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Fusion gene ID: 25126 |
FusionGeneSummary for NUF2_TIMM17A |
Fusion gene summary |
Fusion gene information | Fusion gene name: NUF2_TIMM17A | Fusion gene ID: 25126 | Hgene | Tgene | Gene symbol | NUF2 | TIMM17A | Gene ID | 83540 | 10440 |
Gene name | NUF2, NDC80 kinetochore complex component | translocase of inner mitochondrial membrane 17A | |
Synonyms | CDCA1|CT106|NUF2R | TIM17|TIM17A | |
Cytomap | 1q23.3 | 1q32.1 | |
Type of gene | protein-coding | protein-coding | |
Description | kinetochore protein Nuf2NUF2, NDC80 kinetochore complex component, homologcancer/testis antigen 106cell division cycle associated 1cell division cycle-associated protein 1hNuf2hNuf2RhsNuf2 | mitochondrial import inner membrane translocase subunit Tim17-Ainner membrane preprotein translocase Tim17amitochondrial inner membrane translocasepreprotein translocasetranslocase of inner mitochondrial membrane 17 homolog A | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9BZD4 | Q99595 | |
Ensembl transtripts involved in fusion gene | ENST00000524800, ENST00000367900, ENST00000271452, ENST00000490881, | ENST00000367287, ENST00000482943, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 4 X 6=120 |
# samples | 2 | 6 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NUF2 [Title/Abstract] AND TIMM17A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-78-7159-01A | NUF2 | chr1 | 163317728 | + | TIMM17A | chr1 | 201926409 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000524800 | ENST00000367287 | NUF2 | chr1 | 163317728 | + | TIMM17A | chr1 | 201926409 | + |
5CDS-intron | ENST00000524800 | ENST00000482943 | NUF2 | chr1 | 163317728 | + | TIMM17A | chr1 | 201926409 | + |
In-frame | ENST00000367900 | ENST00000367287 | NUF2 | chr1 | 163317728 | + | TIMM17A | chr1 | 201926409 | + |
5CDS-intron | ENST00000367900 | ENST00000482943 | NUF2 | chr1 | 163317728 | + | TIMM17A | chr1 | 201926409 | + |
In-frame | ENST00000271452 | ENST00000367287 | NUF2 | chr1 | 163317728 | + | TIMM17A | chr1 | 201926409 | + |
5CDS-intron | ENST00000271452 | ENST00000482943 | NUF2 | chr1 | 163317728 | + | TIMM17A | chr1 | 201926409 | + |
intron-3CDS | ENST00000490881 | ENST00000367287 | NUF2 | chr1 | 163317728 | + | TIMM17A | chr1 | 201926409 | + |
intron-intron | ENST00000490881 | ENST00000482943 | NUF2 | chr1 | 163317728 | + | TIMM17A | chr1 | 201926409 | + |
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FusionProtFeatures for NUF2_TIMM17A |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
NUF2 | TIMM17A |
