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Fusion gene ID: 25127 |
FusionGeneSummary for NUFIP1_FAAH |
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Fusion gene information | Fusion gene name: NUFIP1_FAAH | Fusion gene ID: 25127 | Hgene | Tgene | Gene symbol | NUFIP1 | FAAH | Gene ID | 26747 | 79152 |
Gene name | NUFIP1, FMR1 interacting protein 1 | fatty acid 2-hydroxylase | |
Synonyms | NUFIP|bA540M5.1 | FAAH|FAH1|FAXDC1|SCS7|SPG35 | |
Cytomap | 13q14.12 | 16q23.1 | |
Type of gene | protein-coding | protein-coding | |
Description | nuclear fragile X mental retardation-interacting protein 1nuclear FMRP-interacting protein 1nuclear fragile X mental retardation protein interacting protein 1 | fatty acid 2-hydroxylasefatty acid alpha-hydroxylasefatty acid hydroxylase domain containing 1spastic paraplegia 35 (autosomal recessive) | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UHK0 | O00519 | |
Ensembl transtripts involved in fusion gene | ENST00000379161, | ENST00000243167, ENST00000493735, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: NUFIP1 [Title/Abstract] AND FAAH [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NUFIP1 | GO:0051259 | protein complex oligomerization | 17636026 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-85-A4JC-01A | NUFIP1 | chr13 | 45533516 | - | FAAH | chr1 | 46879119 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000379161 | ENST00000243167 | NUFIP1 | chr13 | 45533516 | - | FAAH | chr1 | 46879119 | + |
5CDS-intron | ENST00000379161 | ENST00000493735 | NUFIP1 | chr13 | 45533516 | - | FAAH | chr1 | 46879119 | + |
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FusionProtFeatures for NUFIP1_FAAH |
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Hgene | Tgene |
NUFIP1 | FAAH |
Binds RNA. {ECO:0000269|PubMed:10556305}. | Degrades bioactive fatty acid amides like oleamide, theendogenous cannabinoid, anandamide and myristic amide to theircorresponding acids, thereby serving to terminate the signalingfunctions of these molecules. Hydrolyzes polyunsaturated substrateanandamide preferentially as compared to monounsaturatedsubstrates. {ECO:0000269|PubMed:17015445}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NUFIP1_FAAH |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NUFIP1_FAAH |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NUFIP1 | FMR1, CCNT1, CDK9, BRCA1, KLF6, TAF9, RUVBL1, RUVBL2, NCAM1, CRMP1, DPYSL3, DPYSL2, DPYSL5, STXBP1, ATP4A, RAB14, ATP2B2, GPM6B, HIST1H1B, DNM1L, HIST1H2BL, ATP6V0A1, CNTN1, DCX, DCLK1, SCAMP5, SYN1, TRIM2, FAM49B, SNAP91, SYT1, ZNHIT3, MAP2, HPCAL4, VSNL1, AMPH, BIN1, DNM3, DNM1, CDH13, EPB41L1, STX1A, STX1B, GNAZ, GNA11, GNAQ, GPD2, GNAO1, GNG2, GPM6A, PDE2A, ANK2, SNCB, SNCA, GRIA2, RAB6B, RAB3B, RAB3A, CAMK2B, CAMK2A, EEF1A2, HPCA, NCALD, RAB5B, HBA2, MAP1LC3B2, NDRG4, SLC12A5, NTM, CADM2, NAPB, MAPT, DPYSL4, MAP2K1, CAMKV, HBD, NCS1, PLXNA2, CALB2, SRCIN1, VAMP2, H2AFY2, CPE, SYP, EDIL3, ADD2, GLS, GSK3B, L1CAM, SNAP25, SFXN3, RBM4B, NHP2L1, XPO1, NXF2, ZNF324B, MAP1A, GPATCH4, MAPRE3, ATP6V1C1, RSBN1, PPAN, RPL13, GNG7, PPP3R1, PRKAR2B, NOP58, ZNHIT6, PRPF31, RNU4-1, SMN1, GEMIN2, DDX20, GEMIN4, GEMIN6 | FAAH | MME, NOTCH2NL |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NUFIP1_FAAH |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | FAAH | O00519 | DB00316 | Acetaminophen | Fatty-acid amide hydrolase 1 | small molecule | approved |
Tgene | FAAH | O00519 | DB00599 | Thiopental | Fatty-acid amide hydrolase 1 | small molecule | approved|vet_approved |
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RelatedDiseases for NUFIP1_FAAH |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | FAAH | C0024809 | Marijuana Abuse | 3 | PSYGENET |
Tgene | FAAH | C0028754 | Obesity | 2 | CTD_human |
Tgene | FAAH | C0038587 | Substance Withdrawal Syndrome | 2 | CTD_human |
Tgene | FAAH | C0236969 | Substance-Related Disorders | 2 | CTD_human |
Tgene | FAAH | C0006870 | Cannabis Dependence | 1 | PSYGENET |
Tgene | FAAH | C0020179 | Huntington Disease | 1 | CTD_human |
Tgene | FAAH | C0032962 | Pregnancy Complications | 1 | CTD_human |
Tgene | FAAH | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Tgene | FAAH | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | FAAH | C0036572 | Seizures | 1 | CTD_human |
Tgene | FAAH | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | FAAH | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
Tgene | FAAH | C0525045 | Mood Disorders | 1 | PSYGENET |
Tgene | FAAH | C1269683 | Major Depressive Disorder | 1 | PSYGENET |