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Fusion gene ID: 2487 |
FusionGeneSummary for ARHGDIA_ERBB3 |
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Fusion gene information | Fusion gene name: ARHGDIA_ERBB3 | Fusion gene ID: 2487 | Hgene | Tgene | Gene symbol | ARHGDIA | ERBB3 | Gene ID | 396 | 2065 |
Gene name | Rho GDP dissociation inhibitor alpha | erb-b2 receptor tyrosine kinase 3 | |
Synonyms | GDIA1|HEL-S-47e|NPHS8|RHOGDI|RHOGDI-1 | ErbB-3|HER3|LCCS2|MDA-BF-1|c-erbB-3|c-erbB3|erbB3-S|p180-ErbB3|p45-sErbB3|p85-sErbB3 | |
Cytomap | 17q25.3 | 12q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | rho GDP-dissociation inhibitor 1GDP-dissociation inhibitor, aplysia RAS-related 1Rho GDP dissociation inhibitor (GDI) alphaepididymis secretory sperm binding protein Li 47e | receptor tyrosine-protein kinase erbB-3human epidermal growth factor receptor 3proto-oncogene-like protein c-ErbB-3tyrosine kinase-type cell surface receptor HER3v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | P52565 | P21860 | |
Ensembl transtripts involved in fusion gene | ENST00000582520, ENST00000269321, ENST00000400721, ENST00000584461, ENST00000541078, ENST00000580685, ENST00000581876, | ENST00000267101, ENST00000450146, ENST00000415288, ENST00000553131, ENST00000411731, ENST00000549832, | |
Fusion gene scores | * DoF score | 5 X 2 X 5=50 | 25 X 8 X 14=2800 |
# samples | 6 | 25 | |
** MAII score | log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(25/2800*10)=-3.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ARHGDIA [Title/Abstract] AND ERBB3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ERBB3 | GO:0007162 | negative regulation of cell adhesion | 7556068 |
Tgene | ERBB3 | GO:0007165 | signal transduction | 10572067 |
Tgene | ERBB3 | GO:0009968 | negative regulation of signal transduction | 11389077 |
Tgene | ERBB3 | GO:0014065 | phosphatidylinositol 3-kinase signaling | 7556068 |
Tgene | ERBB3 | GO:0042127 | regulation of cell proliferation | 11389077 |
Tgene | ERBB3 | GO:0051048 | negative regulation of secretion | 10559227 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | HNSC | TCGA-BA-5555-01A | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000582520 | ENST00000267101 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
5CDS-intron | ENST00000582520 | ENST00000450146 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
5CDS-intron | ENST00000582520 | ENST00000415288 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
5CDS-intron | ENST00000582520 | ENST00000553131 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
5CDS-intron | ENST00000582520 | ENST00000411731 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
5CDS-intron | ENST00000582520 | ENST00000549832 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
5CDS-intron | ENST00000269321 | ENST00000267101 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
5CDS-intron | ENST00000269321 | ENST00000450146 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
5CDS-intron | ENST00000269321 | ENST00000415288 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
5CDS-intron | ENST00000269321 | ENST00000553131 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
5CDS-intron | ENST00000269321 | ENST00000411731 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
5CDS-intron | ENST00000269321 | ENST00000549832 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000400721 | ENST00000267101 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000400721 | ENST00000450146 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000400721 | ENST00000415288 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000400721 | ENST00000553131 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000400721 | ENST00000411731 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000400721 | ENST00000549832 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000584461 | ENST00000267101 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000584461 | ENST00000450146 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000584461 | ENST00000415288 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000584461 | ENST00000553131 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000584461 | ENST00000411731 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000584461 | ENST00000549832 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000541078 | ENST00000267101 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000541078 | ENST00000450146 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000541078 | ENST00000415288 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000541078 | ENST00000553131 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000541078 | ENST00000411731 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000541078 | ENST00000549832 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000580685 | ENST00000267101 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000580685 | ENST00000450146 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000580685 | ENST00000415288 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000580685 | ENST00000553131 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000580685 | ENST00000411731 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000580685 | ENST00000549832 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000581876 | ENST00000267101 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000581876 | ENST00000450146 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000581876 | ENST00000415288 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000581876 | ENST00000553131 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000581876 | ENST00000411731 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
intron-intron | ENST00000581876 | ENST00000549832 | ARHGDIA | chr17 | 79825598 | - | ERBB3 | chr12 | 56492035 | + |
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FusionProtFeatures for ARHGDIA_ERBB3 |
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Hgene | Tgene |
ARHGDIA | ERBB3 |
Controls Rho proteins homeostasis. Regulates the GDP/GTPexchange reaction of the Rho proteins by inhibiting thedissociation of GDP from them, and the subsequent binding of GTPto them. Retains Rho proteins such as CDC42, RAC1 and RHOA in aninactive cytosolic pool, regulating their stability and protectingthem from degradation. Actively involved in the recycling anddistribution of activated Rho GTPases in the cell, mediatesextraction from membranes of both inactive and activated moleculesdue its exceptionally high affinity for prenylated forms. Throughthe modulation of Rho proteins, may play a role in cell motilityregulation. In glioma cells, inhibits cell migration and invasionby mediating the signals of SEMA5A and PLXNB3 that lead toinactivation of RAC1. {ECO:0000269|PubMed:20400958,ECO:0000269|PubMed:23434736}. | Tyrosine-protein kinase that plays an essential role ascell surface receptor for neuregulins. Binds to neuregulin-1(NRG1) and is activated by it; ligand-binding increasesphosphorylation on tyrosine residues and promotes its associationwith the p85 subunit of phosphatidylinositol 3-kinase(PubMed:20682778). May also be activated by CSPG5(PubMed:15358134). {ECO:0000269|PubMed:15358134,ECO:0000269|PubMed:20682778}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ARHGDIA_ERBB3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ARHGDIA_ERBB3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ARHGDIA | RHOA, RAC1, RHOC, CDC42, EIF2B1, DHX9, IGF2BP1, HNRNPAB, EWSR1, HNRNPA3, BID, TNFRSF10B, EZR, FADD, FASLG, MAPK8, MSN, CASP10, CASP8, FAS, TNFRSF1A, ACTL6A, CDKN1B, NEDD4L, SH3GL3, JUP, FEN1, RDX, RHOH, ARHGDIA, RAC2, RHOG, RAC3, BAK1, UBE2R2, CBX5, SDHC, MAPK6, TRIM13, UBE2L6, UFM1, HERPUD1, HAAO, TWF2, XIAP, ESR1, SIRT7, TERF1, TINF2, POT1, CUL3, CDK2, PSMD10, ATXN3, PIR, CASP3, CASP7, ADRB2, IKBKG, CUL7, CCDC8, ALDOA, AHNAK, ALDOC, ASS1, COMMD4, COTL1, DUT, ENO2, HSD17B10, HSPB1, IMPA1, IMPA2, ISYNA1, PCNA, PLS3, RAB11A, RAP1A, TXN, UCHL3, FAM98B, GDI1, HINT1, NPEPL1, PDIA3, PFKM, PFKP, SUMO3, SUMO4, NTRK1, U2AF2, STOM, ANKRD13A, PRRC2B, EIF2B4, FBXW7, UBE2I, EP300, KAT2B, SIRT2, HDAC6 | ERBB3 | GRB2, PIK3R2, CSK, SHC1, CD82, RGS4, ODF2L, GRB7, PA2G4, EGF, RNF41, NRG1, PIK3R1, IL6ST, PTK6, EGFR, MUC1, NRG2, ERBB2, RPN1, EGR1, ZNF207, HDAC6, LRIG1, MDM2, AKT1, PTPN11, HSP90AA1, NCK2, JAK2, SH2D1A, DAB1, ABL1, HCK, FGFR1, SRC, NCK1, FER, PLCG1, RASA1, TXK, ABL2, ZAP70, SYK, CRK, CRKL, JAK3, VAV2, CHN2, ITK, RIN1, BCAR3, TENC1, TNS3, TNS4, SHC3, PIK3R3, VAV1, VAV3, DAPP1, SH2B3, NEDD4, HLA-DPA1, UQCR10, B3GALTL, PDF, TUBA4A, TUBB8, HLA-A, YBEY, SLC31A1, EIF1AX, SRPK2, HLA-B, SLC25A5, SLC25A6, AIFM1, ANXA2, AP1M2, ATP5A1, B2M, C1QBP, CANX, CDC37, DNAJB11, DNAJA1, TUFM, ERBB3, GFAP, HSPA5, HNRNPH1, HNRNPH2, HNRNPF, HSP90AB1, HSPA8, LGALS3BP, MASP1, PHLDA1, PIK3CA, PIK3CB, PTCD3, RAE1, RPL23, RPS27, RPS27A, RPS27L, MRPS14, MRPS17, MRPS23, MRPS27, MRPS28, S100A10, SSR1, TUBB, ACTA2, ACTB, ACTBL2, POTEKP, ACTC1, ACTG1, ACTG2, ACTA1, HBA1, HBB, HBD, HBE1, HBG1, HBG2, HNRNPH3, HSPA1A, LRPPRC, PON2, POTEE, POTEF, HNRNPA2B1, HNRNPAB, MRPS18B, MRPS22, MRPS25, MRPS26, MRPS34, TUBA1B, PCGF1, DPPA4, NANOG, POU5F1, EPN1, L1CAM, MET, NEDD4L, PTK2B, NDRG1, CDH1, PTPRH, UQCRH, PPM1A, PPM1B, PPM1F, PPM1K, PPM1M, ILKAP, PTPRR, PTPN6, PTPN7, PTPN12, PTPN20B, DUSP14, DUSP18, DUSP19, DUSP21, DUPD1, STYX, PTPDC1, PTEN, TPTE, MTMR1, MTMR2, MTMR6, MTMR8, MTMR9, MTMR10, CDC25C, EYA4, CSPG5, HGS |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARHGDIA_ERBB3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARHGDIA_ERBB3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ARHGDIA | C0019693 | HIV Infections | 1 | CTD_human |
Hgene | ARHGDIA | C0022548 | Keloid | 1 | CTD_human |
Hgene | ARHGDIA | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Hgene | ARHGDIA | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | ERBB3 | C0036341 | Schizophrenia | 3 | PSYGENET |
Tgene | ERBB3 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | ERBB3 | C0011570 | Mental Depression | 1 | PSYGENET |
Tgene | ERBB3 | C0016978 | gallbladder neoplasm | 1 | CTD_human |
Tgene | ERBB3 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Tgene | ERBB3 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | ERBB3 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | ERBB3 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Tgene | ERBB3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | ERBB3 | C2931822 | Nasopharyngeal carcinoma | 1 | CTD_human |