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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25083

FusionGeneSummary for NUDT14_BRF1

check button Fusion gene summary
Fusion gene informationFusion gene name: NUDT14_BRF1
Fusion gene ID: 25083
HgeneTgene
Gene symbol

NUDT14

BRF1

Gene ID

256281

2972

Gene namenudix hydrolase 14BRF1, RNA polymerase III transcription initiation factor subunit
SynonymsUGPP|UGPPaseBRF|BRF-1|CFDS|GTF3B|HEL-S-76p|TAF3B2|TAF3C|TAFIII90|TF3B90|TFIIIB90|hBRF
Cytomap

14q32.33

14q32.33

Type of geneprotein-codingprotein-coding
Descriptionuridine diphosphate glucose pyrophosphataseUDP-sugar diphosphataseUDPG pyrophosphatasenudix (nucleoside diphosphate linked moiety X)-type motif 14transcription factor IIIB 90 kDa subunitB - related factor 1BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIBBRF1, RNA polymerase III transcription initiation factor 90 kDa subunitTATA box binding protein (TBP)-associate
Modification date2018051920180519
UniProtAcc

O95848

Q92994

Ensembl transtripts involved in fusion geneENST00000392568, ENST00000550912, 
ENST00000546474, ENST00000327359, 
ENST00000440513, ENST00000392557, 
ENST00000379937, ENST00000547530, 
ENST00000446501, ENST00000379932, 
ENST00000551787, ENST00000549044, 
ENST00000548421, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 6 X 5=180
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUDT14 [Title/Abstract] AND BRF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCESCTCGA-HM-A6W2-01ANUDT14chr14

105647466

-BRF1chr14

105676925

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000392568ENST00000546474NUDT14chr14

105647466

-BRF1chr14

105676925

-
In-frameENST00000392568ENST00000327359NUDT14chr14

105647466

-BRF1chr14

105676925

-
In-frameENST00000392568ENST00000440513NUDT14chr14

105647466

-BRF1chr14

105676925

-
In-frameENST00000392568ENST00000392557NUDT14chr14

105647466

-BRF1chr14

105676925

-
Frame-shiftENST00000392568ENST00000379937NUDT14chr14

105647466

-BRF1chr14

105676925

-
Frame-shiftENST00000392568ENST00000547530NUDT14chr14

105647466

-BRF1chr14

105676925

-
Frame-shiftENST00000392568ENST00000446501NUDT14chr14

105647466

-BRF1chr14

105676925

-
5CDS-intronENST00000392568ENST00000379932NUDT14chr14

105647466

-BRF1chr14

105676925

-
5CDS-intronENST00000392568ENST00000551787NUDT14chr14

105647466

-BRF1chr14

105676925

-
5CDS-intronENST00000392568ENST00000549044NUDT14chr14

105647466

-BRF1chr14

105676925

-
5CDS-intronENST00000392568ENST00000548421NUDT14chr14

105647466

-BRF1chr14

105676925

-
intron-3CDSENST00000550912ENST00000546474NUDT14chr14

105647466

-BRF1chr14

105676925

-
intron-3CDSENST00000550912ENST00000327359NUDT14chr14

105647466

-BRF1chr14

105676925

-
intron-3CDSENST00000550912ENST00000440513NUDT14chr14

105647466

-BRF1chr14

105676925

-
intron-3CDSENST00000550912ENST00000392557NUDT14chr14

105647466

-BRF1chr14

105676925

-
intron-3CDSENST00000550912ENST00000379937NUDT14chr14

105647466

-BRF1chr14

105676925

-
intron-3CDSENST00000550912ENST00000547530NUDT14chr14

105647466

-BRF1chr14

105676925

-
intron-3CDSENST00000550912ENST00000446501NUDT14chr14

105647466

-BRF1chr14

105676925

-
intron-intronENST00000550912ENST00000379932NUDT14chr14

105647466

-BRF1chr14

105676925

-
intron-intronENST00000550912ENST00000551787NUDT14chr14

105647466

-BRF1chr14

105676925

-
intron-intronENST00000550912ENST00000549044NUDT14chr14

105647466

-BRF1chr14

105676925

-
intron-intronENST00000550912ENST00000548421NUDT14chr14

105647466

-BRF1chr14

105676925

-

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FusionProtFeatures for NUDT14_BRF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUDT14

