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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24862

FusionGeneSummary for NRIP1_GDPD1

check button Fusion gene summary
Fusion gene informationFusion gene name: NRIP1_GDPD1
Fusion gene ID: 24862
HgeneTgene
Gene symbol

NRIP1

GDPD1

Gene ID

8204

284161

Gene namenuclear receptor interacting protein 1glycerophosphodiester phosphodiesterase domain containing 1
SynonymsRIP140GDE4
Cytomap

21q11.2-q21.1

17q22

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor-interacting protein 1nuclear factor RIP140receptor-interacting protein 140lysophospholipase D GDPD1glycerophosphodiester phosphodiesterase 4glycerophosphodiester phosphodiesterase domain-containing protein 1
Modification date2018052320180519
UniProtAcc

P48552

Q8N9F7

Ensembl transtripts involved in fusion geneENST00000318948, ENST00000400199, 
ENST00000400202, 
ENST00000284116, 
ENST00000581140, ENST00000581276, 
Fusion gene scores* DoF score10 X 3 X 7=2104 X 3 X 3=36
# samples 104
** MAII scorelog2(10/210*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NRIP1 [Title/Abstract] AND GDPD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNRIP1

GO:0000122

negative regulation of transcription by RNA polymerase II

10364267

HgeneNRIP1

GO:0045944

positive regulation of transcription by RNA polymerase II

7641693|10364267

HgeneNRIP1

GO:0071392

cellular response to estradiol stimulus

15831516


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDHNSCTCGA-BA-A8YP-01ANRIP1chr21

16437066

-GDPD1chr17

57322775

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000318948ENST00000284116NRIP1chr21

16437066

-GDPD1chr17

57322775

+
5UTR-3CDSENST00000318948ENST00000581140NRIP1chr21

16437066

-GDPD1chr17

57322775

+
5UTR-3CDSENST00000318948ENST00000581276NRIP1chr21

16437066

-GDPD1chr17

57322775

+
5UTR-3CDSENST00000400199ENST00000284116NRIP1chr21

16437066

-GDPD1chr17

57322775

+
5UTR-3CDSENST00000400199ENST00000581140NRIP1chr21

16437066

-GDPD1chr17

57322775

+
5UTR-3CDSENST00000400199ENST00000581276NRIP1chr21

16437066

-GDPD1chr17

57322775

+
5UTR-3CDSENST00000400202ENST00000284116NRIP1chr21

16437066

-GDPD1chr17

57322775

+
5UTR-3CDSENST00000400202ENST00000581140NRIP1chr21

16437066

-GDPD1chr17

57322775

+
5UTR-3CDSENST00000400202ENST00000581276NRIP1chr21

16437066

-GDPD1chr17

57322775

+

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FusionProtFeatures for NRIP1_GDPD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NRIP1

P48552

GDPD1

Q8N9F7

Modulates transcriptional activation by steroidreceptors such as NR3C1, NR3C2 and ESR1. Also modulatestranscriptional repression by nuclear hormone receptors. Positiveregulator of the circadian clock gene expression: stimulatestranscription of ARNTL/BMAL1, CLOCK and CRY1 by acting as acoactivator for RORA and RORC. {ECO:0000269|PubMed:10364267,ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808,ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175,ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:7641693}. Hydrolyzes lysoglycerophospholipids to producelysophosphatidic acid (LPA) and the corresponding amines. Shows apreference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF),lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine(lyso-PC). May be involved in bioactive N-acylethanolaminebiosynthesis. Does not display glycerophosphodiesterphosphodiesterase activity, since it cannot hydrolyze eitherglycerophosphoinositol or glycerophosphocholine.{ECO:0000250|UniProtKB:Q9CRY7}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NRIP1_GDPD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NRIP1_GDPD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NRIP1NR5A1, NR0B1, LDOC1, TEX11, CEP70, CTBP2, TRAF2, CCDC85B, CTBP1, HDAC5, RARA, NR3C1, YWHAQ, RXRA, ESR1, AHR, PPARA, PPARG, THRA, RXRB, JUN, PRMT1, HDAC3, CARM1, XPO1, KPNB1, ESRRA, ESRRB, ESRRG, ESR2, E2F1, ACTN2, CIB1, NR1H2, THRB, RORB, NR1H3, VDR, HNF4A, NR5A2, ELAVL1, CDK8, NR3C2, APP, FHL1, DNMT1, DNMT3A, DNMT3B, PPARGC1A, ARPC3, BRCA1, MAGEA10, HDAC1, HDAC2GDPD1TSPAN5, TF, C3, ALB, SERPINA3, ITIH2, APOA1, A2M, IGHG2, IGHG1, APOA4, CP, HP, SERPINA1, CFB, HBD, HBB, APOA2, HBA2, AHSG, HPX, A1BG, C4A, ORM2, ORM1, IGHA1, KNG1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NRIP1_GDPD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NRIP1_GDPD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNRIP1C0014170Endometrial Neoplasms1CTD_human
HgeneNRIP1C0018801Heart failure1CTD_human
HgeneNRIP1C0027051Myocardial Infarction1CTD_human
HgeneNRIP1C0036341Schizophrenia1CTD_human
HgeneNRIP1C1458155Mammary Neoplasms1CTD_human