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Fusion gene ID: 25120 |
FusionGeneSummary for NUDT5_WDR90 |
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Fusion gene information | Fusion gene name: NUDT5_WDR90 | Fusion gene ID: 25120 | Hgene | Tgene | Gene symbol | NUDT5 | WDR90 | Gene ID | 11164 | 197335 |
Gene name | nudix hydrolase 5 | WD repeat domain 90 | |
Synonyms | YSA1|YSA1H|YSAH1|hNUDT5 | C16orf15|C16orf16|C16orf17|C16orf18|C16orf19 | |
Cytomap | 10p14 | 16p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | ADP-sugar pyrophosphatase8-oxo-dGDP phosphatasenuclear ATP-synthesis protein NUDIX5nudix (nucleoside diphosphate linked moiety X)-type motif 5 | WD repeat-containing protein 90 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9UKK9 | Q96KV7 | |
Ensembl transtripts involved in fusion gene | ENST00000491614, ENST00000378937, ENST00000537776, ENST00000378952, ENST00000378940, ENST00000378927, | ENST00000549091, ENST00000293879, ENST00000547543, ENST00000547944, ENST00000315764, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 3 X 3 X 2=18 |
# samples | 2 | 4 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: NUDT5 [Title/Abstract] AND WDR90 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NUDT5 | GO:0006338 | chromatin remodeling | 27257257 |
Hgene | NUDT5 | GO:0009191 | ribonucleoside diphosphate catabolic process | 18462755|19699693|21389046 |
Hgene | NUDT5 | GO:0019303 | D-ribose catabolic process | 21389046 |
Hgene | NUDT5 | GO:1990966 | ATP generation from poly-ADP-D-ribose | 27257257 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA370758 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000491614 | ENST00000549091 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000491614 | ENST00000293879 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000491614 | ENST00000547543 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000491614 | ENST00000547944 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000491614 | ENST00000315764 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000378937 | ENST00000549091 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000378937 | ENST00000293879 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000378937 | ENST00000547543 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000378937 | ENST00000547944 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000378937 | ENST00000315764 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000537776 | ENST00000549091 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000537776 | ENST00000293879 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000537776 | ENST00000547543 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000537776 | ENST00000547944 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000537776 | ENST00000315764 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000378952 | ENST00000549091 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000378952 | ENST00000293879 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000378952 | ENST00000547543 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000378952 | ENST00000547944 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000378952 | ENST00000315764 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000378940 | ENST00000549091 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000378940 | ENST00000293879 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000378940 | ENST00000547543 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000378940 | ENST00000547944 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000378940 | ENST00000315764 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000378927 | ENST00000549091 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000378927 | ENST00000293879 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000378927 | ENST00000547543 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000378927 | ENST00000547944 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
intron-intron | ENST00000378927 | ENST00000315764 | NUDT5 | chr10 | 12214050 | - | WDR90 | chr16 | 714964 | + |
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FusionProtFeatures for NUDT5_WDR90 |
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Hgene | Tgene |
NUDT5 | WDR90 |
Enzyme that can either act as an ADP-sugarpyrophosphatase in absence of diphosphate or catalyze thesynthesis of ATP in presence of diphosphate (PubMed:27257257). Inabsence of diphosphate, hydrolyzes with similar activities variousmodified nucleoside diphosphates such as ADP-ribose, ADP-mannose,ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213,PubMed:10722730, PubMed:19699693, PubMed:21389046,PubMed:17052728). Can also hydrolyze other nucleotide sugars withlow activity (PubMed:19699693, PubMed:21389046). In presence ofdiphosphate, mediates the synthesis of ATP in the nucleus bycatalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylatedat Thr-45 (PubMed:27257257). Nuclear ATP generation is requiredfor extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Does not play a role in U8 snoRNAdecapping activity (By similarity). Binds U8 snoRNA (Bysimilarity). {ECO:0000250|UniProtKB:Q9JKX6,ECO:0000269|PubMed:10567213, ECO:0000269|PubMed:10722730,ECO:0000269|PubMed:17052728, ECO:0000269|PubMed:19699693,ECO:0000269|PubMed:21389046, ECO:0000269|PubMed:27257257}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NUDT5_WDR90 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NUDT5_WDR90 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NUDT5_WDR90 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NUDT5_WDR90 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |