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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24998

FusionGeneSummary for NTM_OTUD7B

check button Fusion gene summary
Fusion gene informationFusion gene name: NTM_OTUD7B
Fusion gene ID: 24998
HgeneTgene
Gene symbol

NTM

OTUD7B

Gene ID

50863

56957

Gene nameneurotriminOTU deubiquitinase 7B
SynonymsCEPU-1|HNT|IGLON2|NTRICEZANNE|ZA20D1
Cytomap

11q25

1q21.2

Type of geneprotein-codingprotein-coding
DescriptionneurotriminIgLON family member 2OTU domain-containing protein 7BOTU domain containing 7Bcellular zinc finger anti-NF-kappa-B proteincellular zinc finger anti-NF-kappaB Cezannezinc finger A20 domain-containing protein 1zinc finger protein Cezannezinc finger, A20 domain containing 1
Modification date2018052220180523
UniProtAcc

Q9P121

Q6GQQ9

Ensembl transtripts involved in fusion geneENST00000374791, ENST00000539799, 
ENST00000427481, ENST00000374786, 
ENST00000425719, ENST00000374784, 
ENST00000474900, 
ENST00000369135, 
ENST00000479905, 
Fusion gene scores* DoF score5 X 4 X 4=804 X 4 X 2=32
# samples 54
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NTM [Title/Abstract] AND OTUD7B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneOTUD7B

GO:0000122

negative regulation of transcription by RNA polymerase II

21097510

TgeneOTUD7B

GO:0032717

negative regulation of interleukin-8 production

21097510

TgeneOTUD7B

GO:0035871

protein K11-linked deubiquitination

20622874|23827681

TgeneOTUD7B

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

11463333

TgeneOTUD7B

GO:0070536

protein K63-linked deubiquitination

20622874

TgeneOTUD7B

GO:0071108

protein K48-linked deubiquitination

21097510

TgeneOTUD7B

GO:1900181

negative regulation of protein localization to nucleus

21097510


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1EB387238NTMchr11

131721427

+OTUD7Bchr1

149914028

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000374791ENST00000369135NTMchr11

131721427

+OTUD7Bchr1

149914028

-
intron-intronENST00000374791ENST00000479905NTMchr11

131721427

+OTUD7Bchr1

149914028

-
intron-3UTRENST00000539799ENST00000369135NTMchr11

131721427

+OTUD7Bchr1

149914028

-
intron-intronENST00000539799ENST00000479905NTMchr11

131721427

+OTUD7Bchr1

149914028

-
intron-3UTRENST00000427481ENST00000369135NTMchr11

131721427

+OTUD7Bchr1

149914028

-
intron-intronENST00000427481ENST00000479905NTMchr11

131721427

+OTUD7Bchr1

149914028

-
intron-3UTRENST00000374786ENST00000369135NTMchr11

131721427

+OTUD7Bchr1

149914028

-
intron-intronENST00000374786ENST00000479905NTMchr11

131721427

+OTUD7Bchr1

149914028

-
intron-3UTRENST00000425719ENST00000369135NTMchr11

131721427

+OTUD7Bchr1

149914028

-
intron-intronENST00000425719ENST00000479905NTMchr11

131721427

+OTUD7Bchr1

149914028

-
intron-3UTRENST00000374784ENST00000369135NTMchr11

131721427

+OTUD7Bchr1

149914028

-
intron-intronENST00000374784ENST00000479905NTMchr11

131721427

+OTUD7Bchr1

149914028

-
intron-3UTRENST00000474900ENST00000369135NTMchr11

131721427

+OTUD7Bchr1

149914028

-
intron-intronENST00000474900ENST00000479905NTMchr11

131721427

+OTUD7Bchr1

149914028

-

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FusionProtFeatures for NTM_OTUD7B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NTM

Q9P121

OTUD7B

Q6GQQ9

Neural cell adhesion molecule. Negative regulator of the non-canonical NF-kappa-Bpathway that acts by mediating deubiquitination of TRAF3, aninhibitor of the NF-kappa-B pathway, thereby acting as a negativeregulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitinchains of TRAF3, preventing TRAF3 proteolysis and over-activationof non-canonical NF-kappa-B. Negatively regulates mucosal immunityagainst infections (By similarity). Deubiquitinates ZAP70, andthereby regulates T cell receptor (TCR) signaling that leads tothe activation of NF-kappa-B (PubMed:26903241). Plays a role in Tcell homeostasis and is required for normal T cell responses,including production of IFNG and IL2 (By similarity). Mediatesdeubiquitination of EGFR (PubMed:22179831). Has deubiquitinatingactivity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linkedpolyubiquitin chains (PubMed:27732584). Has a much highercatalytic rate with 'Lys-11'-linked polyubiquitin chains (invitro); however the physiological significance of these data areunsure (PubMed:27732584). Hydrolyzes both linear and branchedforms of polyubiquitin. {ECO:0000250|UniProtKB:B2RUR8,ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062,ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874,ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681,ECO:0000269|PubMed:27732584}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NTM_OTUD7B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NTM_OTUD7B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NTM_OTUD7B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NTM_OTUD7B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNTMC0041696Unipolar Depression1PSYGENET
HgeneNTMC1269683Major Depressive Disorder1PSYGENET