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosomesegregation and spindle checkpoint activity (PubMed:12438418,PubMed:14654001, PubMed:15062103, PubMed:15235793,PubMed:15239953, PubMed:15548592, PubMed:17535814). Required forkinetochore integrity and the organization of stable microtubulebinding sites in the outer plate of the kinetochore(PubMed:15548592). The NDC80 complex synergistically enhances theaffinity of the SKA1 complex for microtubules and may allow theNDC80 complex to track depolymerizing microtubules(PubMed:23085020). {ECO:0000269|PubMed:12438418,ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:15062103,ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953,ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:17535814,ECO:0000269|PubMed:23085020}. | Essential component of the TIM23 complex, a complex thatmediates the translocation of transit peptide-containing proteinsacross the mitochondrial inner membrane. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | NUF2 | chr1:163317728 | chr1:201926409 | ENST00000271452 | + | 12 | 14 | 147_345 | 374 | 465 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NUF2 | chr1:163317728 | chr1:201926409 | ENST00000367900 | + | 12 | 14 | 147_345 | 374 | 465 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >TIMM17A | chr1:163317728 | chr1:201926409 | ENST00000367287 | + | 0 | 6 | 113_133 | 8 | 172 | Transmembrane | Helical |
Tgene | >TIMM17A | chr1:163317728 | chr1:201926409 | ENST00000367287 | + | 0 | 6 | 17_37 | 8 | 172 | Transmembrane | Helical |
Tgene | >TIMM17A | chr1:163317728 | chr1:201926409 | ENST00000367287 | + | 0 | 6 | 63_77 | 8 | 172 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >NUF2 | chr1:163317728 | chr1:201926409 | ENST00000271452 | + | 12 | 14 | 389_459 | 374 | 465 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >NUF2 | chr1:163317728 | chr1:201926409 | ENST00000367900 | + | 12 | 14 | 389_459 | 374 | 465 | Coiled coil | Ontology_term=ECO:0000255 |
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FusionGeneSequence for NUF2_TIMM17A |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_NUF2_ENST00000524800_chr1_163317728_+_TIMM17A_ENST00000367287_chr1_201926409_+_491aa METLSFPRYNVAEIVIHIRNKILTGADGKNLTKNDLYPNPKPEVLHMIYMRALQIVYGIRLEHFYMMPVNSEVMYPHLMEGFLPFSNLVT HLDSFLPICRVNDFETADILCPKAKRTSRFLSGIINFIHFREACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEF KQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARS LNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIDPWRIVDDCGGAFTMGTIGGGIFQAIKGFRNSP VGVNHRLRGSLTAIKTRAPQLGGSFAVWGGLFSMIDCSMVQVRGKEDPWNSITSGALTGAILAARNGPVAMVGSAAMGGILLALIEGAGI >In-frame_NUF2_ENST00000367900_chr1_163317728_+_TIMM17A_ENST00000367287_chr1_201926409_+_538aa METLSFPRYNVAEIVIHIRNKILTGADGKNLTKNDLYPNPKPEVLHMIYMRALQIVYGIRLEHFYMMPVNSEVMYPHLMEGFLPFSNLVT HLDSFLPICRVNDFETADILCPKAKRTSRFLSGIINFIHFREACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEF KQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQ EVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKIN KKHEDVKQYKRTVIDPWRIVDDCGGAFTMGTIGGGIFQAIKGFRNSPVGVNHRLRGSLTAIKTRAPQLGGSFAVWGGLFSMIDCSMVQVR >In-frame_NUF2_ENST00000271452_chr1_163317728_+_TIMM17A_ENST00000367287_chr1_201926409_+_538aa METLSFPRYNVAEIVIHIRNKILTGADGKNLTKNDLYPNPKPEVLHMIYMRALQIVYGIRLEHFYMMPVNSEVMYPHLMEGFLPFSNLVT HLDSFLPICRVNDFETADILCPKAKRTSRFLSGIINFIHFREACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEF KQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQ EVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKIN KKHEDVKQYKRTVIDPWRIVDDCGGAFTMGTIGGGIFQAIKGFRNSPVGVNHRLRGSLTAIKTRAPQLGGSFAVWGGLFSMIDCSMVQVR |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_NUF2_ENST00000524800_chr1_163317728_+_TIMM17A_ENST00000367287_chr1_201926409_+_1473nt ATGGAAACTTTGTCTTTCCCCAGATATAATGTAGCTGAGATTGTGATTCATATTCGCAATAAGATCTTAACAGGAGCTGATGGTAAAAAC CTCACCAAGAATGATCTTTATCCAAATCCAAAGCCTGAAGTCTTGCACATGATCTACATGAGAGCCTTACAAATAGTATATGGAATTCGA CTGGAACATTTTTACATGATGCCAGTGAACTCTGAAGTCATGTATCCACATTTAATGGAAGGCTTCTTACCATTCAGCAATTTAGTTACT CATCTGGACTCATTTTTGCCTATCTGCCGGGTGAATGACTTTGAGACTGCTGATATTCTATGTCCAAAAGCAAAACGGACAAGTCGGTTT TTAAGTGGCATTATCAACTTTATTCACTTCAGAGAAGCATGCCGTGAAACGTATATGGAATTTCTTTGGCAATATAAATCCTCTGCGGAC AAAATGCAACAGTTAAACGCCGCACACCAGGAGGCATTAATGAAACTGGAGAGACTTGATTCTGTTCCAGTTGAAGAGCAAGAAGAGTTC AAGCAGCTTTCAGATGGAATTCAGGAGCTACAACAATCACTAAATCAGGATTTTCATCAAAAAACGATAGTGCTGCAAGAGGGAAATTCC CAAAAGAAGTCAAATATTTCAGAGAAAACCAAGCGTTTGAATGAACTAAAATTGTCGGTGGTTTCTTTGAAAGAAATACAAGAGAGTTTG AAAACAAAAATTGTGGATTCTCCAGAGAAGTTAAAGAATTATAAAGAAAAAATGAAAGATACGGTCCAGAAGCTTAAAAATGCCAGAAGC CTGAACTTGGAGGACCAAATTGAGAGTGATGAGTCAGAACTGAAGAAATTGAAGACTGAAGAAAATTCGTTCAAAAGACTGATGATTGTG AAGAAGGAAAAACTTGCCACAGCACAATTCAAAATAAATAAGAAGCATGAAGATGTTAAGCAATACAAACGCACAGTAATTGACCCATGG CGAATTGTGGATGACTGTGGTGGGGCCTTTACGATGGGTACCATTGGTGGTGGTATCTTTCAAGCAATCAAAGGTTTTCGCAATTCTCCA GTGGGAGTAAACCACAGACTACGAGGGAGTTTGACAGCTATTAAAACCAGGGCTCCACAGTTAGGAGGTAGCTTTGCAGTTTGGGGAGGG CTGTTTTCCATGATTGACTGTAGTATGGTTCAAGTCAGAGGAAAGGAAGATCCCTGGAACTCCATCACAAGTGGTGCCTTAACGGGAGCC ATACTGGCAGCAAGAAATGGACCAGTGGCCATGGTTGGGTCAGCCGCAATGGGTGGCATTCTCCTAGCTTTAATTGAAGGAGCTGGTATC TTGTTGACAAGATTTGCCTCTGCACAGTTTCCCAATGGTCCTCAGTTTGCAGAAGACCCCTCCCAGTTGCCTTCAACTCAGTTACCTTCC >In-frame_NUF2_ENST00000367900_chr1_163317728_+_TIMM17A_ENST00000367287_chr1_201926409_+_1614nt ATGGAAACTTTGTCTTTCCCCAGATATAATGTAGCTGAGATTGTGATTCATATTCGCAATAAGATCTTAACAGGAGCTGATGGTAAAAAC CTCACCAAGAATGATCTTTATCCAAATCCAAAGCCTGAAGTCTTGCACATGATCTACATGAGAGCCTTACAAATAGTATATGGAATTCGA CTGGAACATTTTTACATGATGCCAGTGAACTCTGAAGTCATGTATCCACATTTAATGGAAGGCTTCTTACCATTCAGCAATTTAGTTACT CATCTGGACTCATTTTTGCCTATCTGCCGGGTGAATGACTTTGAGACTGCTGATATTCTATGTCCAAAAGCAAAACGGACAAGTCGGTTT TTAAGTGGCATTATCAACTTTATTCACTTCAGAGAAGCATGCCGTGAAACGTATATGGAATTTCTTTGGCAATATAAATCCTCTGCGGAC AAAATGCAACAGTTAAACGCCGCACACCAGGAGGCATTAATGAAACTGGAGAGACTTGATTCTGTTCCAGTTGAAGAGCAAGAAGAGTTC AAGCAGCTTTCAGATGGAATTCAGGAGCTACAACAATCACTAAATCAGGATTTTCATCAAAAAACGATAGTGCTGCAAGAGGGAAATTCC CAAAAGAAGTCAAATATTTCAGAGAAAACCAAGCGTTTGAATGAACTAAAATTGTCGGTGGTTTCTTTGAAAGAAATACAAGAGAGTTTG AAAACAAAAATTGTGGATTCTCCAGAGAAGTTAAAGAATTATAAAGAAAAAATGAAAGATACGGTCCAGAAGCTTAAAAATGCCAGACAA GAAGTGGTGGAGAAATATGAAATCTATGGAGACTCAGTTGACTGCCTGCCTTCATGTCAGTTGGAAGTGCAGTTATATCAAAAGAAAATA CAGGACCTTTCAGATAATAGGGAAAAATTAGCCAGTATCTTAAAGGAGAGCCTGAACTTGGAGGACCAAATTGAGAGTGATGAGTCAGAA CTGAAGAAATTGAAGACTGAAGAAAATTCGTTCAAAAGACTGATGATTGTGAAGAAGGAAAAACTTGCCACAGCACAATTCAAAATAAAT AAGAAGCATGAAGATGTTAAGCAATACAAACGCACAGTAATTGACCCATGGCGAATTGTGGATGACTGTGGTGGGGCCTTTACGATGGGT ACCATTGGTGGTGGTATCTTTCAAGCAATCAAAGGTTTTCGCAATTCTCCAGTGGGAGTAAACCACAGACTACGAGGGAGTTTGACAGCT ATTAAAACCAGGGCTCCACAGTTAGGAGGTAGCTTTGCAGTTTGGGGAGGGCTGTTTTCCATGATTGACTGTAGTATGGTTCAAGTCAGA GGAAAGGAAGATCCCTGGAACTCCATCACAAGTGGTGCCTTAACGGGAGCCATACTGGCAGCAAGAAATGGACCAGTGGCCATGGTTGGG TCAGCCGCAATGGGTGGCATTCTCCTAGCTTTAATTGAAGGAGCTGGTATCTTGTTGACAAGATTTGCCTCTGCACAGTTTCCCAATGGT >In-frame_NUF2_ENST00000271452_chr1_163317728_+_TIMM17A_ENST00000367287_chr1_201926409_+_1614nt ATGGAAACTTTGTCTTTCCCCAGATATAATGTAGCTGAGATTGTGATTCATATTCGCAATAAGATCTTAACAGGAGCTGATGGTAAAAAC CTCACCAAGAATGATCTTTATCCAAATCCAAAGCCTGAAGTCTTGCACATGATCTACATGAGAGCCTTACAAATAGTATATGGAATTCGA CTGGAACATTTTTACATGATGCCAGTGAACTCTGAAGTCATGTATCCACATTTAATGGAAGGCTTCTTACCATTCAGCAATTTAGTTACT CATCTGGACTCATTTTTGCCTATCTGCCGGGTGAATGACTTTGAGACTGCTGATATTCTATGTCCAAAAGCAAAACGGACAAGTCGGTTT TTAAGTGGCATTATCAACTTTATTCACTTCAGAGAAGCATGCCGTGAAACGTATATGGAATTTCTTTGGCAATATAAATCCTCTGCGGAC AAAATGCAACAGTTAAACGCCGCACACCAGGAGGCATTAATGAAACTGGAGAGACTTGATTCTGTTCCAGTTGAAGAGCAAGAAGAGTTC AAGCAGCTTTCAGATGGAATTCAGGAGCTACAACAATCACTAAATCAGGATTTTCATCAAAAAACGATAGTGCTGCAAGAGGGAAATTCC CAAAAGAAGTCAAATATTTCAGAGAAAACCAAGCGTTTGAATGAACTAAAATTGTCGGTGGTTTCTTTGAAAGAAATACAAGAGAGTTTG AAAACAAAAATTGTGGATTCTCCAGAGAAGTTAAAGAATTATAAAGAAAAAATGAAAGATACGGTCCAGAAGCTTAAAAATGCCAGACAA GAAGTGGTGGAGAAATATGAAATCTATGGAGACTCAGTTGACTGCCTGCCTTCATGTCAGTTGGAAGTGCAGTTATATCAAAAGAAAATA CAGGACCTTTCAGATAATAGGGAAAAATTAGCCAGTATCTTAAAGGAGAGCCTGAACTTGGAGGACCAAATTGAGAGTGATGAGTCAGAA CTGAAGAAATTGAAGACTGAAGAAAATTCGTTCAAAAGACTGATGATTGTGAAGAAGGAAAAACTTGCCACAGCACAATTCAAAATAAAT AAGAAGCATGAAGATGTTAAGCAATACAAACGCACAGTAATTGACCCATGGCGAATTGTGGATGACTGTGGTGGGGCCTTTACGATGGGT ACCATTGGTGGTGGTATCTTTCAAGCAATCAAAGGTTTTCGCAATTCTCCAGTGGGAGTAAACCACAGACTACGAGGGAGTTTGACAGCT ATTAAAACCAGGGCTCCACAGTTAGGAGGTAGCTTTGCAGTTTGGGGAGGGCTGTTTTCCATGATTGACTGTAGTATGGTTCAAGTCAGA GGAAAGGAAGATCCCTGGAACTCCATCACAAGTGGTGCCTTAACGGGAGCCATACTGGCAGCAAGAAATGGACCAGTGGCCATGGTTGGG TCAGCCGCAATGGGTGGCATTCTCCTAGCTTTAATTGAAGGAGCTGGTATCTTGTTGACAAGATTTGCCTCTGCACAGTTTCCCAATGGT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_NUF2_ENST00000524800_chr1_163317728_+_TIMM17A_ENST00000367287_chr1_201926409_+_2913nt AACCGGCATCCGTCGCGGTTGGACGTGGGCTTGGCGGAATGGGGCGGGACTTCCAGTAGGAGGCGGCAAGTTTGAAAAGTGATGACGGTT GACGTTTGCTGATTTTTGACTTTGCTTGTAGCTGCTCCCCGAACTCGCCGTCTTCCTGTCGGCGGCCGGCACTGTAGGTGAGCGCGAGAG GACGGAGGAAGGAAGCCTGCAGACAGACGCCTTCTCCATCCCAAGGCGCGGGCAGGTGCCGGGACGCTGGGCCTGGCGGTGTTTTCGTCG TGCTCAGCGGTGGGAGGAGGCGGAAGAAACCAGAGCCTGGGAGATTAACAGGAAACTTCCAAGATGGAAACTTTGTCTTTCCCCAGATAT AATGTAGCTGAGATTGTGATTCATATTCGCAATAAGATCTTAACAGGAGCTGATGGTAAAAACCTCACCAAGAATGATCTTTATCCAAAT CCAAAGCCTGAAGTCTTGCACATGATCTACATGAGAGCCTTACAAATAGTATATGGAATTCGACTGGAACATTTTTACATGATGCCAGTG AACTCTGAAGTCATGTATCCACATTTAATGGAAGGCTTCTTACCATTCAGCAATTTAGTTACTCATCTGGACTCATTTTTGCCTATCTGC CGGGTGAATGACTTTGAGACTGCTGATATTCTATGTCCAAAAGCAAAACGGACAAGTCGGTTTTTAAGTGGCATTATCAACTTTATTCAC TTCAGAGAAGCATGCCGTGAAACGTATATGGAATTTCTTTGGCAATATAAATCCTCTGCGGACAAAATGCAACAGTTAAACGCCGCACAC CAGGAGGCATTAATGAAACTGGAGAGACTTGATTCTGTTCCAGTTGAAGAGCAAGAAGAGTTCAAGCAGCTTTCAGATGGAATTCAGGAG CTACAACAATCACTAAATCAGGATTTTCATCAAAAAACGATAGTGCTGCAAGAGGGAAATTCCCAAAAGAAGTCAAATATTTCAGAGAAA ACCAAGCGTTTGAATGAACTAAAATTGTCGGTGGTTTCTTTGAAAGAAATACAAGAGAGTTTGAAAACAAAAATTGTGGATTCTCCAGAG AAGTTAAAGAATTATAAAGAAAAAATGAAAGATACGGTCCAGAAGCTTAAAAATGCCAGAAGCCTGAACTTGGAGGACCAAATTGAGAGT GATGAGTCAGAACTGAAGAAATTGAAGACTGAAGAAAATTCGTTCAAAAGACTGATGATTGTGAAGAAGGAAAAACTTGCCACAGCACAA TTCAAAATAAATAAGAAGCATGAAGATGTTAAGCAATACAAACGCACAGTAATTGACCCATGGCGAATTGTGGATGACTGTGGTGGGGCC TTTACGATGGGTACCATTGGTGGTGGTATCTTTCAAGCAATCAAAGGTTTTCGCAATTCTCCAGTGGGAGTAAACCACAGACTACGAGGG AGTTTGACAGCTATTAAAACCAGGGCTCCACAGTTAGGAGGTAGCTTTGCAGTTTGGGGAGGGCTGTTTTCCATGATTGACTGTAGTATG GTTCAAGTCAGAGGAAAGGAAGATCCCTGGAACTCCATCACAAGTGGTGCCTTAACGGGAGCCATACTGGCAGCAAGAAATGGACCAGTG GCCATGGTTGGGTCAGCCGCAATGGGTGGCATTCTCCTAGCTTTAATTGAAGGAGCTGGTATCTTGTTGACAAGATTTGCCTCTGCACAG TTTCCCAATGGTCCTCAGTTTGCAGAAGACCCCTCCCAGTTGCCTTCAACTCAGTTACCTTCCTCACCTTTTGGAGACTATCGACAATAT CAGTAGGACTTCTTTCCTAGGATTTCTTTAACAGAACGAGTTGTGGTTCGAGAAGGATTTCAGAAGATCAAGTTACAGTCTGTTTTTAAA ACCATAGGTGGGACAGCTATGGCCAATAGGCTATAAAGAGACATTTAGCACTTTTTTCTATTTAAAGGAACAAGCGGGGAAGGGTGCTAA AAGATAATACGTTTATTTATTCACACTTGAATTGCATTTGTGATCAAAATAAATGTTTAAATCGCTAAAGGAAAATACAGTAAGTGCTTG AAAGATGAAGGACCAAAAGGCCAAAAAACAGTGAAATATGATCATCATCTCCTTGCGGACTTCTCTGCCTGGTTTTGTGTGTTCTGTTAT TCAAACAATAAAAAGCTGGTGGAACTTACTCTTTCTTTTAAGATAAGTTGTAGACTTCGATGTTTCATGCTCATGTACTTCAAATAATGC ATGTTTTATAGTTAGTCCCTCATCACTTGAAGTGACTTCTGAGAATTATGCAGAGTCAACATGGATCATTTCACAGTGAGATGCTTTATG GATTGAAGGATATGGTAAAATGTTTATAGTTTACTTTGAAAGTAAAATATACTATGTCTTGGTTTTGAGGATATTGGATACAAAACTCTC TTCCTTTAGGGCTACTGAGTCTTGATTCCTGATCATCAGAAATTTCACCAGAAACAACTTGCTTCCAATATACCCAATTCTATATGAAGA ATTCATGGAGAGTGTACTGGCACTGGAAGAGTTTAGTGTTTCTTGTATGCTTGAAAATAAAGTATGTACTGTTTTGAATGTGTTCCAAGT CCTCTGCATAAACGATGTATTTTGGGGTCTGGTTGGGCCTGGAAAATGGATGAGCACTTCAGAACAGGTCATTTTCCTGATATTGGAAGT GACATGTGGCCCTATAGGAGGCATGATGTTAGTTAATTACACATTTGCCTACATCTGTGGGAAATGGAGAACAAAGCCATGTGGGTACTG TAAACACACGTTTATCTTTTGGCCCAATGCCATACATATGGTAGGCATTTAATTACTGATTGTGTTTGGATAATTTGGGAATTTTCGACT >In-frame_NUF2_ENST00000367900_chr1_163317728_+_TIMM17A_ENST00000367287_chr1_201926409_+_2873nt GGAATGGGGCGGGACTTCCAGTAGGAGGCGGCAAGTTTGAAAAGTGATGACGGTTGACGTTTGCTGATTTTTGACTTTGCTTGTAGCTGC TCCCCGAACTCGCCGTCTTCCTGTCGGCGGCCGGCACTGTAGATTAACAGGAAACTTCCAAGATGGAAACTTTGTCTTTCCCCAGATATA ATGTAGCTGAGATTGTGATTCATATTCGCAATAAGATCTTAACAGGAGCTGATGGTAAAAACCTCACCAAGAATGATCTTTATCCAAATC CAAAGCCTGAAGTCTTGCACATGATCTACATGAGAGCCTTACAAATAGTATATGGAATTCGACTGGAACATTTTTACATGATGCCAGTGA ACTCTGAAGTCATGTATCCACATTTAATGGAAGGCTTCTTACCATTCAGCAATTTAGTTACTCATCTGGACTCATTTTTGCCTATCTGCC GGGTGAATGACTTTGAGACTGCTGATATTCTATGTCCAAAAGCAAAACGGACAAGTCGGTTTTTAAGTGGCATTATCAACTTTATTCACT TCAGAGAAGCATGCCGTGAAACGTATATGGAATTTCTTTGGCAATATAAATCCTCTGCGGACAAAATGCAACAGTTAAACGCCGCACACC AGGAGGCATTAATGAAACTGGAGAGACTTGATTCTGTTCCAGTTGAAGAGCAAGAAGAGTTCAAGCAGCTTTCAGATGGAATTCAGGAGC TACAACAATCACTAAATCAGGATTTTCATCAAAAAACGATAGTGCTGCAAGAGGGAAATTCCCAAAAGAAGTCAAATATTTCAGAGAAAA CCAAGCGTTTGAATGAACTAAAATTGTCGGTGGTTTCTTTGAAAGAAATACAAGAGAGTTTGAAAACAAAAATTGTGGATTCTCCAGAGA AGTTAAAGAATTATAAAGAAAAAATGAAAGATACGGTCCAGAAGCTTAAAAATGCCAGACAAGAAGTGGTGGAGAAATATGAAATCTATG GAGACTCAGTTGACTGCCTGCCTTCATGTCAGTTGGAAGTGCAGTTATATCAAAAGAAAATACAGGACCTTTCAGATAATAGGGAAAAAT TAGCCAGTATCTTAAAGGAGAGCCTGAACTTGGAGGACCAAATTGAGAGTGATGAGTCAGAACTGAAGAAATTGAAGACTGAAGAAAATT CGTTCAAAAGACTGATGATTGTGAAGAAGGAAAAACTTGCCACAGCACAATTCAAAATAAATAAGAAGCATGAAGATGTTAAGCAATACA AACGCACAGTAATTGACCCATGGCGAATTGTGGATGACTGTGGTGGGGCCTTTACGATGGGTACCATTGGTGGTGGTATCTTTCAAGCAA TCAAAGGTTTTCGCAATTCTCCAGTGGGAGTAAACCACAGACTACGAGGGAGTTTGACAGCTATTAAAACCAGGGCTCCACAGTTAGGAG GTAGCTTTGCAGTTTGGGGAGGGCTGTTTTCCATGATTGACTGTAGTATGGTTCAAGTCAGAGGAAAGGAAGATCCCTGGAACTCCATCA CAAGTGGTGCCTTAACGGGAGCCATACTGGCAGCAAGAAATGGACCAGTGGCCATGGTTGGGTCAGCCGCAATGGGTGGCATTCTCCTAG CTTTAATTGAAGGAGCTGGTATCTTGTTGACAAGATTTGCCTCTGCACAGTTTCCCAATGGTCCTCAGTTTGCAGAAGACCCCTCCCAGT TGCCTTCAACTCAGTTACCTTCCTCACCTTTTGGAGACTATCGACAATATCAGTAGGACTTCTTTCCTAGGATTTCTTTAACAGAACGAG TTGTGGTTCGAGAAGGATTTCAGAAGATCAAGTTACAGTCTGTTTTTAAAACCATAGGTGGGACAGCTATGGCCAATAGGCTATAAAGAG ACATTTAGCACTTTTTTCTATTTAAAGGAACAAGCGGGGAAGGGTGCTAAAAGATAATACGTTTATTTATTCACACTTGAATTGCATTTG TGATCAAAATAAATGTTTAAATCGCTAAAGGAAAATACAGTAAGTGCTTGAAAGATGAAGGACCAAAAGGCCAAAAAACAGTGAAATATG ATCATCATCTCCTTGCGGACTTCTCTGCCTGGTTTTGTGTGTTCTGTTATTCAAACAATAAAAAGCTGGTGGAACTTACTCTTTCTTTTA AGATAAGTTGTAGACTTCGATGTTTCATGCTCATGTACTTCAAATAATGCATGTTTTATAGTTAGTCCCTCATCACTTGAAGTGACTTCT GAGAATTATGCAGAGTCAACATGGATCATTTCACAGTGAGATGCTTTATGGATTGAAGGATATGGTAAAATGTTTATAGTTTACTTTGAA AGTAAAATATACTATGTCTTGGTTTTGAGGATATTGGATACAAAACTCTCTTCCTTTAGGGCTACTGAGTCTTGATTCCTGATCATCAGA AATTTCACCAGAAACAACTTGCTTCCAATATACCCAATTCTATATGAAGAATTCATGGAGAGTGTACTGGCACTGGAAGAGTTTAGTGTT TCTTGTATGCTTGAAAATAAAGTATGTACTGTTTTGAATGTGTTCCAAGTCCTCTGCATAAACGATGTATTTTGGGGTCTGGTTGGGCCT GGAAAATGGATGAGCACTTCAGAACAGGTCATTTTCCTGATATTGGAAGTGACATGTGGCCCTATAGGAGGCATGATGTTAGTTAATTAC ACATTTGCCTACATCTGTGGGAAATGGAGAACAAAGCCATGTGGGTACTGTAAACACACGTTTATCTTTTGGCCCAATGCCATACATATG >In-frame_NUF2_ENST00000271452_chr1_163317728_+_TIMM17A_ENST00000367287_chr1_201926409_+_3000nt AGTAGGAGGCGGCAAGTTTGAAAAGTGATGACGGTTGACGTTTGCTGATTTTTGACTTTGCTTGTAGCTGCTCCCCGAACTCGCCGTCTT CCTGTCGGCGGCCGGCACTGTAGGTGAGCGCGAGAGGACGGAGGAAGGAAGCCTGCAGACAGACGCCTTCTCCATCCCAAGGCGCGGGCA GGTGCCGGGACGCTGGGCCTGGCGGTGTTTTCGTCGTGCTCAGCGGTGGGAGGAGGCGGAAGAAACCAGAGCCTGGGAGATTAACAGGAA ACTTCCAAGATGGAAACTTTGTCTTTCCCCAGATATAATGTAGCTGAGATTGTGATTCATATTCGCAATAAGATCTTAACAGGAGCTGAT GGTAAAAACCTCACCAAGAATGATCTTTATCCAAATCCAAAGCCTGAAGTCTTGCACATGATCTACATGAGAGCCTTACAAATAGTATAT GGAATTCGACTGGAACATTTTTACATGATGCCAGTGAACTCTGAAGTCATGTATCCACATTTAATGGAAGGCTTCTTACCATTCAGCAAT TTAGTTACTCATCTGGACTCATTTTTGCCTATCTGCCGGGTGAATGACTTTGAGACTGCTGATATTCTATGTCCAAAAGCAAAACGGACA AGTCGGTTTTTAAGTGGCATTATCAACTTTATTCACTTCAGAGAAGCATGCCGTGAAACGTATATGGAATTTCTTTGGCAATATAAATCC TCTGCGGACAAAATGCAACAGTTAAACGCCGCACACCAGGAGGCATTAATGAAACTGGAGAGACTTGATTCTGTTCCAGTTGAAGAGCAA GAAGAGTTCAAGCAGCTTTCAGATGGAATTCAGGAGCTACAACAATCACTAAATCAGGATTTTCATCAAAAAACGATAGTGCTGCAAGAG GGAAATTCCCAAAAGAAGTCAAATATTTCAGAGAAAACCAAGCGTTTGAATGAACTAAAATTGTCGGTGGTTTCTTTGAAAGAAATACAA GAGAGTTTGAAAACAAAAATTGTGGATTCTCCAGAGAAGTTAAAGAATTATAAAGAAAAAATGAAAGATACGGTCCAGAAGCTTAAAAAT GCCAGACAAGAAGTGGTGGAGAAATATGAAATCTATGGAGACTCAGTTGACTGCCTGCCTTCATGTCAGTTGGAAGTGCAGTTATATCAA AAGAAAATACAGGACCTTTCAGATAATAGGGAAAAATTAGCCAGTATCTTAAAGGAGAGCCTGAACTTGGAGGACCAAATTGAGAGTGAT GAGTCAGAACTGAAGAAATTGAAGACTGAAGAAAATTCGTTCAAAAGACTGATGATTGTGAAGAAGGAAAAACTTGCCACAGCACAATTC AAAATAAATAAGAAGCATGAAGATGTTAAGCAATACAAACGCACAGTAATTGACCCATGGCGAATTGTGGATGACTGTGGTGGGGCCTTT ACGATGGGTACCATTGGTGGTGGTATCTTTCAAGCAATCAAAGGTTTTCGCAATTCTCCAGTGGGAGTAAACCACAGACTACGAGGGAGT TTGACAGCTATTAAAACCAGGGCTCCACAGTTAGGAGGTAGCTTTGCAGTTTGGGGAGGGCTGTTTTCCATGATTGACTGTAGTATGGTT CAAGTCAGAGGAAAGGAAGATCCCTGGAACTCCATCACAAGTGGTGCCTTAACGGGAGCCATACTGGCAGCAAGAAATGGACCAGTGGCC ATGGTTGGGTCAGCCGCAATGGGTGGCATTCTCCTAGCTTTAATTGAAGGAGCTGGTATCTTGTTGACAAGATTTGCCTCTGCACAGTTT CCCAATGGTCCTCAGTTTGCAGAAGACCCCTCCCAGTTGCCTTCAACTCAGTTACCTTCCTCACCTTTTGGAGACTATCGACAATATCAG TAGGACTTCTTTCCTAGGATTTCTTTAACAGAACGAGTTGTGGTTCGAGAAGGATTTCAGAAGATCAAGTTACAGTCTGTTTTTAAAACC ATAGGTGGGACAGCTATGGCCAATAGGCTATAAAGAGACATTTAGCACTTTTTTCTATTTAAAGGAACAAGCGGGGAAGGGTGCTAAAAG ATAATACGTTTATTTATTCACACTTGAATTGCATTTGTGATCAAAATAAATGTTTAAATCGCTAAAGGAAAATACAGTAAGTGCTTGAAA GATGAAGGACCAAAAGGCCAAAAAACAGTGAAATATGATCATCATCTCCTTGCGGACTTCTCTGCCTGGTTTTGTGTGTTCTGTTATTCA AACAATAAAAAGCTGGTGGAACTTACTCTTTCTTTTAAGATAAGTTGTAGACTTCGATGTTTCATGCTCATGTACTTCAAATAATGCATG TTTTATAGTTAGTCCCTCATCACTTGAAGTGACTTCTGAGAATTATGCAGAGTCAACATGGATCATTTCACAGTGAGATGCTTTATGGAT TGAAGGATATGGTAAAATGTTTATAGTTTACTTTGAAAGTAAAATATACTATGTCTTGGTTTTGAGGATATTGGATACAAAACTCTCTTC CTTTAGGGCTACTGAGTCTTGATTCCTGATCATCAGAAATTTCACCAGAAACAACTTGCTTCCAATATACCCAATTCTATATGAAGAATT CATGGAGAGTGTACTGGCACTGGAAGAGTTTAGTGTTTCTTGTATGCTTGAAAATAAAGTATGTACTGTTTTGAATGTGTTCCAAGTCCT CTGCATAAACGATGTATTTTGGGGTCTGGTTGGGCCTGGAAAATGGATGAGCACTTCAGAACAGGTCATTTTCCTGATATTGGAAGTGAC ATGTGGCCCTATAGGAGGCATGATGTTAGTTAATTACACATTTGCCTACATCTGTGGGAAATGGAGAACAAAGCCATGTGGGTACTGTAA ACACACGTTTATCTTTTGGCCCAATGCCATACATATGGTAGGCATTTAATTACTGATTGTGTTTGGATAATTTGGGAATTTTCGACTGTG |
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FusionGenePPI for NUF2_TIMM17A |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NUF2 | MIS12, DGKE, NDC80, CENPE, ZWINT, BUB1, DTNBP1, EXOC1, SPC24, SPC25, AURKA, AURKB, CENPH, AZGP1, SDCBP2, BUB1B, NSL1, PPP1CC, DSN1, NTRK1, PCM1, INPP5B, MYBL2, SP100, CTDP1, PPIG, SRCAP, KIF3A, PMF1, HERC4, COPS7A, NSFL1C, CASC5, TSNAX, SMC1A, ATG4A, SNW1, CDC5L, C6orf141, CENPC, WDYHV1, PKN3, NCKAP5L, TFPT, CCHCR1, YEATS4, TUFT1, RABGAP1L, GOLGA5, CLOCK, PSMD9, VPS53, DZIP3, GRIPAP1, RCOR1, HMG20A, CCDC132, CCDC93, OIP5, PHF21A, PTRF, PHLDB3, HAUS6, RPRD1A, ARNTL, MAX, GIT2, RABGEF1 | TIMM17A | TIMM44, PAM16, DNAJC19, TUBA1A, SRSF3, SFXN3, DNAJC15, DUSP22, P2RX5, ELOVL5, ROMO1, TRIM25 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | NUF2 | chr1:163317728 | chr1:201926409 | ENST00000271452 | + | 12 | 14 | 386_464 | 374 | 465 | the C-terminus of NDC80 and the SPBC24-SPBC25 subcomplex |
Hgene | NUF2 | chr1:163317728 | chr1:201926409 | ENST00000367900 | + | 12 | 14 | 386_464 | 374 | 465 | the C-terminus of NDC80 and the SPBC24-SPBC25 subcomplex |
Hgene | NUF2 | chr1:163317728 | chr1:201926409 | ENST00000271452 | + | 12 | 14 | 1_385 | 374 | 465 | the N-terminus of NDC80 |
Hgene | NUF2 | chr1:163317728 | chr1:201926409 | ENST00000367900 | + | 12 | 14 | 1_385 | 374 | 465 | the N-terminus of NDC80 |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NUF2_TIMM17A |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NUF2_TIMM17A |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |