![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 24994 |
FusionGeneSummary for NTMT1_ZNF208 |
![]() |
Fusion gene information | Fusion gene name: NTMT1_ZNF208 | Fusion gene ID: 24994 | Hgene | Tgene | Gene symbol | NTMT1 | ZNF208 | Gene ID | 28989 | 7757 |
Gene name | N-terminal Xaa-Pro-Lys N-methyltransferase 1 | zinc finger protein 208 | |
Synonyms | AD-003|C9orf32|HOMT1A|METTL11A|NRMT|NRMT1|NTM1A | PMIDP|ZNF95 | |
Cytomap | 9q34.11 | 19p12 | |
Type of gene | protein-coding | protein-coding | |
Description | N-terminal Xaa-Pro-Lys N-methyltransferase 1N-terminal RCC1 methyltransferaseX-Pro-Lys N-terminal protein methyltransferase 1Aalpha N-terminal protein methyltransferase 1Amethyltransferase-like protein 11A | zinc finger protein 208zinc finger protein 95 | |
Modification date | 20180523 | 20180411 | |
UniProtAcc | Q9BV86 | O43345 | |
Ensembl transtripts involved in fusion gene | ENST00000372486, ENST00000372483, ENST00000459968, ENST00000482347, ENST00000372481, ENST00000372480, ENST00000486391, | ENST00000599916, ENST00000601773, ENST00000397126, ENST00000597040, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: NTMT1 [Title/Abstract] AND ZNF208 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NTMT1 | GO:0016571 | histone methylation | 26543159 |
Hgene | NTMT1 | GO:0018013 | N-terminal peptidyl-glycine methylation | 26543159 |
Hgene | NTMT1 | GO:0018016 | N-terminal peptidyl-proline dimethylation | 20481588|20668449 |
Hgene | NTMT1 | GO:0035572 | N-terminal peptidyl-serine dimethylation | 20668449 |
Hgene | NTMT1 | GO:0035573 | N-terminal peptidyl-serine trimethylation | 20668449 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-K1-A42W-01A | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000372486 | ENST00000599916 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
intron-3CDS | ENST00000372486 | ENST00000601773 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
intron-3CDS | ENST00000372486 | ENST00000397126 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
intron-5UTR | ENST00000372486 | ENST00000597040 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
5UTR-3CDS | ENST00000372483 | ENST00000599916 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
5UTR-3CDS | ENST00000372483 | ENST00000601773 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
5UTR-3CDS | ENST00000372483 | ENST00000397126 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
5UTR-5UTR | ENST00000372483 | ENST00000597040 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
5UTR-3CDS | ENST00000459968 | ENST00000599916 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
5UTR-3CDS | ENST00000459968 | ENST00000601773 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
5UTR-3CDS | ENST00000459968 | ENST00000397126 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
5UTR-5UTR | ENST00000459968 | ENST00000597040 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
5UTR-3CDS | ENST00000482347 | ENST00000599916 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
5UTR-3CDS | ENST00000482347 | ENST00000601773 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
5UTR-3CDS | ENST00000482347 | ENST00000397126 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
5UTR-5UTR | ENST00000482347 | ENST00000597040 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
5UTR-3CDS | ENST00000372481 | ENST00000599916 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
5UTR-3CDS | ENST00000372481 | ENST00000601773 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
5UTR-3CDS | ENST00000372481 | ENST00000397126 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
5UTR-5UTR | ENST00000372481 | ENST00000597040 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
intron-3CDS | ENST00000372480 | ENST00000599916 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
intron-3CDS | ENST00000372480 | ENST00000601773 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
intron-3CDS | ENST00000372480 | ENST00000397126 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
intron-5UTR | ENST00000372480 | ENST00000597040 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
intron-3CDS | ENST00000486391 | ENST00000599916 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
intron-3CDS | ENST00000486391 | ENST00000601773 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
intron-3CDS | ENST00000486391 | ENST00000397126 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
intron-5UTR | ENST00000486391 | ENST00000597040 | NTMT1 | chr9 | 132388574 | + | ZNF208 | chr19 | 22171711 | - |
Top |
FusionProtFeatures for NTMT1_ZNF208 |
![]() |
Hgene | Tgene |
NTMT1 | ZNF208 |
Distributive alpha-N-methyltransferase that methylatesthe N-terminus of target proteins containing the N-terminal motif[Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved.Specifically catalyzes mono-, di- or tri-methylation of theexposed alpha-amino group of the Ala, Gly or Ser residue in the[Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro inthe Pro-Pro-Lys motif. Some of the substrates may be primed byMETTL11B-mediated monomethylation (PubMed:24090352). Catalyzes thetrimethylation of the N-terminal Gly in CENPA (after removal ofMet-1). Responsible for the N-terminal methylation of KLHL31,MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis fornormal bipolar spindle formation and chromosome segregation viaits action on RCC1. {ECO:0000269|PubMed:20481588,ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:24090352,ECO:0000269|PubMed:26543159}. | May be involved in transcriptional regulation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for NTMT1_ZNF208 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for NTMT1_ZNF208 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NTMT1 | IKBKG, RCC1, APP, PLCG1, METTL13, CRYZL1, DENND5B, MAPK1, MAPK3, HNRNPD, DIS3, DDB2, DRG1, TIRAP, DPYSL2, NDRG1, RSU1, TSTA3, ZNF131, VAMP4, DENR, CCL5, G3BP1 | ZNF208 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for NTMT1_ZNF208 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for NTMT1_ZNF208 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |