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Fusion gene ID: 25043 |
FusionGeneSummary for NUBPL_PSMA6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NUBPL_PSMA6 | Fusion gene ID: 25043 | Hgene | Tgene | Gene symbol | NUBPL | PSMA6 | Gene ID | 80224 | 5687 |
| Gene name | nucleotide binding protein like | proteasome subunit alpha 6 | |
| Synonyms | C14orf127|IND1|huInd1 | IOTA|PROS27|p27K | |
| Cytomap | 14q12 | 14q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | iron-sulfur protein NUBPLIND1 homologiron-sulfur protein required for NADH dehydrogenase | proteasome subunit alpha type-627 kDa prosomal proteinPROS-27macropain iota chainmacropain subunit iotamulticatalytic endopeptidase complex iota chainprosomal P27K proteinproteasome (prosome, macropain) subunit, alpha type, 6proteasome iota chain | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8TB37 | P60900 | |
| Ensembl transtripts involved in fusion gene | ENST00000281081, ENST00000536705, ENST00000418681, | ENST00000540871, ENST00000261479, ENST00000553809, ENST00000555764, ENST00000556506, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 5 X 3 X 4=60 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NUBPL [Title/Abstract] AND PSMA6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PAAD | TCGA-2J-AABO-01A | NUBPL | chr14 | 32068585 | + | PSMA6 | chr14 | 35782087 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000281081 | ENST00000540871 | NUBPL | chr14 | 32068585 | + | PSMA6 | chr14 | 35782087 | + |
| In-frame | ENST00000281081 | ENST00000261479 | NUBPL | chr14 | 32068585 | + | PSMA6 | chr14 | 35782087 | + |
| In-frame | ENST00000281081 | ENST00000553809 | NUBPL | chr14 | 32068585 | + | PSMA6 | chr14 | 35782087 | + |
| In-frame | ENST00000281081 | ENST00000555764 | NUBPL | chr14 | 32068585 | + | PSMA6 | chr14 | 35782087 | + |
| In-frame | ENST00000281081 | ENST00000556506 | NUBPL | chr14 | 32068585 | + | PSMA6 | chr14 | 35782087 | + |
| In-frame | ENST00000536705 | ENST00000540871 | NUBPL | chr14 | 32068585 | + | PSMA6 | chr14 | 35782087 | + |
| In-frame | ENST00000536705 | ENST00000261479 | NUBPL | chr14 | 32068585 | + | PSMA6 | chr14 | 35782087 | + |
| In-frame | ENST00000536705 | ENST00000553809 | NUBPL | chr14 | 32068585 | + | PSMA6 | chr14 | 35782087 | + |
| In-frame | ENST00000536705 | ENST00000555764 | NUBPL | chr14 | 32068585 | + | PSMA6 | chr14 | 35782087 | + |
| In-frame | ENST00000536705 | ENST00000556506 | NUBPL | chr14 | 32068585 | + | PSMA6 | chr14 | 35782087 | + |
| intron-3CDS | ENST00000418681 | ENST00000540871 | NUBPL | chr14 | 32068585 | + | PSMA6 | chr14 | 35782087 | + |
| intron-3CDS | ENST00000418681 | ENST00000261479 | NUBPL | chr14 | 32068585 | + | PSMA6 | chr14 | 35782087 | + |
| intron-3CDS | ENST00000418681 | ENST00000553809 | NUBPL | chr14 | 32068585 | + | PSMA6 | chr14 | 35782087 | + |
| intron-3CDS | ENST00000418681 | ENST00000555764 | NUBPL | chr14 | 32068585 | + | PSMA6 | chr14 | 35782087 | + |
| intron-3CDS | ENST00000418681 | ENST00000556506 | NUBPL | chr14 | 32068585 | + | PSMA6 | chr14 | 35782087 | + |
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FusionProtFeatures for NUBPL_PSMA6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NUBPL | PSMA6 |
| Required for the assembly of the mitochondrial membranerespiratory chain NADH dehydrogenase (Complex I). May deliver ofone or more Fe-S clusters to complex I subunits.{ECO:0000269|PubMed:19752196}. | Component of the 20S core proteasome complex involved inthe proteolytic degradation of most intracellular proteins. Thiscomplex plays numerous essential roles within the cell byassociating with different regulatory particles. Associated withtwo 19S regulatory particles, forms the 26S proteasome and thusparticipates in the ATP-dependent degradation of ubiquitinatedproteins. The 26S proteasome plays a key role in the maintenanceof protein homeostasis by removing misfolded or damaged proteinsthat could impair cellular functions, and by removing proteinswhose functions are no longer required. Associated with the PA200or PA28, the 20S proteasome mediates ubiquitin-independent proteindegradation. This type of proteolysis is required in severalpathways including spermatogenesis (20S-PA200 complex) orgeneration of a subset of MHC class I-presented antigenic peptides(20S-PA28 complex). {ECO:0000269|PubMed:15244466,ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NUBPL | chr14:32068585 | chr14:35782087 | ENST00000281081 | + | 4 | 11 | 75_82 | 127 | 320 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NUBPL_PSMA6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NUBPL_ENST00000281081_chr14_32068585_+_PSMA6_ENST00000540871_chr14_35782087_+_238aa MGIWQRLLLFGGVSLRAGGGATAPLGGSRAMVCGRQLSGAGSETLKQRRTQIMSRGLPKQKPIEGVKQVIVVASGKGGVGKSTTAVNLAL ALAANDSSKAIGLLDVDVYGPSVPKMMNLKGNPELSQSMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDW >In-frame_NUBPL_ENST00000281081_chr14_32068585_+_PSMA6_ENST00000261479_chr14_35782087_+_238aa MGIWQRLLLFGGVSLRAGGGATAPLGGSRAMVCGRQLSGAGSETLKQRRTQIMSRGLPKQKPIEGVKQVIVVASGKGGVGKSTTAVNLAL ALAANDSSKAIGLLDVDVYGPSVPKMMNLKGNPELSQSMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDW >In-frame_NUBPL_ENST00000281081_chr14_32068585_+_PSMA6_ENST00000553809_chr14_35782087_+_244aa MGIWQRLLLFGGVSLRAGGGATAPLGGSRAMVCGRQLSGAGSETLKQRRTQIMSRGLPKQKPIEGVKQVIVVASGKGGVGKSTTAVNLAL ALAANDSSKAIGLLDVDVYGPSVPKMMNLKGNPELSQRSFLFLGMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKV >In-frame_NUBPL_ENST00000281081_chr14_32068585_+_PSMA6_ENST00000555764_chr14_35782087_+_238aa MGIWQRLLLFGGVSLRAGGGATAPLGGSRAMVCGRQLSGAGSETLKQRRTQIMSRGLPKQKPIEGVKQVIVVASGKGGVGKSTTAVNLAL ALAANDSSKAIGLLDVDVYGPSVPKMMNLKGNPELSQSMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDW >In-frame_NUBPL_ENST00000281081_chr14_32068585_+_PSMA6_ENST00000556506_chr14_35782087_+_195aa MGIWQRLLLFGGVSLRAGGGATAPLGGSRAMVCGRQLSGAGSETLKQRRTQIMSRGLPKQKPIEGVKQVIVVASGKGGVGKSTTAVNLAL ALAANDSSKAIGLLDVDVYGPSVPKMMNLKGNPELSQSMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDW >In-frame_NUBPL_ENST00000536705_chr14_32068585_+_PSMA6_ENST00000540871_chr14_35782087_+_142aa MSKAIGLLDVDVYGPSVPKMMNLKGNPELSQSMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTV >In-frame_NUBPL_ENST00000536705_chr14_32068585_+_PSMA6_ENST00000261479_chr14_35782087_+_142aa MSKAIGLLDVDVYGPSVPKMMNLKGNPELSQSMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTV >In-frame_NUBPL_ENST00000536705_chr14_32068585_+_PSMA6_ENST00000553809_chr14_35782087_+_148aa MSKAIGLLDVDVYGPSVPKMMNLKGNPELSQRSFLFLGMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDW >In-frame_NUBPL_ENST00000536705_chr14_32068585_+_PSMA6_ENST00000555764_chr14_35782087_+_142aa MSKAIGLLDVDVYGPSVPKMMNLKGNPELSQSMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTV >In-frame_NUBPL_ENST00000536705_chr14_32068585_+_PSMA6_ENST00000556506_chr14_35782087_+_99aa MSKAIGLLDVDVYGPSVPKMMNLKGNPELSQSMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NUBPL_ENST00000281081_chr14_32068585_+_PSMA6_ENST00000540871_chr14_35782087_+_714nt ATGGGGATTTGGCAGCGTCTGCTGCTTTTTGGTGGGGTGTCGCTCCGGGCTGGTGGCGGGGCCACTGCCCCGCTTGGGGGAAGCCGAGCG ATGGTTTGTGGGCGCCAGTTGTCTGGCGCCGGGAGTGAGACCCTAAAACAAAGAAGAACACAAATCATGTCCCGAGGACTTCCAAAGCAG AAACCGATAGAAGGTGTTAAACAAGTTATAGTTGTGGCTTCTGGAAAGGGTGGAGTCGGAAAATCTACTACAGCAGTGAATCTTGCACTT GCACTAGCAGCGAACGATTCGTCCAAGGCCATTGGTTTGCTAGATGTGGATGTGTATGGACCTTCAGTTCCAAAGATGATGAATCTGAAA GGAAATCCGGAATTATCACAGAGTATGATTTTAATTGGTATAGATGAAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTGCAGGTTAC TACTGTGGGTTTAAAGCCACTGCAGCGGGAGTTAAACAAACTGAGTCAACCAGCTTCCTTGAAAAAAAAGTGAAGAAGAAATTTGATTGG ACATTTGAACAGACAGTGGAAACTGCAATTACATGCCTGTCTACTGTTCTATCAATTGATTTCAAACCTTCAGAAATAGAAGTTGGAGTA >In-frame_NUBPL_ENST00000281081_chr14_32068585_+_PSMA6_ENST00000261479_chr14_35782087_+_714nt ATGGGGATTTGGCAGCGTCTGCTGCTTTTTGGTGGGGTGTCGCTCCGGGCTGGTGGCGGGGCCACTGCCCCGCTTGGGGGAAGCCGAGCG ATGGTTTGTGGGCGCCAGTTGTCTGGCGCCGGGAGTGAGACCCTAAAACAAAGAAGAACACAAATCATGTCCCGAGGACTTCCAAAGCAG AAACCGATAGAAGGTGTTAAACAAGTTATAGTTGTGGCTTCTGGAAAGGGTGGAGTCGGAAAATCTACTACAGCAGTGAATCTTGCACTT GCACTAGCAGCGAACGATTCGTCCAAGGCCATTGGTTTGCTAGATGTGGATGTGTATGGACCTTCAGTTCCAAAGATGATGAATCTGAAA GGAAATCCGGAATTATCACAGAGTATGATTTTAATTGGTATAGATGAAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTGCAGGTTAC TACTGTGGGTTTAAAGCCACTGCAGCGGGAGTTAAACAAACTGAGTCAACCAGCTTCCTTGAAAAAAAAGTGAAGAAGAAATTTGATTGG ACATTTGAACAGACAGTGGAAACTGCAATTACATGCCTGTCTACTGTTCTATCAATTGATTTCAAACCTTCAGAAATAGAAGTTGGAGTA >In-frame_NUBPL_ENST00000281081_chr14_32068585_+_PSMA6_ENST00000553809_chr14_35782087_+_732nt ATGGGGATTTGGCAGCGTCTGCTGCTTTTTGGTGGGGTGTCGCTCCGGGCTGGTGGCGGGGCCACTGCCCCGCTTGGGGGAAGCCGAGCG ATGGTTTGTGGGCGCCAGTTGTCTGGCGCCGGGAGTGAGACCCTAAAACAAAGAAGAACACAAATCATGTCCCGAGGACTTCCAAAGCAG AAACCGATAGAAGGTGTTAAACAAGTTATAGTTGTGGCTTCTGGAAAGGGTGGAGTCGGAAAATCTACTACAGCAGTGAATCTTGCACTT GCACTAGCAGCGAACGATTCGTCCAAGGCCATTGGTTTGCTAGATGTGGATGTGTATGGACCTTCAGTTCCAAAGATGATGAATCTGAAA GGAAATCCGGAATTATCACAGAGGTCTTTTCTCTTTTTAGGTATGATTTTAATTGGTATAGATGAAGAGCAAGGCCCTCAGGTATATAAG TGTGATCCTGCAGGTTACTACTGTGGGTTTAAAGCCACTGCAGCGGGAGTTAAACAAACTGAGTCAACCAGCTTCCTTGAAAAAAAAGTG AAGAAGAAATTTGATTGGACATTTGAACAGACAGTGGAAACTGCAATTACATGCCTGTCTACTGTTCTATCAATTGATTTCAAACCTTCA GAAATAGAAGTTGGAGTAGTGACAGTTGAAAATCCTAAATTCAGGATTCTTACAGAAGCAGAGATTGATGCTCACCTTGTTGCTCTAGCA >In-frame_NUBPL_ENST00000281081_chr14_32068585_+_PSMA6_ENST00000555764_chr14_35782087_+_714nt ATGGGGATTTGGCAGCGTCTGCTGCTTTTTGGTGGGGTGTCGCTCCGGGCTGGTGGCGGGGCCACTGCCCCGCTTGGGGGAAGCCGAGCG ATGGTTTGTGGGCGCCAGTTGTCTGGCGCCGGGAGTGAGACCCTAAAACAAAGAAGAACACAAATCATGTCCCGAGGACTTCCAAAGCAG AAACCGATAGAAGGTGTTAAACAAGTTATAGTTGTGGCTTCTGGAAAGGGTGGAGTCGGAAAATCTACTACAGCAGTGAATCTTGCACTT GCACTAGCAGCGAACGATTCGTCCAAGGCCATTGGTTTGCTAGATGTGGATGTGTATGGACCTTCAGTTCCAAAGATGATGAATCTGAAA GGAAATCCGGAATTATCACAGAGTATGATTTTAATTGGTATAGATGAAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTGCAGGTTAC TACTGTGGGTTTAAAGCCACTGCAGCGGGAGTTAAACAAACTGAGTCAACCAGCTTCCTTGAAAAAAAAGTGAAGAAGAAATTTGATTGG ACATTTGAACAGACAGTGGAAACTGCAATTACATGCCTGTCTACTGTTCTATCAATTGATTTCAAACCTTCAGAAATAGAAGTTGGAGTA >In-frame_NUBPL_ENST00000281081_chr14_32068585_+_PSMA6_ENST00000556506_chr14_35782087_+_585nt ATGGGGATTTGGCAGCGTCTGCTGCTTTTTGGTGGGGTGTCGCTCCGGGCTGGTGGCGGGGCCACTGCCCCGCTTGGGGGAAGCCGAGCG ATGGTTTGTGGGCGCCAGTTGTCTGGCGCCGGGAGTGAGACCCTAAAACAAAGAAGAACACAAATCATGTCCCGAGGACTTCCAAAGCAG AAACCGATAGAAGGTGTTAAACAAGTTATAGTTGTGGCTTCTGGAAAGGGTGGAGTCGGAAAATCTACTACAGCAGTGAATCTTGCACTT GCACTAGCAGCGAACGATTCGTCCAAGGCCATTGGTTTGCTAGATGTGGATGTGTATGGACCTTCAGTTCCAAAGATGATGAATCTGAAA GGAAATCCGGAATTATCACAGAGTATGATTTTAATTGGTATAGATGAAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTGCAGGTTAC TACTGTGGGTTTAAAGCCACTGCAGCGGGAGTTAAACAAACTGAGTCAACCAGCTTCCTTGAAAAAAAAGTGAAGAAGAAATTTGATTGG >In-frame_NUBPL_ENST00000536705_chr14_32068585_+_PSMA6_ENST00000540871_chr14_35782087_+_426nt ATGTCCAAGGCCATTGGTTTGCTAGATGTGGATGTGTATGGACCTTCAGTTCCAAAGATGATGAATCTGAAAGGAAATCCGGAATTATCA CAGAGTATGATTTTAATTGGTATAGATGAAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTGCAGGTTACTACTGTGGGTTTAAAGCC ACTGCAGCGGGAGTTAAACAAACTGAGTCAACCAGCTTCCTTGAAAAAAAAGTGAAGAAGAAATTTGATTGGACATTTGAACAGACAGTG GAAACTGCAATTACATGCCTGTCTACTGTTCTATCAATTGATTTCAAACCTTCAGAAATAGAAGTTGGAGTAGTGACAGTTGAAAATCCT >In-frame_NUBPL_ENST00000536705_chr14_32068585_+_PSMA6_ENST00000261479_chr14_35782087_+_426nt ATGTCCAAGGCCATTGGTTTGCTAGATGTGGATGTGTATGGACCTTCAGTTCCAAAGATGATGAATCTGAAAGGAAATCCGGAATTATCA CAGAGTATGATTTTAATTGGTATAGATGAAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTGCAGGTTACTACTGTGGGTTTAAAGCC ACTGCAGCGGGAGTTAAACAAACTGAGTCAACCAGCTTCCTTGAAAAAAAAGTGAAGAAGAAATTTGATTGGACATTTGAACAGACAGTG GAAACTGCAATTACATGCCTGTCTACTGTTCTATCAATTGATTTCAAACCTTCAGAAATAGAAGTTGGAGTAGTGACAGTTGAAAATCCT >In-frame_NUBPL_ENST00000536705_chr14_32068585_+_PSMA6_ENST00000553809_chr14_35782087_+_444nt ATGTCCAAGGCCATTGGTTTGCTAGATGTGGATGTGTATGGACCTTCAGTTCCAAAGATGATGAATCTGAAAGGAAATCCGGAATTATCA CAGAGGTCTTTTCTCTTTTTAGGTATGATTTTAATTGGTATAGATGAAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTGCAGGTTAC TACTGTGGGTTTAAAGCCACTGCAGCGGGAGTTAAACAAACTGAGTCAACCAGCTTCCTTGAAAAAAAAGTGAAGAAGAAATTTGATTGG ACATTTGAACAGACAGTGGAAACTGCAATTACATGCCTGTCTACTGTTCTATCAATTGATTTCAAACCTTCAGAAATAGAAGTTGGAGTA >In-frame_NUBPL_ENST00000536705_chr14_32068585_+_PSMA6_ENST00000555764_chr14_35782087_+_426nt ATGTCCAAGGCCATTGGTTTGCTAGATGTGGATGTGTATGGACCTTCAGTTCCAAAGATGATGAATCTGAAAGGAAATCCGGAATTATCA CAGAGTATGATTTTAATTGGTATAGATGAAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTGCAGGTTACTACTGTGGGTTTAAAGCC ACTGCAGCGGGAGTTAAACAAACTGAGTCAACCAGCTTCCTTGAAAAAAAAGTGAAGAAGAAATTTGATTGGACATTTGAACAGACAGTG GAAACTGCAATTACATGCCTGTCTACTGTTCTATCAATTGATTTCAAACCTTCAGAAATAGAAGTTGGAGTAGTGACAGTTGAAAATCCT >In-frame_NUBPL_ENST00000536705_chr14_32068585_+_PSMA6_ENST00000556506_chr14_35782087_+_297nt ATGTCCAAGGCCATTGGTTTGCTAGATGTGGATGTGTATGGACCTTCAGTTCCAAAGATGATGAATCTGAAAGGAAATCCGGAATTATCA CAGAGTATGATTTTAATTGGTATAGATGAAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTGCAGGTTACTACTGTGGGTTTAAAGCC ACTGCAGCGGGAGTTAAACAAACTGAGTCAACCAGCTTCCTTGAAAAAAAAGTGAAGAAGAAATTTGATTGGACATTTGAACAGACAGTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NUBPL_ENST00000281081_chr14_32068585_+_PSMA6_ENST00000540871_chr14_35782087_+_920nt ACCCGCGACAGTTTCCCAGCAGGGCTCACAGCAGCGTTCCGCGTCATGGGGATTTGGCAGCGTCTGCTGCTTTTTGGTGGGGTGTCGCTC CGGGCTGGTGGCGGGGCCACTGCCCCGCTTGGGGGAAGCCGAGCGATGGTTTGTGGGCGCCAGTTGTCTGGCGCCGGGAGTGAGACCCTA AAACAAAGAAGAACACAAATCATGTCCCGAGGACTTCCAAAGCAGAAACCGATAGAAGGTGTTAAACAAGTTATAGTTGTGGCTTCTGGA AAGGGTGGAGTCGGAAAATCTACTACAGCAGTGAATCTTGCACTTGCACTAGCAGCGAACGATTCGTCCAAGGCCATTGGTTTGCTAGAT GTGGATGTGTATGGACCTTCAGTTCCAAAGATGATGAATCTGAAAGGAAATCCGGAATTATCACAGAGTATGATTTTAATTGGTATAGAT GAAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTGCAGGTTACTACTGTGGGTTTAAAGCCACTGCAGCGGGAGTTAAACAAACTGAG TCAACCAGCTTCCTTGAAAAAAAAGTGAAGAAGAAATTTGATTGGACATTTGAACAGACAGTGGAAACTGCAATTACATGCCTGTCTACT GTTCTATCAATTGATTTCAAACCTTCAGAAATAGAAGTTGGAGTAGTGACAGTTGAAAATCCTAAATTCAGGATTCTTACAGAAGCAGAG ATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTGATGCCACTTACCTGTGTGTTTGG TAACAACAAACCAACATCATGGAGGTCCCTGGATTGAAAAAGGAGCCTCTCCCACTCCTCCTACCACCGAAGTGGTTAGGACTCTATATA >In-frame_NUBPL_ENST00000281081_chr14_32068585_+_PSMA6_ENST00000261479_chr14_35782087_+_927nt ACCCGCGACAGTTTCCCAGCAGGGCTCACAGCAGCGTTCCGCGTCATGGGGATTTGGCAGCGTCTGCTGCTTTTTGGTGGGGTGTCGCTC CGGGCTGGTGGCGGGGCCACTGCCCCGCTTGGGGGAAGCCGAGCGATGGTTTGTGGGCGCCAGTTGTCTGGCGCCGGGAGTGAGACCCTA AAACAAAGAAGAACACAAATCATGTCCCGAGGACTTCCAAAGCAGAAACCGATAGAAGGTGTTAAACAAGTTATAGTTGTGGCTTCTGGA AAGGGTGGAGTCGGAAAATCTACTACAGCAGTGAATCTTGCACTTGCACTAGCAGCGAACGATTCGTCCAAGGCCATTGGTTTGCTAGAT GTGGATGTGTATGGACCTTCAGTTCCAAAGATGATGAATCTGAAAGGAAATCCGGAATTATCACAGAGTATGATTTTAATTGGTATAGAT GAAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTGCAGGTTACTACTGTGGGTTTAAAGCCACTGCAGCGGGAGTTAAACAAACTGAG TCAACCAGCTTCCTTGAAAAAAAAGTGAAGAAGAAATTTGATTGGACATTTGAACAGACAGTGGAAACTGCAATTACATGCCTGTCTACT GTTCTATCAATTGATTTCAAACCTTCAGAAATAGAAGTTGGAGTAGTGACAGTTGAAAATCCTAAATTCAGGATTCTTACAGAAGCAGAG ATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTGATGCCACTTACCTGTGTGTTTGG TAACAACAAACCAACATCATGGAGGTCCCTGGATTGAAAAAGGAGCCTCTCCCACTCCTCCTACCACCGAAGTGGTTAGGACTCTATATA >In-frame_NUBPL_ENST00000281081_chr14_32068585_+_PSMA6_ENST00000553809_chr14_35782087_+_799nt ACCCGCGACAGTTTCCCAGCAGGGCTCACAGCAGCGTTCCGCGTCATGGGGATTTGGCAGCGTCTGCTGCTTTTTGGTGGGGTGTCGCTC CGGGCTGGTGGCGGGGCCACTGCCCCGCTTGGGGGAAGCCGAGCGATGGTTTGTGGGCGCCAGTTGTCTGGCGCCGGGAGTGAGACCCTA AAACAAAGAAGAACACAAATCATGTCCCGAGGACTTCCAAAGCAGAAACCGATAGAAGGTGTTAAACAAGTTATAGTTGTGGCTTCTGGA AAGGGTGGAGTCGGAAAATCTACTACAGCAGTGAATCTTGCACTTGCACTAGCAGCGAACGATTCGTCCAAGGCCATTGGTTTGCTAGAT GTGGATGTGTATGGACCTTCAGTTCCAAAGATGATGAATCTGAAAGGAAATCCGGAATTATCACAGATATGATTTTAATTGGTATAGATG AAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTGCAGGTTACTACTGTGGGTTTAAAGCCACTGCAGCGGGAGTTAAACAAACTGAGT CAACCAGCTTCCTTGAAAAAAAAGTGAAGAAGAAATTTGATTGGACATTTGAACAGACAGTGGAAACTGCAATTACATGCCTGTCTACTG TTCTATCAATTGATTTCAAACCTTCAGAAATAGAAGTTGGAGTAGTGACAGTTGAAAATCCTAAATTCAGGATTCTTACAGAAGCAGAGA >In-frame_NUBPL_ENST00000281081_chr14_32068585_+_PSMA6_ENST00000555764_chr14_35782087_+_946nt ACCCGCGACAGTTTCCCAGCAGGGCTCACAGCAGCGTTCCGCGTCATGGGGATTTGGCAGCGTCTGCTGCTTTTTGGTGGGGTGTCGCTC CGGGCTGGTGGCGGGGCCACTGCCCCGCTTGGGGGAAGCCGAGCGATGGTTTGTGGGCGCCAGTTGTCTGGCGCCGGGAGTGAGACCCTA AAACAAAGAAGAACACAAATCATGTCCCGAGGACTTCCAAAGCAGAAACCGATAGAAGGTGTTAAACAAGTTATAGTTGTGGCTTCTGGA AAGGGTGGAGTCGGAAAATCTACTACAGCAGTGAATCTTGCACTTGCACTAGCAGCGAACGATTCGTCCAAGGCCATTGGTTTGCTAGAT GTGGATGTGTATGGACCTTCAGTTCCAAAGATGATGAATCTGAAAGGAAATCCGGAATTATCACAGAGTATGATTTTAATTGGTATAGAT GAAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTGCAGGTTACTACTGTGGGTTTAAAGCCACTGCAGCGGGAGTTAAACAAACTGAG TCAACCAGCTTCCTTGAAAAAAAAGTGAAGAAGAAATTTGATTGGACATTTGAACAGACAGTGGAAACTGCAATTACATGCCTGTCTACT GTTCTATCAATTGATTTCAAACCTTCAGAAATAGAAGTTGGAGTAGTGACAGTTGAAAATCCTAAATTCAGGATTCTTACAGAAGCAGAG ATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTGATGCCACTTACCTGTGTGTTTGG