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Fusion gene ID: 24957 |
FusionGeneSummary for NSRP1_JAK1 |
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Fusion gene information | Fusion gene name: NSRP1_JAK1 | Fusion gene ID: 24957 | Hgene | Tgene | Gene symbol | NSRP1 | JAK1 | Gene ID | 84081 | 3716 |
Gene name | nuclear speckle splicing regulatory protein 1 | Janus kinase 1 | |
Synonyms | CCDC55|HSPC095|NSrp70 | JAK1A|JAK1B|JTK3 | |
Cytomap | 17q11.2 | 1p31.3 | |
Type of gene | protein-coding | protein-coding | |
Description | nuclear speckle splicing regulatory protein 1coiled-coil domain containing 55coiled-coil domain-containing protein 55nuclear speckle-related protein 70 | tyrosine-protein kinase JAK1 | |
Modification date | 20180522 | 20180527 | |
UniProtAcc | Q9H0G5 | P23458 | |
Ensembl transtripts involved in fusion gene | ENST00000540900, ENST00000584423, ENST00000247026, ENST00000479218, | ENST00000342505, ENST00000465376, | |
Fusion gene scores | * DoF score | 7 X 5 X 4=140 | 9 X 8 X 4=288 |
# samples | 8 | 10 | |
** MAII score | log2(8/140*10)=-0.807354922057604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NSRP1 [Title/Abstract] AND JAK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NSRP1 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | 21296756 |
Tgene | JAK1 | GO:0038110 | interleukin-2-mediated signaling pathway | 11909529 |
Tgene | JAK1 | GO:0046677 | response to antibiotic | 16280321 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE843948 | NSRP1 | chr17 | 28482426 | + | JAK1 | chr1 | 65299385 | + | ||
ChiTaRS3.1 | BE843909 | NSRP1 | chr17 | 28482426 | + | JAK1 | chr1 | 65299385 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000540900 | ENST00000342505 | NSRP1 | chr17 | 28482426 | + | JAK1 | chr1 | 65299385 | + |
intron-intron | ENST00000540900 | ENST00000465376 | NSRP1 | chr17 | 28482426 | + | JAK1 | chr1 | 65299385 | + |
intron-3UTR | ENST00000584423 | ENST00000342505 | NSRP1 | chr17 | 28482426 | + | JAK1 | chr1 | 65299385 | + |
intron-intron | ENST00000584423 | ENST00000465376 | NSRP1 | chr17 | 28482426 | + | JAK1 | chr1 | 65299385 | + |
intron-3UTR | ENST00000247026 | ENST00000342505 | NSRP1 | chr17 | 28482426 | + | JAK1 | chr1 | 65299385 | + |
intron-intron | ENST00000247026 | ENST00000465376 | NSRP1 | chr17 | 28482426 | + | JAK1 | chr1 | 65299385 | + |
intron-3UTR | ENST00000479218 | ENST00000342505 | NSRP1 | chr17 | 28482426 | + | JAK1 | chr1 | 65299385 | + |
intron-intron | ENST00000479218 | ENST00000465376 | NSRP1 | chr17 | 28482426 | + | JAK1 | chr1 | 65299385 | + |
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FusionProtFeatures for NSRP1_JAK1 |
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Hgene | Tgene |
NSRP1 | JAK1 |
RNA-binding protein that mediates pre-mRNA alternativesplicing regulation. {ECO:0000269|PubMed:21296756}. | Tyrosine kinase of the non-receptor type, involved inthe IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinasepartner for the interleukin (IL)-2 receptor (PubMed:11909529).{ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:7615558}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NSRP1_JAK1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NSRP1_JAK1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NSRP1_JAK1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | JAK1 | P23458 | DB08877 | Ruxolitinib | Tyrosine-protein kinase JAK1 | small molecule | approved |
Tgene | JAK1 | P23458 | DB08895 | Tofacitinib | Tyrosine-protein kinase JAK1 | small molecule | approved|investigational |
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RelatedDiseases for NSRP1_JAK1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |