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Fusion gene ID: 24996 |
FusionGeneSummary for NTM_CCDC86 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NTM_CCDC86 | Fusion gene ID: 24996 | Hgene | Tgene | Gene symbol | NTM | CCDC86 | Gene ID | 50863 | 79080 |
| Gene name | neurotrimin | coiled-coil domain containing 86 | |
| Synonyms | CEPU-1|HNT|IGLON2|NTRI | - | |
| Cytomap | 11q25 | 11q12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | neurotriminIgLON family member 2 | coiled-coil domain-containing protein 86cycloncytokine-induced protein with coiled-coil domain | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q9P121 | Q9H6F5 | |
| Ensembl transtripts involved in fusion gene | ENST00000374791, ENST00000539799, ENST00000427481, ENST00000374786, ENST00000425719, ENST00000374784, ENST00000474900, | ENST00000227520, ENST00000545580, | |
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 3 X 3 X 3=27 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: NTM [Title/Abstract] AND CCDC86 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-HT-7686-01A | NTM | chr11 | 131781542 | + | CCDC86 | chr11 | 60615397 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000374791 | ENST00000227520 | NTM | chr11 | 131781542 | + | CCDC86 | chr11 | 60615397 | + |
| 5CDS-5UTR | ENST00000374791 | ENST00000545580 | NTM | chr11 | 131781542 | + | CCDC86 | chr11 | 60615397 | + |
| In-frame | ENST00000539799 | ENST00000227520 | NTM | chr11 | 131781542 | + | CCDC86 | chr11 | 60615397 | + |
| 5CDS-5UTR | ENST00000539799 | ENST00000545580 | NTM | chr11 | 131781542 | + | CCDC86 | chr11 | 60615397 | + |
| In-frame | ENST00000427481 | ENST00000227520 | NTM | chr11 | 131781542 | + | CCDC86 | chr11 | 60615397 | + |
| 5CDS-5UTR | ENST00000427481 | ENST00000545580 | NTM | chr11 | 131781542 | + | CCDC86 | chr11 | 60615397 | + |
| In-frame | ENST00000374786 | ENST00000227520 | NTM | chr11 | 131781542 | + | CCDC86 | chr11 | 60615397 | + |
| 5CDS-5UTR | ENST00000374786 | ENST00000545580 | NTM | chr11 | 131781542 | + | CCDC86 | chr11 | 60615397 | + |
| In-frame | ENST00000425719 | ENST00000227520 | NTM | chr11 | 131781542 | + | CCDC86 | chr11 | 60615397 | + |
| 5CDS-5UTR | ENST00000425719 | ENST00000545580 | NTM | chr11 | 131781542 | + | CCDC86 | chr11 | 60615397 | + |
| In-frame | ENST00000374784 | ENST00000227520 | NTM | chr11 | 131781542 | + | CCDC86 | chr11 | 60615397 | + |
| 5CDS-5UTR | ENST00000374784 | ENST00000545580 | NTM | chr11 | 131781542 | + | CCDC86 | chr11 | 60615397 | + |
| intron-3CDS | ENST00000474900 | ENST00000227520 | NTM | chr11 | 131781542 | + | CCDC86 | chr11 | 60615397 | + |
| intron-5UTR | ENST00000474900 | ENST00000545580 | NTM | chr11 | 131781542 | + | CCDC86 | chr11 | 60615397 | + |
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FusionProtFeatures for NTM_CCDC86 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NTM | CCDC86 |
| Neural cell adhesion molecule. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >CCDC86 | chr11:131781542 | chr11:60615397 | ENST00000227520 | + | 0 | 4 | 272_323 | 252 | 361 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NTM | chr11:131781542 | chr11:60615397 | ENST00000374784 | + | 1 | 6 | 136_218 | 55 | 317 | Domain | Note=Ig-like C2-type 2 |
| Hgene | >NTM | chr11:131781542 | chr11:60615397 | ENST00000374784 | + | 1 | 6 | 222_309 | 55 | 317 | Domain | Note=Ig-like C2-type 3 |
| Hgene | >NTM | chr11:131781542 | chr11:60615397 | ENST00000374784 | + | 1 | 6 | 39_126 | 55 | 317 | Domain | Note=Ig-like C2-type 1 |
| Hgene | >NTM | chr11:131781542 | chr11:60615397 | ENST00000374786 | + | 1 | 7 | 136_218 | 55 | 345 | Domain | Note=Ig-like C2-type 2 |
| Hgene | >NTM | chr11:131781542 | chr11:60615397 | ENST00000374786 | + | 1 | 7 | 222_309 | 55 | 345 | Domain | Note=Ig-like C2-type 3 |
| Hgene | >NTM | chr11:131781542 | chr11:60615397 | ENST00000374786 | + | 1 | 7 | 39_126 | 55 | 345 | Domain | Note=Ig-like C2-type 1 |
| Hgene | >NTM | chr11:131781542 | chr11:60615397 | ENST00000374791 | + | 2 | 8 | 136_218 | 55 | 345 | Domain | Note=Ig-like C2-type 2 |
| Hgene | >NTM | chr11:131781542 | chr11:60615397 | ENST00000374791 | + | 2 | 8 | 222_309 | 55 | 345 | Domain | Note=Ig-like C2-type 3 |
| Hgene | >NTM | chr11:131781542 | chr11:60615397 | ENST00000374791 | + | 2 | 8 | 39_126 | 55 | 345 | Domain | Note=Ig-like C2-type 1 |
| Hgene | >NTM | chr11:131781542 | chr11:60615397 | ENST00000425719 | + | 1 | 8 | 136_218 | 55 | 356 | Domain | Note=Ig-like C2-type 2 |
| Hgene | >NTM | chr11:131781542 | chr11:60615397 | ENST00000425719 | + | 1 | 8 | 222_309 | 55 | 356 | Domain | Note=Ig-like C2-type 3 |
| Hgene | >NTM | chr11:131781542 | chr11:60615397 | ENST00000425719 | + | 1 | 8 | 39_126 | 55 | 356 | Domain | Note=Ig-like C2-type 1 |
| Tgene | CCDC86 | chr11:131781542 | chr11:60615397 | ENST00000227520 | + | 0 | 4 | 45_200 | 252 | 361 | Compositional bias | Note=Pro-rich |
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FusionGeneSequence for NTM_CCDC86 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NTM_ENST00000374791_chr11_131781542_+_CCDC86_ENST00000227520_chr11_60615397_+_164aa MKTIQPKMHNSISWAIFTGLAALCLFQGVPVRSGDATFPKAMDNVTVRQGESATLRFSQMLQDKPLRTSWQRKMKERQERKLAKDFARHL >In-frame_NTM_ENST00000539799_chr11_131781542_+_CCDC86_ENST00000227520_chr11_60615397_+_164aa MKTIQPKMHNSISWAIFTGLAALCLFQGVPVRSGDATFPKAMDNVTVRQGESATLRFSQMLQDKPLRTSWQRKMKERQERKLAKDFARHL >In-frame_NTM_ENST00000427481_chr11_131781542_+_CCDC86_ENST00000227520_chr11_60615397_+_155aa MNGKRNGEGGKRWKWKGTGVPVRSGDATFPKAMDNVTVRQGESATLRFSQMLQDKPLRTSWQRKMKERQERKLAKDFARHLEEEKERRRQ >In-frame_NTM_ENST00000374786_chr11_131781542_+_CCDC86_ENST00000227520_chr11_60615397_+_164aa MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRFSQMLQDKPLRTSWQRKMKERQERKLAKDFARHL >In-frame_NTM_ENST00000425719_chr11_131781542_+_CCDC86_ENST00000227520_chr11_60615397_+_164aa MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRFSQMLQDKPLRTSWQRKMKERQERKLAKDFARHL >In-frame_NTM_ENST00000374784_chr11_131781542_+_CCDC86_ENST00000227520_chr11_60615397_+_164aa MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRFSQMLQDKPLRTSWQRKMKERQERKLAKDFARHL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NTM_ENST00000374791_chr11_131781542_+_CCDC86_ENST00000227520_chr11_60615397_+_492nt ATGAAAACCATCCAGCCAAAAATGCACAATTCTATCTCTTGGGCAATCTTCACGGGGCTGGCTGCTCTGTGTCTCTTCCAAGGAGTGCCC GTGCGCAGCGGAGATGCCACCTTCCCCAAAGCTATGGACAACGTGACGGTCCGGCAGGGGGAGAGCGCCACCCTCAGATTCTCCCAGATG CTTCAGGACAAGCCCCTGCGCACATCGTGGCAGCGGAAGATGAAGGAACGACAGGAGAGGAAGCTGGCCAAGGACTTTGCCCGTCACCTG GAGGAGGAGAAGGAGAGGCGCCGCCAGGAGAAGAAACAGCGCCGGGCTGAGAACCTGAAACGCCGCCTGGAGAATGAGCGGAAGGCAGAG GTCGTCCAAGTGATCCGAAACCCCGCCAAGCTCAAGCGGGCAAAGAAGAAGCAGCTGCGCTCCATTGAGAAGCGGGACACCCTGGCCCTG >In-frame_NTM_ENST00000539799_chr11_131781542_+_CCDC86_ENST00000227520_chr11_60615397_+_492nt ATGAAAACCATCCAGCCAAAAATGCACAATTCTATCTCTTGGGCAATCTTCACGGGGCTGGCTGCTCTGTGTCTCTTCCAAGGAGTGCCC GTGCGCAGCGGAGATGCCACCTTCCCCAAAGCTATGGACAACGTGACGGTCCGGCAGGGGGAGAGCGCCACCCTCAGATTCTCCCAGATG CTTCAGGACAAGCCCCTGCGCACATCGTGGCAGCGGAAGATGAAGGAACGACAGGAGAGGAAGCTGGCCAAGGACTTTGCCCGTCACCTG GAGGAGGAGAAGGAGAGGCGCCGCCAGGAGAAGAAACAGCGCCGGGCTGAGAACCTGAAACGCCGCCTGGAGAATGAGCGGAAGGCAGAG GTCGTCCAAGTGATCCGAAACCCCGCCAAGCTCAAGCGGGCAAAGAAGAAGCAGCTGCGCTCCATTGAGAAGCGGGACACCCTGGCCCTG >In-frame_NTM_ENST00000427481_chr11_131781542_+_CCDC86_ENST00000227520_chr11_60615397_+_465nt ATGAACGGAAAAAGAAACGGGGAAGGTGGGAAGAGGTGGAAATGGAAGGGCACAGGAGTGCCCGTGCGCAGCGGAGATGCCACCTTCCCC AAAGCTATGGACAACGTGACGGTCCGGCAGGGGGAGAGCGCCACCCTCAGATTCTCCCAGATGCTTCAGGACAAGCCCCTGCGCACATCG TGGCAGCGGAAGATGAAGGAACGACAGGAGAGGAAGCTGGCCAAGGACTTTGCCCGTCACCTGGAGGAGGAGAAGGAGAGGCGCCGCCAG GAGAAGAAACAGCGCCGGGCTGAGAACCTGAAACGCCGCCTGGAGAATGAGCGGAAGGCAGAGGTCGTCCAAGTGATCCGAAACCCCGCC AAGCTCAAGCGGGCAAAGAAGAAGCAGCTGCGCTCCATTGAGAAGCGGGACACCCTGGCCCTGCTGCAGAAGCAGCCGCCCCAGCAGCCG >In-frame_NTM_ENST00000374786_chr11_131781542_+_CCDC86_ENST00000227520_chr11_60615397_+_492nt ATGGGGGTCTGTGGGTACCTGTTCCTGCCCTGGAAGTGCCTCGTGGTCGTGTCTCTCAGGCTGCTGTTCCTTGTACCCACAGGAGTGCCC GTGCGCAGCGGAGATGCCACCTTCCCCAAAGCTATGGACAACGTGACGGTCCGGCAGGGGGAGAGCGCCACCCTCAGATTCTCCCAGATG CTTCAGGACAAGCCCCTGCGCACATCGTGGCAGCGGAAGATGAAGGAACGACAGGAGAGGAAGCTGGCCAAGGACTTTGCCCGTCACCTG GAGGAGGAGAAGGAGAGGCGCCGCCAGGAGAAGAAACAGCGCCGGGCTGAGAACCTGAAACGCCGCCTGGAGAATGAGCGGAAGGCAGAG GTCGTCCAAGTGATCCGAAACCCCGCCAAGCTCAAGCGGGCAAAGAAGAAGCAGCTGCGCTCCATTGAGAAGCGGGACACCCTGGCCCTG >In-frame_NTM_ENST00000425719_chr11_131781542_+_CCDC86_ENST00000227520_chr11_60615397_+_492nt ATGGGGGTCTGTGGGTACCTGTTCCTGCCCTGGAAGTGCCTCGTGGTCGTGTCTCTCAGGCTGCTGTTCCTTGTACCCACAGGAGTGCCC GTGCGCAGCGGAGATGCCACCTTCCCCAAAGCTATGGACAACGTGACGGTCCGGCAGGGGGAGAGCGCCACCCTCAGATTCTCCCAGATG CTTCAGGACAAGCCCCTGCGCACATCGTGGCAGCGGAAGATGAAGGAACGACAGGAGAGGAAGCTGGCCAAGGACTTTGCCCGTCACCTG GAGGAGGAGAAGGAGAGGCGCCGCCAGGAGAAGAAACAGCGCCGGGCTGAGAACCTGAAACGCCGCCTGGAGAATGAGCGGAAGGCAGAG GTCGTCCAAGTGATCCGAAACCCCGCCAAGCTCAAGCGGGCAAAGAAGAAGCAGCTGCGCTCCATTGAGAAGCGGGACACCCTGGCCCTG >In-frame_NTM_ENST00000374784_chr11_131781542_+_CCDC86_ENST00000227520_chr11_60615397_+_492nt ATGGGGGTCTGTGGGTACCTGTTCCTGCCCTGGAAGTGCCTCGTGGTCGTGTCTCTCAGGCTGCTGTTCCTTGTACCCACAGGAGTGCCC GTGCGCAGCGGAGATGCCACCTTCCCCAAAGCTATGGACAACGTGACGGTCCGGCAGGGGGAGAGCGCCACCCTCAGATTCTCCCAGATG CTTCAGGACAAGCCCCTGCGCACATCGTGGCAGCGGAAGATGAAGGAACGACAGGAGAGGAAGCTGGCCAAGGACTTTGCCCGTCACCTG GAGGAGGAGAAGGAGAGGCGCCGCCAGGAGAAGAAACAGCGCCGGGCTGAGAACCTGAAACGCCGCCTGGAGAATGAGCGGAAGGCAGAG GTCGTCCAAGTGATCCGAAACCCCGCCAAGCTCAAGCGGGCAAAGAAGAAGCAGCTGCGCTCCATTGAGAAGCGGGACACCCTGGCCCTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NTM_ENST00000374791_chr11_131781542_+_CCDC86_ENST00000227520_chr11_60615397_+_1577nt AGAGTGTGTGTGCGTGTGTGTGTGTGTGTGTGCCCGCGCGCGTGTGTTGTAGCTCTGTCAATCCTTGGATTAGAACCAATGATTGCAGCT TGTAGGAGGGCTGTCCAGGGCCAGATTGTACAATGTGTCTCAGTGCCAGAGTATGAGTGGAGATAATTACGGAGAAGTCATACTCTCTCA CACCCTCGGCTTTCTTGTTGTGTCCTTCAGCAAAACAGTGGATTTAAATCTCCTTGCACAAGCTTGAGAGCAACACAATCTATCAGGAAA GAAAGAAAGAAAAAAACCGAACCTGACAAAAAAGAAGAAAAAGAAGAAGAAAAAAAATCATGAAAACCATCCAGCCAAAAATGCACAATT CTATCTCTTGGGCAATCTTCACGGGGCTGGCTGCTCTGTGTCTCTTCCAAGGAGTGCCCGTGCGCAGCGGAGATGCCACCTTCCCCAAAG CTATGGACAACGTGACGGTCCGGCAGGGGGAGAGCGCCACCCTCAGATTCTCCCAGATGCTTCAGGACAAGCCCCTGCGCACATCGTGGC AGCGGAAGATGAAGGAACGACAGGAGAGGAAGCTGGCCAAGGACTTTGCCCGTCACCTGGAGGAGGAGAAGGAGAGGCGCCGCCAGGAGA AGAAACAGCGCCGGGCTGAGAACCTGAAACGCCGCCTGGAGAATGAGCGGAAGGCAGAGGTCGTCCAAGTGATCCGAAACCCCGCCAAGC TCAAGCGGGCAAAGAAGAAGCAGCTGCGCTCCATTGAGAAGCGGGACACCCTGGCCCTGCTGCAGAAGCAGCCGCCCCAGCAGCCGGCAG CCAAGATCTGAGCTCAGGACGGCCCGAGGCCTTCCATGGCCAACAACCATGTCAGACACAGCACCTCAGGCCGCTGCTCAGATGCCTCTG CTGGAGCTGGCACTCCAAACCCATGGCTCCAGAACAGGGACCCCCACCCCGACCGGGGCTCCTCGGCCTTTGAAGGCTTCCAGGCAGGTC TGTGTGGGACAGAAGCCCAGAGGGGGCCTGGGACCTGGCAGAGATGGGGGCGGGAAGAGATTCAGCTCCCATCCCTCCTTCCTCTCCTTC TCCAAGTGCCTTCAAACCAAGAACTGTACATTCTTCTGGTTCCTCAGTGAGCTGGTGACTGGCAGGTGACTCCCTCAGCAGTGTATGCCC TTTCTCAGCATCCTAGGTCCATCCCAGGCCTGGAGGCTGACAGTTGGGAATCCAGCTTCCCCCACACCTTCCCAAAGGCTGCTCTGAGCA CCTCCACACCCCACTGCCTCTGTCCCCAGCAGACTGAATCCGGTTCCTCTCCACTTTTCAATACTGAAAGATTAAAATGGGGAGGTTGCA GGGAGCAGAGCTTTTCCCTAGCACCCACTTTCCCAAACCAGTCTCTGCAGAAGCCCCAGAGAATCTAACTCATGCCTGTCCAGTCTACAG CAAAAATATTTATTGAGTGCCTGTTGCATACAGGCACAATCCTAGGCACCGGCAAATACAGACAATAGACCAAAGTCCCTGCCCTCGAGG >In-frame_NTM_ENST00000539799_chr11_131781542_+_CCDC86_ENST00000227520_chr11_60615397_+_1248nt ATGAAAACCATCCAGCCAAAAATGCACAATTCTATCTCTTGGGCAATCTTCACGGGGCTGGCTGCTCTGTGTCTCTTCCAAGGAGTGCCC GTGCGCAGCGGAGATGCCACCTTCCCCAAAGCTATGGACAACGTGACGGTCCGGCAGGGGGAGAGCGCCACCCTCAGATTCTCCCAGATG CTTCAGGACAAGCCCCTGCGCACATCGTGGCAGCGGAAGATGAAGGAACGACAGGAGAGGAAGCTGGCCAAGGACTTTGCCCGTCACCTG GAGGAGGAGAAGGAGAGGCGCCGCCAGGAGAAGAAACAGCGCCGGGCTGAGAACCTGAAACGCCGCCTGGAGAATGAGCGGAAGGCAGAG GTCGTCCAAGTGATCCGAAACCCCGCCAAGCTCAAGCGGGCAAAGAAGAAGCAGCTGCGCTCCATTGAGAAGCGGGACACCCTGGCCCTG CTGCAGAAGCAGCCGCCCCAGCAGCCGGCAGCCAAGATCTGAGCTCAGGACGGCCCGAGGCCTTCCATGGCCAACAACCATGTCAGACAC AGCACCTCAGGCCGCTGCTCAGATGCCTCTGCTGGAGCTGGCACTCCAAACCCATGGCTCCAGAACAGGGACCCCCACCCCGACCGGGGC TCCTCGGCCTTTGAAGGCTTCCAGGCAGGTCTGTGTGGGACAGAAGCCCAGAGGGGGCCTGGGACCTGGCAGAGATGGGGGCGGGAAGAG ATTCAGCTCCCATCCCTCCTTCCTCTCCTTCTCCAAGTGCCTTCAAACCAAGAACTGTACATTCTTCTGGTTCCTCAGTGAGCTGGTGAC TGGCAGGTGACTCCCTCAGCAGTGTATGCCCTTTCTCAGCATCCTAGGTCCATCCCAGGCCTGGAGGCTGACAGTTGGGAATCCAGCTTC CCCCACACCTTCCCAAAGGCTGCTCTGAGCACCTCCACACCCCACTGCCTCTGTCCCCAGCAGACTGAATCCGGTTCCTCTCCACTTTTC AATACTGAAAGATTAAAATGGGGAGGTTGCAGGGAGCAGAGCTTTTCCCTAGCACCCACTTTCCCAAACCAGTCTCTGCAGAAGCCCCAG AGAATCTAACTCATGCCTGTCCAGTCTACAGCAAAAATATTTATTGAGTGCCTGTTGCATACAGGCACAATCCTAGGCACCGGCAAATAC >In-frame_NTM_ENST00000427481_chr11_131781542_+_CCDC86_ENST00000227520_chr11_60615397_+_1221nt ATGAACGGAAAAAGAAACGGGGAAGGTGGGAAGAGGTGGAAATGGAAGGGCACAGGAGTGCCCGTGCGCAGCGGAGATGCCACCTTCCCC AAAGCTATGGACAACGTGACGGTCCGGCAGGGGGAGAGCGCCACCCTCAGATTCTCCCAGATGCTTCAGGACAAGCCCCTGCGCACATCG TGGCAGCGGAAGATGAAGGAACGACAGGAGAGGAAGCTGGCCAAGGACTTTGCCCGTCACCTGGAGGAGGAGAAGGAGAGGCGCCGCCAG GAGAAGAAACAGCGCCGGGCTGAGAACCTGAAACGCCGCCTGGAGAATGAGCGGAAGGCAGAGGTCGTCCAAGTGATCCGAAACCCCGCC AAGCTCAAGCGGGCAAAGAAGAAGCAGCTGCGCTCCATTGAGAAGCGGGACACCCTGGCCCTGCTGCAGAAGCAGCCGCCCCAGCAGCCG GCAGCCAAGATCTGAGCTCAGGACGGCCCGAGGCCTTCCATGGCCAACAACCATGTCAGACACAGCACCTCAGGCCGCTGCTCAGATGCC TCTGCTGGAGCTGGCACTCCAAACCCATGGCTCCAGAACAGGGACCCCCACCCCGACCGGGGCTCCTCGGCCTTTGAAGGCTTCCAGGCA GGTCTGTGTGGGACAGAAGCCCAGAGGGGGCCTGGGACCTGGCAGAGATGGGGGCGGGAAGAGATTCAGCTCCCATCCCTCCTTCCTCTC CTTCTCCAAGTGCCTTCAAACCAAGAACTGTACATTCTTCTGGTTCCTCAGTGAGCTGGTGACTGGCAGGTGACTCCCTCAGCAGTGTAT GCCCTTTCTCAGCATCCTAGGTCCATCCCAGGCCTGGAGGCTGACAGTTGGGAATCCAGCTTCCCCCACACCTTCCCAAAGGCTGCTCTG AGCACCTCCACACCCCACTGCCTCTGTCCCCAGCAGACTGAATCCGGTTCCTCTCCACTTTTCAATACTGAAAGATTAAAATGGGGAGGT TGCAGGGAGCAGAGCTTTTCCCTAGCACCCACTTTCCCAAACCAGTCTCTGCAGAAGCCCCAGAGAATCTAACTCATGCCTGTCCAGTCT ACAGCAAAAATATTTATTGAGTGCCTGTTGCATACAGGCACAATCCTAGGCACCGGCAAATACAGACAATAGACCAAAGTCCCTGCCCTC >In-frame_NTM_ENST00000374786_chr11_131781542_+_CCDC86_ENST00000227520_chr11_60615397_+_1727nt AACTTACAAAGTGTTGGATGTCCCCCGTTCGAACTGAGGGACTGCAGACCGCCTCTGGGTAGCTGGATGAAGCCCACCCCGTCCCCTTCT GGTACCAAAGTGCTTACTCCTCTCCAAAGTGCCGTGTCTGAACTGCCGCTGGGAAGAAGCGGCTCCTGAGACGCGCCCACACCTTTCACC TGCCGCGCGCTTCCCCCTCCTCGGCCACCTTCCCGGCGGAAGCAGCGAGGAGGGAGCCCCCTTTGGCCGTCCTCCGTGGAACCGGTTTTC CGAGGCTGGCAAAAGCCGAGGCTGGATTTGGGGGAGGAATATTAGACTCGGAGGAGTCTGCGCGCTTTTCTCCTCCCCGCGCCTCCCGGT CGCCGCGGGTTCACCGCTCAGTCCCCGCGCTCGCTCCGCACCCCACCCACTTCCTGTGCTCGCCCGGGGGGCGTGTGCCGTGCGGCTGCC GGAGTTCGGGGAAGTTGTGGCTGTCGAGAATGGGGGTCTGTGGGTACCTGTTCCTGCCCTGGAAGTGCCTCGTGGTCGTGTCTCTCAGGC