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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25124

FusionGeneSummary for NUDT9_FAM13A

check button Fusion gene summary
Fusion gene informationFusion gene name: NUDT9_FAM13A
Fusion gene ID: 25124
HgeneTgene
Gene symbol

NUDT9

FAM13A

Gene ID

53343

10144

Gene namenudix hydrolase 9family with sequence similarity 13 member A
SynonymsNUDT10ARHGAP48|FAM13A1
Cytomap

4q22.1

4q22.1

Type of geneprotein-codingprotein-coding
DescriptionADP-ribose pyrophosphatase, mitochondrialADP-ribose diphosphataseADP-ribose phosphohydrolaseADP-ribose pyrosphosphatase NUDT9ADPR-PPaseadenosine diphosphoribose pyrophosphatasenucleoside diphosphate linked moiety X-type motif 9nudix (nucleoside dipprotein FAM13AFAM13A1_v2 proteinfamily with sequence similarity 13, member A1
Modification date2018052320180519
UniProtAcc

Q9BW91

O94988

Ensembl transtripts involved in fusion geneENST00000302174, ENST00000473942, 
ENST00000515371, 		ENST00000395002, 
ENST00000264344, ENST00000503556, 
ENST00000511976, ENST00000508369, 
ENST00000513837, ENST00000502459, 
ENST00000509094, ENST00000515600, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 3=48
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUDT9 [Title/Abstract] AND FAM13A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-B6-A0I6-01ANUDT9chr4

88370405

+FAM13Achr4

89912301

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000302174ENST00000395002NUDT9chr4

88370405

+FAM13Achr4

89912301

-
5CDS-intronENST00000302174ENST00000264344NUDT9chr4

88370405

+FAM13Achr4

89912301

-
5CDS-intronENST00000302174ENST00000503556NUDT9chr4

88370405

+FAM13Achr4

89912301

-
5CDS-intronENST00000302174ENST00000511976NUDT9chr4

88370405

+FAM13Achr4

89912301

-
5CDS-intronENST00000302174ENST00000508369NUDT9chr4

88370405

+FAM13Achr4

89912301

-
5CDS-intronENST00000302174ENST00000513837NUDT9chr4

88370405

+FAM13Achr4

89912301

-
5CDS-5UTRENST00000302174ENST00000502459NUDT9chr4

88370405

+FAM13Achr4

89912301

-
5CDS-5UTRENST00000302174ENST00000509094NUDT9chr4

88370405

+FAM13Achr4

89912301

-
5CDS-5UTRENST00000302174ENST00000515600NUDT9chr4

88370405

+FAM13Achr4

89912301

-
5CDS-intronENST00000473942ENST00000395002NUDT9chr4

88370405

+FAM13Achr4

89912301

-
5CDS-intronENST00000473942ENST00000264344NUDT9chr4

88370405

+FAM13Achr4

89912301

-
5CDS-intronENST00000473942ENST00000503556NUDT9chr4

88370405

+FAM13Achr4

89912301

-
5CDS-intronENST00000473942ENST00000511976NUDT9chr4

88370405

+FAM13Achr4

89912301

-
5CDS-intronENST00000473942ENST00000508369NUDT9chr4

88370405

+FAM13Achr4

89912301

-
5CDS-intronENST00000473942ENST00000513837NUDT9chr4

88370405

+FAM13Achr4

89912301

-
5CDS-5UTRENST00000473942ENST00000502459NUDT9chr4

88370405

+FAM13Achr4

89912301

-
5CDS-5UTRENST00000473942ENST00000509094NUDT9chr4

88370405

+FAM13Achr4

89912301

-
5CDS-5UTRENST00000473942ENST00000515600NUDT9chr4

88370405

+FAM13Achr4

89912301

-
3UTR-intronENST00000515371ENST00000395002NUDT9chr4

88370405

+FAM13Achr4

89912301

-
3UTR-intronENST00000515371ENST00000264344NUDT9chr4

88370405

+FAM13Achr4

89912301

-
3UTR-intronENST00000515371ENST00000503556NUDT9chr4

88370405

+FAM13Achr4

89912301

-
3UTR-intronENST00000515371ENST00000511976NUDT9chr4

88370405

+FAM13Achr4

89912301

-
3UTR-intronENST00000515371ENST00000508369NUDT9chr4

88370405

+FAM13Achr4

89912301

-
3UTR-intronENST00000515371ENST00000513837NUDT9chr4

88370405

+FAM13Achr4

89912301

-
3UTR-5UTRENST00000515371ENST00000502459NUDT9chr4

88370405

+FAM13Achr4

89912301

-
3UTR-5UTRENST00000515371ENST00000509094NUDT9chr4

88370405

+FAM13Achr4

89912301

-
3UTR-5UTRENST00000515371ENST00000515600NUDT9chr4

88370405

+FAM13Achr4

89912301

-

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FusionProtFeatures for NUDT9_FAM13A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUDT9

Q9BW91

FAM13A

O94988

Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NUDT9_FAM13A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NUDT9_FAM13A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NUDT9APP, EPHA2, FBXO6, DUT, IMPA1, IMPA2, MAN2A1, NIT1, GSTO1, PHGDH, PHPT1, WDR5B, ASNA1, TRIM11FAM13AMPP1, PCNA, PPP2R1A, ERP44, RTEL1, UNC119, TBCCD1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NUDT9_FAM13A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NUDT9_FAM13A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFAM13AC0024117Chronic Obstructive Airway Disease1CTD_human
TgeneFAM13AC1800706Idiopathic Pulmonary Fibrosis1CTD_human;ORPHANET