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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25121

FusionGeneSummary for NUDT5_ZMYND11

check button Fusion gene summary
Fusion gene informationFusion gene name: NUDT5_ZMYND11
Fusion gene ID: 25121
HgeneTgene
Gene symbol

NUDT5

ZMYND11

Gene ID

11164

10771

Gene namenudix hydrolase 5zinc finger MYND-type containing 11
SynonymsYSA1|YSA1H|YSAH1|hNUDT5BRAM1|BS69|MRD30
Cytomap

10p14

10p15.3

Type of geneprotein-codingprotein-coding
DescriptionADP-sugar pyrophosphatase8-oxo-dGDP phosphatasenuclear ATP-synthesis protein NUDIX5nudix (nucleoside diphosphate linked moiety X)-type motif 5zinc finger MYND domain-containing protein 11adenovirus 5 E1A-binding proteinbone morphogenetic protein receptor-associated molecule 1
Modification date2018051920180522
UniProtAcc

Q9UKK9

Q15326

Ensembl transtripts involved in fusion geneENST00000491614, ENST00000378937, 
ENST00000537776, ENST00000378952, 
ENST00000378940, ENST00000378927, 
ENST00000381602, ENST00000397962, 
ENST00000309776, ENST00000509513, 
ENST00000397959, ENST00000381591, 
ENST00000403354, ENST00000381607, 
ENST00000402736, ENST00000602682, 
ENST00000381604, ENST00000381584, 
ENST00000558098, ENST00000545619, 
ENST00000535374, ENST00000473115, 
Fusion gene scores* DoF score2 X 2 X 1=46 X 5 X 6=180
# samples 27
** MAII scorelog2(2/4*10)=2.32192809488736log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUDT5 [Title/Abstract] AND ZMYND11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNUDT5

GO:0006338

chromatin remodeling

27257257

HgeneNUDT5

GO:0009191

ribonucleoside diphosphate catabolic process

18462755|19699693|21389046

HgeneNUDT5

GO:0019303

D-ribose catabolic process

21389046

HgeneNUDT5

GO:1990966

ATP generation from poly-ADP-D-ribose

27257257

TgeneZMYND11

GO:0051607

defense response to virus

26845565


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DC322982NUDT5chr10

12228228

-ZMYND11chr10

225932

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000491614ENST00000381602NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000491614ENST00000397962NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000491614ENST00000309776NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000491614ENST00000509513NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000491614ENST00000397959NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000491614ENST00000381591NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000491614ENST00000403354NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000491614ENST00000381607NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000491614ENST00000402736NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000491614ENST00000602682NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000491614ENST00000381604NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000491614ENST00000381584NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-intronENST00000491614ENST00000558098NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-intronENST00000491614ENST00000545619NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-intronENST00000491614ENST00000535374NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-intronENST00000491614ENST00000473115NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378937ENST00000381602NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378937ENST00000397962NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378937ENST00000309776NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378937ENST00000509513NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378937ENST00000397959NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378937ENST00000381591NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378937ENST00000403354NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378937ENST00000381607NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378937ENST00000402736NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378937ENST00000602682NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378937ENST00000381604NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378937ENST00000381584NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-intronENST00000378937ENST00000558098NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-intronENST00000378937ENST00000545619NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-intronENST00000378937ENST00000535374NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-intronENST00000378937ENST00000473115NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000537776ENST00000381602NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000537776ENST00000397962NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000537776ENST00000309776NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000537776ENST00000509513NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000537776ENST00000397959NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000537776ENST00000381591NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000537776ENST00000403354NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000537776ENST00000381607NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000537776ENST00000402736NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000537776ENST00000602682NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000537776ENST00000381604NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000537776ENST00000381584NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-intronENST00000537776ENST00000558098NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-intronENST00000537776ENST00000545619NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-intronENST00000537776ENST00000535374NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-intronENST00000537776ENST00000473115NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5UTR-5UTRENST00000378952ENST00000381602NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5UTR-5UTRENST00000378952ENST00000397962NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5UTR-5UTRENST00000378952ENST00000309776NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5UTR-5UTRENST00000378952ENST00000509513NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5UTR-5UTRENST00000378952ENST00000397959NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5UTR-5UTRENST00000378952ENST00000381591NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5UTR-5UTRENST00000378952ENST00000403354NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5UTR-5UTRENST00000378952ENST00000381607NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5UTR-5UTRENST00000378952ENST00000402736NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5UTR-5UTRENST00000378952ENST00000602682NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5UTR-5UTRENST00000378952ENST00000381604NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5UTR-5UTRENST00000378952ENST00000381584NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5UTR-intronENST00000378952ENST00000558098NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5UTR-intronENST00000378952ENST00000545619NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5UTR-intronENST00000378952ENST00000535374NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5UTR-intronENST00000378952ENST00000473115NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378940ENST00000381602NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378940ENST00000397962NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378940ENST00000309776NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378940ENST00000509513NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378940ENST00000397959NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378940ENST00000381591NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378940ENST00000403354NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378940ENST00000381607NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378940ENST00000402736NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378940ENST00000602682NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378940ENST00000381604NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378940ENST00000381584NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-intronENST00000378940ENST00000558098NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-intronENST00000378940ENST00000545619NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-intronENST00000378940ENST00000535374NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-intronENST00000378940ENST00000473115NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378927ENST00000381602NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378927ENST00000397962NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378927ENST00000309776NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378927ENST00000509513NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378927ENST00000397959NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378927ENST00000381591NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378927ENST00000403354NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378927ENST00000381607NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378927ENST00000402736NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378927ENST00000602682NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378927ENST00000381604NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-5UTRENST00000378927ENST00000381584NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-intronENST00000378927ENST00000558098NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-intronENST00000378927ENST00000545619NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-intronENST00000378927ENST00000535374NUDT5chr10

12228228

-ZMYND11chr10

225932

+
5CDS-intronENST00000378927ENST00000473115NUDT5chr10

12228228

-ZMYND11chr10

225932

+

Top

FusionProtFeatures for NUDT5_ZMYND11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUDT5

Q9UKK9

ZMYND11

Q15326

Enzyme that can either act as an ADP-sugarpyrophosphatase in absence of diphosphate or catalyze thesynthesis of ATP in presence of diphosphate (PubMed:27257257). Inabsence of diphosphate, hydrolyzes with similar activities variousmodified nucleoside diphosphates such as ADP-ribose, ADP-mannose,ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213,PubMed:10722730, PubMed:19699693, PubMed:21389046,PubMed:17052728). Can also hydrolyze other nucleotide sugars withlow activity (PubMed:19699693, PubMed:21389046). In presence ofdiphosphate, mediates the synthesis of ATP in the nucleus bycatalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylatedat Thr-45 (PubMed:27257257). Nuclear ATP generation is requiredfor extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Does not play a role in U8 snoRNAdecapping activity (By similarity). Binds U8 snoRNA (Bysimilarity). {ECO:0000250|UniProtKB:Q9JKX6,ECO:0000269|PubMed:10567213, ECO:0000269|PubMed:10722730,ECO:0000269|PubMed:17052728, ECO:0000269|PubMed:19699693,ECO:0000269|PubMed:21389046, ECO:0000269|PubMed:27257257}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NUDT5_ZMYND11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NUDT5_ZMYND11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NUDT5MCM3AP, NUDT3, MAPK6, SKA3, RPA2, SMURF1, CUL1, PPP1R12A, TRIM47, PYCR1, PYCR2, NTRK1, HIST1H2BG, EWSR1, MAD2L1, SKA1, CDH1, DUSP14, PPAT, SLC9A3R2, YAP1, CTNNB1ZMYND11C11orf30, ETS2, ZHX1, NCOR1, BMPR1A, TAB1, MYB, SMARCA2, HDAC1, EZH2, EZH1, E2F6, TP53, EP400, PDLIM7, TRAF6, HOXD4, ELAVL1, LTBR, ZMYND11, PIAS1, UBE2I, TRAF1, TRAF2, TRAF3, TRAF5, SMAD2, TRADD, SMAD3, SRPK1, MAGEC2, H3F3A, HIST3H3, PRPF8, SRRM2, SNRNP200, SRRM1, PNN, SRSF4, SRSF1, PABPC1, EFTUD2, SAP18, PPIG, MAGOHB, SRSF10, RNU4-1, RNU5A-1, RNU6-1, CDK2, GBA, RPL10


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NUDT5_ZMYND11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NUDT5_ZMYND11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneZMYND11C0004352Autistic Disorder1CTD_human