TGCTGTTCCTTGTACCCACAGGAGTGCCCGTGCGCAGCGGAGATGCCACCTTCCCCAAAGCTATGGACAACGTGACGGTCCGGCAGGGGG AGAGCGCCACCCTCAGATTCTCCCAGATGCTTCAGGACAAGCCCCTGCGCACATCGTGGCAGCGGAAGATGAAGGAACGACAGGAGAGGA AGCTGGCCAAGGACTTTGCCCGTCACCTGGAGGAGGAGAAGGAGAGGCGCCGCCAGGAGAAGAAACAGCGCCGGGCTGAGAACCTGAAAC GCCGCCTGGAGAATGAGCGGAAGGCAGAGGTCGTCCAAGTGATCCGAAACCCCGCCAAGCTCAAGCGGGCAAAGAAGAAGCAGCTGCGCT CCATTGAGAAGCGGGACACCCTGGCCCTGCTGCAGAAGCAGCCGCCCCAGCAGCCGGCAGCCAAGATCTGAGCTCAGGACGGCCCGAGGC CTTCCATGGCCAACAACCATGTCAGACACAGCACCTCAGGCCGCTGCTCAGATGCCTCTGCTGGAGCTGGCACTCCAAACCCATGGCTCC AGAACAGGGACCCCCACCCCGACCGGGGCTCCTCGGCCTTTGAAGGCTTCCAGGCAGGTCTGTGTGGGACAGAAGCCCAGAGGGGGCCTG GGACCTGGCAGAGATGGGGGCGGGAAGAGATTCAGCTCCCATCCCTCCTTCCTCTCCTTCTCCAAGTGCCTTCAAACCAAGAACTGTACA TTCTTCTGGTTCCTCAGTGAGCTGGTGACTGGCAGGTGACTCCCTCAGCAGTGTATGCCCTTTCTCAGCATCCTAGGTCCATCCCAGGCC TGGAGGCTGACAGTTGGGAATCCAGCTTCCCCCACACCTTCCCAAAGGCTGCTCTGAGCACCTCCACACCCCACTGCCTCTGTCCCCAGC AGACTGAATCCGGTTCCTCTCCACTTTTCAATACTGAAAGATTAAAATGGGGAGGTTGCAGGGAGCAGAGCTTTTCCCTAGCACCCACTT TCCCAAACCAGTCTCTGCAGAAGCCCCAGAGAATCTAACTCATGCCTGTCCAGTCTACAGCAAAAATATTTATTGAGTGCCTGTTGCATA CAGGCACAATCCTAGGCACCGGCAAATACAGACAATAGACCAAAGTCCCTGCCCTCGAGGAGCTTTCATTCTGATGGAGAGAAAACATAA >In-frame_NTM_ENST00000425719_chr11_131781542_+_CCDC86_ENST00000227520_chr11_60615397_+_1268nt GGAAGTTGTGGCTGTCGAGAATGGGGGTCTGTGGGTACCTGTTCCTGCCCTGGAAGTGCCTCGTGGTCGTGTCTCTCAGGCTGCTGTTCC TTGTACCCACAGGAGTGCCCGTGCGCAGCGGAGATGCCACCTTCCCCAAAGCTATGGACAACGTGACGGTCCGGCAGGGGGAGAGCGCCA CCCTCAGATTCTCCCAGATGCTTCAGGACAAGCCCCTGCGCACATCGTGGCAGCGGAAGATGAAGGAACGACAGGAGAGGAAGCTGGCCA AGGACTTTGCCCGTCACCTGGAGGAGGAGAAGGAGAGGCGCCGCCAGGAGAAGAAACAGCGCCGGGCTGAGAACCTGAAACGCCGCCTGG AGAATGAGCGGAAGGCAGAGGTCGTCCAAGTGATCCGAAACCCCGCCAAGCTCAAGCGGGCAAAGAAGAAGCAGCTGCGCTCCATTGAGA AGCGGGACACCCTGGCCCTGCTGCAGAAGCAGCCGCCCCAGCAGCCGGCAGCCAAGATCTGAGCTCAGGACGGCCCGAGGCCTTCCATGG CCAACAACCATGTCAGACACAGCACCTCAGGCCGCTGCTCAGATGCCTCTGCTGGAGCTGGCACTCCAAACCCATGGCTCCAGAACAGGG ACCCCCACCCCGACCGGGGCTCCTCGGCCTTTGAAGGCTTCCAGGCAGGTCTGTGTGGGACAGAAGCCCAGAGGGGGCCTGGGACCTGGC AGAGATGGGGGCGGGAAGAGATTCAGCTCCCATCCCTCCTTCCTCTCCTTCTCCAAGTGCCTTCAAACCAAGAACTGTACATTCTTCTGG TTCCTCAGTGAGCTGGTGACTGGCAGGTGACTCCCTCAGCAGTGTATGCCCTTTCTCAGCATCCTAGGTCCATCCCAGGCCTGGAGGCTG ACAGTTGGGAATCCAGCTTCCCCCACACCTTCCCAAAGGCTGCTCTGAGCACCTCCACACCCCACTGCCTCTGTCCCCAGCAGACTGAAT CCGGTTCCTCTCCACTTTTCAATACTGAAAGATTAAAATGGGGAGGTTGCAGGGAGCAGAGCTTTTCCCTAGCACCCACTTTCCCAAACC AGTCTCTGCAGAAGCCCCAGAGAATCTAACTCATGCCTGTCCAGTCTACAGCAAAAATATTTATTGAGTGCCTGTTGCATACAGGCACAA