TAACAACAAACCAACATCATGGAGGTCCCTGGATTGAAAAAGGAGCCTCTCCCACTCCTCCTACCACCGAAGTGGTTAGGACTCTATATA >In-frame_NUBPL_ENST00000281081_chr14_32068585_+_PSMA6_ENST00000556506_chr14_35782087_+_777nt ACCCGCGACAGTTTCCCAGCAGGGCTCACAGCAGCGTTCCGCGTCATGGGGATTTGGCAGCGTCTGCTGCTTTTTGGTGGGGTGTCGCTC CGGGCTGGTGGCGGGGCCACTGCCCCGCTTGGGGGAAGCCGAGCGATGGTTTGTGGGCGCCAGTTGTCTGGCGCCGGGAGTGAGACCCTA AAACAAAGAAGAACACAAATCATGTCCCGAGGACTTCCAAAGCAGAAACCGATAGAAGGTGTTAAACAAGTTATAGTTGTGGCTTCTGGA AAGGGTGGAGTCGGAAAATCTACTACAGCAGTGAATCTTGCACTTGCACTAGCAGCGAACGATTCGTCCAAGGCCATTGGTTTGCTAGAT GTGGATGTGTATGGACCTTCAGTTCCAAAGATGATGAATCTGAAAGGAAATCCGGAATTATCACAGAGTATGATTTTAATTGGTATAGAT GAAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTGCAGGTTACTACTGTGGGTTTAAAGCCACTGCAGCGGGAGTTAAACAAACTGAG TCAACCAGCTTCCTTGAAAAAAAAGTGAAGAAGAAATTTGATTGGACATTTGAACAGACAGTGGAAGATTCTTACAGAAGCAGAGATTGA TGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTGATGCCACTTACCTGTGTGTTTGGTAACA >In-frame_NUBPL_ENST00000536705_chr14_32068585_+_PSMA6_ENST00000540871_chr14_35782087_+_587nt ATGTCCAAGGCCATTGGTTTGCTAGATGTGGATGTGTATGGACCTTCAGTTCCAAAGATGATGAATCTGAAAGGAAATCCGGAATTATCA CAGAGTATGATTTTAATTGGTATAGATGAAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTGCAGGTTACTACTGTGGGTTTAAAGCC ACTGCAGCGGGAGTTAAACAAACTGAGTCAACCAGCTTCCTTGAAAAAAAAGTGAAGAAGAAATTTGATTGGACATTTGAACAGACAGTG GAAACTGCAATTACATGCCTGTCTACTGTTCTATCAATTGATTTCAAACCTTCAGAAATAGAAGTTGGAGTAGTGACAGTTGAAAATCCT AAATTCAGGATTCTTACAGAAGCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATC CGTGATGCCACTTACCTGTGTGTTTGGTAACAACAAACCAACATCATGGAGGTCCCTGGATTGAAAAAGGAGCCTCTCCCACTCCTCCTA >In-frame_NUBPL_ENST00000536705_chr14_32068585_+_PSMA6_ENST00000261479_chr14_35782087_+_594nt ATGTCCAAGGCCATTGGTTTGCTAGATGTGGATGTGTATGGACCTTCAGTTCCAAAGATGATGAATCTGAAAGGAAATCCGGAATTATCA CAGAGTATGATTTTAATTGGTATAGATGAAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTGCAGGTTACTACTGTGGGTTTAAAGCC ACTGCAGCGGGAGTTAAACAAACTGAGTCAACCAGCTTCCTTGAAAAAAAAGTGAAGAAGAAATTTGATTGGACATTTGAACAGACAGTG GAAACTGCAATTACATGCCTGTCTACTGTTCTATCAATTGATTTCAAACCTTCAGAAATAGAAGTTGGAGTAGTGACAGTTGAAAATCCT AAATTCAGGATTCTTACAGAAGCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATC CGTGATGCCACTTACCTGTGTGTTTGGTAACAACAAACCAACATCATGGAGGTCCCTGGATTGAAAAAGGAGCCTCTCCCACTCCTCCTA >In-frame_NUBPL_ENST00000536705_chr14_32068585_+_PSMA6_ENST00000553809_chr14_35782087_+_466nt ATGTCCAAGGCCATTGGTTTGCTAGATGTGGATGTGTATGGACCTTCAGTTCCAAAGATGATGAATCTGAAAGGAAATCCGGAATTATCA CAGATATGATTTTAATTGGTATAGATGAAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTGCAGGTTACTACTGTGGGTTTAAAGCCA CTGCAGCGGGAGTTAAACAAACTGAGTCAACCAGCTTCCTTGAAAAAAAAGTGAAGAAGAAATTTGATTGGACATTTGAACAGACAGTGG AAACTGCAATTACATGCCTGTCTACTGTTCTATCAATTGATTTCAAACCTTCAGAAATAGAAGTTGGAGTAGTGACAGTTGAAAATCCTA AATTCAGGATTCTTACAGAAGCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCC >In-frame_NUBPL_ENST00000536705_chr14_32068585_+_PSMA6_ENST00000555764_chr14_35782087_+_613nt ATGTCCAAGGCCATTGGTTTGCTAGATGTGGATGTGTATGGACCTTCAGTTCCAAAGATGATGAATCTGAAAGGAAATCCGGAATTATCA CAGAGTATGATTTTAATTGGTATAGATGAAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTGCAGGTTACTACTGTGGGTTTAAAGCC ACTGCAGCGGGAGTTAAACAAACTGAGTCAACCAGCTTCCTTGAAAAAAAAGTGAAGAAGAAATTTGATTGGACATTTGAACAGACAGTG GAAACTGCAATTACATGCCTGTCTACTGTTCTATCAATTGATTTCAAACCTTCAGAAATAGAAGTTGGAGTAGTGACAGTTGAAAATCCT AAATTCAGGATTCTTACAGAAGCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATC CGTGATGCCACTTACCTGTGTGTTTGGTAACAACAAACCAACATCATGGAGGTCCCTGGATTGAAAAAGGAGCCTCTCCCACTCCTCCTA >In-frame_NUBPL_ENST00000536705_chr14_32068585_+_PSMA6_ENST00000556506_chr14_35782087_+_444nt ATGTCCAAGGCCATTGGTTTGCTAGATGTGGATGTGTATGGACCTTCAGTTCCAAAGATGATGAATCTGAAAGGAAATCCGGAATTATCA CAGAGTATGATTTTAATTGGTATAGATGAAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTGCAGGTTACTACTGTGGGTTTAAAGCC ACTGCAGCGGGAGTTAAACAAACTGAGTCAACCAGCTTCCTTGAAAAAAAAGTGAAGAAGAAATTTGATTGGACATTTGAACAGACAGTG GAAGATTCTTACAGAAGCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTGA |
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FusionGenePPI for NUBPL_PSMA6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NUBPL | MTUS2, RNF2, DNAJB11, UFD1L | PSMA6 | PSMD13, PSMA3, PLK1, UBQLN2, USP14, USP53, SLX1B, CUL1, RBX1, PSMA4, PSMA2, RNF185, UBC, XBP1, UBD, PSMD4, PSMD14, ADRM1, PSMD1, TXNL1, RAD23A, SHFM1, PSME1, PSMA7, PSMA1, PPP3CA, CCND1, CCNE1, CCNA2, CCNB1, CDK4, CDK1, CDK2, CCNF, GPS1, COPS5, PSMD6, PSMC1, FKBP8, NEDD8, DNAJB2, KIAA0368, COPS2, UCHL5, POMP, PSMB6, PSMB5, PSMB8, USP4, PSMA5, PSMB1, PSMB2, PSMB3, PSMB4, PSMB7, PSMC6, PSMC3, PSMC4, PSMC2, PSMD2, PSMD3, PSMD8, PSMC5, PSMD12, PSMD11, PSMD7, PSMD5, PSME2, PSME3, PSMA8, SF3A1, CCT5, SNRPA1, TPM4, CCT4, CCT3, EEF1A1, CCT8, TARDBP, BRCA1, ECT2, LIG4, PAXIP1, FN1, VCAM1, IQCB1, NOS2, ITGA4, PARK2, BAG3, CAST, HNRNPA2B1, PYCRL, RPP30, RPP38, PSMG1, PSMG3, PSMG2, AURKA, HUWE1, CADM1, ZBTB44, TRIM39, C19orf57, LIMD2, RNF170, KRTAP4-2, RTP5, RNF2, AMFR, SYVN1, BUB1B, VCP, UBQLN1, UBXN4, PSMB9, HSPB1, AMBRA1, ACTN4, CAND2, CAPZA1, ELP6, EXOSC4, EXOSC6, EXOSC9, ISY1-RAB43, ISY1, NELFE, PGK1, POLR2A, DNAJA2, EXOSC5, TPM3, WDR11, NTRK1, FBXO7, MID1, CEP85, PSMA6, DERL1, CYLD, SOD1, MAP1LC3B, SQSTM1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NUBPL_PSMA6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NUBPL_PSMA6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NUBPL | C0751651 | Mitochondrial Diseases | 1 | CTD_human |
| Hgene | NUBPL | C1838979 | MITOCHONDRIAL COMPLEX I DEFICIENCY | 1 | CTD_human;UNIPROT |
| Tgene | PSMA6 | C0019693 | HIV Infections | 1 | CTD_human |
| Tgene | PSMA6 | C0027051 | Myocardial Infarction | 1 | CTD_human |
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