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Fusion gene ID: 24998 |
FusionGeneSummary for NTM_OTUD7B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NTM_OTUD7B | Fusion gene ID: 24998 | Hgene | Tgene | Gene symbol | NTM | OTUD7B | Gene ID | 50863 | 56957 |
| Gene name | neurotrimin | OTU deubiquitinase 7B | |
| Synonyms | CEPU-1|HNT|IGLON2|NTRI | CEZANNE|ZA20D1 | |
| Cytomap | 11q25 | 1q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | neurotriminIgLON family member 2 | OTU domain-containing protein 7BOTU domain containing 7Bcellular zinc finger anti-NF-kappa-B proteincellular zinc finger anti-NF-kappaB Cezannezinc finger A20 domain-containing protein 1zinc finger protein Cezannezinc finger, A20 domain containing 1 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9P121 | Q6GQQ9 | |
| Ensembl transtripts involved in fusion gene | ENST00000374791, ENST00000539799, ENST00000427481, ENST00000374786, ENST00000425719, ENST00000374784, ENST00000474900, | ENST00000369135, ENST00000479905, | |
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 4 X 4 X 2=32 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: NTM [Title/Abstract] AND OTUD7B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | OTUD7B | GO:0000122 | negative regulation of transcription by RNA polymerase II | 21097510 |
| Tgene | OTUD7B | GO:0032717 | negative regulation of interleukin-8 production | 21097510 |
| Tgene | OTUD7B | GO:0035871 | protein K11-linked deubiquitination | 20622874|23827681 |
| Tgene | OTUD7B | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling | 11463333 |
| Tgene | OTUD7B | GO:0070536 | protein K63-linked deubiquitination | 20622874 |
| Tgene | OTUD7B | GO:0071108 | protein K48-linked deubiquitination | 21097510 |
| Tgene | OTUD7B | GO:1900181 | negative regulation of protein localization to nucleus | 21097510 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | EB387238 | NTM | chr11 | 131721427 | + | OTUD7B | chr1 | 149914028 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000374791 | ENST00000369135 | NTM | chr11 | 131721427 | + | OTUD7B | chr1 | 149914028 | - |
| intron-intron | ENST00000374791 | ENST00000479905 | NTM | chr11 | 131721427 | + | OTUD7B | chr1 | 149914028 | - |
| intron-3UTR | ENST00000539799 | ENST00000369135 | NTM | chr11 | 131721427 | + | OTUD7B | chr1 | 149914028 | - |
| intron-intron | ENST00000539799 | ENST00000479905 | NTM | chr11 | 131721427 | + | OTUD7B | chr1 | 149914028 | - |
| intron-3UTR | ENST00000427481 | ENST00000369135 | NTM | chr11 | 131721427 | + | OTUD7B | chr1 | 149914028 | - |
| intron-intron | ENST00000427481 | ENST00000479905 | NTM | chr11 | 131721427 | + | OTUD7B | chr1 | 149914028 | - |
| intron-3UTR | ENST00000374786 | ENST00000369135 | NTM | chr11 | 131721427 | + | OTUD7B | chr1 | 149914028 | - |
| intron-intron | ENST00000374786 | ENST00000479905 | NTM | chr11 | 131721427 | + | OTUD7B | chr1 | 149914028 | - |
| intron-3UTR | ENST00000425719 | ENST00000369135 | NTM | chr11 | 131721427 | + | OTUD7B | chr1 | 149914028 | - |
| intron-intron | ENST00000425719 | ENST00000479905 | NTM | chr11 | 131721427 | + | OTUD7B | chr1 | 149914028 | - |
| intron-3UTR | ENST00000374784 | ENST00000369135 | NTM | chr11 | 131721427 | + | OTUD7B | chr1 | 149914028 | - |
| intron-intron | ENST00000374784 | ENST00000479905 | NTM | chr11 | 131721427 | + | OTUD7B | chr1 | 149914028 | - |
| intron-3UTR | ENST00000474900 | ENST00000369135 | NTM | chr11 | 131721427 | + | OTUD7B | chr1 | 149914028 | - |
| intron-intron | ENST00000474900 | ENST00000479905 | NTM | chr11 | 131721427 | + | OTUD7B | chr1 | 149914028 | - |
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FusionProtFeatures for NTM_OTUD7B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NTM | OTUD7B |
| Neural cell adhesion molecule. | Negative regulator of the non-canonical NF-kappa-Bpathway that acts by mediating deubiquitination of TRAF3, aninhibitor of the NF-kappa-B pathway, thereby acting as a negativeregulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitinchains of TRAF3, preventing TRAF3 proteolysis and over-activationof non-canonical NF-kappa-B. Negatively regulates mucosal immunityagainst infections (By similarity). Deubiquitinates ZAP70, andthereby regulates T cell receptor (TCR) signaling that leads tothe activation of NF-kappa-B (PubMed:26903241). Plays a role in Tcell homeostasis and is required for normal T cell responses,including production of IFNG and IL2 (By similarity). Mediatesdeubiquitination of EGFR (PubMed:22179831). Has deubiquitinatingactivity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linkedpolyubiquitin chains (PubMed:27732584). Has a much highercatalytic rate with 'Lys-11'-linked polyubiquitin chains (invitro); however the physiological significance of these data areunsure (PubMed:27732584). Hydrolyzes both linear and branchedforms of polyubiquitin. {ECO:0000250|UniProtKB:B2RUR8,ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062,ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874,ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681,ECO:0000269|PubMed:27732584}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NTM_OTUD7B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NTM_OTUD7B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NTM_OTUD7B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NTM_OTUD7B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NTM | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Hgene | NTM | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
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