAGGTGATACTATCAACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGG ACAAATGTGGACCTTGGAACACTGGAAGGAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCT >In-frame_NUMA1_ENST00000393695_chr11_71746948_-_YAP1_ENST00000524575_chr11_102094353_+_525nt ATGACACTCCACGCCACCCGGGGGGCTGCACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGG ACTCAAAATCCAGTGTCTTCTCCCGGGATGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACC TATCACTCTCGAGATGAGAGTACAGACAGTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTG GATGAGATGGATACAGGTGATACTATCAACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGG ACAAATGTGGACCTTGGAACACTGGAAGGAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NUMA1_ENST00000351960_chr11_71746948_-_YAP1_ENST00000526343_chr11_102094353_+_1349nt GTGCTGGAGAGGCCGCTGCGAGCGGAAGGCCTCCTCCATAACCGAGTCCGAAAGGGCAGAATCTATGGGGGTGGAAACTAATTCTAAGCC AGACTGCTGGAGATCACCCTGTTCTAGTGTGTGGAGGCTTCCACCAGGAGGCGCATTGGAGTGACTGTCTGGCATCACCAAGATGACACT CCACGCCACCCGGGGGGCTGCACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGGACTCAAAA TCCAGTGTCTTCTCCCGGGATGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACCTATCACTC TCGAGATGAGAGTACAGACAGTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTGGATGAGAT GGATACAGGTGATACTATCAACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGGACAAATGT GGACCTTGGAACACTGGAAGGAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCTGACATCCT TAATGACATGGAGTCTGTTTTGGCTGCCACCAAGCTAGATAAAGAAAGCTTTCTTACATGGTTATAGAGCCCTCAGGCAGACTGAATTCT AAATCTGTGAAGGATCTAAGGAGACACATGCACCGGAAATTTCCATAAGCCAGTTGCAGTTTTCAGGCTAATACAGAAAAAGATGAACAA ACGTCCAGCAAGATACTTTAATCCTCTATTTTGCTCTTCCTTGTCCATTGCTGCTGTTAATGTATTGCTGACCTCTTTCACAGTTGGCTC TAAAGAATCAAAAGAAAAAAACTTTTTATTTCTTTTGCTATTAAAACTACTGTTCATTTTGGGGGCTGGGGGAAGTGAGCCTGTTTGGAT GATGGATGCCATTCCTTTTGCCCAGTTAAATGTTCACCAATCATTTTAACTAAATACTCAGACTTAGAAGTCAGATGCTTCATGTCACAG CATTTAGTTTGTTCAACAGTTGTTTCTTCAGCTTCCTTTGTCCAGTGGAAAAACATGATTTACTGGTCTGACAAGCCAAAAATGTTATAT CTGATATTAAATACTTAATGCTGATTTGAAGAGATAGCTGAAACCAAGGCTGAAGACTGTTTTACTTTCAGTATTTTCTTTTCCTCCTAG >In-frame_NUMA1_ENST00000351960_chr11_71746948_-_YAP1_ENST00000282441_chr11_102094353_+_4180nt GTGCTGGAGAGGCCGCTGCGAGCGGAAGGCCTCCTCCATAACCGAGTCCGAAAGGGCAGAATCTATGGGGGTGGAAACTAATTCTAAGCC AGACTGCTGGAGATCACCCTGTTCTAGTGTGTGGAGGCTTCCACCAGGAGGCGCATTGGAGTGACTGTCTGGCATCACCAAGATGACACT CCACGCCACCCGGGGGGCTGCACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGGACTCAAAA TCCAGTGTCTTCTCCCGGGATGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACCTATCACTC TCGAGATGAGAGTACAGACAGTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTGGATGAGAT GGATACAGGTGATACTATCAACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGGACAAATGT GGACCTTGGAACACTGGAAGGAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCTGACATCCT TAATGACATGGAGTCTGTTTTGGCTGCCACCAAGCTAGATAAAGAAAGCTTTCTTACATGGTTATAGAGCCCTCAGGCAGACTGAATTCT AAATCTGTGAAGGATCTAAGGAGACACATGCACCGGAAATTTCCATAAGCCAGTTGCAGTTTTCAGGCTAATACAGAAAAAGATGAACAA ACGTCCAGCAAGATACTTTAATCCTCTATTTTGCTCTTCCTTGTCCATTGCTGCTGTTAATGTATTGCTGACCTCTTTCACAGTTGGCTC TAAAGAATCAAAAGAAAAAAACTTTTTATTTCTTTTGCTATTAAAACTACTGTTCATTTTGGGGGCTGGGGGAAGTGAGCCTGTTTGGAT GATGGATGCCATTCCTTTTGCCCAGTTAAATGTTCACCAATCATTTTAACTAAATACTCAGACTTAGAAGTCAGATGCTTCATGTCACAG CATTTAGTTTGTTCAACAGTTGTTTCTTCAGCTTCCTTTGTCCAGTGGAAAAACATGATTTACTGGTCTGACAAGCCAAAAATGTTATAT CTGATATTAAATACTTAATGCTGATTTGAAGAGATAGCTGAAACCAAGGCTGAAGACTGTTTTACTTTCAGTATTTTCTTTTCCTCCTAG TGCTATCATTAGTCACATAATGACCTTGATTTTATTTTAGGAGCTTATAAGGCATGAGACAATTTCCATATAAATATATTAATTATTGCC ACATACTCTAATATAGATTTTGGTGGATAATTTTGTGGGTGTGCATTTTGTTCTGTTTTGTTGGGTTTTTTGTTTTTTTTGTTTTTGGCA GGGTCGGTGGGGGGGTTGGTTGGTTGGTTGGTTTTGTCGGAACCTAGGCAAATGACCATATTAGTGAATCTGTTAATAGTTGTAGCTTGG GATGGTTATTGTAGTTGTTTTGGTAAAATCTTCATTTCCTGGTTTTTTTTACCACCTTATTTAAATCTCGATTATCTGCTCTCTCTTTTA TATACATACACACACCCAAACATAACATTTATAATAGTGTGGTAGTGGAATGTATCCTTTTTTAGGTTTCCCTGCTTTCCAGTTAATTTT TAAAATGGTAGCGCTTTGTATGCATTTAGAATACATGACTAGTAGTTTATATTTCACTGGTAGTTTAAATCTGGTTGGGGCAGTCTGCAG ATGTTTGAAGTAGTTTAGTGTTCTAGAAAGAGCTATTACTGTGGATAGTGCCTAGGGGAGTGCTCCACGCCCTCTGGGCATACGGTAGAT ATTATCTGATGAATTGGAAAGGAGCAAACCAGAAATGGCTTTATTTTCTCCCTTGGACTAATTTTTAAGTCTCGATTGGAATTCAGTGAG TAGGTTCATAATGTGCATGACAGAAATAAGCTTTATAGTGGTTTACCTTCATTTAGCTTTGGAAGTTTTCTTTGCCTTAGTTTTGGAAGT AAATTCTAGTTTGTAGTTCTCATTTGTAATGAACACATTAACGACTAGATTAAAATATTGCCTTCAAGATTGTTCTTACTTACAAGACTT GCTCCTACTTCTATGCTGAAAATTGACCCTGGATAGAATACTATAAGGTTTTGAGTTAGCTGGAAAAGTGATCAGATTAATAAATGTATA TTGGTAGTTGAATTTAGCAAAGAAATAGAGATAATCATGATTATACCTTTATTTTTACAGGAAGAGATGATGTAACTAGAGTATGTGTCT ACAGGAGTAATAATGGTTTCCAAAGAGTATTTTTTAAAGGAACAAAACGAGCATGAATTAACTCTTCAATATAAGCTATGAAGTAATAGT TGGTTGTGAATTAAAGTGGCACCAGCTAGCACCTCTGTGTTTTAAGGGTCTTTCAATGTTTCTAGAATAAGCCCTTATTTTCAAGGGTTC ATAACAGGCATAAAATCTCTTCTCCTGGCAAAAGCTGCTATGAAAAGCCTCAGCTTGGGAAGATAGATTTTTTTCCCCCCAATTACAAAA TCTAAGTATTTTGGCCCTTCAATTTGGAGGAGGGCAAAAGTTGGAAGTAAGAAGTTTTATTTTAAGTACTTTCAGTGCTCAAAAAAATGC AATCACTGTGTTGTATATAATAGTTCATAGGTTGATCACTCATAATAATTGACTCTAAGGCTTTTATTAAGAAAACAGCAGAAAGATTAA ATCTTGAATTAAGTCTGGGGGGAAATGGCCACTGCAGATGGAGTTTTAGAGTAGTAATGAAATTCTACCTAGAATGCAAAATTGGGTATA TGAATTACATAGCATGTTGTTGGGATTTTTTTTAATGTGCAGAAGATCAAAGCTACTTGGAAGGAGTGCCTATAATTTGCCAGTAGCCAC AGATTAAGATTATATCTTATATATCAGCAGATTAGCTTTAGCTTAGGGGGAGGGTGGGAAAGTTTGGGGGGGGGGTTGTGAAGATTTAGG GGGACCTTGATAGAGAACTTTATAAACTTCTTTCTCTTTAATAAAGACTTGTCTTACACCGTGCTGCCATTAAAGGCAGCTGTTCTAGAG TTTCAGTCACCTAAGTACACCCACAAAACAATATGAATATGGAGATCTTCCTTTACCCCTCAACTTTAATTTGCCCAGTTATACCTCAGT GTTGTAGCAGTACTGTGATACCTGGCACAGTGCTTTGATCTTACGATGCCCTCTGTACTGACCTGAAGGAGACCTAAGAGTCCTTTCCCT TTTTGAGTTTGAATCATAGCCTTGATGTGGTCTCTTGTTTTATGTCCTTGTTCCTAATGTAAAAGTGCTTAACTGCTTCTTGGTTGTATT GGGTAGCATTGGGATAAGATTTTAACTGGGTATTCTTGAATTGCTTTTACAATAAACCAATTTTATAATCTTTAAATTTATCAACTTTTT ACATTTGTGTTATTTTCAGTCAGGGCTTCTTAGATCTACTTATGGTTGATGGAGCACATTGATTTGGAGTTTCAGATCTTCCAAAGCACT ATTTGTTGTAATAACTTTTCTAAATGTAGTGCCTTTAAAGGAAAAATGAACACAGGGAAGTGACTTTGCTACAAATAATGTTGCTGTGTT AAGTATTCATATTAAATACATGCCTTCTATATGGAACATGGCAGAAAGACTGAAAAATAACAGTAATTAATTGTGTAATTCAGAATTCAT ACCAATCAGTGTTGAAACTCAAACATTGCAAAAGTGGGTGGCAATATTCAGTGCTTAACACTTTTCTAGCGTTGGTACATCTGAGAAATG AGTGCTCAGGTGGATTTTATCCTCGCAAGCATGTTGTTATAAGAATTGTGGGTGTGCCTATCATAACAATTGTTTTCTGTATCTTGAAAA AGTATTCTCCACATTTTAAATGTTTTATATTAGAGAATTCTTTAATGCACACTTGTCAAATATATATATATAGTACCAATGTTACCTTTT TATTTTTTGTTTTAGATGTAAGAGCATGCTCATATGTTAGGTACTTACATAAATTGTTACATTATTTTTTCTTATGTAATACCTTTTTGT >In-frame_NUMA1_ENST00000351960_chr11_71746948_-_YAP1_ENST00000537274_chr11_102094353_+_4180nt GTGCTGGAGAGGCCGCTGCGAGCGGAAGGCCTCCTCCATAACCGAGTCCGAAAGGGCAGAATCTATGGGGGTGGAAACTAATTCTAAGCC AGACTGCTGGAGATCACCCTGTTCTAGTGTGTGGAGGCTTCCACCAGGAGGCGCATTGGAGTGACTGTCTGGCATCACCAAGATGACACT CCACGCCACCCGGGGGGCTGCACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGGACTCAAAA TCCAGTGTCTTCTCCCGGGATGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACCTATCACTC TCGAGATGAGAGTACAGACAGTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTGGATGAGAT GGATACAGGTGATACTATCAACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGGACAAATGT GGACCTTGGAACACTGGAAGGAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCTGACATCCT TAATGACATGGAGTCTGTTTTGGCTGCCACCAAGCTAGATAAAGAAAGCTTTCTTACATGGTTATAGAGCCCTCAGGCAGACTGAATTCT AAATCTGTGAAGGATCTAAGGAGACACATGCACCGGAAATTTCCATAAGCCAGTTGCAGTTTTCAGGCTAATACAGAAAAAGATGAACAA ACGTCCAGCAAGATACTTTAATCCTCTATTTTGCTCTTCCTTGTCCATTGCTGCTGTTAATGTATTGCTGACCTCTTTCACAGTTGGCTC TAAAGAATCAAAAGAAAAAAACTTTTTATTTCTTTTGCTATTAAAACTACTGTTCATTTTGGGGGCTGGGGGAAGTGAGCCTGTTTGGAT GATGGATGCCATTCCTTTTGCCCAGTTAAATGTTCACCAATCATTTTAACTAAATACTCAGACTTAGAAGTCAGATGCTTCATGTCACAG CATTTAGTTTGTTCAACAGTTGTTTCTTCAGCTTCCTTTGTCCAGTGGAAAAACATGATTTACTGGTCTGACAAGCCAAAAATGTTATAT CTGATATTAAATACTTAATGCTGATTTGAAGAGATAGCTGAAACCAAGGCTGAAGACTGTTTTACTTTCAGTATTTTCTTTTCCTCCTAG TGCTATCATTAGTCACATAATGACCTTGATTTTATTTTAGGAGCTTATAAGGCATGAGACAATTTCCATATAAATATATTAATTATTGCC ACATACTCTAATATAGATTTTGGTGGATAATTTTGTGGGTGTGCATTTTGTTCTGTTTTGTTGGGTTTTTTGTTTTTTTTGTTTTTGGCA GGGTCGGTGGGGGGGTTGGTTGGTTGGTTGGTTTTGTCGGAACCTAGGCAAATGACCATATTAGTGAATCTGTTAATAGTTGTAGCTTGG GATGGTTATTGTAGTTGTTTTGGTAAAATCTTCATTTCCTGGTTTTTTTTACCACCTTATTTAAATCTCGATTATCTGCTCTCTCTTTTA TATACATACACACACCCAAACATAACATTTATAATAGTGTGGTAGTGGAATGTATCCTTTTTTAGGTTTCCCTGCTTTCCAGTTAATTTT TAAAATGGTAGCGCTTTGTATGCATTTAGAATACATGACTAGTAGTTTATATTTCACTGGTAGTTTAAATCTGGTTGGGGCAGTCTGCAG ATGTTTGAAGTAGTTTAGTGTTCTAGAAAGAGCTATTACTGTGGATAGTGCCTAGGGGAGTGCTCCACGCCCTCTGGGCATACGGTAGAT ATTATCTGATGAATTGGAAAGGAGCAAACCAGAAATGGCTTTATTTTCTCCCTTGGACTAATTTTTAAGTCTCGATTGGAATTCAGTGAG TAGGTTCATAATGTGCATGACAGAAATAAGCTTTATAGTGGTTTACCTTCATTTAGCTTTGGAAGTTTTCTTTGCCTTAGTTTTGGAAGT AAATTCTAGTTTGTAGTTCTCATTTGTAATGAACACATTAACGACTAGATTAAAATATTGCCTTCAAGATTGTTCTTACTTACAAGACTT GCTCCTACTTCTATGCTGAAAATTGACCCTGGATAGAATACTATAAGGTTTTGAGTTAGCTGGAAAAGTGATCAGATTAATAAATGTATA TTGGTAGTTGAATTTAGCAAAGAAATAGAGATAATCATGATTATACCTTTATTTTTACAGGAAGAGATGATGTAACTAGAGTATGTGTCT ACAGGAGTAATAATGGTTTCCAAAGAGTATTTTTTAAAGGAACAAAACGAGCATGAATTAACTCTTCAATATAAGCTATGAAGTAATAGT TGGTTGTGAATTAAAGTGGCACCAGCTAGCACCTCTGTGTTTTAAGGGTCTTTCAATGTTTCTAGAATAAGCCCTTATTTTCAAGGGTTC ATAACAGGCATAAAATCTCTTCTCCTGGCAAAAGCTGCTATGAAAAGCCTCAGCTTGGGAAGATAGATTTTTTTCCCCCCAATTACAAAA TCTAAGTATTTTGGCCCTTCAATTTGGAGGAGGGCAAAAGTTGGAAGTAAGAAGTTTTATTTTAAGTACTTTCAGTGCTCAAAAAAATGC AATCACTGTGTTGTATATAATAGTTCATAGGTTGATCACTCATAATAATTGACTCTAAGGCTTTTATTAAGAAAACAGCAGAAAGATTAA ATCTTGAATTAAGTCTGGGGGGAAATGGCCACTGCAGATGGAGTTTTAGAGTAGTAATGAAATTCTACCTAGAATGCAAAATTGGGTATA TGAATTACATAGCATGTTGTTGGGATTTTTTTTAATGTGCAGAAGATCAAAGCTACTTGGAAGGAGTGCCTATAATTTGCCAGTAGCCAC AGATTAAGATTATATCTTATATATCAGCAGATTAGCTTTAGCTTAGGGGGAGGGTGGGAAAGTTTGGGGGGGGGGTTGTGAAGATTTAGG GGGACCTTGATAGAGAACTTTATAAACTTCTTTCTCTTTAATAAAGACTTGTCTTACACCGTGCTGCCATTAAAGGCAGCTGTTCTAGAG TTTCAGTCACCTAAGTACACCCACAAAACAATATGAATATGGAGATCTTCCTTTACCCCTCAACTTTAATTTGCCCAGTTATACCTCAGT GTTGTAGCAGTACTGTGATACCTGGCACAGTGCTTTGATCTTACGATGCCCTCTGTACTGACCTGAAGGAGACCTAAGAGTCCTTTCCCT TTTTGAGTTTGAATCATAGCCTTGATGTGGTCTCTTGTTTTATGTCCTTGTTCCTAATGTAAAAGTGCTTAACTGCTTCTTGGTTGTATT GGGTAGCATTGGGATAAGATTTTAACTGGGTATTCTTGAATTGCTTTTACAATAAACCAATTTTATAATCTTTAAATTTATCAACTTTTT ACATTTGTGTTATTTTCAGTCAGGGCTTCTTAGATCTACTTATGGTTGATGGAGCACATTGATTTGGAGTTTCAGATCTTCCAAAGCACT ATTTGTTGTAATAACTTTTCTAAATGTAGTGCCTTTAAAGGAAAAATGAACACAGGGAAGTGACTTTGCTACAAATAATGTTGCTGTGTT AAGTATTCATATTAAATACATGCCTTCTATATGGAACATGGCAGAAAGACTGAAAAATAACAGTAATTAATTGTGTAATTCAGAATTCAT ACCAATCAGTGTTGAAACTCAAACATTGCAAAAGTGGGTGGCAATATTCAGTGCTTAACACTTTTCTAGCGTTGGTACATCTGAGAAATG AGTGCTCAGGTGGATTTTATCCTCGCAAGCATGTTGTTATAAGAATTGTGGGTGTGCCTATCATAACAATTGTTTTCTGTATCTTGAAAA AGTATTCTCCACATTTTAAATGTTTTATATTAGAGAATTCTTTAATGCACACTTGTCAAATATATATATATAGTACCAATGTTACCTTTT TATTTTTTGTTTTAGATGTAAGAGCATGCTCATATGTTAGGTACTTACATAAATTGTTACATTATTTTTTCTTATGTAATACCTTTTTGT >In-frame_NUMA1_ENST00000351960_chr11_71746948_-_YAP1_ENST00000345877_chr11_102094353_+_4180nt GTGCTGGAGAGGCCGCTGCGAGCGGAAGGCCTCCTCCATAACCGAGTCCGAAAGGGCAGAATCTATGGGGGTGGAAACTAATTCTAAGCC AGACTGCTGGAGATCACCCTGTTCTAGTGTGTGGAGGCTTCCACCAGGAGGCGCATTGGAGTGACTGTCTGGCATCACCAAGATGACACT CCACGCCACCCGGGGGGCTGCACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGGACTCAAAA TCCAGTGTCTTCTCCCGGGATGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACCTATCACTC TCGAGATGAGAGTACAGACAGTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTGGATGAGAT GGATACAGGTGATACTATCAACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGGACAAATGT GGACCTTGGAACACTGGAAGGAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCTGACATCCT TAATGACATGGAGTCTGTTTTGGCTGCCACCAAGCTAGATAAAGAAAGCTTTCTTACATGGTTATAGAGCCCTCAGGCAGACTGAATTCT AAATCTGTGAAGGATCTAAGGAGACACATGCACCGGAAATTTCCATAAGCCAGTTGCAGTTTTCAGGCTAATACAGAAAAAGATGAACAA ACGTCCAGCAAGATACTTTAATCCTCTATTTTGCTCTTCCTTGTCCATTGCTGCTGTTAATGTATTGCTGACCTCTTTCACAGTTGGCTC TAAAGAATCAAAAGAAAAAAACTTTTTATTTCTTTTGCTATTAAAACTACTGTTCATTTTGGGGGCTGGGGGAAGTGAGCCTGTTTGGAT GATGGATGCCATTCCTTTTGCCCAGTTAAATGTTCACCAATCATTTTAACTAAATACTCAGACTTAGAAGTCAGATGCTTCATGTCACAG CATTTAGTTTGTTCAACAGTTGTTTCTTCAGCTTCCTTTGTCCAGTGGAAAAACATGATTTACTGGTCTGACAAGCCAAAAATGTTATAT CTGATATTAAATACTTAATGCTGATTTGAAGAGATAGCTGAAACCAAGGCTGAAGACTGTTTTACTTTCAGTATTTTCTTTTCCTCCTAG TGCTATCATTAGTCACATAATGACCTTGATTTTATTTTAGGAGCTTATAAGGCATGAGACAATTTCCATATAAATATATTAATTATTGCC ACATACTCTAATATAGATTTTGGTGGATAATTTTGTGGGTGTGCATTTTGTTCTGTTTTGTTGGGTTTTTTGTTTTTTTTGTTTTTGGCA GGGTCGGTGGGGGGGTTGGTTGGTTGGTTGGTTTTGTCGGAACCTAGGCAAATGACCATATTAGTGAATCTGTTAATAGTTGTAGCTTGG GATGGTTATTGTAGTTGTTTTGGTAAAATCTTCATTTCCTGGTTTTTTTTACCACCTTATTTAAATCTCGATTATCTGCTCTCTCTTTTA TATACATACACACACCCAAACATAACATTTATAATAGTGTGGTAGTGGAATGTATCCTTTTTTAGGTTTCCCTGCTTTCCAGTTAATTTT TAAAATGGTAGCGCTTTGTATGCATTTAGAATACATGACTAGTAGTTTATATTTCACTGGTAGTTTAAATCTGGTTGGGGCAGTCTGCAG ATGTTTGAAGTAGTTTAGTGTTCTAGAAAGAGCTATTACTGTGGATAGTGCCTAGGGGAGTGCTCCACGCCCTCTGGGCATACGGTAGAT ATTATCTGATGAATTGGAAAGGAGCAAACCAGAAATGGCTTTATTTTCTCCCTTGGACTAATTTTTAAGTCTCGATTGGAATTCAGTGAG TAGGTTCATAATGTGCATGACAGAAATAAGCTTTATAGTGGTTTACCTTCATTTAGCTTTGGAAGTTTTCTTTGCCTTAGTTTTGGAAGT AAATTCTAGTTTGTAGTTCTCATTTGTAATGAACACATTAACGACTAGATTAAAATATTGCCTTCAAGATTGTTCTTACTTACAAGACTT GCTCCTACTTCTATGCTGAAAATTGACCCTGGATAGAATACTATAAGGTTTTGAGTTAGCTGGAAAAGTGATCAGATTAATAAATGTATA TTGGTAGTTGAATTTAGCAAAGAAATAGAGATAATCATGATTATACCTTTATTTTTACAGGAAGAGATGATGTAACTAGAGTATGTGTCT ACAGGAGTAATAATGGTTTCCAAAGAGTATTTTTTAAAGGAACAAAACGAGCATGAATTAACTCTTCAATATAAGCTATGAAGTAATAGT TGGTTGTGAATTAAAGTGGCACCAGCTAGCACCTCTGTGTTTTAAGGGTCTTTCAATGTTTCTAGAATAAGCCCTTATTTTCAAGGGTTC ATAACAGGCATAAAATCTCTTCTCCTGGCAAAAGCTGCTATGAAAAGCCTCAGCTTGGGAAGATAGATTTTTTTCCCCCCAATTACAAAA TCTAAGTATTTTGGCCCTTCAATTTGGAGGAGGGCAAAAGTTGGAAGTAAGAAGTTTTATTTTAAGTACTTTCAGTGCTCAAAAAAATGC AATCACTGTGTTGTATATAATAGTTCATAGGTTGATCACTCATAATAATTGACTCTAAGGCTTTTATTAAGAAAACAGCAGAAAGATTAA ATCTTGAATTAAGTCTGGGGGGAAATGGCCACTGCAGATGGAGTTTTAGAGTAGTAATGAAATTCTACCTAGAATGCAAAATTGGGTATA TGAATTACATAGCATGTTGTTGGGATTTTTTTTAATGTGCAGAAGATCAAAGCTACTTGGAAGGAGTGCCTATAATTTGCCAGTAGCCAC AGATTAAGATTATATCTTATATATCAGCAGATTAGCTTTAGCTTAGGGGGAGGGTGGGAAAGTTTGGGGGGGGGGTTGTGAAGATTTAGG GGGACCTTGATAGAGAACTTTATAAACTTCTTTCTCTTTAATAAAGACTTGTCTTACACCGTGCTGCCATTAAAGGCAGCTGTTCTAGAG TTTCAGTCACCTAAGTACACCCACAAAACAATATGAATATGGAGATCTTCCTTTACCCCTCAACTTTAATTTGCCCAGTTATACCTCAGT GTTGTAGCAGTACTGTGATACCTGGCACAGTGCTTTGATCTTACGATGCCCTCTGTACTGACCTGAAGGAGACCTAAGAGTCCTTTCCCT TTTTGAGTTTGAATCATAGCCTTGATGTGGTCTCTTGTTTTATGTCCTTGTTCCTAATGTAAAAGTGCTTAACTGCTTCTTGGTTGTATT GGGTAGCATTGGGATAAGATTTTAACTGGGTATTCTTGAATTGCTTTTACAATAAACCAATTTTATAATCTTTAAATTTATCAACTTTTT ACATTTGTGTTATTTTCAGTCAGGGCTTCTTAGATCTACTTATGGTTGATGGAGCACATTGATTTGGAGTTTCAGATCTTCCAAAGCACT ATTTGTTGTAATAACTTTTCTAAATGTAGTGCCTTTAAAGGAAAAATGAACACAGGGAAGTGACTTTGCTACAAATAATGTTGCTGTGTT AAGTATTCATATTAAATACATGCCTTCTATATGGAACATGGCAGAAAGACTGAAAAATAACAGTAATTAATTGTGTAATTCAGAATTCAT ACCAATCAGTGTTGAAACTCAAACATTGCAAAAGTGGGTGGCAATATTCAGTGCTTAACACTTTTCTAGCGTTGGTACATCTGAGAAATG AGTGCTCAGGTGGATTTTATCCTCGCAAGCATGTTGTTATAAGAATTGTGGGTGTGCCTATCATAACAATTGTTTTCTGTATCTTGAAAA AGTATTCTCCACATTTTAAATGTTTTATATTAGAGAATTCTTTAATGCACACTTGTCAAATATATATATATAGTACCAATGTTACCTTTT TATTTTTTGTTTTAGATGTAAGAGCATGCTCATATGTTAGGTACTTACATAAATTGTTACATTATTTTTTCTTATGTAATACCTTTTTGT >In-frame_NUMA1_ENST00000351960_chr11_71746948_-_YAP1_ENST00000531439_chr11_102094353_+_720nt GTGCTGGAGAGGCCGCTGCGAGCGGAAGGCCTCCTCCATAACCGAGTCCGAAAGGGCAGAATCTATGGGGGTGGAAACTAATTCTAAGCC AGACTGCTGGAGATCACCCTGTTCTAGTGTGTGGAGGCTTCCACCAGGAGGCGCATTGGAGTGACTGTCTGGCATCACCAAGATGACACT CCACGCCACCCGGGGGGCTGCACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGGACTCAAAA TCCAGTGTCTTCTCCCGGGATGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACCTATCACTC TCGAGATGAGAGTACAGACAGTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTGGATGAGAT GGATACAGGTGATACTATCAACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGGACAAATGT GGACCTTGGAACACTGGAAGGAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCTGACATCCT TAATGACATGGAGTCTGTTTTGGCTGCCACCAAGCTAGATAAAGAAAGCTTTCTTACATGGTTATAGAGCCCTCAGGCAGACTGAATTCT >In-frame_NUMA1_ENST00000351960_chr11_71746948_-_YAP1_ENST00000524575_chr11_102094353_+_909nt GTGCTGGAGAGGCCGCTGCGAGCGGAAGGCCTCCTCCATAACCGAGTCCGAAAGGGCAGAATCTATGGGGGTGGAAACTAATTCTAAGCC AGACTGCTGGAGATCACCCTGTTCTAGTGTGTGGAGGCTTCCACCAGGAGGCGCATTGGAGTGACTGTCTGGCATCACCAAGATGACACT CCACGCCACCCGGGGGGCTGCACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGGACTCAAAA TCCAGTGTCTTCTCCCGGGATGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACCTATCACTC TCGAGATGAGAGTACAGACAGTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTGGATGAGAT GGATACAGGTGATACTATCAACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGGACAAATGT GGACCTTGGAACACTGGAAGGAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCTGACATCCT TAATGACATGGAGTCTGTTTTGGCTGCCACCAAGCTAGATAAAGAAAGCTTTCTTACATGGTTATAGAGCCCTCAGGCAGACTGAATTCT AAATCTGTGAAGGATCTAAGGAGACACATGCACCGGAAATTTCCATAAGCCAGTTGCAGTTTTCAGGCTAATACAGAAAAAGATGAACAA ACGTCCAGCAAGATACTTTAATCCTCTATTTTGCTCTTCCTTGTCCATTGCTGCTGTTAATGTATTGCTGACCTCTTTCACAGTTGGCTC >In-frame_NUMA1_ENST00000393695_chr11_71746948_-_YAP1_ENST00000526343_chr11_102094353_+_1509nt AAGTACAGGCCGGGGTCCGGAAGCGGTGATACCCCTTCTCTTTCCCAGTGGCCCTCAAACTTCCTTTTCCCGGGTCCTTAAGCGGGCCCC GCCGACAGAGGCCAATCAGAGGGCAGCGCGAGGGGGCGGGGCCATAGTTTAAACTAATTGTGCGCTCACAGCGCTGGCGCGAGCCCACGA AGAGGTACGATTCCGGAGAATCGCGAGGCAGAGCGGGAGCGCGCAGCCAGGTGGAAACTAATTCTAAGCCAGACTGCTGGAGATCACCCT GTTCTAGTGTGTGGAGGCTTCCACCAGGAGGCGCATTGGAGTGACTGTCTGGCATCACCAAGATGACACTCCACGCCACCCGGGGGGCTG CACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGGACTCAAAATCCAGTGTCTTCTCCCGGGA TGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACCTATCACTCTCGAGATGAGAGTACAGACA GTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTGGATGAGATGGATACAGGTGATACTATCA ACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGGACAAATGTGGACCTTGGAACACTGGAAG GAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCTGACATCCTTAATGACATGGAGTCTGTTT TGGCTGCCACCAAGCTAGATAAAGAAAGCTTTCTTACATGGTTATAGAGCCCTCAGGCAGACTGAATTCTAAATCTGTGAAGGATCTAAG GAGACACATGCACCGGAAATTTCCATAAGCCAGTTGCAGTTTTCAGGCTAATACAGAAAAAGATGAACAAACGTCCAGCAAGATACTTTA ATCCTCTATTTTGCTCTTCCTTGTCCATTGCTGCTGTTAATGTATTGCTGACCTCTTTCACAGTTGGCTCTAAAGAATCAAAAGAAAAAA ACTTTTTATTTCTTTTGCTATTAAAACTACTGTTCATTTTGGGGGCTGGGGGAAGTGAGCCTGTTTGGATGATGGATGCCATTCCTTTTG CCCAGTTAAATGTTCACCAATCATTTTAACTAAATACTCAGACTTAGAAGTCAGATGCTTCATGTCACAGCATTTAGTTTGTTCAACAGT TGTTTCTTCAGCTTCCTTTGTCCAGTGGAAAAACATGATTTACTGGTCTGACAAGCCAAAAATGTTATATCTGATATTAAATACTTAATG CTGATTTGAAGAGATAGCTGAAACCAAGGCTGAAGACTGTTTTACTTTCAGTATTTTCTTTTCCTCCTAGTGCTATCATTAGTCACATAA >In-frame_NUMA1_ENST00000393695_chr11_71746948_-_YAP1_ENST00000282441_chr11_102094353_+_4340nt AAGTACAGGCCGGGGTCCGGAAGCGGTGATACCCCTTCTCTTTCCCAGTGGCCCTCAAACTTCCTTTTCCCGGGTCCTTAAGCGGGCCCC GCCGACAGAGGCCAATCAGAGGGCAGCGCGAGGGGGCGGGGCCATAGTTTAAACTAATTGTGCGCTCACAGCGCTGGCGCGAGCCCACGA AGAGGTACGATTCCGGAGAATCGCGAGGCAGAGCGGGAGCGCGCAGCCAGGTGGAAACTAATTCTAAGCCAGACTGCTGGAGATCACCCT GTTCTAGTGTGTGGAGGCTTCCACCAGGAGGCGCATTGGAGTGACTGTCTGGCATCACCAAGATGACACTCCACGCCACCCGGGGGGCTG CACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGGACTCAAAATCCAGTGTCTTCTCCCGGGA TGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACCTATCACTCTCGAGATGAGAGTACAGACA GTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTGGATGAGATGGATACAGGTGATACTATCA ACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGGACAAATGTGGACCTTGGAACACTGGAAG GAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCTGACATCCTTAATGACATGGAGTCTGTTT TGGCTGCCACCAAGCTAGATAAAGAAAGCTTTCTTACATGGTTATAGAGCCCTCAGGCAGACTGAATTCTAAATCTGTGAAGGATCTAAG GAGACACATGCACCGGAAATTTCCATAAGCCAGTTGCAGTTTTCAGGCTAATACAGAAAAAGATGAACAAACGTCCAGCAAGATACTTTA ATCCTCTATTTTGCTCTTCCTTGTCCATTGCTGCTGTTAATGTATTGCTGACCTCTTTCACAGTTGGCTCTAAAGAATCAAAAGAAAAAA ACTTTTTATTTCTTTTGCTATTAAAACTACTGTTCATTTTGGGGGCTGGGGGAAGTGAGCCTGTTTGGATGATGGATGCCATTCCTTTTG CCCAGTTAAATGTTCACCAATCATTTTAACTAAATACTCAGACTTAGAAGTCAGATGCTTCATGTCACAGCATTTAGTTTGTTCAACAGT TGTTTCTTCAGCTTCCTTTGTCCAGTGGAAAAACATGATTTACTGGTCTGACAAGCCAAAAATGTTATATCTGATATTAAATACTTAATG CTGATTTGAAGAGATAGCTGAAACCAAGGCTGAAGACTGTTTTACTTTCAGTATTTTCTTTTCCTCCTAGTGCTATCATTAGTCACATAA TGACCTTGATTTTATTTTAGGAGCTTATAAGGCATGAGACAATTTCCATATAAATATATTAATTATTGCCACATACTCTAATATAGATTT TGGTGGATAATTTTGTGGGTGTGCATTTTGTTCTGTTTTGTTGGGTTTTTTGTTTTTTTTGTTTTTGGCAGGGTCGGTGGGGGGGTTGGT TGGTTGGTTGGTTTTGTCGGAACCTAGGCAAATGACCATATTAGTGAATCTGTTAATAGTTGTAGCTTGGGATGGTTATTGTAGTTGTTT TGGTAAAATCTTCATTTCCTGGTTTTTTTTACCACCTTATTTAAATCTCGATTATCTGCTCTCTCTTTTATATACATACACACACCCAAA CATAACATTTATAATAGTGTGGTAGTGGAATGTATCCTTTTTTAGGTTTCCCTGCTTTCCAGTTAATTTTTAAAATGGTAGCGCTTTGTA TGCATTTAGAATACATGACTAGTAGTTTATATTTCACTGGTAGTTTAAATCTGGTTGGGGCAGTCTGCAGATGTTTGAAGTAGTTTAGTG TTCTAGAAAGAGCTATTACTGTGGATAGTGCCTAGGGGAGTGCTCCACGCCCTCTGGGCATACGGTAGATATTATCTGATGAATTGGAAA GGAGCAAACCAGAAATGGCTTTATTTTCTCCCTTGGACTAATTTTTAAGTCTCGATTGGAATTCAGTGAGTAGGTTCATAATGTGCATGA CAGAAATAAGCTTTATAGTGGTTTACCTTCATTTAGCTTTGGAAGTTTTCTTTGCCTTAGTTTTGGAAGTAAATTCTAGTTTGTAGTTCT CATTTGTAATGAACACATTAACGACTAGATTAAAATATTGCCTTCAAGATTGTTCTTACTTACAAGACTTGCTCCTACTTCTATGCTGAA AATTGACCCTGGATAGAATACTATAAGGTTTTGAGTTAGCTGGAAAAGTGATCAGATTAATAAATGTATATTGGTAGTTGAATTTAGCAA AGAAATAGAGATAATCATGATTATACCTTTATTTTTACAGGAAGAGATGATGTAACTAGAGTATGTGTCTACAGGAGTAATAATGGTTTC CAAAGAGTATTTTTTAAAGGAACAAAACGAGCATGAATTAACTCTTCAATATAAGCTATGAAGTAATAGTTGGTTGTGAATTAAAGTGGC ACCAGCTAGCACCTCTGTGTTTTAAGGGTCTTTCAATGTTTCTAGAATAAGCCCTTATTTTCAAGGGTTCATAACAGGCATAAAATCTCT TCTCCTGGCAAAAGCTGCTATGAAAAGCCTCAGCTTGGGAAGATAGATTTTTTTCCCCCCAATTACAAAATCTAAGTATTTTGGCCCTTC AATTTGGAGGAGGGCAAAAGTTGGAAGTAAGAAGTTTTATTTTAAGTACTTTCAGTGCTCAAAAAAATGCAATCACTGTGTTGTATATAA TAGTTCATAGGTTGATCACTCATAATAATTGACTCTAAGGCTTTTATTAAGAAAACAGCAGAAAGATTAAATCTTGAATTAAGTCTGGGG GGAAATGGCCACTGCAGATGGAGTTTTAGAGTAGTAATGAAATTCTACCTAGAATGCAAAATTGGGTATATGAATTACATAGCATGTTGT TGGGATTTTTTTTAATGTGCAGAAGATCAAAGCTACTTGGAAGGAGTGCCTATAATTTGCCAGTAGCCACAGATTAAGATTATATCTTAT ATATCAGCAGATTAGCTTTAGCTTAGGGGGAGGGTGGGAAAGTTTGGGGGGGGGGTTGTGAAGATTTAGGGGGACCTTGATAGAGAACTT TATAAACTTCTTTCTCTTTAATAAAGACTTGTCTTACACCGTGCTGCCATTAAAGGCAGCTGTTCTAGAGTTTCAGTCACCTAAGTACAC CCACAAAACAATATGAATATGGAGATCTTCCTTTACCCCTCAACTTTAATTTGCCCAGTTATACCTCAGTGTTGTAGCAGTACTGTGATA CCTGGCACAGTGCTTTGATCTTACGATGCCCTCTGTACTGACCTGAAGGAGACCTAAGAGTCCTTTCCCTTTTTGAGTTTGAATCATAGC CTTGATGTGGTCTCTTGTTTTATGTCCTTGTTCCTAATGTAAAAGTGCTTAACTGCTTCTTGGTTGTATTGGGTAGCATTGGGATAAGAT TTTAACTGGGTATTCTTGAATTGCTTTTACAATAAACCAATTTTATAATCTTTAAATTTATCAACTTTTTACATTTGTGTTATTTTCAGT CAGGGCTTCTTAGATCTACTTATGGTTGATGGAGCACATTGATTTGGAGTTTCAGATCTTCCAAAGCACTATTTGTTGTAATAACTTTTC TAAATGTAGTGCCTTTAAAGGAAAAATGAACACAGGGAAGTGACTTTGCTACAAATAATGTTGCTGTGTTAAGTATTCATATTAAATACA TGCCTTCTATATGGAACATGGCAGAAAGACTGAAAAATAACAGTAATTAATTGTGTAATTCAGAATTCATACCAATCAGTGTTGAAACTC AAACATTGCAAAAGTGGGTGGCAATATTCAGTGCTTAACACTTTTCTAGCGTTGGTACATCTGAGAAATGAGTGCTCAGGTGGATTTTAT CCTCGCAAGCATGTTGTTATAAGAATTGTGGGTGTGCCTATCATAACAATTGTTTTCTGTATCTTGAAAAAGTATTCTCCACATTTTAAA TGTTTTATATTAGAGAATTCTTTAATGCACACTTGTCAAATATATATATATAGTACCAATGTTACCTTTTTATTTTTTGTTTTAGATGTA AGAGCATGCTCATATGTTAGGTACTTACATAAATTGTTACATTATTTTTTCTTATGTAATACCTTTTTGTTTGTTTATGTGGTTCAAATA >In-frame_NUMA1_ENST00000393695_chr11_71746948_-_YAP1_ENST00000537274_chr11_102094353_+_4340nt AAGTACAGGCCGGGGTCCGGAAGCGGTGATACCCCTTCTCTTTCCCAGTGGCCCTCAAACTTCCTTTTCCCGGGTCCTTAAGCGGGCCCC GCCGACAGAGGCCAATCAGAGGGCAGCGCGAGGGGGCGGGGCCATAGTTTAAACTAATTGTGCGCTCACAGCGCTGGCGCGAGCCCACGA