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Fusion gene ID: 25114 |
FusionGeneSummary for NUDT3_SORBS2 |
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Fusion gene information | Fusion gene name: NUDT3_SORBS2 | Fusion gene ID: 25114 | Hgene | Tgene | Gene symbol | NUDT3 | SORBS2 | Gene ID | 11165 | 8470 |
Gene name | nudix hydrolase 3 | sorbin and SH3 domain containing 2 | |
Synonyms | DIPP|DIPP-1|DIPP1 | ARGBP2|PRO0618 | |
Cytomap | 6p21.31 | 4q35.1 | |
Type of gene | protein-coding | protein-coding | |
Description | diphosphoinositol polyphosphate phosphohydrolase 1diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1nucleoside diphosphate-linked moiety X motif 3nudix (nucleoside diphosphate linked moiety X)-type motif 3nudix motif 3 | sorbin and SH3 domain-containing protein 2Arg binding protein 2Arg/Abl-interacting protein 2arg-binding protein 2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O95989 | O94875 | |
Ensembl transtripts involved in fusion gene | ENST00000607016, | ENST00000448662, ENST00000431808, ENST00000284776, ENST00000437304, ENST00000319471, ENST00000449407, ENST00000355634, ENST00000393528, ENST00000418609, ENST00000498125, | |
Fusion gene scores | * DoF score | 13 X 9 X 7=819 | 11 X 12 X 7=924 |
# samples | 16 | 15 | |
** MAII score | log2(16/819*10)=-2.35579154675365 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/924*10)=-2.62293035092018 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NUDT3 [Title/Abstract] AND SORBS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NUDT3 | GO:0071544 | diphosphoinositol polyphosphate catabolic process | 10585413 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF326208 | NUDT3 | chr6 | 34349556 | + | SORBS2 | chr4 | 186726911 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000607016 | ENST00000448662 | NUDT3 | chr6 | 34349556 | + | SORBS2 | chr4 | 186726911 | + |
intron-intron | ENST00000607016 | ENST00000431808 | NUDT3 | chr6 | 34349556 | + | SORBS2 | chr4 | 186726911 | + |
intron-intron | ENST00000607016 | ENST00000284776 | NUDT3 | chr6 | 34349556 | + | SORBS2 | chr4 | 186726911 | + |
intron-intron | ENST00000607016 | ENST00000437304 | NUDT3 | chr6 | 34349556 | + | SORBS2 | chr4 | 186726911 | + |
intron-intron | ENST00000607016 | ENST00000319471 | NUDT3 | chr6 | 34349556 | + | SORBS2 | chr4 | 186726911 | + |
intron-intron | ENST00000607016 | ENST00000449407 | NUDT3 | chr6 | 34349556 | + | SORBS2 | chr4 | 186726911 | + |
intron-intron | ENST00000607016 | ENST00000355634 | NUDT3 | chr6 | 34349556 | + | SORBS2 | chr4 | 186726911 | + |
intron-intron | ENST00000607016 | ENST00000393528 | NUDT3 | chr6 | 34349556 | + | SORBS2 | chr4 | 186726911 | + |
intron-intron | ENST00000607016 | ENST00000418609 | NUDT3 | chr6 | 34349556 | + | SORBS2 | chr4 | 186726911 | + |
intron-intron | ENST00000607016 | ENST00000498125 | NUDT3 | chr6 | 34349556 | + | SORBS2 | chr4 | 186726911 | + |
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FusionProtFeatures for NUDT3_SORBS2 |
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Hgene | Tgene |
NUDT3 | SORBS2 |
Cleaves a beta-phosphate from the diphosphate groups inPP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4(bisdiphosphoinositol tetrakisphosphate), suggesting that it mayplay a role in signal transduction. InsP6 (inositolhexakisphophate) is not a substrate. Acts as a negative regulatorof the ERK1/2 pathway. Also able to catalyze the hydrolysis ofdinucleoside oligophosphates, with Ap6A and Ap5A being thepreferred substrates. The major reaction products are ADP and p4afrom Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. {ECO:0000269|PubMed:9822604}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NUDT3_SORBS2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NUDT3_SORBS2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NUDT3_SORBS2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NUDT3_SORBS2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SORBS2 | C0043094 | Weight Gain | 1 | CTD_human |