O95848

BRF1

Q92994

Hydrolyzes UDP-glucose to glucose 1-phosphate and UMPand ADP-ribose to ribose 5-phosphate and AMP. The physiologicalsubstrate is probably UDP-glucose. Poor activity on othersubstrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBRF1chr14:105647466chr14:105676925ENST00000548421-04185_269-217209RepeatNote=2
TgeneBRF1chr14:105647466chr14:105676925ENST00000548421-0491_172-217209RepeatNote=1
TgeneBRF1chr14:105647466chr14:105676925ENST00000548421-042_33-217209Zinc fingerTFIIB-type

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNUDT14chr14:105647466chr14:105676925ENST00000392568-1538_20627223DomainNudix hydrolase
HgeneNUDT14chr14:105647466chr14:105676925ENST00000392568-15111_12927223MotifNote=Nudix box
TgeneBRF1chr14:105647466chr14:105676925ENST00000327359-1618185_269550563RepeatNote=2
TgeneBRF1chr14:105647466chr14:105676925ENST00000327359-161891_172550563RepeatNote=1
TgeneBRF1chr14:105647466chr14:105676925ENST00000379937-1517185_269638651RepeatNote=2
TgeneBRF1chr14:105647466chr14:105676925ENST00000379937-151791_172638651RepeatNote=1
TgeneBRF1chr14:105647466chr14:105676925ENST00000392557-1214185_269461474RepeatNote=2
TgeneBRF1chr14:105647466chr14:105676925ENST00000392557-121491_172461474RepeatNote=1
TgeneBRF1chr14:105647466chr14:105676925ENST00000440513-1618185_269572585RepeatNote=2
TgeneBRF1chr14:105647466chr14:105676925ENST00000440513-161891_172572585RepeatNote=1
TgeneBRF1chr14:105647466chr14:105676925ENST00000446501-1113185_269427440RepeatNote=2
TgeneBRF1chr14:105647466chr14:105676925ENST00000446501-111391_172427440RepeatNote=1
TgeneBRF1chr14:105647466chr14:105676925ENST00000546474-1618185_269665678RepeatNote=2
TgeneBRF1chr14:105647466chr14:105676925ENST00000546474-161891_172665678RepeatNote=1
TgeneBRF1chr14:105647466chr14:105676925ENST00000327359-16182_33550563Zinc fingerTFIIB-type
TgeneBRF1chr14:105647466chr14:105676925ENST00000379937-15172_33638651Zinc fingerTFIIB-type
TgeneBRF1chr14:105647466chr14:105676925ENST00000392557-12142_33461474Zinc fingerTFIIB-type
TgeneBRF1chr14:105647466chr14:105676925ENST00000440513-16182_33572585Zinc fingerTFIIB-type
TgeneBRF1chr14:105647466chr14:105676925ENST00000446501-11132_33427440Zinc fingerTFIIB-type
TgeneBRF1chr14:105647466chr14:105676925ENST00000546474-16182_33665678Zinc fingerTFIIB-type


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FusionGeneSequence for NUDT14_BRF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NUDT14_BRF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NUDT14TERF1, TERF2IP, REL, ZCCHC10, WDYHV1, NIF3L1, LNX1, NUDT14BRF1GTF3C5, GTF3C3, RB1, CSNK2A1, CSNK2A2, TP53, TBP, RBL1, RBL2, PCBD2, DTNBP1, APP, UBC, ACSL4, TCF20, CCDC132, POLR3E, RHOU


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NUDT14_BRF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NUDT14_BRF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneBRF1C4015495CEREBELLOFACIODENTAL SYNDROME1ORPHANET;UNIPROT