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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25116

FusionGeneSummary for NUDT4_ADD1

check button Fusion gene summary
Fusion gene informationFusion gene name: NUDT4_ADD1
Fusion gene ID: 25116
HgeneTgene
Gene symbol

NUDT4

ADD1

Gene ID

11163

118

Gene namenudix hydrolase 4adducin 1
SynonymsDIPP2|DIPP2alpha|DIPP2beta|HDCMB47PADDA
Cytomap

12q22

4p16.3

Type of geneprotein-codingprotein-coding
Descriptiondiphosphoinositol polyphosphate phosphohydrolase 2DIPP-2diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2diphosphoinositol polyphosphate phosphohydrolase type 2nudix (nucleoside diphosphate linked moiety X)-type motif 4alpha-adducinadducin 1 (alpha)erythrocyte adducin alpha subunit
Modification date2018052320180523
UniProtAcc

Q9NZJ9

P35611

Ensembl transtripts involved in fusion geneENST00000337179, ENST00000415493, 
ENST00000549992, ENST00000548662, 
ENST00000547014, 		ENST00000446856, 
ENST00000264758, ENST00000398125, 
ENST00000513328, ENST00000503455, 
ENST00000355842, ENST00000398123, 
ENST00000398129, ENST00000538860, 
Fusion gene scores* DoF score4 X 4 X 4=645 X 5 X 3=75
# samples 45
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUDT4 [Title/Abstract] AND ADD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneADD1

GO:0032092

positive regulation of protein binding

3693401|7642559

TgeneADD1

GO:0051016

barbed-end actin filament capping

8626479

TgeneADD1

GO:0051017

actin filament bundle assembly

3693401

TgeneADD1

GO:0071277

cellular response to calcium ion

25978380

TgeneADD1

GO:1903142

positive regulation of establishment of endothelial barrier

25978380

TgeneADD1

GO:1903393

positive regulation of adherens junction organization

25978380


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-69-7760-01ANUDT4chr12

93772197

+ADD1chr4

2877623

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000337179ENST00000446856NUDT4chr12

93772197

+ADD1chr4

2877623

+
5CDS-5UTRENST00000337179ENST00000264758NUDT4chr12

93772197

+ADD1chr4

2877623

+
5CDS-5UTRENST00000337179ENST00000398125NUDT4chr12

93772197

+ADD1chr4

2877623

+
5CDS-5UTRENST00000337179ENST00000513328NUDT4chr12

93772197

+ADD1chr4

2877623

+
5CDS-5UTRENST00000337179ENST00000503455NUDT4chr12

93772197

+ADD1chr4

2877623

+
5CDS-5UTRENST00000337179ENST00000355842NUDT4chr12

93772197

+ADD1chr4

2877623

+
5CDS-5UTRENST00000337179ENST00000398123NUDT4chr12

93772197

+ADD1chr4

2877623

+
5CDS-5UTRENST00000337179ENST00000398129NUDT4chr12

93772197

+ADD1chr4

2877623

+
5CDS-intronENST00000337179ENST00000538860NUDT4chr12

93772197

+ADD1chr4

2877623

+
5CDS-5UTRENST00000415493ENST00000446856NUDT4chr12

93772197

+ADD1chr4

2877623

+
5CDS-5UTRENST00000415493ENST00000264758NUDT4chr12

93772197

+ADD1chr4

2877623

+
5CDS-5UTRENST00000415493ENST00000398125NUDT4chr12

93772197

+ADD1chr4

2877623

+
5CDS-5UTRENST00000415493ENST00000513328NUDT4chr12

93772197

+ADD1chr4

2877623

+
5CDS-5UTRENST00000415493ENST00000503455NUDT4chr12

93772197

+ADD1chr4

2877623

+
5CDS-5UTRENST00000415493ENST00000355842NUDT4chr12

93772197

+ADD1chr4

2877623

+
5CDS-5UTRENST00000415493ENST00000398123NUDT4chr12

93772197

+ADD1chr4

2877623

+
5CDS-5UTRENST00000415493ENST00000398129NUDT4chr12

93772197

+ADD1chr4

2877623

+
5CDS-intronENST00000415493ENST00000538860NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000549992ENST00000446856NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000549992ENST00000264758NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000549992ENST00000398125NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000549992ENST00000513328NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000549992ENST00000503455NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000549992ENST00000355842NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000549992ENST00000398123NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000549992ENST00000398129NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-intronENST00000549992ENST00000538860NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000548662ENST00000446856NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000548662ENST00000264758NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000548662ENST00000398125NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000548662ENST00000513328NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000548662ENST00000503455NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000548662ENST00000355842NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000548662ENST00000398123NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000548662ENST00000398129NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-intronENST00000548662ENST00000538860NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000547014ENST00000446856NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000547014ENST00000264758NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000547014ENST00000398125NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000547014ENST00000513328NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000547014ENST00000503455NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000547014ENST00000355842NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000547014ENST00000398123NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-5UTRENST00000547014ENST00000398129NUDT4chr12

93772197

+ADD1chr4

2877623

+
intron-intronENST00000547014ENST00000538860NUDT4chr12

93772197

+ADD1chr4

2877623

+

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FusionProtFeatures for NUDT4_ADD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUDT4

Q9NZJ9

ADD1

P35611


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NUDT4_ADD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NUDT4_ADD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NUDT4KEAP1ADD1HSPH1, CALM1, SPTB, SMARCA4, SMARCC1, SMARCA2, SIN3A, HDAC1, CSNK2B, TK1, MAP1LC3B, GEMIN7, VCP, MMS19, RPA3, RPA2, RPA1, HMG20A, ZDHHC17, FAM78A, DPPA4, ANKRD29, DYNC1I2, NTRK1, IFI16, DYNLT1, XPO1, CAPZA2, MYO1C, IQGAP1, NES, MAPRE1, CDKN2AIP, ATL2, LRWD1, ADD3, DST, HSPG2, SPTAN1, SPTBN1, SVIL, TMOD1, TPM2, TPM3, TPM4, UBIAD1, NUP54, INF2, CDH1, ADD2, GBP2, PDHA1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NUDT4_ADD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NUDT4_ADD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneADD1C0020538Hypertensive disease2CTD_human
TgeneADD1C2239176Liver carcinoma1CTD_human