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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24843

FusionGeneSummary for NRF1_RHEB

check button Fusion gene summary
Fusion gene informationFusion gene name: NRF1_RHEB
Fusion gene ID: 24843
HgeneTgene
Gene symbol

NRF1

RHEB

Gene ID

4899

6009

Gene namenuclear respiratory factor 1Ras homolog, mTORC1 binding
SynonymsALPHA-PALRHEB2
Cytomap

7q32.2

7q36.1

Type of geneprotein-codingprotein-coding
Descriptionnuclear respiratory factor 1alpha palindromic-binding proteinGTP-binding protein RhebRas homolog enriched in brain 2
Modification date2018052320180527
UniProtAcc

Q16656

Q15382

Ensembl transtripts involved in fusion geneENST00000393232, ENST00000353868, 
ENST00000539636, ENST00000311967, 
ENST00000223190, ENST00000393230, 
ENST00000393231, ENST00000477428, 
ENST00000262187, ENST00000472642, 
ENST00000496004, 
Fusion gene scores* DoF score8 X 5 X 4=1605 X 5 X 4=100
# samples 85
** MAII scorelog2(8/160*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NRF1 [Title/Abstract] AND RHEB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-D3-A3C3-06ANRF1chr7

129357216

+RHEBchr7

151181890

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000393232ENST00000262187NRF1chr7

129357216

+RHEBchr7

151181890

-
5CDS-5UTRENST00000393232ENST00000472642NRF1chr7

129357216

+RHEBchr7

151181890

-
5CDS-5UTRENST00000393232ENST00000496004NRF1chr7

129357216

+RHEBchr7

151181890

-
Frame-shiftENST00000353868ENST00000262187NRF1chr7

129357216

+RHEBchr7

151181890

-
5CDS-5UTRENST00000353868ENST00000472642NRF1chr7

129357216

+RHEBchr7

151181890

-
5CDS-5UTRENST00000353868ENST00000496004NRF1chr7

129357216

+RHEBchr7

151181890

-
Frame-shiftENST00000539636ENST00000262187NRF1chr7

129357216

+RHEBchr7

151181890

-
5CDS-5UTRENST00000539636ENST00000472642NRF1chr7

129357216

+RHEBchr7

151181890

-
5CDS-5UTRENST00000539636ENST00000496004NRF1chr7

129357216

+RHEBchr7

151181890

-
Frame-shiftENST00000311967ENST00000262187NRF1chr7

129357216

+RHEBchr7

151181890

-
5CDS-5UTRENST00000311967ENST00000472642NRF1chr7

129357216

+RHEBchr7

151181890

-
5CDS-5UTRENST00000311967ENST00000496004NRF1chr7

129357216

+RHEBchr7

151181890

-
Frame-shiftENST00000223190ENST00000262187NRF1chr7

129357216

+RHEBchr7

151181890

-
5CDS-5UTRENST00000223190ENST00000472642NRF1chr7

129357216

+RHEBchr7

151181890

-
5CDS-5UTRENST00000223190ENST00000496004NRF1chr7

129357216

+RHEBchr7

151181890

-
Frame-shiftENST00000393230ENST00000262187NRF1chr7

129357216

+RHEBchr7

151181890

-
5CDS-5UTRENST00000393230ENST00000472642NRF1chr7

129357216

+RHEBchr7

151181890

-
5CDS-5UTRENST00000393230ENST00000496004NRF1chr7

129357216

+RHEBchr7

151181890

-
Frame-shiftENST00000393231ENST00000262187NRF1chr7

129357216

+RHEBchr7

151181890

-
5CDS-5UTRENST00000393231ENST00000472642NRF1chr7

129357216

+RHEBchr7

151181890

-
5CDS-5UTRENST00000393231ENST00000496004NRF1chr7

129357216

+RHEBchr7

151181890

-
intron-3CDSENST00000477428ENST00000262187NRF1chr7

129357216

+RHEBchr7

151181890

-
intron-5UTRENST00000477428ENST00000472642NRF1chr7

129357216

+RHEBchr7

151181890

-
intron-5UTRENST00000477428ENST00000496004NRF1chr7

129357216

+RHEBchr7

151181890

-

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FusionProtFeatures for NRF1_RHEB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NRF1

Q16656

RHEB

Q15382

Transcription factor that activates the expression ofthe EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulationof key metabolic genes to cellular growth and development.Implicated in the control of nuclear genes required forrespiration, heme biosynthesis, and mitochondrial DNAtranscription and replication. Activates the protein kinase activity of mTORC1, andthereby plays a role in the regulation of apoptosis. Stimulatesthe phosphorylation of S6K1 and EIF4EBP1 through activation ofmTORC1 signaling. Has low intrinsic GTPase activity.{ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12869586,ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:15854902,ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:20381137}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NRF1_RHEB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NRF1_RHEB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NRF1DYNLL1, MAFF, PPARGC1A, PPRC1, PARP1, CEBPB, CSNK2A1, CSNK2B, FHL2, SP4, TRAF2, POGZ, PLXDC1, FOXJ2, FOXK2, FOXP3, WDR59, DYNLL2RHEBTSC2, PDE6D, ATM, ATR, MTOR, HRAS, RAF1, RAP1A, TSC1, RAB7A, RAB9A, RPTOR, A2M, ECSIT, PSEN2, APOE, PSEN1, BNIP3, BNIP3L, RABAC1, TRAF2, ARIH2, NCAM1, FKBP8, PLD1, RPS6KB1, VPS4A, ITGB8, TNF, LDHB, CREB3, DUSP19, SPATA19, NEDD9, NFATC2IP, RAC1, UBB, IL20RA, LAMP2, SRPRB, SLC15A1, ENPP7, LGALS7, TMEM52B, RELL2, HTT, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NRF1_RHEB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NRF1_RHEB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNRF1C0006079Bowen's Disease1CTD_human
TgeneRHEBC0007131Non-Small Cell Lung Carcinoma1CTD_human