AGAGGTACGATTCCGGAGAATCGCGAGGCAGAGCGGGAGCGCGCAGCCAGGTGGAAACTAATTCTAAGCCAGACTGCTGGAGATCACCCT GTTCTAGTGTGTGGAGGCTTCCACCAGGAGGCGCATTGGAGTGACTGTCTGGCATCACCAAGATGACACTCCACGCCACCCGGGGGGCTG CACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGGACTCAAAATCCAGTGTCTTCTCCCGGGA TGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACCTATCACTCTCGAGATGAGAGTACAGACA GTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTGGATGAGATGGATACAGGTGATACTATCA ACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGGACAAATGTGGACCTTGGAACACTGGAAG GAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCTGACATCCTTAATGACATGGAGTCTGTTT TGGCTGCCACCAAGCTAGATAAAGAAAGCTTTCTTACATGGTTATAGAGCCCTCAGGCAGACTGAATTCTAAATCTGTGAAGGATCTAAG GAGACACATGCACCGGAAATTTCCATAAGCCAGTTGCAGTTTTCAGGCTAATACAGAAAAAGATGAACAAACGTCCAGCAAGATACTTTA ATCCTCTATTTTGCTCTTCCTTGTCCATTGCTGCTGTTAATGTATTGCTGACCTCTTTCACAGTTGGCTCTAAAGAATCAAAAGAAAAAA ACTTTTTATTTCTTTTGCTATTAAAACTACTGTTCATTTTGGGGGCTGGGGGAAGTGAGCCTGTTTGGATGATGGATGCCATTCCTTTTG CCCAGTTAAATGTTCACCAATCATTTTAACTAAATACTCAGACTTAGAAGTCAGATGCTTCATGTCACAGCATTTAGTTTGTTCAACAGT TGTTTCTTCAGCTTCCTTTGTCCAGTGGAAAAACATGATTTACTGGTCTGACAAGCCAAAAATGTTATATCTGATATTAAATACTTAATG CTGATTTGAAGAGATAGCTGAAACCAAGGCTGAAGACTGTTTTACTTTCAGTATTTTCTTTTCCTCCTAGTGCTATCATTAGTCACATAA TGACCTTGATTTTATTTTAGGAGCTTATAAGGCATGAGACAATTTCCATATAAATATATTAATTATTGCCACATACTCTAATATAGATTT TGGTGGATAATTTTGTGGGTGTGCATTTTGTTCTGTTTTGTTGGGTTTTTTGTTTTTTTTGTTTTTGGCAGGGTCGGTGGGGGGGTTGGT TGGTTGGTTGGTTTTGTCGGAACCTAGGCAAATGACCATATTAGTGAATCTGTTAATAGTTGTAGCTTGGGATGGTTATTGTAGTTGTTT TGGTAAAATCTTCATTTCCTGGTTTTTTTTACCACCTTATTTAAATCTCGATTATCTGCTCTCTCTTTTATATACATACACACACCCAAA CATAACATTTATAATAGTGTGGTAGTGGAATGTATCCTTTTTTAGGTTTCCCTGCTTTCCAGTTAATTTTTAAAATGGTAGCGCTTTGTA TGCATTTAGAATACATGACTAGTAGTTTATATTTCACTGGTAGTTTAAATCTGGTTGGGGCAGTCTGCAGATGTTTGAAGTAGTTTAGTG TTCTAGAAAGAGCTATTACTGTGGATAGTGCCTAGGGGAGTGCTCCACGCCCTCTGGGCATACGGTAGATATTATCTGATGAATTGGAAA GGAGCAAACCAGAAATGGCTTTATTTTCTCCCTTGGACTAATTTTTAAGTCTCGATTGGAATTCAGTGAGTAGGTTCATAATGTGCATGA CAGAAATAAGCTTTATAGTGGTTTACCTTCATTTAGCTTTGGAAGTTTTCTTTGCCTTAGTTTTGGAAGTAAATTCTAGTTTGTAGTTCT CATTTGTAATGAACACATTAACGACTAGATTAAAATATTGCCTTCAAGATTGTTCTTACTTACAAGACTTGCTCCTACTTCTATGCTGAA AATTGACCCTGGATAGAATACTATAAGGTTTTGAGTTAGCTGGAAAAGTGATCAGATTAATAAATGTATATTGGTAGTTGAATTTAGCAA AGAAATAGAGATAATCATGATTATACCTTTATTTTTACAGGAAGAGATGATGTAACTAGAGTATGTGTCTACAGGAGTAATAATGGTTTC CAAAGAGTATTTTTTAAAGGAACAAAACGAGCATGAATTAACTCTTCAATATAAGCTATGAAGTAATAGTTGGTTGTGAATTAAAGTGGC ACCAGCTAGCACCTCTGTGTTTTAAGGGTCTTTCAATGTTTCTAGAATAAGCCCTTATTTTCAAGGGTTCATAACAGGCATAAAATCTCT TCTCCTGGCAAAAGCTGCTATGAAAAGCCTCAGCTTGGGAAGATAGATTTTTTTCCCCCCAATTACAAAATCTAAGTATTTTGGCCCTTC AATTTGGAGGAGGGCAAAAGTTGGAAGTAAGAAGTTTTATTTTAAGTACTTTCAGTGCTCAAAAAAATGCAATCACTGTGTTGTATATAA TAGTTCATAGGTTGATCACTCATAATAATTGACTCTAAGGCTTTTATTAAGAAAACAGCAGAAAGATTAAATCTTGAATTAAGTCTGGGG GGAAATGGCCACTGCAGATGGAGTTTTAGAGTAGTAATGAAATTCTACCTAGAATGCAAAATTGGGTATATGAATTACATAGCATGTTGT TGGGATTTTTTTTAATGTGCAGAAGATCAAAGCTACTTGGAAGGAGTGCCTATAATTTGCCAGTAGCCACAGATTAAGATTATATCTTAT ATATCAGCAGATTAGCTTTAGCTTAGGGGGAGGGTGGGAAAGTTTGGGGGGGGGGTTGTGAAGATTTAGGGGGACCTTGATAGAGAACTT TATAAACTTCTTTCTCTTTAATAAAGACTTGTCTTACACCGTGCTGCCATTAAAGGCAGCTGTTCTAGAGTTTCAGTCACCTAAGTACAC CCACAAAACAATATGAATATGGAGATCTTCCTTTACCCCTCAACTTTAATTTGCCCAGTTATACCTCAGTGTTGTAGCAGTACTGTGATA CCTGGCACAGTGCTTTGATCTTACGATGCCCTCTGTACTGACCTGAAGGAGACCTAAGAGTCCTTTCCCTTTTTGAGTTTGAATCATAGC CTTGATGTGGTCTCTTGTTTTATGTCCTTGTTCCTAATGTAAAAGTGCTTAACTGCTTCTTGGTTGTATTGGGTAGCATTGGGATAAGAT TTTAACTGGGTATTCTTGAATTGCTTTTACAATAAACCAATTTTATAATCTTTAAATTTATCAACTTTTTACATTTGTGTTATTTTCAGT CAGGGCTTCTTAGATCTACTTATGGTTGATGGAGCACATTGATTTGGAGTTTCAGATCTTCCAAAGCACTATTTGTTGTAATAACTTTTC TAAATGTAGTGCCTTTAAAGGAAAAATGAACACAGGGAAGTGACTTTGCTACAAATAATGTTGCTGTGTTAAGTATTCATATTAAATACA TGCCTTCTATATGGAACATGGCAGAAAGACTGAAAAATAACAGTAATTAATTGTGTAATTCAGAATTCATACCAATCAGTGTTGAAACTC AAACATTGCAAAAGTGGGTGGCAATATTCAGTGCTTAACACTTTTCTAGCGTTGGTACATCTGAGAAATGAGTGCTCAGGTGGATTTTAT CCTCGCAAGCATGTTGTTATAAGAATTGTGGGTGTGCCTATCATAACAATTGTTTTCTGTATCTTGAAAAAGTATTCTCCACATTTTAAA TGTTTTATATTAGAGAATTCTTTAATGCACACTTGTCAAATATATATATATAGTACCAATGTTACCTTTTTATTTTTTGTTTTAGATGTA AGAGCATGCTCATATGTTAGGTACTTACATAAATTGTTACATTATTTTTTCTTATGTAATACCTTTTTGTTTGTTTATGTGGTTCAAATA >In-frame_NUMA1_ENST00000393695_chr11_71746948_-_YAP1_ENST00000345877_chr11_102094353_+_4340nt AAGTACAGGCCGGGGTCCGGAAGCGGTGATACCCCTTCTCTTTCCCAGTGGCCCTCAAACTTCCTTTTCCCGGGTCCTTAAGCGGGCCCC GCCGACAGAGGCCAATCAGAGGGCAGCGCGAGGGGGCGGGGCCATAGTTTAAACTAATTGTGCGCTCACAGCGCTGGCGCGAGCCCACGA AGAGGTACGATTCCGGAGAATCGCGAGGCAGAGCGGGAGCGCGCAGCCAGGTGGAAACTAATTCTAAGCCAGACTGCTGGAGATCACCCT GTTCTAGTGTGTGGAGGCTTCCACCAGGAGGCGCATTGGAGTGACTGTCTGGCATCACCAAGATGACACTCCACGCCACCCGGGGGGCTG CACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGGACTCAAAATCCAGTGTCTTCTCCCGGGA TGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACCTATCACTCTCGAGATGAGAGTACAGACA GTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTGGATGAGATGGATACAGGTGATACTATCA ACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGGACAAATGTGGACCTTGGAACACTGGAAG GAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCTGACATCCTTAATGACATGGAGTCTGTTT TGGCTGCCACCAAGCTAGATAAAGAAAGCTTTCTTACATGGTTATAGAGCCCTCAGGCAGACTGAATTCTAAATCTGTGAAGGATCTAAG GAGACACATGCACCGGAAATTTCCATAAGCCAGTTGCAGTTTTCAGGCTAATACAGAAAAAGATGAACAAACGTCCAGCAAGATACTTTA ATCCTCTATTTTGCTCTTCCTTGTCCATTGCTGCTGTTAATGTATTGCTGACCTCTTTCACAGTTGGCTCTAAAGAATCAAAAGAAAAAA ACTTTTTATTTCTTTTGCTATTAAAACTACTGTTCATTTTGGGGGCTGGGGGAAGTGAGCCTGTTTGGATGATGGATGCCATTCCTTTTG CCCAGTTAAATGTTCACCAATCATTTTAACTAAATACTCAGACTTAGAAGTCAGATGCTTCATGTCACAGCATTTAGTTTGTTCAACAGT TGTTTCTTCAGCTTCCTTTGTCCAGTGGAAAAACATGATTTACTGGTCTGACAAGCCAAAAATGTTATATCTGATATTAAATACTTAATG CTGATTTGAAGAGATAGCTGAAACCAAGGCTGAAGACTGTTTTACTTTCAGTATTTTCTTTTCCTCCTAGTGCTATCATTAGTCACATAA TGACCTTGATTTTATTTTAGGAGCTTATAAGGCATGAGACAATTTCCATATAAATATATTAATTATTGCCACATACTCTAATATAGATTT TGGTGGATAATTTTGTGGGTGTGCATTTTGTTCTGTTTTGTTGGGTTTTTTGTTTTTTTTGTTTTTGGCAGGGTCGGTGGGGGGGTTGGT TGGTTGGTTGGTTTTGTCGGAACCTAGGCAAATGACCATATTAGTGAATCTGTTAATAGTTGTAGCTTGGGATGGTTATTGTAGTTGTTT TGGTAAAATCTTCATTTCCTGGTTTTTTTTACCACCTTATTTAAATCTCGATTATCTGCTCTCTCTTTTATATACATACACACACCCAAA CATAACATTTATAATAGTGTGGTAGTGGAATGTATCCTTTTTTAGGTTTCCCTGCTTTCCAGTTAATTTTTAAAATGGTAGCGCTTTGTA TGCATTTAGAATACATGACTAGTAGTTTATATTTCACTGGTAGTTTAAATCTGGTTGGGGCAGTCTGCAGATGTTTGAAGTAGTTTAGTG TTCTAGAAAGAGCTATTACTGTGGATAGTGCCTAGGGGAGTGCTCCACGCCCTCTGGGCATACGGTAGATATTATCTGATGAATTGGAAA GGAGCAAACCAGAAATGGCTTTATTTTCTCCCTTGGACTAATTTTTAAGTCTCGATTGGAATTCAGTGAGTAGGTTCATAATGTGCATGA CAGAAATAAGCTTTATAGTGGTTTACCTTCATTTAGCTTTGGAAGTTTTCTTTGCCTTAGTTTTGGAAGTAAATTCTAGTTTGTAGTTCT CATTTGTAATGAACACATTAACGACTAGATTAAAATATTGCCTTCAAGATTGTTCTTACTTACAAGACTTGCTCCTACTTCTATGCTGAA AATTGACCCTGGATAGAATACTATAAGGTTTTGAGTTAGCTGGAAAAGTGATCAGATTAATAAATGTATATTGGTAGTTGAATTTAGCAA AGAAATAGAGATAATCATGATTATACCTTTATTTTTACAGGAAGAGATGATGTAACTAGAGTATGTGTCTACAGGAGTAATAATGGTTTC CAAAGAGTATTTTTTAAAGGAACAAAACGAGCATGAATTAACTCTTCAATATAAGCTATGAAGTAATAGTTGGTTGTGAATTAAAGTGGC ACCAGCTAGCACCTCTGTGTTTTAAGGGTCTTTCAATGTTTCTAGAATAAGCCCTTATTTTCAAGGGTTCATAACAGGCATAAAATCTCT TCTCCTGGCAAAAGCTGCTATGAAAAGCCTCAGCTTGGGAAGATAGATTTTTTTCCCCCCAATTACAAAATCTAAGTATTTTGGCCCTTC AATTTGGAGGAGGGCAAAAGTTGGAAGTAAGAAGTTTTATTTTAAGTACTTTCAGTGCTCAAAAAAATGCAATCACTGTGTTGTATATAA TAGTTCATAGGTTGATCACTCATAATAATTGACTCTAAGGCTTTTATTAAGAAAACAGCAGAAAGATTAAATCTTGAATTAAGTCTGGGG GGAAATGGCCACTGCAGATGGAGTTTTAGAGTAGTAATGAAATTCTACCTAGAATGCAAAATTGGGTATATGAATTACATAGCATGTTGT TGGGATTTTTTTTAATGTGCAGAAGATCAAAGCTACTTGGAAGGAGTGCCTATAATTTGCCAGTAGCCACAGATTAAGATTATATCTTAT ATATCAGCAGATTAGCTTTAGCTTAGGGGGAGGGTGGGAAAGTTTGGGGGGGGGGTTGTGAAGATTTAGGGGGACCTTGATAGAGAACTT TATAAACTTCTTTCTCTTTAATAAAGACTTGTCTTACACCGTGCTGCCATTAAAGGCAGCTGTTCTAGAGTTTCAGTCACCTAAGTACAC CCACAAAACAATATGAATATGGAGATCTTCCTTTACCCCTCAACTTTAATTTGCCCAGTTATACCTCAGTGTTGTAGCAGTACTGTGATA CCTGGCACAGTGCTTTGATCTTACGATGCCCTCTGTACTGACCTGAAGGAGACCTAAGAGTCCTTTCCCTTTTTGAGTTTGAATCATAGC CTTGATGTGGTCTCTTGTTTTATGTCCTTGTTCCTAATGTAAAAGTGCTTAACTGCTTCTTGGTTGTATTGGGTAGCATTGGGATAAGAT TTTAACTGGGTATTCTTGAATTGCTTTTACAATAAACCAATTTTATAATCTTTAAATTTATCAACTTTTTACATTTGTGTTATTTTCAGT CAGGGCTTCTTAGATCTACTTATGGTTGATGGAGCACATTGATTTGGAGTTTCAGATCTTCCAAAGCACTATTTGTTGTAATAACTTTTC TAAATGTAGTGCCTTTAAAGGAAAAATGAACACAGGGAAGTGACTTTGCTACAAATAATGTTGCTGTGTTAAGTATTCATATTAAATACA TGCCTTCTATATGGAACATGGCAGAAAGACTGAAAAATAACAGTAATTAATTGTGTAATTCAGAATTCATACCAATCAGTGTTGAAACTC AAACATTGCAAAAGTGGGTGGCAATATTCAGTGCTTAACACTTTTCTAGCGTTGGTACATCTGAGAAATGAGTGCTCAGGTGGATTTTAT CCTCGCAAGCATGTTGTTATAAGAATTGTGGGTGTGCCTATCATAACAATTGTTTTCTGTATCTTGAAAAAGTATTCTCCACATTTTAAA TGTTTTATATTAGAGAATTCTTTAATGCACACTTGTCAAATATATATATATAGTACCAATGTTACCTTTTTATTTTTTGTTTTAGATGTA AGAGCATGCTCATATGTTAGGTACTTACATAAATTGTTACATTATTTTTTCTTATGTAATACCTTTTTGTTTGTTTATGTGGTTCAAATA >In-frame_NUMA1_ENST00000393695_chr11_71746948_-_YAP1_ENST00000531439_chr11_102094353_+_880nt AAGTACAGGCCGGGGTCCGGAAGCGGTGATACCCCTTCTCTTTCCCAGTGGCCCTCAAACTTCCTTTTCCCGGGTCCTTAAGCGGGCCCC GCCGACAGAGGCCAATCAGAGGGCAGCGCGAGGGGGCGGGGCCATAGTTTAAACTAATTGTGCGCTCACAGCGCTGGCGCGAGCCCACGA AGAGGTACGATTCCGGAGAATCGCGAGGCAGAGCGGGAGCGCGCAGCCAGGTGGAAACTAATTCTAAGCCAGACTGCTGGAGATCACCCT GTTCTAGTGTGTGGAGGCTTCCACCAGGAGGCGCATTGGAGTGACTGTCTGGCATCACCAAGATGACACTCCACGCCACCCGGGGGGCTG CACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGGACTCAAAATCCAGTGTCTTCTCCCGGGA TGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACCTATCACTCTCGAGATGAGAGTACAGACA GTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTGGATGAGATGGATACAGGTGATACTATCA ACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGGACAAATGTGGACCTTGGAACACTGGAAG GAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCTGACATCCTTAATGACATGGAGTCTGTTT >In-frame_NUMA1_ENST00000393695_chr11_71746948_-_YAP1_ENST00000524575_chr11_102094353_+_1069nt AAGTACAGGCCGGGGTCCGGAAGCGGTGATACCCCTTCTCTTTCCCAGTGGCCCTCAAACTTCCTTTTCCCGGGTCCTTAAGCGGGCCCC GCCGACAGAGGCCAATCAGAGGGCAGCGCGAGGGGGCGGGGCCATAGTTTAAACTAATTGTGCGCTCACAGCGCTGGCGCGAGCCCACGA AGAGGTACGATTCCGGAGAATCGCGAGGCAGAGCGGGAGCGCGCAGCCAGGTGGAAACTAATTCTAAGCCAGACTGCTGGAGATCACCCT GTTCTAGTGTGTGGAGGCTTCCACCAGGAGGCGCATTGGAGTGACTGTCTGGCATCACCAAGATGACACTCCACGCCACCCGGGGGGCTG CACTCCTCTCTTGGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGGACTCAAAATCCAGTGTCTTCTCCCGGGA TGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACCTATCACTCTCGAGATGAGAGTACAGACA GTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTGGATGAGATGGATACAGGTGATACTATCA ACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGGACAAATGTGGACCTTGGAACACTGGAAG GAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCTGACATCCTTAATGACATGGAGTCTGTTT TGGCTGCCACCAAGCTAGATAAAGAAAGCTTTCTTACATGGTTATAGAGCCCTCAGGCAGACTGAATTCTAAATCTGTGAAGGATCTAAG GAGACACATGCACCGGAAATTTCCATAAGCCAGTTGCAGTTTTCAGGCTAATACAGAAAAAGATGAACAAACGTCCAGCAAGATACTTTA 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FusionGenePPI for NUMA1_YAP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NUMA1 | EPB41, EPB41L1, YEATS4, GPSM2, TNKS, ACTR1A, SMC1A, SMC3, EPB41L2, NCOA6, PIM1, RPAP1, NPM1, BANF1, HDAC5, SMARCAD1, SIRT7, TERF1, TERF2IP, TERF2, CDK2, EMILIN1, RAE1, NUP98, DYNLL1, NCSTN, DDB1, ESR1, ECT2, MDC1, TP53BP1, SMURF1, VCP, HSP90AB1, HSP90AA1, CDK6, CBX6, KIAA0101, CCDC57, LMNA, YWHAQ, RPA3, RPA2, RPA1, ERG, LGR4, BRAP, DVL1, DVL2, DVL3, GMCL1, ENO1, MOV10, NXF1, BRCA1, CUL7, OBSL1, CCDC8, EZH2, SUZ12, EED, RNF2, BMI1, SUMO2, ABCE1, WDR83, GPSM1, EPB41L3, BRD4, EIF3H, CDC73, EIF3E, EIF3I, EIF3L, RPS13, SRRM1, RPL35A, RTF1, RUVBL1, ZC3H18, NTRK1, SCARNA22, PTTG1, IFI16, SSX2IP, CRK, MATR3, KIF20A, MPHOSPH8, CBX8, PAPD5, ASPM, DYNC1H1, KPNB1, FAM175B, BRCC3, U2AF2, SCOC, TCP10L, PDHA1, YAP1, TXNIP | YAP1 | ERBB4, TP53BP2, KIF5A, SLC9A3R1, YWHAQ, RUNX3, RUNX2, RUNX1, TP73, TP63, WBP1, SMAD7, SMAD6, SCAMP3, AMOT, ITCH, EP300, BTRC, YWHAG, FBXW11, SMAD1, SMAD5, SMAD3, EGFR, ELAVL1, KLF5, LATS2, LATS1, PML, SUMO1, PTPN14, NFE2, POLR2A, AMOTL2, SRSF2, AHCYL1, UBQLN2, SULT1A1, UNK, UBA2, ZFYVE19, VPS4B, PRDX1, IGBP1, THUMPD1, ZPR1, NUBP2, UBE2L3, PIN1, USP9X, TTC9C, UCHL3, UBE2D1, UFM1, UBE2C, UBXN7, VPS25, TEAD1, CREB1, PPP1CA, AMOTL1, ARID1A, ARID1B, ATPIF1, BCL9L, CCDC85C, DPF2, INADL, LIN7C, MPDZ, MPP5, NF2, PARD3, PDLIM7, RAE1, RAPGEF2, RASSF8, SLC9A3R2, SMARCD1, TEAD3, TJP2, WBP2, YWHAB, YWHAE, YWHAH, YWHAZ, MAP2K1, ARFIP1, PAPOLA, PRMT3, RTF1, STAT1, TSNAX, TOM1, FBXW7, ABL1, ENO1, MOV10, NXF1, FAM189B, PRRG4, CYYR1, TEAD4, ARRDC1, LDLRAD4, STUB1, CPVL, ERP44, FASN, HSPH1, HSPA4L, HSPA4, HYOU1, MCMBP, RAPGEF6, PTCH1, PRRG2, NEDD8, TEAD2, XPO1, SMAD2, ENAH, CDH1, PTPN21, DEFA6, BAG4, CTNNB1, NUDT5, PRKD1, XRCC5, XRCC6, AHNAK, EPRS, THBS1, EEF1A1, EEF1A1P5, WWC3, TUBB, HRNR, PFKP, RPL6, COPA, VCP, EIF3B, CAD, RBM10, SUN2, SLC25A5, PSMD2, ACTN1, RRBP1, DDX3X, RPS4X, FAM120A, NCL, CSTF1, TMPO, MAP4, USP15, RPL7A, SNRPB, RPL18, SF3B3, FLG2, HSPB1, CCT2, SND1, PRPF8, EIF4B, HSP90B1, NPM1, PPP2R1A, CYFIP1, MATR3, TUBB6, HNRNPA2B1, RPS6, PSMC2, EIF3L, HNRNPR, IMMT, PHB2, RPS8, PTRF, RPL10A, PARP1, HIST1H1E, LMNB1, PA2G4, HNRNPF, ITGB1, NUMA1, SRSF6, TGM2, OGDH, PDIA3, RPL24, PHGDH, IPO5, TSR1, TRIP6, YBX1, SMARCA4, ATAD3A, RPL19, CCT5, PGAM5, SEC16A, AJUBA, PSMC5, UPF1, RPL15, XRN2, RPL13A, PSMC6, CNN2, HDAC1, HDAC2, SFN, SUPT16H, RBBP7, PRDX6, SEPT2, UQCRC2, MVD, MYH10, PLOD2, PSMD6, ADSS, PAICS, FUBP1, CIAPIN1, SFXN1, PSMA5, RPL9, DNAJC10, PTBP1, ANXA5, KPNA2, WDR1, C11orf84, H2AFY, JUN, RTN4, RPL14, H1FX, IGFBP7, ACTL6A, RPL17, ZYX, PSMB4, TWF1, HIST1H1B, TK1, CDC20, RAN, RPL21, SV2B, HN1L |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NUMA1_YAP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NUMA1_YAP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NUMA1 | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
| Tgene | YAP1 | C0027819 | Neuroblastoma | 1 | CTD_human |
| Tgene | YAP1 | C0919267 | ovarian neoplasm | 1 | CTD_human |
| Tgene | YAP1 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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