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Fusion gene ID: 24842 |
FusionGeneSummary for NRF1_PPP2R5A |
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Fusion gene information | Fusion gene name: NRF1_PPP2R5A | Fusion gene ID: 24842 | Hgene | Tgene | Gene symbol | NRF1 | PPP2R5A | Gene ID | 4899 | 5525 |
Gene name | nuclear respiratory factor 1 | protein phosphatase 2 regulatory subunit B'alpha | |
Synonyms | ALPHA-PAL | B56A|B56alpha|PR61A | |
Cytomap | 7q32.2 | 1q32.3 | |
Type of gene | protein-coding | protein-coding | |
Description | nuclear respiratory factor 1alpha palindromic-binding protein | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoformPP2A B subunit isoform B'-alphaPP2A B subunit isoform B56-alphaPP2A B subunit isoform PR61-alphaPP2A B subunit isoform R5-alphaPP2A, B subunit, B' alpha isoformPP2A, B su | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q16656 | Q15172 | |
Ensembl transtripts involved in fusion gene | ENST00000393232, ENST00000353868, ENST00000539636, ENST00000311967, ENST00000223190, ENST00000393230, ENST00000393231, ENST00000477428, | ENST00000261461, ENST00000537030, ENST00000498129, | |
Fusion gene scores | * DoF score | 8 X 5 X 4=160 | 2 X 2 X 1=4 |
# samples | 8 | 2 | |
** MAII score | log2(8/160*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: NRF1 [Title/Abstract] AND PPP2R5A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PPP2R5A | GO:0006470 | protein dephosphorylation | 24157919 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-YL-A8HL-01A | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000393232 | ENST00000261461 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
Frame-shift | ENST00000393232 | ENST00000537030 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
5CDS-3UTR | ENST00000393232 | ENST00000498129 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
Frame-shift | ENST00000353868 | ENST00000261461 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
Frame-shift | ENST00000353868 | ENST00000537030 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
5CDS-3UTR | ENST00000353868 | ENST00000498129 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
Frame-shift | ENST00000539636 | ENST00000261461 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
Frame-shift | ENST00000539636 | ENST00000537030 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
5CDS-3UTR | ENST00000539636 | ENST00000498129 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
Frame-shift | ENST00000311967 | ENST00000261461 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
Frame-shift | ENST00000311967 | ENST00000537030 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
5CDS-3UTR | ENST00000311967 | ENST00000498129 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
Frame-shift | ENST00000223190 | ENST00000261461 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
Frame-shift | ENST00000223190 | ENST00000537030 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
5CDS-3UTR | ENST00000223190 | ENST00000498129 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
Frame-shift | ENST00000393230 | ENST00000261461 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
Frame-shift | ENST00000393230 | ENST00000537030 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
5CDS-3UTR | ENST00000393230 | ENST00000498129 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
Frame-shift | ENST00000393231 | ENST00000261461 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
Frame-shift | ENST00000393231 | ENST00000537030 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
5CDS-3UTR | ENST00000393231 | ENST00000498129 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
intron-3CDS | ENST00000477428 | ENST00000261461 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
intron-3CDS | ENST00000477428 | ENST00000537030 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
intron-3UTR | ENST00000477428 | ENST00000498129 | NRF1 | chr7 | 129357216 | + | PPP2R5A | chr1 | 212502477 | + |
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FusionProtFeatures for NRF1_PPP2R5A |
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Hgene | Tgene |
NRF1 | PPP2R5A |
Transcription factor that activates the expression ofthe EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulationof key metabolic genes to cellular growth and development.Implicated in the control of nuclear genes required forrespiration, heme biosynthesis, and mitochondrial DNAtranscription and replication. | The B regulatory subunit might modulate substrateselectivity and catalytic activity, and also might direct thelocalization of the catalytic enzyme to a particular subcellularcompartment. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NRF1_PPP2R5A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NRF1_PPP2R5A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NRF1 | DYNLL1, MAFF, PPARGC1A, PPRC1, PARP1, CEBPB, CSNK2A1, CSNK2B, FHL2, SP4, TRAF2, POGZ, PLXDC1, FOXJ2, FOXK2, FOXP3, WDR59, DYNLL2 | PPP2R5A | APC, BCL2, PPP2R5C, EIF2AK2, PPP2CA, PPP2R1A, PPP2R1B, AXIN1, CTLA4, MYC, CHEK2, NEK1, CBX5, ESPL1, PTTG1, PPP2R2D, DAPK1, PPP2CB, MOS, FAM43A, WNT3A, PPP2R5D, CDC20, CDC27, BUB1B, UBE2S, PRR14, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NRF1_PPP2R5A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NRF1_PPP2R5A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NRF1 | C0006079 | Bowen's Disease | 1 | CTD_human |
Tgene | PPP2R5A | C0013990 | Pathological accumulation of air in tissues | 1 | CTD_human |