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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24842

FusionGeneSummary for NRF1_PPP2R5A

check button Fusion gene summary
Fusion gene informationFusion gene name: NRF1_PPP2R5A
Fusion gene ID: 24842
HgeneTgene
Gene symbol

NRF1

PPP2R5A

Gene ID

4899

5525

Gene namenuclear respiratory factor 1protein phosphatase 2 regulatory subunit B'alpha
SynonymsALPHA-PALB56A|B56alpha|PR61A
Cytomap

7q32.2

1q32.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear respiratory factor 1alpha palindromic-binding proteinserine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoformPP2A B subunit isoform B'-alphaPP2A B subunit isoform B56-alphaPP2A B subunit isoform PR61-alphaPP2A B subunit isoform R5-alphaPP2A, B subunit, B' alpha isoformPP2A, B su
Modification date2018052320180523
UniProtAcc

Q16656

Q15172

Ensembl transtripts involved in fusion geneENST00000393232, ENST00000353868, 
ENST00000539636, ENST00000311967, 
ENST00000223190, ENST00000393230, 
ENST00000393231, ENST00000477428, 
ENST00000261461, ENST00000537030, 
ENST00000498129, 
Fusion gene scores* DoF score8 X 5 X 4=1602 X 2 X 1=4
# samples 82
** MAII scorelog2(8/160*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: NRF1 [Title/Abstract] AND PPP2R5A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPP2R5A

GO:0006470

protein dephosphorylation

24157919


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-YL-A8HL-01ANRF1chr7

129357216

+PPP2R5Achr1

212502477

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000393232ENST00000261461NRF1chr7

129357216

+PPP2R5Achr1

212502477

+
Frame-shiftENST00000393232ENST00000537030NRF1chr7

129357216

+PPP2R5Achr1

212502477

+
5CDS-3UTRENST00000393232ENST00000498129NRF1chr7

129357216

+PPP2R5Achr1

212502477

+
Frame-shiftENST00000353868ENST00000261461NRF1chr7

129357216

+PPP2R5Achr1

212502477

+
Frame-shiftENST00000353868ENST00000537030NRF1chr7

129357216

+PPP2R5Achr1

212502477

+
5CDS-3UTRENST00000353868ENST00000498129NRF1chr7

129357216

+PPP2R5Achr1

212502477

+
Frame-shiftENST00000539636ENST00000261461NRF1chr7

129357216

+PPP2R5Achr1

212502477

+
Frame-shiftENST00000539636ENST00000537030NRF1chr7

129357216

+PPP2R5Achr1

212502477

+
5CDS-3UTRENST00000539636ENST00000498129NRF1chr7

129357216

+PPP2R5Achr1

212502477

+
Frame-shiftENST00000311967ENST00000261461NRF1chr7

129357216

+PPP2R5Achr1

212502477

+
Frame-shiftENST00000311967ENST00000537030NRF1chr7

129357216

+PPP2R5Achr1

212502477

+
5CDS-3UTRENST00000311967ENST00000498129NRF1chr7

129357216

+PPP2R5Achr1

212502477

+
Frame-shiftENST00000223190ENST00000261461NRF1chr7

129357216

+PPP2R5Achr1

212502477

+
Frame-shiftENST00000223190ENST00000537030NRF1chr7

129357216

+PPP2R5Achr1

212502477

+
5CDS-3UTRENST00000223190ENST00000498129NRF1chr7

129357216

+PPP2R5Achr1

212502477

+
Frame-shiftENST00000393230ENST00000261461NRF1chr7

129357216

+PPP2R5Achr1

212502477

+
Frame-shiftENST00000393230ENST00000537030NRF1chr7

129357216

+PPP2R5Achr1

212502477

+
5CDS-3UTRENST00000393230ENST00000498129NRF1chr7

129357216

+PPP2R5Achr1

212502477

+
Frame-shiftENST00000393231ENST00000261461NRF1chr7

129357216

+PPP2R5Achr1

212502477

+
Frame-shiftENST00000393231ENST00000537030NRF1chr7

129357216

+PPP2R5Achr1

212502477

+
5CDS-3UTRENST00000393231ENST00000498129NRF1chr7

129357216

+PPP2R5Achr1

212502477

+
intron-3CDSENST00000477428ENST00000261461NRF1chr7

129357216

+PPP2R5Achr1

212502477

+
intron-3CDSENST00000477428ENST00000537030NRF1chr7

129357216

+PPP2R5Achr1

212502477

+
intron-3UTRENST00000477428ENST00000498129NRF1chr7

129357216

+PPP2R5Achr1

212502477

+

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FusionProtFeatures for NRF1_PPP2R5A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NRF1

Q16656

PPP2R5A

Q15172

Transcription factor that activates the expression ofthe EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulationof key metabolic genes to cellular growth and development.Implicated in the control of nuclear genes required forrespiration, heme biosynthesis, and mitochondrial DNAtranscription and replication. The B regulatory subunit might modulate substrateselectivity and catalytic activity, and also might direct thelocalization of the catalytic enzyme to a particular subcellularcompartment.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NRF1_PPP2R5A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NRF1_PPP2R5A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NRF1DYNLL1, MAFF, PPARGC1A, PPRC1, PARP1, CEBPB, CSNK2A1, CSNK2B, FHL2, SP4, TRAF2, POGZ, PLXDC1, FOXJ2, FOXK2, FOXP3, WDR59, DYNLL2PPP2R5AAPC, BCL2, PPP2R5C, EIF2AK2, PPP2CA, PPP2R1A, PPP2R1B, AXIN1, CTLA4, MYC, CHEK2, NEK1, CBX5, ESPL1, PTTG1, PPP2R2D, DAPK1, PPP2CB, MOS, FAM43A, WNT3A, PPP2R5D, CDC20, CDC27, BUB1B, UBE2S, PRR14, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NRF1_PPP2R5A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NRF1_PPP2R5A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNRF1C0006079Bowen's Disease1CTD_human
TgenePPP2R5AC0013990Pathological accumulation of air in tissues1CTD_human