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Fusion gene ID: 24864 |
FusionGeneSummary for NRIP1_IGSF8 |
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Fusion gene information | Fusion gene name: NRIP1_IGSF8 | Fusion gene ID: 24864 | Hgene | Tgene | Gene symbol | NRIP1 | IGSF8 | Gene ID | 8204 | 93185 |
Gene name | nuclear receptor interacting protein 1 | immunoglobulin superfamily member 8 | |
Synonyms | RIP140 | CD316|CD81P3|EWI-2|EWI2|KCT-4|LIR-D1|PGRL | |
Cytomap | 21q11.2-q21.1 | 1q23.2 | |
Type of gene | protein-coding | protein-coding | |
Description | nuclear receptor-interacting protein 1nuclear factor RIP140receptor-interacting protein 140 | immunoglobulin superfamily member 8CD81 partner 3glu-Trp-Ile EWI motif-containing protein 2keratinocytes-associated transmembrane protein 4prostaglandin regulatory-like protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P48552 | Q969P0 | |
Ensembl transtripts involved in fusion gene | ENST00000318948, ENST00000400199, ENST00000400202, | ENST00000314485, ENST00000368086, ENST00000460351, | |
Fusion gene scores | * DoF score | 10 X 3 X 7=210 | 7 X 4 X 7=196 |
# samples | 10 | 7 | |
** MAII score | log2(10/210*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NRIP1 [Title/Abstract] AND IGSF8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NRIP1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10364267 |
Hgene | NRIP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 7641693|10364267 |
Hgene | NRIP1 | GO:0071392 | cellular response to estradiol stimulus | 15831516 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | MESO | TCGA-TS-A7OZ-01A | NRIP1 | chr21 | 16386665 | - | IGSF8 | chr1 | 160062485 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000318948 | ENST00000314485 | NRIP1 | chr21 | 16386665 | - | IGSF8 | chr1 | 160062485 | - |
5UTR-3CDS | ENST00000318948 | ENST00000368086 | NRIP1 | chr21 | 16386665 | - | IGSF8 | chr1 | 160062485 | - |
5UTR-intron | ENST00000318948 | ENST00000460351 | NRIP1 | chr21 | 16386665 | - | IGSF8 | chr1 | 160062485 | - |
intron-3CDS | ENST00000400199 | ENST00000314485 | NRIP1 | chr21 | 16386665 | - | IGSF8 | chr1 | 160062485 | - |
intron-3CDS | ENST00000400199 | ENST00000368086 | NRIP1 | chr21 | 16386665 | - | IGSF8 | chr1 | 160062485 | - |
intron-intron | ENST00000400199 | ENST00000460351 | NRIP1 | chr21 | 16386665 | - | IGSF8 | chr1 | 160062485 | - |
5UTR-3CDS | ENST00000400202 | ENST00000314485 | NRIP1 | chr21 | 16386665 | - | IGSF8 | chr1 | 160062485 | - |
5UTR-3CDS | ENST00000400202 | ENST00000368086 | NRIP1 | chr21 | 16386665 | - | IGSF8 | chr1 | 160062485 | - |
5UTR-intron | ENST00000400202 | ENST00000460351 | NRIP1 | chr21 | 16386665 | - | IGSF8 | chr1 | 160062485 | - |
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FusionProtFeatures for NRIP1_IGSF8 |
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Hgene | Tgene |
NRIP1 | IGSF8 |
Modulates transcriptional activation by steroidreceptors such as NR3C1, NR3C2 and ESR1. Also modulatestranscriptional repression by nuclear hormone receptors. Positiveregulator of the circadian clock gene expression: stimulatestranscription of ARNTL/BMAL1, CLOCK and CRY1 by acting as acoactivator for RORA and RORC. {ECO:0000269|PubMed:10364267,ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808,ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175,ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:7641693}. | May play a key role in diverse functions ascribed toCD81 and CD9 such as oocytes fertilization or hepatitis C virusfunction. May regulate proliferation and differentiation ofkeratinocytes. May be a negative regulator of cell motility:suppresses T-cell mobility coordinately with CD81, associates withCD82 to suppress prostate cancer cell migration, regulatesepidermoid cell reaggregation and motility on laminin-5 with CD9and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate inthe regulation of neurite outgrowth and maintenance of the neuralnetwork in the adult brain. {ECO:0000269|PubMed:11504738,ECO:0000269|PubMed:12750295, ECO:0000269|PubMed:12752121,ECO:0000269|PubMed:14662754, ECO:0000269|PubMed:15070678}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NRIP1_IGSF8 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NRIP1_IGSF8 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NRIP1 | NR5A1, NR0B1, LDOC1, TEX11, CEP70, CTBP2, TRAF2, CCDC85B, CTBP1, HDAC5, RARA, NR3C1, YWHAQ, RXRA, ESR1, AHR, PPARA, PPARG, THRA, RXRB, JUN, PRMT1, HDAC3, CARM1, XPO1, KPNB1, ESRRA, ESRRB, ESRRG, ESR2, E2F1, ACTN2, CIB1, NR1H2, THRB, RORB, NR1H3, VDR, HNF4A, NR5A2, ELAVL1, CDK8, NR3C2, APP, FHL1, DNMT1, DNMT3A, DNMT3B, PPARGC1A, ARPC3, BRCA1, MAGEA10, HDAC1, HDAC2 | IGSF8 | CD82, CD9, CD81, A2M, ACTN1, FLNA, NCL, AKT1, MSN, ACTN4, CFL1, ACTN2, MYH3, CFL2, FLNC, CSNK2A1, SERPINB9, IBTK, CCT3, CCT4, HIST1H1D, HIST1H1C, HIST1H1E, HIST1H2BD, HIST1H2BJ, HIST1H2BK, HIST1H2BH, HIST1H2BO, HIST1H2BL, HIST1H2BM, HIST1H2BN, HIST1H1A, HIST1H2BB, HIST1H2BE, HIST2H2BF, HIST1H3E, HIST3H3, HIST2H3C, H3F3B, RBBP4, HIST1H2BA, PKM, FTH1, PDIA6, FTL, EIF3A, XRCC6, DDX17, XRCC5, HNRNPU, SYNCRIP, SART3, EIF3L, PABPC1, EIF3B, EIF3C, EIF3CL, SUPT16H, HNRNPA2B1, YBX1, DHX15, HNRNPA1, SET, EIF3F, PRPF8, HNRNPK, NPM1, YBX3, EIF3E, HNRNPH1, ILF3, DDX3X, DDX5, MCM5, ILF2, ANP32B, EEF1A2, EIF3I, HNRNPD, EEF1G, HNRNPA3, SNRPD3, PDCD4, EIF3H, SNRPD1, SRSF3, PURA, YBX2, EEF1D, HNRNPM, DDX3Y, IFI16, SRP14, SNRPB, ALYREF, EIF3G, EIF3K, EEF1B2, SF3B3, TCOF1, SNRPA1, LSM3, IKBKAP, CAPRIN1, PCBP2, SRSF8, TUBB, TUBA1A, TUBA1B, TUBB4A, TUBA4A, TUBB7P, TUBB6, TUBA8, TUBE1, VPS35, RPS4X, RPS9, RPS18, RPL7A, RPS19, RPLP0, RPS3, RPL12, RPL6, RPS25, RPS8, RPLP2, RPS16, RPS2, RPS3A, RPL18, RPL4, RPL22, RPL27, RPS13, RPS4Y1, RPL30, RPS14, RPL5, RPL23A, RPL27A, RPL31, RPS6, RPL11, FAU, RPL13, RPL17, RPL8, RPL26L1, RPL35A, RPL35, RPL13A, RPL26, RPS15, RPL19, RPL9, RPS23, RPL24, RPL36, RPS28, RPS26P11, FBXO6, KRTAP10-4, KRTAP10-7, KRTAP10-9, KRTAP10-8, KRTAP10-3, EIF2B5, HADHB, TMEM160, EIF2B4, TBRG4, DNM3, EIF2B2, DNAJC14, ADPRHL2, DNAH14, HBD, HBA2, DAGLB, OCLN, MBLAC2, KRTAP4-12, GDPD5, TMX1, TMEM30B, CD19, EFNB3, RFX3, MMRN1, TMX4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NRIP1_IGSF8 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NRIP1_IGSF8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NRIP1 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
Hgene | NRIP1 | C0018801 | Heart failure | 1 | CTD_human |
Hgene | NRIP1 | C0027051 | Myocardial Infarction | 1 | CTD_human |
Hgene | NRIP1 | C0036341 | Schizophrenia | 1 | CTD_human |
Hgene | NRIP1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |