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Fusion gene ID: 24868 |
FusionGeneSummary for NRK_NRK |
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Fusion gene information | Fusion gene name: NRK_NRK | Fusion gene ID: 24868 | Hgene | Tgene | Gene symbol | NRK | NRK | Gene ID | 203447 | 203447 |
Gene name | Nik related kinase | Nik related kinase | |
Synonyms | NESK | NESK | |
Cytomap | Xq22.3 | Xq22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | nik-related protein kinase | nik-related protein kinase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q7Z2Y5 | Q7Z2Y5 | |
Ensembl transtripts involved in fusion gene | ENST00000428173, ENST00000243300, ENST00000536164, ENST00000540278, | ENST00000428173, ENST00000243300, ENST00000536164, ENST00000540278, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
# samples | 1 | 1 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: NRK [Title/Abstract] AND NRK [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AL036710 | NRK | chrX | 105109866 | - | NRK | chrX | 105109300 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000428173 | ENST00000428173 | NRK | chrX | 105109866 | - | NRK | chrX | 105109300 | + |
intron-intron | ENST00000428173 | ENST00000243300 | NRK | chrX | 105109866 | - | NRK | chrX | 105109300 | + |
intron-intron | ENST00000428173 | ENST00000536164 | NRK | chrX | 105109866 | - | NRK | chrX | 105109300 | + |
intron-intron | ENST00000428173 | ENST00000540278 | NRK | chrX | 105109866 | - | NRK | chrX | 105109300 | + |
intron-intron | ENST00000243300 | ENST00000428173 | NRK | chrX | 105109866 | - | NRK | chrX | 105109300 | + |
intron-intron | ENST00000243300 | ENST00000243300 | NRK | chrX | 105109866 | - | NRK | chrX | 105109300 | + |
intron-intron | ENST00000243300 | ENST00000536164 | NRK | chrX | 105109866 | - | NRK | chrX | 105109300 | + |
intron-intron | ENST00000243300 | ENST00000540278 | NRK | chrX | 105109866 | - | NRK | chrX | 105109300 | + |
intron-intron | ENST00000536164 | ENST00000428173 | NRK | chrX | 105109866 | - | NRK | chrX | 105109300 | + |
intron-intron | ENST00000536164 | ENST00000243300 | NRK | chrX | 105109866 | - | NRK | chrX | 105109300 | + |
intron-intron | ENST00000536164 | ENST00000536164 | NRK | chrX | 105109866 | - | NRK | chrX | 105109300 | + |
intron-intron | ENST00000536164 | ENST00000540278 | NRK | chrX | 105109866 | - | NRK | chrX | 105109300 | + |
intron-intron | ENST00000540278 | ENST00000428173 | NRK | chrX | 105109866 | - | NRK | chrX | 105109300 | + |
intron-intron | ENST00000540278 | ENST00000243300 | NRK | chrX | 105109866 | - | NRK | chrX | 105109300 | + |
intron-intron | ENST00000540278 | ENST00000536164 | NRK | chrX | 105109866 | - | NRK | chrX | 105109300 | + |
intron-intron | ENST00000540278 | ENST00000540278 | NRK | chrX | 105109866 | - | NRK | chrX | 105109300 | + |
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FusionProtFeatures for NRK_NRK |
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Hgene | Tgene |
NRK | NRK |
May phosphorylate cofilin-1 and induce actinpolymerization through this process, during the late stages ofembryogenesis. Involved in the TNF-alpha-induced signaling pathway(By similarity). {ECO:0000250}. | May phosphorylate cofilin-1 and induce actinpolymerization through this process, during the late stages ofembryogenesis. Involved in the TNF-alpha-induced signaling pathway(By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NRK_NRK |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NRK_NRK |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NRK_NRK |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NRK_NRK |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |