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Fusion gene ID: 24860 |
FusionGeneSummary for NRIP1_DECR1 |
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Fusion gene information | Fusion gene name: NRIP1_DECR1 | Fusion gene ID: 24860 | Hgene | Tgene | Gene symbol | NRIP1 | DECR1 | Gene ID | 8204 | 1666 |
Gene name | nuclear receptor interacting protein 1 | 2,4-dienoyl-CoA reductase 1 | |
Synonyms | RIP140 | DECR|NADPH|SDR18C1 | |
Cytomap | 21q11.2-q21.1 | 8q21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | nuclear receptor-interacting protein 1nuclear factor RIP140receptor-interacting protein 140 | 2,4-dienoyl-CoA reductase, mitochondrial2,4-dienoyl-CoA reductase 1, mitochondrial4-enoyl-CoA reductaseshort chain dehydrogenase/reductase family 18C member 1 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P48552 | Q16698 | |
Ensembl transtripts involved in fusion gene | ENST00000318948, ENST00000400199, ENST00000400202, | ENST00000220764, ENST00000519007, ENST00000522161, | |
Fusion gene scores | * DoF score | 10 X 3 X 7=210 | 5 X 5 X 7=175 |
# samples | 10 | 8 | |
** MAII score | log2(10/210*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/175*10)=-1.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NRIP1 [Title/Abstract] AND DECR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NRIP1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10364267 |
Hgene | NRIP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 7641693|10364267 |
Hgene | NRIP1 | GO:0071392 | cellular response to estradiol stimulus | 15831516 |
Tgene | DECR1 | GO:0006635 | fatty acid beta-oxidation | 15531764 |
Tgene | DECR1 | GO:0051289 | protein homotetramerization | 15531764 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BLCA | TCGA-ZF-AA5P-01A | NRIP1 | chr21 | 16386665 | - | DECR1 | chr8 | 91054956 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000318948 | ENST00000220764 | NRIP1 | chr21 | 16386665 | - | DECR1 | chr8 | 91054956 | + |
5UTR-intron | ENST00000318948 | ENST00000519007 | NRIP1 | chr21 | 16386665 | - | DECR1 | chr8 | 91054956 | + |
5UTR-intron | ENST00000318948 | ENST00000522161 | NRIP1 | chr21 | 16386665 | - | DECR1 | chr8 | 91054956 | + |
intron-3CDS | ENST00000400199 | ENST00000220764 | NRIP1 | chr21 | 16386665 | - | DECR1 | chr8 | 91054956 | + |
intron-intron | ENST00000400199 | ENST00000519007 | NRIP1 | chr21 | 16386665 | - | DECR1 | chr8 | 91054956 | + |
intron-intron | ENST00000400199 | ENST00000522161 | NRIP1 | chr21 | 16386665 | - | DECR1 | chr8 | 91054956 | + |
5UTR-3CDS | ENST00000400202 | ENST00000220764 | NRIP1 | chr21 | 16386665 | - | DECR1 | chr8 | 91054956 | + |
5UTR-intron | ENST00000400202 | ENST00000519007 | NRIP1 | chr21 | 16386665 | - | DECR1 | chr8 | 91054956 | + |
5UTR-intron | ENST00000400202 | ENST00000522161 | NRIP1 | chr21 | 16386665 | - | DECR1 | chr8 | 91054956 | + |
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FusionProtFeatures for NRIP1_DECR1 |
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Hgene | Tgene |
NRIP1 | DECR1 |
Modulates transcriptional activation by steroidreceptors such as NR3C1, NR3C2 and ESR1. Also modulatestranscriptional repression by nuclear hormone receptors. Positiveregulator of the circadian clock gene expression: stimulatestranscription of ARNTL/BMAL1, CLOCK and CRY1 by acting as acoactivator for RORA and RORC. {ECO:0000269|PubMed:10364267,ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808,ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175,ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:7641693}. | Auxiliary enzyme of beta-oxidation. It participates inthe metabolism of unsaturated fatty enoyl-CoA esters having doublebonds in both even- and odd-numbered positions. Catalyzes theNADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NRIP1_DECR1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NRIP1_DECR1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NRIP1 | NR5A1, NR0B1, LDOC1, TEX11, CEP70, CTBP2, TRAF2, CCDC85B, CTBP1, HDAC5, RARA, NR3C1, YWHAQ, RXRA, ESR1, AHR, PPARA, PPARG, THRA, RXRB, JUN, PRMT1, HDAC3, CARM1, XPO1, KPNB1, ESRRA, ESRRB, ESRRG, ESR2, E2F1, ACTN2, CIB1, NR1H2, THRB, RORB, NR1H3, VDR, HNF4A, NR5A2, ELAVL1, CDK8, NR3C2, APP, FHL1, DNMT1, DNMT3A, DNMT3B, PPARGC1A, ARPC3, BRCA1, MAGEA10, HDAC1, HDAC2 | DECR1 | HGS, PTTG1, APP, ESR1, FN1, VCAM1, ITGA4, SHMT2, NXF1, NDUFA10, CREB3, ECSIT, NTRK1, HSD17B4, AK1, MSH6, JAK3, KIF11, NPM1, RPL10, BAIAP2, NOP56, GEMIN5, C10orf12, CCDC22, EXOSC5, NLRP5, NF2, FAM118B, CHMP2A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NRIP1_DECR1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NRIP1_DECR1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NRIP1 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
Hgene | NRIP1 | C0018801 | Heart failure | 1 | CTD_human |
Hgene | NRIP1 | C0027051 | Myocardial Infarction | 1 | CTD_human |
Hgene | NRIP1 | C0036341 | Schizophrenia | 1 | CTD_human |
Hgene | NRIP1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | DECR1 | C0009171 | Cocaine Abuse | 1 | PSYGENET |
Tgene | DECR1 | C0023772 | Lipid Metabolism, Inborn Errors | 1 | CTD_human |
Tgene | DECR1 | C1857252 | 2,4-Dienoyl-CoA Reductase Deficiency | 1 | CTD_human |