TCCTAGGCACCGGCAAATACAGACAATAGACCAAAGTCCCTGCCCTCGAGGAGCTTTCATTCTGATGGAGAGAAAACATAATAAACAAGC >In-frame_NTM_ENST00000374784_chr11_131781542_+_CCDC86_ENST00000227520_chr11_60615397_+_1262nt TGTGGCTGTCGAGAATGGGGGTCTGTGGGTACCTGTTCCTGCCCTGGAAGTGCCTCGTGGTCGTGTCTCTCAGGCTGCTGTTCCTTGTAC CCACAGGAGTGCCCGTGCGCAGCGGAGATGCCACCTTCCCCAAAGCTATGGACAACGTGACGGTCCGGCAGGGGGAGAGCGCCACCCTCA GATTCTCCCAGATGCTTCAGGACAAGCCCCTGCGCACATCGTGGCAGCGGAAGATGAAGGAACGACAGGAGAGGAAGCTGGCCAAGGACT TTGCCCGTCACCTGGAGGAGGAGAAGGAGAGGCGCCGCCAGGAGAAGAAACAGCGCCGGGCTGAGAACCTGAAACGCCGCCTGGAGAATG AGCGGAAGGCAGAGGTCGTCCAAGTGATCCGAAACCCCGCCAAGCTCAAGCGGGCAAAGAAGAAGCAGCTGCGCTCCATTGAGAAGCGGG ACACCCTGGCCCTGCTGCAGAAGCAGCCGCCCCAGCAGCCGGCAGCCAAGATCTGAGCTCAGGACGGCCCGAGGCCTTCCATGGCCAACA ACCATGTCAGACACAGCACCTCAGGCCGCTGCTCAGATGCCTCTGCTGGAGCTGGCACTCCAAACCCATGGCTCCAGAACAGGGACCCCC ACCCCGACCGGGGCTCCTCGGCCTTTGAAGGCTTCCAGGCAGGTCTGTGTGGGACAGAAGCCCAGAGGGGGCCTGGGACCTGGCAGAGAT GGGGGCGGGAAGAGATTCAGCTCCCATCCCTCCTTCCTCTCCTTCTCCAAGTGCCTTCAAACCAAGAACTGTACATTCTTCTGGTTCCTC AGTGAGCTGGTGACTGGCAGGTGACTCCCTCAGCAGTGTATGCCCTTTCTCAGCATCCTAGGTCCATCCCAGGCCTGGAGGCTGACAGTT GGGAATCCAGCTTCCCCCACACCTTCCCAAAGGCTGCTCTGAGCACCTCCACACCCCACTGCCTCTGTCCCCAGCAGACTGAATCCGGTT CCTCTCCACTTTTCAATACTGAAAGATTAAAATGGGGAGGTTGCAGGGAGCAGAGCTTTTCCCTAGCACCCACTTTCCCAAACCAGTCTC TGCAGAAGCCCCAGAGAATCTAACTCATGCCTGTCCAGTCTACAGCAAAAATATTTATTGAGTGCCTGTTGCATACAGGCACAATCCTAG GCACCGGCAAATACAGACAATAGACCAAAGTCCCTGCCCTCGAGGAGCTTTCATTCTGATGGAGAGAAAACATAATAAACAAGCAAAATG |
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FusionGenePPI for NTM_CCDC86 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NTM | APP, LSAMP, NEGR1, NTM, CCKBR, KRTAP5-9, KRTAP3-2, C19orf47, HAX1, NUFIP1, DGUOK, OPCML, CALR, PDIA5, FBXO2 | CCDC86 | DLST, SIRT7, SRPK3, OBSL1, NSA2, RPL8, FBL, PRR11, NOP56, IFI16, HIST1H2BG, SRPK2, HIST1H3E, HNRNPU, NPM1, NLRP3, FOXQ1, NANOG, CDC14B, H2AFX, ZCRB1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NTM_CCDC86 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NTM_CCDC86 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NTM | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Hgene | NTM | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| Tgene | CCDC86 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | CCDC86 | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human |
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